Regulators of G-protein signaling in receptor complexes

Trends in Cardiovascular Medicine

Volumn 10, Issue 6, 2000, Pages 263-268

  Sierra, David A ^a   Popov, Serguei ^a   Wilkie, Thomas M ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN SUBUNIT; RECEPTOR; RGS PROTEIN;

CARDIOVASCULAR DISEASE; HEART DEVELOPMENT; HEART FUNCTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; GTP-BINDING PROTEIN REGULATORS; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HUMANS; MOLECULAR STRUCTURE; MYOCARDIUM; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 0034467579     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(00)00072-4     Document Type: Review

References (46)

1. Enhanced Gαq signaling; a common pathway mediates cardiac hypertrophy and apoptotic heart failure
2. Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator
3. Regulation of phospholipase C-β1 by Gq and m1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation
4. Regulators of G-protein signaling (RGS) proteins constitutively activate Gβγ-gated potassium channels
5. Identification of the Gβ5-RGS7 protein complex in the retina
6. Selective regulation of Gαq/11 by an RGS domain in the G-protein-coupled receptor kinase, GRK2
7. Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and α factor pheromones
8. Transgenic Gαq overexpression induces cardiac contractile failure in mice
9. RGS proteins; more than just GAPs for heterotrimeric G-proteins
10. Solution structure of human GAIP (G alpha interacting protein); a regulator of G-protein signaling
11. Calcium oscillations increase the efficiency and specificity of gene expression
12. + channels
13. G-proteins; transducers of receptor-generated signals
14. Antagonism between Goα and Gqα in Caenorhabditis elegans; the RGS protein EAT-16 is necessary for Goα signaling and regulates Gqα activity
15. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13
16. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
17. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity
18. Cardiac myocytes express mRNA for ten RGS proteins; changes in RGS mRNA expression in ventricular myocytes and cultured atria
19. EGL-10 regulates G-protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
20. p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
21. Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta; DAG binding to UNC-13 is required to stimulate acetylcholine release
22. FluG and flbA function interdependently to initiate conidiophore development in Aspergillus nidulans through brlA β activation
23. 2+ spike frequency can optimize gene expression
24. i oscillations
25. Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways
26. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
27. 2+ signaling complexes in polarized cells
28. Gβγ-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy
29. Embryonic cardiomyocyte hypoplasia and craniofacial defects in Gαq/Gα11-mutant mice
30. Regulation of RGS mRNAs by cAMP in PC12 cells
31. G-protein-coupled receptor kinases
32. +/calmodulin reverses phosphatidylinositol 3,4,5-trisphosphate-dependent inhibition of regulators of G-protein-signaling GTPase-activating protein activity
33. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload
34. GTPase-activating proteins for heterotrimeric G-proteins; regulators of G-protein signaling (RGS) and RGS-like proteins
35. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype
36. RGS8 accelerates G-protein-mediated modulation of K+ currents
37. Diversity of G-proteins in signal transduction
38. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain
39. A G-protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits
40. A regulator of G-protein signaling interaction surface linked to effector specificity
41. Structural basis of the axin-adenomatous polyposis coli interaction
42. --activated Giα1; stabilization of the transition state for GTP hydrolysis
43. G-protein regulation of ion channels
44. RGS proteins determine signaling specificity of Gq-coupled receptors
45. The N-terminal domain of RGS4 confers receptor-selective inhibition of G-protein signaling
46. MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16