Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infection

Apoptosis

Volumn 5, Issue 5, 2000, Pages 431-734

  Plunkett, F J ^a   Soares, M V D ^a   Salmon, M ^b   Akbar, A N ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b Medical School   (United Kingdom)

Author keywords

Telomerase; Telomeres; Type 1 interferons; Common chain cytokines

Indexed keywords

CD8 ANTIGEN; TELOMERASE;

APOPTOSIS; ARTICLE; CELL AGING; CELL DIVISION; HUMAN; MEMORY CELL; PRIORITY JOURNAL; SUPPRESSOR CELL; TELOMERE; VIRUS INFECTION;

EID: 0034467258     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009672331030     Document Type: Article

References (41)

1. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral-infections - The role of apoptosis in T-cell memory
2. Apoptotic cell-death of primed CD45RO+ lymphocytes in Epstein-Barr Virus-induced infectious-mononucleosis
3. Direct visualization of antigen-specific CD8(+) T cells during the primary immune response to Epstein-Barr virus in vivo
4. Mortality and immortality at the cellular level. A review
5. T cell immunosenescence in vitro and in vivo
6. A possible role for bcl-2 in regulating T-cell memory-a balancing act between cell-death and survival
7. Cytokine-induced survival of activated T cells in vitro and in vivo
8. Multiple BCL-2 family members demonstrate selective dimerizations with BAX
9. BID, a BCL-2 interacting protein, mediates cytochrome C release from mitochondria in response to activation of cell surface death receptors
10. Cutting Edge: Increased expression of Bcl-2 in antigen specific memory CD8+ T cells
11. Role of Fas-mediated cell death in the regulation of immune responses
12. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes
13. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (BCL-2, BCL-X(L)) but not pro-apoptotic (BAX, BCL-X(S)) gene expression
14. Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: A selective effect on BCL-X(L) expression
15. Type I interferons keep activated T cells alive
16. Cellular environments and apoptosis: Tissue microenvironments control activated T-cell death
17. Interferon-beta mediates stromal cell rescue of T cells from apoptosis
18. Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta
19. Structure and function of telomeres
20. Telomere shortening is associated with cell-division in-vitro and in-vivo
21. Evidence for a critical telomere length in senescent human fibroblasts
22. Synthesis of telomeres by the ribonucleoprotein telomerase
23. The RNA component of human telomerase
24. Functional-characterization and developmental regulation of mouse telomerase RNA
25. Essential role of mouse telomerase in highly proliferative organs
26. Activation of telomerase in human-lymphocytes and hematopoietic progenitor cells
27. Cutting edge: Antigen-dependent regulation of telomerase activity in murine T cells
28. Mechanism of telomerase induction during T cell activation
29. Extension of life-span by introduction of telomerase into normal human cells
30. Tales of tails: Regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
31. Long-term culture of monoclonal human T lymphocytes-models for immunosenescence
32. Human naive and memory t-lymphocytes differ in telomeric length and replicative potential
33. Evidence for a mitotic clock in human hematopoietic stem-cells-loss of telomeric DNA with age
34. Large clonal expansions of CD8(+) T cells in acute infectious mononucleosis
35. Human CD28(-)CD8(+) T cells contain greatly expanded functional virus-specific memory CTL clones
36. Factors that influence activated CD8(+) T-cell apoptosis in patients with acute herpesvirus infections: Loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of BAX and BCL-X expression
37. CD28 expression in T cell aging and human longevity
38. Decline in CD28(+) t-cells in centenarians and in long-term T-cell cultures-a possible cause for both in-vivo and in-vitro immunosenescence
39. Shortened telomeres in the expanded CD28- CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
40. Shortened telomeres in clonally expanded CD28(-)CD8(+) T cells imply a replicative history that is distinct from their CD28(+)CD8(+) counterparts
41. Virus-induced CD8(+) T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: A mechanism for rescue from replicative senescence