The search for Lps: 1993-1998

Journal of Endotoxin Research

Volumn 6, Issue 4, 2000, Pages 269-293

  Beutler, B ^a   Poltorak, A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; BACTERIAL ARTIFICIAL CHROMOSOME; COMPUTER; CONTROLLED STUDY; GENE MAPPING; IMMUNITY; INFORMATION PROCESSING; MOLECULAR CLONING; MOUSE; NONHUMAN; RECORDING; REVIEW; SIGNAL TRANSDUCTION; TECHNIQUE; TRANSGENE; YEAST ARTIFICIAL CHROMOSOME;

ALLERGY AND IMMUNOLOGY; ANIMALS; CALIFORNIA; CHROMOSOME MAPPING; CLONING, MOLECULAR; DROSOPHILA PROTEINS; DRUG RESISTANCE; HISTORY, 20TH CENTURY; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MONOMERIC GTP-BINDING PROTEINS; MUTATION; RAN GTP-BINDING PROTEIN; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTORS; UNITED STATES;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0034483810     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805100101532153     Document Type: Review

References (73)

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3. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
4. Identification of a domain in soluble CD14 essential for lipopolysaccharide (LPS) signaling but not LPS binding
5. Antibodies against CD14 protect primates from endotoxin-induced shock
6. Resistance to endotoxin shock and reduced dissemination of Gram-negative bacteria in CD14-deficient mice
7. Generation of new oncogenic murine retroviruses by cotransfection of cloned AKR and MH2 proviruses
8. Mouse macrophage clones immortalized by retroviruses are functionally heterogeneous
9. Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide
10. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice
11. The response of recombinant inbred strains of mice to bacterial lipopolysaccharides
12. The genetic mapping of a defective LPS response gene in C3H/HeJ mice
13. Macrophage sensitivity to endotoxin. Genetic control by a single codominant gene
14. Gamma interferon production in endotoxin-responder and -nonresponder mice during infection
15. Interferon beta, a cofactor in the interferon gamma production induced by Gram-negative bacteria in mice
16. Gamma interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice
17. d and tumor necrosis factor receptor-deficient mice
18. Passive immunization against cachectin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin
19. The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin
20. Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin
21. A genetic map of the mouse suitable for typing intraspecific crosses
22. The Lps gene: Insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation
23. d allele: Analysis of chromosome 4 markers surrounding the Lps gene
24. Genetic and physical mapping of the Lps locus - Identification of the Toll-4 receptor as a candidate gene in the critical region
25. Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions
26. A high-resolution map of the brown (b, Tyrp1) deletion complex of mouse chromosome 4
27. Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4)
28. Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4)
29. A high-resolution map in the chromosomal region surrounding the Lps locus
30. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1
31. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
32. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
33. Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14
34. A family of human receptors structurally related to Drosophila Toll
35. Lps gene-associated functions
36. Restoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-binding protein
37. Mice genetically hyporesponsive to lipopolysaccharide (LPS) exhibit a defect in endocytic uptake of LPS and ceramide
38. Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
39. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
40. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
41. For whom the bell tolls
42. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
43. Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections
44. Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
45. Physical contact between LPS and Tlr4 revealed by genetic complementation
46. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
47. Three novel mammalian Toll-like receptors: Gene structure, expression, and evolution
48. Cloning and characterization of a subfamily of human toll-like receptors: hTLR7, hTLR8, and hTLR9
49. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
50. Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses
51. Dominant negative down-regulation of endotoxin-induced tumor necrosis factor alpha production by Lpsd/Ran
52. n gene: In vivo evidence for a dominant negative mutation
53. Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice
54. Functional nuclei of LPS-nonresponder C3H/HeJ mice after transfer into LPS-responder C3H/HeN cells by cell fusion
55. Correction of defective macrophage differentiation in C3H/HeJ mice by an interferon-like molecule
56. Interferon-induced enhancement of macrophages Fc receptor expression: Beta-interferon treatment of C3H/HeJ macrophages results in increased numbers and density of Fc receptors
57. The effect of interferon-gamma on cachectin expression by mononuclear phagocytes: Reversal of the lps-d (endotoxin resistance) phenotype
58. Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems
59. Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation
60. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages
61. Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity
62. The activation of protein kinase C by biologically active lipid moieties of lipopolysaccharide
63. Lipopolysaccharide nonresponder cells: The C3H/HeJ defect
64. Recognition of bacterial endotoxins by receptor-dependent mechanisms
65. A two-component system that regulates an osmosensing MAP kinase cascade in yeast
66. Signal transduction. Histidine kinases hog the limelight
67. Shared actions of endotoxin and taxol on TNF receptors and TNF release
68. Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents
69. d) macrophages
70. Does endotoxin stimulate cells by mimicking ceramide?
71. Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells
72. Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)