Disruption of cell cycle kinetics by benzo[a]pyrene: Inverse expression patterns of BRCA-1 and p53 in MCF-7 cells arrested in S and G2

Neoplasia

Volumn 2, Issue 5, 2000, Pages 460-470

  Jeffy, B D ^a   Chen, E J ^b   Gudas, J M ^b   Romagnolo, D F ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b AMGEN INC   (United States)

Author keywords

Benzo a pyrene; BPDE; BRCA 1; Cell cycle kinetics; P53; Sporadic breast cancer

Indexed keywords

ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; BRCA1 PROTEIN; PROTEIN P53;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; GENE DISRUPTION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034518955     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900104     Document Type: Article

References (39)

1. BRCA- 1 required for transcription-coupled repair of oxidative damage
2. Association of BRCA-1 with Rad51 in mitotic and meiotic cells
3. BRCA-1, BRCA-2 and DNA damage response: Collision or collusion
4. Association of BRCA-1 with the hRad50-hMre11-p95 complex and the DNA damage response
5. Partial rescue of BRCA-1 (5-6) early embryonic lethality by p53 or p21 null mutation
6. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of BRCA-1, BRCA-2, BRCA-1/BRCA-2, BRCA-1/p53, and BRCA-2/p53 nullizygous embryos
7. Dynamic changes of BRCA-1 subnuclear location and phosphorylation state are initiated by DNA damage
8. Induction of phosphorylation on BRCA-1 during the cell cycle and after DNA damage
9. Requirement o ATM-dependent phosphorylation of BRCA-1 in the DNA damage response to double-strand breaks
10. BRCA-1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
11. BRCA-1 regulates p53-dependent gene expression
12. Binding of CtlP to the BRCT repeats of BRCA-1 involved in the transcription regulation of p21 is disrupted upon DNA damage
13. Arrest of the cell cycle by the tumor suppressor BRCA-1 requires the CDK inhibitor p21 WAF1/CiP1
14. 2-M cell cycle control in human mammary epithelial cells
15. 2-M cell cycle checkpoint induce genetic instability in BRCA-1 exon 11 isoform-deficient cells
16. Cell cycle control and cancer
17. 2 arrest after DNA damage
18. Double indemnity: p53, BRCA and cancer
19. Regulation of BRCA-1 and BRCA-2 expression in human breast cancer cells by DNA-damaging agents
20. 1 arrest in 3T3 fibroblasts
21. Cell cycle control, checkpoint mechanisms, and genotoxic stress
22. Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide
23. Estrogen upregulation of expression of BRCA-1 with no effect on localization
24. Hormone-dependent regulation of BRCA-1 in human breast cancer cells
25. Physical interactions of isomeric benzo[a]pyrene diol epoxides with DNA
26. Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[a]phenan-threne-3,4-diol-1,2-epoxide
27. The role of individual susceptibility in cancer burden related to environmental exposure
28. Cellular responses to oxidative stress: The Ah gene battery as a paradigm
29. Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: The role of apurinic sites
30. An analysis of DNA replication in synchronized CHO cells treated with benzo[a]pyrene diol epoxide
31. S-phase block and cell death in human lymphoblasts exposed to benzo[a]pyrene diol epoxide or N-acetoxy-2-acetylaminofluorene
32. Mammary tumor formation in p53- and BRCA-1-deficient mice
33. 2 progression, and results in apoptosis
34. A mitotic spindle requirement for DNA damage-induced apoptosis in Chinese hamster ovary cells
35. BRCA-1 protein products: Functional motifs
36. Benzo[a]pyrene-resistant MCF-7 human breast cancer cells
37. BRCA-1-associated growth arrest is RB-dependent
38. Environmental factors as regulators and effectors of multistep carcinogenesis
39. Cancer susceptibility genes: Gatekeepers and caretakers