Preventive effects of saponins from Puerariae Radix (the root of Pueraria lobata OHWI) on in Vitro immunological injury of rat primary hepatocyte cultures

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 9, 1997, Pages 988-991

  Arao, Tomonori ^a   Udayama, Manabu ^a   Kinjo, Junei ^a   Nohara, Toshihiro ^a   Funakoshi, Takayuki ^a   Kojima, Shoji ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Hepatoprotective effect; Primary cultured rat hepatocytes; Pueraria lobata; Triterpenoidal saponin

Indexed keywords

ALANINE AMINOTRANSFERASE; GLYCYRRHIZIC ACID; KUDZUSAPONIN SA 3; SAPONIN DERIVATIVE; SOYASAPONIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMMON COLD; CONTROLLED STUDY; DOSE RESPONSE; FEVER; INFLAMMATION; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; RAT; SWEATING;

EID: 0030825696     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.988     Document Type: Article

References (25)

1. Part 2 in a series of studies on the hepatoprotective drugs; part 55 in a series of studies on the constituents of leguminous plants.
2. Kinjo J., Miyamoto I., Murakami K., Kida K., Tomimatsu T., Yamasaki M., Nohara T., Chem. Pharm. Bull., 33, 1293-1296 (1985); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 43, 1176-1179 (1995); Arao T., Idzu T., Kinjo J., Nohara T., Isobe R., ibid., 44, 1970-1972 (1996); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 45, 362-366 (1997).
3. Kinjo J., Miyamoto I., Murakami K., Kida K., Tomimatsu T., Yamasaki M., Nohara T., Chem. Pharm. Bull., 33, 1293-1296 (1985); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 43, 1176-1179 (1995); Arao T., Idzu T., Kinjo J., Nohara T., Isobe R., ibid., 44, 1970-1972 (1996); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 45, 362-366 (1997).
4. Kinjo J., Miyamoto I., Murakami K., Kida K., Tomimatsu T., Yamasaki M., Nohara T., Chem. Pharm. Bull., 33, 1293-1296 (1985); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 43, 1176-1179 (1995); Arao T., Idzu T., Kinjo J., Nohara T., Isobe R., ibid., 44, 1970-1972 (1996); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 45, 362-366 (1997).
5. Kinjo J., Miyamoto I., Murakami K., Kida K., Tomimatsu T., Yamasaki M., Nohara T., Chem. Pharm. Bull., 33, 1293-1296 (1985); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 43, 1176-1179 (1995); Arao T., Idzu T., Kinjo J., Nohara T., Isobe R., ibid., 44, 1970-1972 (1996); Arao T., Kinjo J., Nohara T., Isobe R., ibid., 45, 362-366 (1997).
6. Shibata S., Harada M., Murakami T., Yakugaku Zasshi, 79, 863-868 (1959); Shibata S., Shoyakugaku Zasshi, 40, 1-18 (1986)
7. Shibata S., Harada M., Murakami T., Yakugaku Zasshi, 79, 863-868 (1959); Shibata S., Shoyakugaku Zasshi, 40, 1-18 (1986)
8. Kurokawa M., Iwakita M., Kumeda C., Yukawa T., Shiraki K., J. Trad. Med., 13, 201-209 (1996).
9. Nohara T., Takeshita T., Kinjo J., Ito H., Niiho Y., Yamasaki T., Wakan-Iyaku Gakkaishi, 5, 408-409 (1988); Niiho Y., Yamasaki T., Nakajima Y., Itoh H., Takeshita T., Kinjo J., Nohara T., Yakugaku Zasshi, 109, 424-431 (1989); Idem, ibid., 110, 604-611 (1990).
10. Nohara T., Takeshita T., Kinjo J., Ito H., Niiho Y., Yamasaki T., Wakan-Iyaku Gakkaishi, 5, 408-409 (1988); Niiho Y., Yamasaki T., Nakajima Y., Itoh H., Takeshita T., Kinjo J., Nohara T., Yakugaku Zasshi, 109, 424-431 (1989); Idem, ibid., 110, 604-611 (1990).
11. Nohara T., Takeshita T., Kinjo J., Ito H., Niiho Y., Yamasaki T., Wakan-Iyaku Gakkaishi, 5, 408-409 (1988); Niiho Y., Yamasaki T., Nakajima Y., Itoh H., Takeshita T., Kinjo J., Nohara T., Yakugaku Zasshi, 109, 424-431 (1989); Idem, ibid., 110, 604-611 (1990).
12. a) Takeshita T., Ito Y., Sakai Y., Nohara T., Yasuhara M., Saito H., Kitagawa I., Ariga T., Irino N., Takaoka T., J. Pharmacobio-Dyn., 13, s-54 (1990);
13. b) Kinjo J., Natural Medicines, 50, 79-85 (1996);
14. Miyao H., Arao T., Udayama M., Kinjo J., Nohara T., Planta Med., accepted.
15. Higuchi T., Nishida K., Nagamura Y., Ito M., Ishiguro I., Sumita S., Saito S., Igaku To Seibutugaku, 124, 57-61 (1992).
16. Shiki Y., Shirai K., Saito Y., Yoshida S., Wakashin M., Kumagai A., Wakan-Iyaku Gakkaishi, 1, 11-14 (1984); Kiso Y., Kawakami Y., Kikuchi K., Hikino H., Planta Med., 57, 241-247 (1987).
17. Shiki Y., Shirai K., Saito Y., Yoshida S., Wakashin M., Kumagai A., Wakan-Iyaku Gakkaishi, 1, 11-14 (1984); Kiso Y., Kawakami Y., Kikuchi K., Hikino H., Planta Med., 57, 241-247 (1987).
18. Berry M. N., Friend D. S., J. Cell. Biol., 43, 506-520 (1969).
19. Loten E. G., Redshaw-Loten J. C., Anal. Biochem., 154, 183-185 (1986).
20. Harboe N., Ingild A., Scand. J. Immunol., 2 (Suppl. I), 161-164 (1973).
21. Heerspink W., Hafkenscheid J. C., Siepel H., van der Ven-Jongekryg J., Dijt C. C., Enzyme, 25, 333-341 (1980).
22. Shibayama Y., Experimental and Molecular Pathology, 51, 48-55 (1989).
23. Kinjo J., Imagire M., Udayama M., Arao T., Nohara T., Planta Med., submitted.
24. Shinohara M., Kaise Y., Nakano Y., Izawa T., Miyazaki K., Japan. Patent Sho 54-151136 (1979) [Chem. Abstr., 92, 153139B (1980)].
25. Shinohara M., Kaise Y., Nakano Y., Izawa T., Miyazaki K., Japan. Patent Sho 54-151136 (1979) [Chem. Abstr., 92, 153139B (1980)].