Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 5 43-5, 1998, Pages

  Jung, Unsu ^a   Ramos, Carroll L ^a   Bullard, Daniel C ^b   Ley, Klaus ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Inflammation; Intravital microscopy; Knockout mice; Leukocyte adhesion

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; L SELECTIN; MONOCLONAL ANTIBODY; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREMASTER MUSCLE; FLOW CYTOMETRY; GENE TARGETING; HEMODYNAMIC MONITORING; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE COUNT; MALE; MICROSCOPY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; VENULE;

EID: 0031804957     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.5.h1785     Document Type: Article

References (37)

1. Alon, R., R. C. Fuhlbrigge, E. B. Finger, and T. A. Springer. Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow. J. Cell Biol. 135: 849-865, 1996.
2. Arbones, M. L., D. C. Ord, K. Ley, H. Ratech, C. Maynard-Curry, G. Otten, D. J. Capon, and T. F. Tedder. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1: 247-260, 1994.
3. Bargatze, R. F., S. Kurk, E. C. Butcher, and M. A. Jutila. Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells. J. Exp. Med. 180: 1785-1792, 1994.
4. Bosse, R., and D. Vestweber. Only simultaneous blocking of the L- and P-selectin completely inhibits neutrophil migration into mouse peritoneum. Eur. J. Immunol. 24: 3019-3024, 1994.
5. Brady, H. R., O. Spertini, W. Jimenez, B. M. Brenner, P. A. Marsden, and T. F. Tedder. Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro. J. Immunol. 149: 2437-2444, 1992.
6. Bullard, D. C., E. J. Kunkel, H. Kubo, M. J. Hicks, I. Lorenzo, N. A. Doyle, C. M. Doerschuk, K. Ley, and A. L. Beaudet. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 183: 2329-2336, 1996.
7. Bullard, D. C., L. Qin, I. Lorenzo, W. M. Quinlin, N. A. Doyle, R. Bosse, D. Vestweber, C. M. Doerschuk, and A. L. Beaudet. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal in pulmonary alveoli. J. Clin. Invest. 95: 1782-1788, 1995.
8. Etzioni, A., M. Frydman, S. Pollack, I. Avidor, M. L. Phillips, J. C. Paulson, and R. Gershoni-Baruch. Recurrent severe infections caused by a novel leukocyte adhesion deficiency. N. Engl. J. Med. 327: 1789-1792, 1993.
9. Fiebig, E., K. Ley, and K.-E. Arfors. Rapid leukocyte accumulation by "spontaneous" rolling and adhesion in the exteriorized rabbit mesentery. Int. J. Microcirc. Clin. Exp. 10: 127-144, 1991.
10. Frenette, P. S., T. N. Mayadas, H. Rayburn, R. O. Hynes, and D. D. Wagner. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 84: 563-574, 1996.
11. Gaboury, J. P., and P. Kubes. Reductions in physiologic shear rates lead to CD11/CD18-dependent, selectin-independent leukocyte rolling in vivo. Blood 83: 345-350, 1994.
12. Gallatin, W. M., I. L. Weissman, and E. C. Butcher. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304: 30-34, 1983.
13. 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venuels in vivo. J. Exp. Med. 183: 1995-2006, 1996.
14. Jones, D. A., C. W. Smith, L. J. Picker, and L. V. McIntire. Neutrophil adhesion to 24-hour IL-1-stimulated endothelial cells under flow conditions. J. Immunol. 157: 858-863, 1996.
15. Jung, U., D. C. Bullard, T. F. Tedder, and K. Ley. Velocity difference between L-selectin- and P-selectin-dependent neutrophil rolling in venules of the mouse cremaster muscle in vivo. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H2740-H2747, 1996.
16. Kishimoto, T. K., M. A. Jutila, E. L. Berg, and E. C. Butcher. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245: 1238-1241, 1989.
17. Kunkel, E. J., J. E. Chomas, and K. Ley. Role of primary and secondary capture for leukocyte accumulation in vivo. Circ. Res. 82: 30-38, 1998.
18. Kunkel, E. J., U. Jung, D. C. Bullard, K. E. Norman, B. A. Wolitzky, D. Vestweber, A. L. Beaudet, and K. Ley. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and InterCellular Adhesion Molecule-1 (ICAM-1). J. Exp. Med. 183: 57-65, 1996.
19. Kunkel, E. J., and K. Ley. Distinct phenotype of E-selectin deficient mice: E-selectin is required for slow leukocyte rolling in vivo. Circ. Res. 79: 1196-1204, 1996.
20. Labow, M. A., C. R. Norton, J. M. Rumberger, K. M. Lombard-Gillooly, D. J. Shuster, J. Hubbard, R. Bertko, P.A. Knaack, R. W. Terry, M. L. Harbison, F. Kontgen, C. L. Stewart, K. W. McIntyre, P. C. Will, D. K. Burns, and B. A. Wolitzky. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1: 709-720, 1994.
21. Lewinsohn, D. M., R. F. Bargatze, and E. C. Butcher. Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. J. Immunol. 138: 4313-4321, 1987.
22. Ley, K., D. C. Bullard, M. L. Arbones, R. Bosse, D. Vestweber, T. F. Tedder, and A. L. Beaudet. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. J. Exp. Med. 181: 669-675, 1995.
23. Ley, K., T. F. Tedder, and G. S. Kansas. L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. Blood 82: 1632-1638, 1993.
24. Ley, K., A. Zakrzewicz, C. Hanski, L. M. Stoolman, and G. S. Kansas. Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo. Blood 85: 3727-3735, 1995.
25. Lipowsky, H. H., and B. W. Zweifach. Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc. Res. 15: 93-101, 1978.
26. Mayadas, T. N., R. C. Johnson, H. Rayburn, R. O. Hynes, and D. D. Wagner. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74: 541-554, 1993.
27. Pries, A. R. A versatile video image analysis system for microcirculatory research. Int. J. Microcirc. Clin. Exp. 7: 327-345, 1988.
28. Reneman, R. S., B. Woldhuis, M. G. A. oude Egbrink, D. W. Slaaf, and G. J. Tangelder. Concentration and velocity profiles of blood cells in the microcirculation. In: Advances in Cardiovascular Engineering, edited by N. H. C. Hwang, V. T. Turitto, and M. R. T. Yen. New York: Plenum, 1992, p. 25-40.
29. Schleiffenbaum, B., O. Spertini, and T. F. Tedder. Soluble L-selectin is present in human plasma at high levels and retains functional activity. J. Cell Biol. 119: 229-238, 1992.
30. Spertini, O., F. W. Luscinskas, G. S. Kansas, J. M. Munro, J. D. Griffin, M. A. Gimbrone, Jr., and T. F. Tedder. Leukocyte adhesion molecule-1 (LAM-1) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J. Immunol. 147: 2565-2573, 1991.
31. Sriramarao, P., U. H. von Andrian, E. C. Butcher, M. A. Bourdon, and D. H. Broide. L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. J. Immunol. 153: 4238-4246, 1994.
32. Suguri, T., A. Kikuta, H. Iwagaki, T. Yoshino, N. Tanaka, and K. Orita. Increased plasma GlyCAM-1, a mouse L-selectin ligand, in response to an inflammatory stimulus. J. Leukoc. Biol. 60: 593-597, 1996.
33. Tedder, T. F., D. A. Steeber, and P. Pizcueta. L-selectin deficient mice have impaired leukocyte recruitment into inflammatory sites. J. Exp. Med. 181: 2259-2264, 1995.
34. Vestweber, D. The Selectins. Amsterdam, The Netherlands: Harwood Academic, 1997, p. 1-225.
35. x-dependent and -independent recognition pathways. Blood 82: 182-191, 1993.
36. Xu, J. C., I. S. Grewal, G. P. Geba, and R. A. Flavell. Impaired primary T cell responses in L-selectin-deficient mice. J. Exp. Med. 183: 589-598, 1996.
37. Zakrzewicz, A., M. Grafe, D. Terbeek, M. Bongrazio, W. Auch-Schwelk, B. Walzog, K. Graf, E. Fleck, K. Ley, and P. Gaehtgens. L-selectin-dependent leukocyte adhesion to microvascular but not to macrovascular endothelial cells of the human coronary system. Blood 89: 3228-3235, 1997.