Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking

Molecular Endocrinology

Volumn 10, Issue 1, 1996, Pages 3-13

  Yang, Jun ^a   DeFranco, Donald B ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE TRANSPORT; HORMONE RECEPTOR INTERACTION; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMALS; CELL LINE; CELL NUCLEUS; CYTOPLASM; DEXAMETHASONE; HAPLORHINI; HSP90 HEAT-SHOCK PROTEINS; KIDNEY; LIVER NEOPLASMS, EXPERIMENTAL; MOLYBDENUM; RATS; RECEPTORS, GLUCOCORTICOID; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030046766     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.1.3     Document Type: Article

References (65)

1. Hunter T, Karin M 1992 The regulation of transcription by phosphorylation. Cell 70:375-387
2. Picard D, Yamamoto KR 1987 Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6:3333-3340
3. Wang X, Sato R, Brown MS, Hua X, Goldstein JL 1994 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77:53-62
4. Liou H-C, Baltimore D 1993 Regulation of the NF-κB/rel transcription factor and IκB inhibitor system. Curr Opin Cell Biol 5:477-487
5. Roth S, Stein D, Nusslein-Volhard C 1989 A gradient of nuclear localization of the dorsal protein determine dorsoventral pattern in the Drosophila embryo. Cell 59:1189-1202
6. Rushlow CA, Han K, Manley JL, Levine M 1989 The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell 59: 1165-1177
7. Pines J, Hunter T 1991 Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol 115:1-17
8. Moll T, Tebb G, Surana U, Robitsch H, Nasmyth K 1991 The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66:743-758
9. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
10. Wikstrom AC, Bakke O, Okret S, Bronnegard M, Gustafsson JÅ 1987 Intracellular localization of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localization. Endocrinology 120:1232-1242
11. Cidlowski JA, Bellingham DL, Powell-Oliver FE, Lubahn DB, Sar M 1990 Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple distinct receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors. Mol Endocrinol 4:1427-1437
12. Qi M, Hamilton BJ, DeFranco D 1989 v-mos oncoproteins affect the nuclear retention and reutilization of glucocorticoid receptors. Mol Endocrinol 3:1279-1288
13. Pratt WB 1993 The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J Biol Chem 268:21455-21458
14. Smith DF, Toft DO 1993 Steroid receptors and their associated proteins. Mol Endocrinol 7:4-11
15. Tai PK, Albers MW, Chang H, Faber LE, Schreiber SL 1992 Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 256:1315-1318
16. Rexin M, Busch W, Gehring U 1991 Protein components of the nonactivated glucocorticoid receptor. J Biol Chem 266:24601-24605
17. Picard D, Khursheed B, Garabedian MJ, Fortin MG, Lindquist S, Yamamoto KR 1990 Reduced levels of hsp90 compromise steroid action in vivo. Nature 348: 166-168
18. Bohen SP, Yamamoto KR 1993 Isolation of hsp90 mutants by screening for decreased steroid receptor function. Proc Natl Acad Sci USA 90:11424-11428
19. Pratt WB, Jolly DJ, Pratt DV, Hollenberg SM, Giguere V, Cadepond FM, Schweizer-Groyer G, Catelli MG, Evans RM, Baulieu EE 1988 A region in the steroid binding domain determines formation of the non-DNA binding, 9S glucocorticoid receptor complex. J Biol Chem 263: 267-273
20. Dalman FC, Scherrer LC, Taylor LP, Akil H, Pratt WB 1991 Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition. J Biol Chem 266:3482-3490
21. Howard KJ, Holley SJ, Yamamoto KR, Distelhorst CW 1990 Mapping the HSP90 binding region of the glucocorticoid receptor. J Biol Chem 265:11928-11935
22. Bresnick EH, Dalman FC, Sanchez ER, Pratt WB 1989 Evidence that the 90- kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. J Biol Chem 264:4992-4997
23. Chambraud B, Berry M, Redeuilh G, Chambon P, Baulieu EE 1990 Several regions of the human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes. J Biol Chem 265:20686-20691
24. Nemoto T, Ohara-Nemoto Y, Minoru O 1992 Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptors. J Steroid Biochem Mol Biol 42:803-812
25. Denis M, Poellinger L, Wikstrom AC, Gustafsson JÅ 1988 Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state. Nature 333:686-688
26. Picard D, Salser SJ, Yamamoto KR 1988 A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 54:1073-1080
27. Eilers M, Picard D, Yamamoto KR, Bishop JM 1989 Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340:66-68
28. Jackson P, Baltimore D, Picard D 1993 Hormone-conditional transformation by fusion proteins of c-abl and its transforming variants. EMBO J 12:2809-2820
29. Spanjaard RA, Chin WW 1993 Reconstitution of ligand-mediated glucocorticoid receptor activity by trans-acting functional domains. Mol Endocrinol 7:12-16
30. Pratt WB 1990 Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts. Mol Cell Endocrinol 74:C69-C76
31. Cadepond F, Gasc JM, Delahaye F, Jibard N, Schweizer GG, Segard MI, Evans R, Baulieu EE 1992 Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor. Exp Cell Res 201:99-108
32. DeFranco DB, Madan AP, Tang Y, Chandran UR, Xiao N, Yang J 1995 Nucleocytoplasmic shuttling of steroid receptors. In: Litwack G (ed) Vitamins and Hormones. Academic Press, New York, vol 51:315-338
33. Urda LA, Yen PM, Simons Jr SS, Harmon JM 1989 Region-specific antiglucocorticoid receptor antibodies selectively recognize the activated form of the ligand-occupied receptor and inhibit the binding of activated complexes to deoxyribonucleic acid. Mol Endocrinol 3:251-260
34. Yang J, DeFranco DB 1994 Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen. Mol Cell Biol 14:5088-5098
35. Sanchez ER, Hirst M, Scherrer LC, Tang HY, Welsh MJ, Harmon JM, Simons SSJ, Ringold GM, Pratt WB 1990 Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90. J Biol Chem 265:20123-20130
36. Hsu SC, Qi M, DeFranco DB 1992 Cell cycle regulation of glucocorticoid receptor function. EMBO J 11:3457-3468
37. Guiochon-Mantel A, Lescop P, Christin-Maitre S, Loosefelt H, Perrot-Applanat M, Milgrom E 1991 Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J 10:3851-3859
38. Chandran UR, DeFranco DB 1992 Internuclear migration of chicken progesterone receptor, but not simian virus-40 large tumor antigen, in transient heterokaryons. Mol Endocrinol 6:837-844
39. Madan AP, DeFranco DB 1993 Bidirectional transport of glucocorticoid receptors across the nuclear envelope. Proc Natl Acad Sci USA 90:3588-3592
40. Dauvois S, White R, Parker MG 1993 The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci 106:1377-1388
41. Guiochon-Mantel A, Loosfelt H, Lescop P, Sar S, Atger M, Perrot-Applanat M, Milgrom E 1989 Mechanisms of nuclear localization of the progesterone receptor: evidence for interactions between monomers. Cell 57: 1147-1154
42. Picard D, Kumar V, Chambon P, Yamamoto KR 1990 Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and progesterone receptors. Cell Regul 1:291-299
43. Ylikomi T, Bocquel MT, Berry M, Gronemeyer H, Chambon P 1992 Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors. EMBO J 11:3681-3694
44. Smith DF 1993 Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes. Mol Endocrinol 7:1418-1429
45. Tuohimaa P, Pekki A, Bläuer M, Jonensuu T, Vilja P, Ylikomi T 1993 Nuclear progesterone receptor is mainly heat shock protein 90-free in vivo. Proc Natl Acad Sci USA 90:5848-5852
46. Renoir JM, Radanyi C, Jung-Testas I, Faber LE, Baulieu EE 1990 The nonactivated progesterone receptor is a nuclear heterooligomer. J Biol Chem 265:14402-14406
47. Gething MJ, Sambrook J 1992 Protein folding in the cell. Nature 355:33-45
48. Gasc JM, Renoir JM, Delahaye F, Baulieu EE 1990 Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59. Exp Cell Res 186:362-367
49. Borer RA, Lehner CF, Eppenberger HM, Nigg EA 1989 Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56:379-390
50. Dong Y, Poellinger L, Gustafsson JÅ, Okret S 1988 Regulation of glucocorticoid receptor expression. Evidence for transcriptional and post-translational mechanisms. Mol Endocrinol 2:1256-1264
51. Kang KI, Devin J, Cadepond F, Jibard N, Guiochon-Mantel A, Baulieu EE, Catelli MG 1994 In vivo functional protein-protein interaction: nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus. Proc Natl Acad Sci USA 91:340-344
52. McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike JW 1995 Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endocrinol 9:659-669
53. Bohen SP, Yamamoto KR 1994 Modulation of steroid receptor signal transduction by heat shock proteins. In: The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 313-334
54. Whitelaw ML, McGuire J, Picard D, Gustafsson JÅ, Poellinger L 1995 Heat shock protein hsp90 regulates dioxin receptor function in vivo. Proc Natl Acad Sci USA 92:4437-4441
55. Denner LA, Weigel NL, Maxwell BL, Schrader WT, O'Malley BW 1990 Regulation of progesterone receptor-mediated transcription by phosphorylation. Science 250: 1740-1743
56. Shaknovich R, Shue G, Kohtz S 1992 Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84). Mol Cell Biol 12:5059-5068
57. Shue G, Kohtz DS 1994 Structural and functional aspects of basic helix-loop-helix protein folding by heat shock protein 90. J Biol Chem 269:2707-2711
58. Guiochon-Mantel A, Delabre K, Lescop P, Milgrom E 1994 Nuclear localization signals also mediate the outward movement of proteins from the nucleus. Proc Natl Acad Sci USA 91:7179-7183
59. Schmidt-Zachmann MS, Dargemont C, Kuhn LC, Nigg EA 1993 Nuclear export of proteins: the role of nuclear retention. Cell 74:493-504
60. Meyer BE, Malim MH 1994 The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev 8:1538-1547
61. Wen W, Harootunian AT, Adams SR, Feramisco J, Tsien RY, Meinkoth JL, Taylor SS 1994 Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. J Biol Chem 269:32214-32220
62. Gametchu B, Harrison RW 1984 Characterization of a monoclonal antibody to the rat liver glucocorticoid receptor. Endocrinology 114:274-288
63. Sullivan WP, Beito TG, Proper J, Krco CJ, Toft DO 1986 Preparation of monoclonal antibodies to the avian progesterone receptor. Endocrinology 119:1549-1557
64. Finch RA, Revankar GR, Chan PK 1993 Nucleolar localization of nucleophosmin/B23 requires GTP. J Biol Chem 268:5823-5827
65. Godowski PJ, Rusconi S, Miesfeld R, Yamamoto KR 1987 Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 325:365-368