Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines

Clinical and Experimental Metastasis

Volumn 15, Issue 4, 1997, Pages 368-381

  Heidtmann, Hans Heinrich ^a   Salge, Ursula ^a   Abrahamson, Magnus ^b   Benčina, Mojca ^c   Kastelic, Lili ^c   Kopitar Jerala, Nataša ^c   Turk, Vito ^c   Lah, Tamara T ^c,d  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b LUND UNIVERSITY   (Sweden)

^c JO EF STEFAN INSTITUTE   (Slovenia)

^d NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

Author keywords

Cathespin B; Cystatins; Kininogens; Lung cancer; Lung carcinoma cells; Proteinase inhibitors; Stefins

Indexed keywords

CATHEPSIN B; CYSTATIN; KININOGEN; PHORBOL ESTER; PROTEINASE INHIBITOR; STEFIN;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; HUMAN; LUNG CANCER; TUMOR CELL LINE;

CARCINOGENS; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CATHEPSIN B; CYSTATINS; CYSTEINE PROTEINASE INHIBITORS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INSULIN-LIKE GROWTH FACTOR I; ISOELECTRIC FOCUSING; ISOENZYMES; LUNG NEOPLASMS; MOLECULAR WEIGHT; PROTEIN KINASE C; TETRADECANOYLPHORBOL ACETATE;

EID: 0030849275     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018494020001     Document Type: Article

References (57)

1. Liotta LA, Steeg PS and Stetler-Stevenson WG, 1991, Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64, 327-36.
2. Schmitt M, Janicke H and Graeff H, 1992, Tumor-associated proteases. Fibrinolysis, 6, Suppl 4: 3-26.
3. Heidtmann H-H, Hofmann M, Jacob E, Erbil C, Havemann K and Schwartz-Albiez R, 1989, Synthesis and secretion of plasminogen activators and plasminogen activator inhibitors in cell lines of different groups of human lung tumors. Cancer Res, 49, 6965-9.
4. Heidtmann H-H, Havemann K and Schwartz-Albiez R, 1992, Regulation of the plasminogen activator system in non-small cell lung cancer cell lines by growth factors EGF, TGF-alpha, and TGF-beta. Br J Cancer, 65, 154-6.
5. Sloane BF, 1990, Cathepsin B and cystatins in tumor progression. Sem Cancer Biol, 1, 153-60.
6. Sloane BF, Moin K and Lah TT, 1994, Lysosomal enzymes and their endogenous inhibitors in neoplasia. In: Pretlow TG and Pretlow TH, eds. Aspects of the Biochemistry and Molecular Biology of Tumors, Vol. 2. Academic Press, New York, pp. 411-66.
7. Calkins CC and Sloane BF, 1995, Mammalian cysteine protease inhibitors: biochemical properties and possible roles in tumor progression. Biol Chem Hoppe Seyler, 376, 71-150.
8. Sloane BF, Dunn J and Honn K, 1981, Lysosomal cathepsin B: correlation with metastatic potential. Science, 212, 1151-3.
9. Denhardt DT, Greenberg AH, Egan SE, Hamilton RT and Wright AJ, 1987, Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts. Cancer Res, 46, 4590-3.
10. Chambers AF, Colella R, Denhardt DT and Wilson SM, 1992, Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells. Mol Carcinogenesis, 5, 238-45.
11. Kane SE and Gottesman MM, 1990, The role of cathepsin L in malignant transformation. Sem Cancer Biol, 1, 127-36.
12. Rozhin J, Sameni M, Ziegler G and Sloane BF, 1994, Pericellular pH affects distribution and secretion of Cat B in malignant cells. Cancer Res, 54, 6517-25.
13. Spiess E, Bruning A, Gack S, Ulbricht B, Spring H, Trefz G and Ebert W, 1994, Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level. J Histochem Cytochem, 42, 917-29.
14. Honn KV, Timar J, Rozhin J, et al. 1994, A lipoxygenase metabolite, 12-(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Exp Cell Res, 214, 120-30.
15. Pagano M, Dalet-Fumeron V and Engler R, 1989, The glycosylation stale of the precursors of the cathepsin B-like proteinase from human malignant ascites fluid: possible implications in the secretory pathway of these proenzymes. Cancer Lett, 45, 13-19.
16. Maciewicz RA, Wardale RJ, Etherington DJ and Paraskeva C, 1989, Immunodetection of cathepsin B and L present in and secreted from human promalignant and malignant colorectal tumour cell lines. Int J Cancer, 43, 478-86.
17. McCormik D, 1993, Secretion of cathepsin B by human gliomas in vitro. Neuropathol Appl Neurobiol, 19, 146-51.
18. Heidtmann H-H, Salge , Havemann K, Kirschke H and Wiederanders B, 1993, Secretion of a latent, acid activatable cathepsin L precursor by human non-small lung cancer cell lines. Oncology Res, 5, 441-51.
19. Krepela E, Prochazka J, Mynarikova H, et al. 1995, Multiple forms of cathepsin B in human lung cancer. Int J Cancer, 61, 44-53.
20. Krepela E, Kasafirek E, Novak K and Viklicky J, 1990, Increased cathepsin B activity in human lung tumors. Neoplasma, 37, 61-70.
21. Ebert W, Knoch H, Werle B, Trefz G, Muley Th and Spiess E, 1994, Prognostic value of increased lung tumor tissue cathepsin B. Anticancer Res, 14, 895-900.
22. Knoch H, Werle B, Ebert W and Spiess E, 1994, Imbalance between cathepsin B and cysteine proteinase inhibitors is of prognostic significance in human lung cancer. Int J Cancer, 5, 77-85.
23. Sukoh N, Shosaku A, Ogura S, et al. 1994, Immunohistochemical study of cathepsins B: prognostic significance in human lung cancer. Cancer, 74, 46-51.
24. Higashiyama M, Doi O, Kodama K, Yokouchi H and Tateishi R, 1993, Cathepsin B expression in tumor cells and laminin distribution in pulmonary adenocarcinoma. J Clin Pathol, 46, 18-22.
25. Inoue T, Ishida T, Sugio K and Sugimachi K, 1994, Cathepsin B expression and laminin degradation as factors influencing prognosis of surgically treated patients with lung adenocarcinoma. Cancer Res, 54, 6133-6.
26. Turk V and Bode W, 1991, The cystatins: protein inhibitors of cysteine proteinases. FEBS Lett, 285, 213-19.
27. Colella R, Chambers AF and Denhardt DT, 1993, Anticancerogenic activities of naturally occurring cysteine proteinase inhibitors. In: Troll W and Kennedy A, eds. Proteinase Inhibitors as Cancer Chemopreventive Agents. New York: Plenum Press, pp. 199-217.
28. Luethgens K, Gabrijelčič D, Turk V, Ebert W, Trefz G and Lah T, 1993, Cathepsin B and cysteine proteinase inhibitors in bronchoalveolar lavage fluid of cancer patients. Cancer Detection and Prevention, 17, 387-97.
29. Bepler G, Koehler A, Kiefer P, et al. 1988, Characterization of the state of differentiation of six newly established human non-small cell lung cancer cell lines. Differentiation, 37, 158-71.
30. Bepler G, Jaques G, Koehler A, Gropp C and Havemann K, 1987, Markers and characteristics of human SCLC cell lines. J Cancer Res Clin Oncol, 113, 253-9.
31. Bergh J, Nilsson K, Zech L and Giovanella B, 1981, Establishment and characterization of a continuous lung squamous cell carcinoma cell line (U-1752). Anticancer Res, 1, 317-22.
32. Bergh J, Nilsson K, Ekman R and Giovanella B, 1985, Establishment and characterization of cell lines from human small cell and large cell carcinomas of the lung. Acta Path Microbiol Immunol Scand, 93, 133-47.
33. Barrett AJ and Kirschke H, 1981, Cathepsin B, cathepsin H, and cathepsin L. Meth Enzymol, 80, 535-60.
34. Lah TT, Kokalj-Kunovar M, Štrukelj B, et al. 1992, Stefins and lysosomal cathepsins B, L and D in human breast carcinoma. Int J Cancer, 50, 36-44.
35. Buttle DJ, Kembhavi AA, Sharp SI, Shute R, Rich DH and Barrett AJ, 1989, Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex. Biochem J, 261, 469-76.
36. Lah TT, Kokalj-Kunovar M, Kastelic L, et al. 1991, Cystatins and stefins in ascites fluid from ovarian carcinoma. Cancer Lett, 61, 243-53.
37. Laemmli UK, 1970, Cleavage of structural proteins during the assembly of head bacteriophage T4. Nature, 227, 680-5.
38. Towbin H, Staehlin T and Osborne J, 1979, Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA, 76, 369-75.
39. Taketa K, 1987, A tetrazolium method for peroxidase staining: application to the antibody affinity blotting of α-fetoprotein, separated by electin-affinity electrophoresis. Electrophoresis, 8, 409-14.
40. Lah TT, Kokalj-Kunovar M, Drobnič-Košorok M, et al. 1992, Cystatins and cathepsins in breast carcinoma. Biol Chem Hoppe-Seyler, Suppl 371, 595-604.
41. Kopitar-Jerala N, Čurin-Šerbec V, Jerala R, Križaj I, Gubenšek F and Turk V, 1993, Monoclonal antibodies to human stefin B and determination of their epitopes. Biochim Biophys Acta, 1164, 75-80.
42. Olafson I, Lofberg H, Abrahamson M and Grubb A, 1988, Production, characterization and use of monoclonal antibodies against the major extracellular human cysteine proteinase inhibitor cystatin C and kininogen. Scan J Clin Lab Invest, 48, 573-82.
43. Bradford MM, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-54.
44. Machleidt-Assflag I, Jochum M, Klaubert W, Inthorn D and Machleidt W, 1988, Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients with septic shock and some malignant tumors. Biol Chem Hoppe-Seyler, Suppl 369, 263-9.
45. Gazdar AF, 1986, Advances in the biology of non-small cell lung cancer. Chest, 89, 277S-83S.
46. Salge U, Kilian P, Neumann K, Elsässer HP, Havemann K and Heidtmann H-H, 1990, Differentiation capacity of human non-small-cell lung cancer cell lines after exposure to phorbol ester. Int J Cancer, 45, 1143-50.
47. Momiki S, Baba M, Caamano T, et al. 1991, In vivo and in vitro invasiveness of human lung carcinoma cell lines. Invasion Metastasis, 11, 66-75.
48. Kobayashi H, Moniwa N, Sugimura M, Shinohara H, Ohi H and Terao T, 1993, Effects of membrane-associated cathepsin B on the activation of receptor-bound urokinase and subsequent invasion of reconstituted basement membranes. Biochim Biophys Acta, 1178, 55-62.
49. Gabel CA, Goldberg DE and Kornfeld S, 1983, Identification and characterization of cells deficient of the mannose-6phosphate receptors: evidence for an alternative pathway for lysosomal enzyme targeting. Proc Natl Acad Sci, USA, 80, 775-82.
50. Lah TT, Calaf G, Kalman E, et al. 1995, Cathepsins D, B and L in breast carcinoma and transformed human breast epithelial cells (HBEC). Biol Chem Hoppe-Seyler, 376, 357-63.
51. Keppler D, Waridel P, Abrahamson M, Bachmann D, Berdoz J and Sordat B, 1994, Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase. Biochim Biophys Acta, 1226, 117-25.
52. Werle B, Ebert W, Klein W and Spiess E, 1994, Cathepsin B in tumors, normal tissue and isolated cells from the human lung. Anticancer Res, 14, 1169-76.
53. Abrahamson M, Barrett AJ, Salvesen G and Grubb A, 1989, Isolation of six cysteine proteinase inhibitors from human urine. J Biol Chem, 261, 11282-9.
54. Abrahamson M, Grubb A, Olafsson I and Lundwall A, 1987, Molecular cloning and sequence analysis of cDNA coding for the presence of the human cysteine proteinase inhibitor cystatin C. FEBS Lett, 216, 229-33.
55. Rabin MS, Doherty PJ and Gottesman MM, 1986, The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes. Proc Nat Acad Sci, USA, 83, 357-60.
56. Ward CJ, Crocker J, Chan SJ, Stockley RA and Burnett D, 1990, Changes in the expression of elastase and cathepsin B with dfferentiation of U937 promonocytes by GMCSF. Biochem Res Commun, 167, 659-64.
57. Takahashi M, Tadashi T, Towatari T and Katunuma N, 1990, Properties and nature of a cysteine proteinase inhibitor located in keratohyalin granules of rat epidermis. FEBS Lett, 267, 261-4.