Factors that influence activated CD8+ T-cell apoptosis in patients with acute herpesvirus infections: Loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of Bax and Bcl-X expression

Immunology

Volumn 88, Issue 4, 1996, Pages 508-515

  Borthwick, N J ^a   Bofill, M ^a   Hassan, I ^a   Panayiotidis, P ^a   Janossy, G ^a   Salmon, M ^b   Akbar, A N ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD5 ANTIGEN; CD6 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; INTERLEUKIN 2;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ACUTE DISEASE; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD5; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CD8-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CELL DIVISION; CHICKENPOX; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOBLOTTING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0030016592     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. REINHERZ E.L., O'BRIEN C., ROSENTHAL P. & SCHLOSSMAN S.F. (1980) The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies. J Immunol 125, 1269.
2. CRAWFORD D.H., BRICKELI P., TIDMAN N., McCoNNELL I., HOFFBRAND A.V. & JANOSSYG. (1981) Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis. Clin Exp Immunol 43, 291.
3. + subset. Clin Exp Imnninol 62, 515.
4. + T cells as a sign of in vivo activation in infectious mononucleosis. Clin Exp Immunol 83, 447.
5. + cytotoxic T lymphocytes in infectious mononucleosis. Clin Exp Immunol 79, 409.
6. AKHAR A.N., SALMON M., SAVILL J. & JANOSSY G. (1993) A possible role for bcl-2 in regulating T-cell memory - a 'balancing act' between cell death and survival, Immunol Today 14, 526.
7. DUVALL F., WYLLIE A.M. & MORRIS R.G. (1985) Macrophage recognition of cells undergoing programmed cell death (apoptosis). Immunology 56, 351.
8. KORSMEYER S.J. (1992) Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80, 879.
9. OUTVAI Z.N., MILLIMAN C.L. & KORSMEYER S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609.
10. BOISE L.H., GONZALEZ-GARCIA M., POSTEMA C.E. et al. (1993) bel-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597.
11. COHEN J.J. (1991) Programmed cell death in the immune system. Adv Immunol 50, 55.
12. L.) gene expression. Eur J Immunol 26, 294.
13. ITOII N., YONEHARA S., ISHII A. et al. (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66, 233.
14. SUDA T. & NAGATA S. (1994) Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med 179, 873.
15. KABELITZ D., PoHL T. & PECHHOLD K. (1993) Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol Today 14, 338.
16. LIU Y. & JANEWAY C.A. (1990) Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J Exp Med 172, 1735.
17. DHHIN J., WALCZAK H., BAUMLER C., DEBATIN K.M. & KRAMMER P.H. (1995) Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373, 438.
18. BRUNNER T., MOGIL R.J., LAFACE D. et al. (1995) Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373, 441.
19. Ju S.T., PANKA D.J., CUI H. et al. (1995) Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373, 444.
20. LIU Y. & LINSLEY P.S. (1992) Costimulation of T-cell growth. Curr Opin Immunol 4, 265.
21. JENKINS M.K.,TAYLOR P.S., NORTON S.D. & URDAHI K.B. (1991) CD28 delivers a costimulatory signal involved in antigen-specific 1L-2 production by human T cells. J Immunol 147, 2461.
22. CEUPPENS J.L. & BAROJA M.L. (1986) Monoclonal antibodies to the CD5 antigen can provide the necessary second signal for activation of isolated resting T cells by solid-phase-bound OKT3. J Immunol 137, 1816.
23. SWACK J.A., MIER J.W., ROMAIN P.L., HULL S.R. & RUDD C.E. (1991) Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. J Biochem 266, 7137.
24. AKBAR A.N., BORTHWICK N., SALMON M. et al. (1993) The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J EXp Med 178, 427.
25. + T lymphocytes in Epstein Barr virus-induced infectious mononucleosis. Blood 80, 452.
26. RAZVI E.S. & WELSH R.M. (1993) Programmed cell death of T lymphocytes during acute viral infections: a mechanism for virus-induced immune deficiency. J Virol 67, 5754.
27. PANAYIOTIDIS P., GANESHAGURU K., JABBAR S.A. & HOFFBRAND A.V. (1994) Alpha-interferon (x-IFN) protects B-chronic lymphocytic leukaemia cells from apoptotic cell death in vitro. Br J Haematol 86, 169.
28. + T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections. J Exp Med 180, 1943.
29. OHTA K., IWAI K., KASAHARA Y. et al. (1995) Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues. Int Immunol 7, 1817.
30. KRAJEWSKI S., KRAJEWSKA M., SHABAIK A. et al. (1994) Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res. 54, 5501.
31. - T cells. AIDS 8, 431.
32. NORTH M.E., AKBAR A.N., BORTHWICK N., SAGAWA K., FUNAUCHI M. & WEBSTER A.D. (1994) Co-stimulation with anti-CD28 (Kolt-2) enhances DNA synthesis by defective T cells in common variable immunodeficiency. Clin Exp Immunol 95, 204.
33. RUSSELL J.H., WHITE C.L., LOH D.Y. & MELEEDY-REY P. (1991) Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc Natl Acad Sci USA 88, 2151.
34. BRETSCHER P. & COHN M. (1970) A theory of self-nonself discrimination. Science 169, 1042.
35. MUEELER D.L., JENKINS M.K. & SCHWARTZ R.H. (1989) Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 7, 445.
36. HARDING F.A., McARTHUR J.G., GROSS J.A., RAULET D.H. & ALLISON J.P. (1992) CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356, 607.
37. TAN P., ANASETTI C., HANSEN J.A. et al. (1993) Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7 BB1. J Exp Med 177, 165.
38. LINSLEY P.S., BRADY W., GROSMAIRE L., ARUFFO A., DAMLE N.K. & LEDBETTER J.A. (1991) Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 173, 721.
39. CAUX C., VANBERVLIET B., MASSACRIER C., AZUMA M., OKUMURA K. & LANIER L.L. (1994) B70/B7 2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J Exp Med 180, 1841.
40. SHI Y., RADVANYI L.G., SHARMA A. et al. (1995) CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J Immunol 155, 1829.
41. BOISE L.H., MINN A.J., NOEL P.J., JUNE C.H., ACCAVITTI M.A. & LINDSTEN T. (1995) CD28 costimulation can promote T cell survival by enhancing the expression of Bel-XL. Immunity 3, 87.
42. + T cells from HlV-gp120-induced apoptosis. Eur J Immunol 25, 2917.
43. ITOH N., TSUJIMOTO Y. & NAGATA S. (1993) Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol 151, 621.
44. SALMON M., PILLING D., BORTHWICK N.J. et al. (1994) The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol 24, 892.
45. TESTI R.& LANIER L.L. (1989) Functional expression of CD28 on T cell antigen receptor γ/δ-bearing T lymphocytes. Eur J Immunol 19, 185.
46. HOCKENBERY D.M., ZUTTER M., HICKEY W., NAHM M. & KORSMEYER S.J. (1991) BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88, 6961.
47. + Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-I + patients. Am J Pathol 146, 1542.