Gene therapy in wound repair and regeneration

Wound Repair and Regeneration

Volumn 8, Issue 6, 2000, Pages 443-451

  Yao, F ^a   Eriksson, E ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; LIPOSOME; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ARTICLE; CLINICAL GENETICS; DNA TRANSFER; DNA VECTOR; DOSE CALCULATION; DRUG DELIVERY SYSTEM; GENE DOSAGE; GENE EXPRESSION SYSTEM; GENE GUN; GENE TARGETING; GENE THERAPY; HERPES SIMPLEX VIRUS 1; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS; TRANSGENE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

GENE THERAPY; GENETIC VECTORS; HUMANS; PROGNOSIS; REGENERATION; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0034483798     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2000.00443.x     Document Type: Article

References (98)

1. Skin replacements
2. Wound healing: Practical aspects
3. Clinical management of non-healing wounds
4. Growth factors and wound healing: Biochemical properties of growth factors and their receptors
5. Wound healing - Aiming for perfect skin regeneration
6. Regulation of angiogenesis and wound repair: Interactive role of the matrix and growth factors
7. Peptide growth factors are multifunctional
8. The future of recombinant growth factors in wound healing
9. Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor
10. In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair
11. One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing
12. Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin
13. Growth factors in the repair of partial thickness porcine skin wounds
14. Stimulation of healing of chronic wounds by epidermal growth factor
15. PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse
16. Sustained release of epidermal growth factor accelerates wound repair
17. Epidermal growth factor increases granulation tissue formation dose dependently
18. Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft
19. Particle-mediated gene transfer of PDGF isoforms promotes wound repair
20. Topical use of human recombinant epidermal growth factor (h-EGF) in venous ulcers
21. PDGF and FGF stimulate wound healing in the genetically diabetic mouse
22. Basic fibroblast growth factor stimulation of epidermal wound healing in pigs
23. Role of platelet-derived growth factor in wound healing: Synergistic effects with other growth factors
24. A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration
25. Acidic fibroblast growth factor accelerates dermal wound healing
26. Epidemal growth factor-induced effects on wound healing
27. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers
28. Defining a model to predict the distribution of topically applied growth factors and other solutes in excisional full-thickness wounds
29. In vivo gene transfer to skin and wound by microseeding
30. Genetically modified keratinocytes transplanted to wounds reconstitute the epidermis
31. Persistent transgene expression and normal differentiation of immortalized human keratinocytes in vivo
32. Transfection with aFGF cDNA improves wound healing
33. Human gene therapy
34. The basic science of gene therapy
35. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
36. In vivo gene delivery by lentiviral vectors
37. Expression of an exogenous growth hormone gene by transplantable human epidermal cells
38. Recombinant adenoviral mediated gene transfer in ischemic impaired wound healing
39. Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing
40. Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma
41. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
42. Rescue, propagation, and partial purification of a helper virus- dependent adenovirus vector
43. A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
44. Expanded-capacity adenoviral vectors the helper-dependent vectors
45. In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes
46. Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis
47. A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase
48. An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
49. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
50. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination
51. Site-specific integration by adeno-associated virus
52. Gene therapy vectors based on adeno-associated virus type 1
53. Herpes simplex viruses
54. The function of herpes simplex virus genes: A primer for genetic engineering of novel vectors
55. Engineering herpes simplex virus vectors for human gene therapy
56. Replication-defective herpes simplex virus vectors for gene transfer in vivo
57. Design and application of HSV vectors for neuroprotection
58. A novel anti-herpes simplex virus type 1-specific herpes simplex virus type 1 recombinant
59. Gene therapy in the CNS
60. Gene expression following direct injection of DNA into liver
61. Expression of recombinant genes in myocardium in vivo after direct injection of DNA
62. Cytokine gene expression in epidermis with biological effects following injection of naked DNA
63. Expression of naked DNA in human, pig, and mouse skin
64. Direct gene transfer into mouse muscle in vivo
65. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia
66. Gene therapy for myocardial angiogenesis: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia
67. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo
68. Depth-targeted efficient gene delivery and expression in the skin by pulsed electric fields: An approach to gene therapy of skin aging and other diseases
69. In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA
70. High-velocity microprojectiles for delivering nucleic acids into living cells
71. Particle bombardment technology for gene transfer
72. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles
73. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment
74. In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment
75. Developing particle-mediated gene transfer technology for research into gene therapy of cancer
76. Gene gun-based nucleic acid immunization: Elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA
77. Immunization of pigs with a particle-mediated DNA vaccine to influenza A virus protects against challenge with homologous virus
78. In vivo cytokine gene transfer by gene gun reduces tumor growth in mice
79. Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors
80. Microseeding provides efficienct in vivo gene transfer to the periosteum
81. In vivo gene transfer to the internal organs of rat by microseeding
82. Puncture-mediated gene transfer to the skin
83. Cationic liposome-mediated intravenous gene delivery
84. Systemic gene expression after intravenous DNA delivery into adult mice
85. Human APC gene expression in rodent colonic epithelium in vivo using liposomal gene delivery
86. Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): Reciprocal effect of cationic lipid for in vitro and in vivo gene transfer
87. Locally administered vascular endothelial growth factor cDNA increases survival of ischemic experimental skin flaps
88. Tight control of gene expression in mammalian cells by tetracycline- responsive promoters
89. Transcriptional activation by tetracyclines in mammalian cells
90. Ecdysone-inducible gene expression in mammalian cells and transgenic mice
91. A regulatory system for use in gene transfer
92. A humanized system for pharmacologic control of gene expression
93. Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells
94. Negative effect of the transcriptional activator GALA
95. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
96. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
97. Powerful and versatile enhancer-promoter unit for mammalian expression vectors
98. The cytomegalovirus enhancer: A pan-active control element in transgenic mice