Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice

FASEB Journal

Volumn 13, Issue 6, 1999, Pages 667-675

  Witting, Paul K ^a   Pettersson, Knut ^b   Östlund Lindqvist, Anne Margret ^b   Westerlund, Christer ^b   Eriksson, Annika Westin ^b   Stocker, Roland ^a  

^a HEART RESEARCH INSTITUTE   (Australia)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Antioxidants; Coantioxidation; LDL; tocopherol

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOPHERYLQUINONE; ANTIOXIDANT; APOLIPOPROTEIN E; BUTYLCRESOL; DRUG METABOLITE; H 212 43; H 330 68; LOW DENSITY LIPOPROTEIN RECEPTOR; PHENOL DERIVATIVE; PROBUCOL; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; KNOCKOUT MOUSE; LIPID PEROXIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; PERO;

EID: 0032893420     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.6.667     Document Type: Article

References (47)

1. Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., and Witztum, J. L. 1989. Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320, 915-924
2. Witztum, J. L. (1993) Murine models for study of lipoprotein metabolism and atherosclerosis. J. Clin. Invest. 92, 536-537
3. Berliner, J. A., and Heinecke, J. W. (1996) The role of oxidized lipoproteins in atherogenesis. Free Rad. Biol. Med. 20, 707-727
4. Witztum, J. L., and Steinberg, D. (1991) Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88, 1785-1792
5. Chin, J. H., Azhar, S., and Hoffman, B. B. (1992) Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J. Clin. Invest. 89, 10-18
6. i protein functions by minimally oxidized LDL. Arterioscler. Thromb. Vasc. Biol. 15, 2019-2024
7. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (London) 362, 801-809
8. Ohlsson, B. G., Englund, M. C., Karlsson, A. L., Knutsen, E., Erixon, C., Skribeck, H., Liu, Y., Bondjers, G., and Wiklund, O. (1996) Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-κB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages. J. Clin. Invest. 98, 78-89
9. Witting, P. K., Upston, J. M., and Stocker, R. (1998) The molecular action of α-tocopherol in lipoprotein lipid peroxidation: pro-and antioxidant activity of vitamin E in complex heterogeneous lipid emulsions. In: Subcellular Biochemistry: Fat-Soluble Vitamins (Quinn, P., and Kagan, V., eds) pp. 345-390, Plenum, London
10. Sparrow, C. P., Doebber, T. W., Olszewski, J., Wu, M. S., Ventre, J., Stevens, K. A., and Chao, Y. S. (1992) Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N′-diphenyl-phenylenediamine. J. Clin. Invest. 89, 1885-1891
11. Williams, R. J., Motteram, J. M., Sharp, C. H., and Gallagher, P. J. (1992) Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis 94, 153-159
12. Kita, T., Nagano, Y., Yokode, M., Ishii, K., Kume, N., Ooshima, A., Yoshida, H., and Kawai, C. (1987) Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc. Natl. Acad. Sci. USA 84, 5928-5931
13. Shaish, A., Daugherty, A., O'Sullivan, F., Schonfeld, G., and Heinecke, J. W. (1995) β-Carotene inhibits atherosclerosis in hypercholesterolemic rabbits. J. Clin. Invest. 96, 2075-2082
14. Stein, Y., Stein, O., Delplanque, B., Fesmire, J. D., Lee, D. M., and Alaupovic, P. (1989) Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels. Atherosclerosis 75, 145-155
15. Fruebis, J., Carew, T. E., and Palinski, W. (1995) Effect of vitamin E on atherogenesis in LDL receptor-deficient rabbits. Atherosclerosis 117, 217-224
16. Zhang, S. H., Reddick, R. L., Avdievich, E., Surles, L. K., Jones, R. G., Reynolds, J. B., Quarfordt, S. H., and Maeda, N. (1997) Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice. J. Clin. Invest. 99, 2858-2866
17. Munday, J. S., Thompson, K. G., James, K. A., and Manktelow, B. W. (1998) Dietary antioxidants do not reduce fatty streak formation in the C57BL/6 mouse atherosclerosis model. Arterioscler. Thromb. Vasc. Biol. 18, 114-119
18. Fruebis, J., Bird, D. A., Pattison, J., and Palinski, W. (1997) Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants. J. Lipid Res. 38, 2455-2464
19. Carpenter, K. L., Taylor, S. E., van der Veen, C., Williamson, B. K., Ballantine, J. A., and Mitchinson, M. J. (1995) Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. Biochim. Biophys. Acta 1256, 141-150
20. Suarna, C., Dean, R. T., May, J., and Stocker, R. (1995) Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of α-tocopherol and ascorbate. Arterioscler. Thromb. Vasc. Biol. 15, 1616-1624
21. Bowry, V. W., and Stocker, R. (1993) Tocopherol-mediated peroxidation. The pro-oxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein. J. Am. Chem. Soc. 115, 6029-6044
22. Ingold, K. U., Bowry, V. W., Stocker, R., and Walling, C. (1993) Autoxidation of lipids and antioxidation by α-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids. The unrecognized consequences of lipid particle size as exemplified by the oxidation of human low density lipoprotein. Proc. Natl. Acad. Sci. USA 90, 45-49
23. Bowry, V. W., Mohr, D., Cleary, J., and Stocker, R. (1995) Prevention of tocopherol-mediated peroxidation of ubiquinol-10-free human low density lipoprotein. J. Biol. Chem. 270, 5756-5763
24. Witting, P. K., Westerlund, C., and Stocker, R. (1996) A rapid and simple screening test for potential inhibitors of tocopherol-mediated peroxidation of LDL lipids. J. Lipid Res. 37, 853-867
25. Björkhem, I., Henriksson-Freyschuss, A., Breuer, O., Diczfalusy, U., Berglund, L, and Henriksson, P. (1991) The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arterioscler. Thromb. 11, 15-22
26. Xiu, R. J., Freyschuss, A., Ying, X., Berglund, L. Henriksson, P., and Björkhem, I. (1994) The antioxidant butylated hydroxytoluene prevents early cholesterol-induced microcirculatory changes in rabbits. J. Clin. Invest. 93, 2732-2737
27. O'Leary, V. J., Tilling, L., Fleetwood, G., Stone, D., and Darley-Usmar, V. (1996) The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy. Atherosclerosis 119, 169-179
28. Buettner, G. R. (1990) Use of ascorbate as test for catalytic metals in simple buffers. Methods Enzymol. 186, 125-127
29. Pelter, A., and Elgendy, S. (1988) Phenolic oxidation with (diacetoxyiodo)benzene. Tetrahedron Lett. 29, 677-680
30. Suarna, C., Hood, R. L., Dean, R. T., and Stocker, R. (1993) Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins. Biochim. Biophys. Acta 1166, 163-170
31. Yamamoto, Y., Brodsky, M. H., Baker, J. C., and Ames, B. N. (1987) Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography. Anal. Biochem. 160, 7-13
32. Piedrahita J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., and Maeda, N. (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. USA 89, 4471-4475
33. Ishibashi, S., Herz, J., Maeda, N., Goldstein, J. L., and Brown, M. S. (1994) The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc. Natl. Acad. Sci. USA 91, 4431-4435
34. Christison, J. K., Rye, K.-A., and Stocker, R. (1995) Exchange of oxidised cholesteryllinoleate between LDL and HDL mediated by cholesteryl ester transfer protein. J. Lipid Res., 36, 2017-2026.
35. Sattler, W., Mohr, D., and Stocker, R. (1994) Rapid isolation of lipoproteins and assessment of their peroxidation by HPLC postcolumn chemiluminescence. Methods Enzymol. 233, 469-489
36. Witting, P. K., Mohr, D., and Stocker, R. (1998) Assessment of pro-or anti-oxidant activity of vitamin E in human low density lipoprotein and plasma. Methods Enzymol. 299, 362-375
37. Neuzil, J., Christison, J. K., Iheanacho, E., Fragonas, J.-C., Zammit, V., Hunt, N. H., and Stocker, R. (1998) Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/-mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis. J. Lipid Res. 39, 354-368
38. Frank, J. S., and Fogelman, A. M. (1989) Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching. J. Lipid Res. 30, 967-978
39. Hazell, L. J., and Stocker, R. (1997) α-Tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low density lipoprotein. FEBS Lett. 414, 541-544
40. Lynch, S. M., and Frei, B. (1994) Antioxidants as antiatherogens: animal studies. In: Natural Antioxidants in Human Health and Disease (Frei, B., ed) pp. 353-385, Academic Press: New York
41. Pryor, W. A., Cornicelli, J. A., Devall, L. J., Tait, B., Trivedi, B. K., Witiak, D. T., and Wu, M. (1993) A rapid screening test to determine the antioxidant potencies of natural and synthetic antioxidants. J. Org. Chem. 58, 3521-3532
42. Bird, D. A., Tangirala, R. K., Fruebis, J., Steinberg, D., Witztum, J. L., and Palinski, W. (1998) The effect of probucol on LDL oxidation and atherosclerosis in LDL receptor deficient mice. J. Lipid Res. 39, 1079-109
43. Cynshi, O., Kawabe, Y., Suzuki, T., Takashima, Y., Kaise, H., Nakamura, M., Ohba, Y., Kato, Y., Tamura, K., Hayasaka, A., Higashida, A., Sakaguchi, H., Takeya, M., Takahashi, K., Inoue, K., Noguchi, N., Niki, E., and Kodama, T. (1998) Antiatherogenic effects of the antioxidant BO-653 in three different animal models. Proc. Natl. Acad. Sci. USA 95, 10123-10128
44. Walldius, G., Erikson U., Olsson, A. G., Bergstrand, L., Hadell, K., Johansson, J., Kaijser, L., Lassvik, C., Molgaard, J., Nilsson, S., et al. (1994) The effect of probucol on femoral atherosclerosis: the Probucol Quantitative Regression Swedish Trial (PQRST). Am. J. Cardiol. 74, 875-883
45. Tasinato, A., Boscoboinik, D., Bartoli, G. M., Maroni, P., and Azzi, A (1995) d-α-Tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc. Natl. Acad. Sci. USA 92, 12190-12194
46. Freedman, J. E., Farhat, J. H., Loscalzo, J., and Keaney, J. F., Jr. (1996) α-Tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 94, 2434-244028
47. Lindqvist, A.-M., Pettersson, K., Stocker, R., Westerlund, C., and Witting P. K. (1997) A method for detection of potential co-antioxidants. WPI Acc No: 97-535465/199749