Study of structure-hepatoprotective relationships of oleanene-type triterpenoidal glucuronides obtained from several fabaceous plants on rat primary hepatocyte cultures

Biological and Pharmaceutical Bulletin

Volumn 22, Issue 2, 1999, Pages 203-206

  Kinjo, Junei ^a   Udayama, Manabu ^a   Okawa, Masafumi ^a   Nohara, Toshihiro ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Fabaceae; Hepatoprotective activity; Immunological liver injury; Oleanene glucuronide; Primary cultured rat hepatocyte; Triterpenoidal saponin

Indexed keywords

GLUCURONIDE; PLANT EXTRACT; SAPONIN; TRITERPENOID;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; LIVER CELL CULTURE; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; PLANT; RABBIT; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0032949721     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.22.203     Document Type: Article

References (19)

1. Part 7 in the series of studies on hepatoprotective drugs.
2. Safayhi H., Sailer E. R., Planta Medica, 63, 487-493 (1997).
3. Kinjo J., Natural Medicines, 50, 79-85 (1996).
4. Arao T., Udayama M., Kinjo J., Nohara T., Funakoshi T., Kojima S., Biol. Pharm. Bull., 20, 988-991 (1997).
5. a) Shiki Y., Shirai K., Saito Y., Yoshida S., Wakashin M., Kumagai A., Wakan-Iyaku Gakkaishi, 1, 11-14 (1984);
6. b) Kiso Y., Kawakami Y., Kikuchi K., Hikino H., Planta Meidica, 57, 241-247 (1987);
7. c) Higuchi T., Nishida K., Nagamura Y., Honda Y., Ito M., Ishiguro I., Kiso to Rinsho, 26, 257-263 (1992).
8. Kinjo J., Imagire M., Udayama M., Arao T., Nohara T., Planta Medica, 64, 233-236 (1998).
9. Ikeda T., Udayama M., Ohkawa M., Arao T., Kinjo J., Nohara T., Chem. Pharm. Bull., 46, 359-361 (1998).
10. Arao T., Udayama M., Kinjo J., Nohara T., Planta Medica, 64, 413-416 (1998).
11. Kinjo J., Kishida F., Watanabe K., Hashimoto F., Nohara T., Chem. Pharm. Bull.,42, 1874-1878 (1994).
12. Cui B., Sakai Y., Takeshita T., Kinjo J., Nohara T., Chem. Pharm. Bull., 40, 136-138 (1992).
13. Kinjo J., Fujishima Y., Saino K., Tian R., Nohara T., Chem Pharm. Bull., 43, 636-640 (1995).
14. Udayama M., Ohkawa M., Yoshida N., Kinjo J., Nohara T., Chem. Pharm. Bull., 46, 1412-1415 (1998).
15. Nakamura T., Komori C., Lee Y., Hashimoto F., Yahara S., Nohara T., Ejima A., Biol. Pharm. Bull., 19, 564-566 (1996).
16. Shiraki H., Wakan-Iyaku Gaku Zasshi, 12, 24-28 (1995).
17. Hayashi K., Hayashi H., Hiraoka N., Ikeshiro Y., Planta Medica, 63, 102-105 (1997).
18. Shinohara M., Kaise Y., Nakano Y., Izawa T., Miyazaki K., Japan. Patent Sho 54-151136 (1979) [Chem. Abstr., 92, 153139B(1980)].
19. Kang S. S., Woo W. S., J. Nat. Prod., 51, 35-338 (1988).