Growth factors in the repair of partial thickness porcine skin wounds

Plastic and Reconstructive Surgery

Volumn 100, Issue 3, 1997, Pages 657-664

  Breuing, Karl ^a   Andree, Christoph ^a   Helo, Giselle ^a   Slama, Jaromir ^a   Liu, Paul Y ^a   Eriksson, Elof ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CHOLERA TOXIN; EPIDERMAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CONCENTRATION RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIZATION; HISTOLOGY; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; WOUND HEALING;

ANIMALS; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTOR; EXUDATES AND TRANSUDATES; FIBROBLAST GROWTH FACTOR 2; GROWTH SUBSTANCES; INSULIN-LIKE GROWTH FACTOR I; PLATELET-DERIVED GROWTH FACTOR; RECOMBINANT PROTEINS; REGENERATION; SKIN; SKIN PHYSIOLOGY; SWINE; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 0030769821     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-199709000-00018     Document Type: Article

References (25)

1. Breuing, K., Eriksson, E., Liu, P. Y., and Miller, D. R. Healing of partial thickness porcine skin wounds in a liquid environment. J Surg. Res. 52: 50, 1992.
2. Vogt, P. M., Thompson, S., Andree, C., Liu, P., Breuing, K., Hatzis, D., Brown, H., Mulligan, R. C., and Eriksson, E. Genetically modified keratinocytes transplanted to wounds reconstitute the epidermis. Proc. Natl. Acad. Sci. USA 91: 9307, 1994.
3. Lynch, S. E., Colvin, R. B., and Antoniades, H. N. Growth factors in wound healing. J. Clin. Invest. 84: 640, 1989.
4. Lynch, S. E. Interactions of growth factors in tissue repair. In A. Barbul et al. (Eds.), Clinical and Experimental Approaches to Dermal and Epidermal Repair: Nonnal and Chronic Wounds. New York: Wiley-Liss, 1991. Pp. 341-357.
5. Jijon, A. J., Gallup, D. G., and Behzadian, M. A., and Metheny, W. P. Assessment of epidermal growth factor in the healing process of clean full-thickness skin wounds. Am. J. Obstet. Gynecol. 161: 1658, 1989.
6. Brown, G. L., Nanney, L. B., Griffen, J., Cramer, A. B., Yancey, J. M., Curtsinger, L. J., 3rd, Holtzin, L., Schultz, G. S., Jurkiewicz, M. J., and Lynch, J. B. Enhancement of wound healing by topical treatment with epidermal growth factor. N. Engl. J. Med. 321: 76, 1989.
7. Brown, G. L., Curtsinger, L. J., White, M., Mitchell, R. O., Pietsch, J., Nordquist, R., Von Frauenhofer, A., and Schultz, G. S. Acceleration of tensile strength of incisions treated with EGF and TGF-beta. Ann. Surg. 208: 788, 1988.
8. Brown, G. L., Curtsinger, L., 3rd, Brightwell, J. R., Ackerman, D. M., Tobin, G. R., Polk, H. C., George-Nascimento, C., Lalenzuela, P., and Schultz, G. S. Enhancement of epidermal regeneration by biosynthetic epidermal growth factor. J. Exp. Med. 163: 1319, 1986.
9. Laato, M., Ninikoski, J., Lebel, L., and Gerdin, B. Stimulation of wound healing by epidermal growth factor: A dose-dependent effect. Ann. Surg. 203: 379, 1986.
10. Franklin, J. D., and Lynch, J. B. Effects of topical applications of epidermal growth factor on wound heal-ing. Experimental study on rabbit cars. Plast. Reconstr. Surg. 64: 766, 1979.
11. Greaves, M. W. Lack of effect of topically applied epidermal growth factor (EGF) on epidermal growth in man in vivo. Clin. Exp. Dermatol. 5: 101, 1980.
12. Buckley, A., Davidson, J. M., Kamerath, C. D., Wolt, T. B., and Woodward, S. C. Sustained release of epidermal growth factor accelerates wound repair. Proc. Natl. Acad. Sci. USA 82: 7340, 1985.
13. Arturson, G. Epidermal growth factor in the healing of corneal wounds, epidermal wounds and partial-thickness scalds: A controlled animal study. Scand. J. Plast. Reconstr. Surg. 18: 33, 1984.
14. Seyfer, A. E., Nassaux, P., Emory, R., Wray, H. L., and Schaudies, R. P. Intracellular processing of epidermal growth factor by early wound healing cells. Surgery 107: 69, 1990.
15. Carpenter, G., and Cohen, S. Epidermal Growth Factor. J Biol. Chem. 265: 7709, 1990.
16. O'Keefe, E. J., Chiu, M. L., and Payne, R. E., Jr. Stimulation of growth of keratinocytes by basic fibroblast growth factor. J. Invest. Dermatol. 90: 767, 1988.
17. McGee, G. S., Broadley, K. N., Buckley, A., Aquino, A., Woodward, S. C., Demetriou, A. A., and Davidson, J. M. Recombinant transforming growth factor beta accelerates incisional wound healing. Curr. Surg. 46: 103, 1989.
18. Rappolee, D. A., Mark, D., Banda, M. J., and Werb, Z. Wound macrophages express TGF-a and other growth factors in vivo: Analysis by mRNA phenotyping. Science 241: 708, 1988.
19. Broadley, K. N., Aquino, A. M., Hicks, B., Ditesheim, J. A., McGee, G. S., Demetriou, A. A., Woodward, S. C., and Davidson, J. M. The diabetic rat as an impaired wound model: Stimulatory effects of transforming growth factor-beta and basic fibroblast growth factor. Biotechnol. Ther. 1: 55, 1989-1990.
20. Hebda, P. A., Klingbeil, C. K., Abraham, J. A., and Fiddes, J. C. Basic fibroblast growth factor stimulation of epidermal wound healing in pigs. J. Invest. Dermatol. 95: 626, 1990.
21. Stroobant, P., and Waterfield, M. D. Purification and properties of porcine platelet-derived growth factor. EMBO J. 3: 2963, 1984.
22. Antoniades, H. N., Galanopoulos, T., Neville-Golden, J., Kiritsy, C. P., and Lynch, S. E. Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts. Proc. Natl. Acad. Sci. USA 88: 565, 1991.
23. Greenhalgh, D. G., Hummel, R. P., Albertson, S., and Breeden, M. P. Synergistic actions of platelet-derived growth factor and the insulin-like growth factors in vivo. Enhancement of tissue repair in genetically diabetic mice. Wound Rep. Reg. 1: 69, 1993.
24. Knighton, D. R., Ciresi, K., Fiegel, V. A., Schmuerth, S., Butler, E., and Cerra, F. Stimulation of repair in chronic wound healing, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg. Gynecol. Obstet. 170: 56, 1990.
25. Andree, C., Swain, W. F., Page, C. P., Macklin, M. D., Slama, J., Hatzis, D., and Eriksson, E. In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc. Natl. Acad. Sci. USA 91: 12188, 1994.