Subnuclear organization and trafficking of regulatory proteins: Implications for biological control and cancer

Journal of Cellular Biochemistry

Volumn 80, Issue SUPPL. 35, 2000, Pages 84-92

  Bode, J ^a   Benham, C ^b   Ernst, E ^a   Knopp, A ^a   Marschalek, R ^c   Strick, R ^d   Strissel, P ^d  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Gene expression; Nuclear matrix; Nuclear organization; Runx; Transcription

Indexed keywords

REGULATOR PROTEIN; TRANSCRIPTION FACTOR;

CANCER CONTROL; CELL NUCLEUS MATRIX; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CELL NUCLEUS; GENE EXPRESSION REGULATION; HUMAN; LEUKEMIA; METABOLISM; NEOPLASM;

ANIMALS; CELL NUCLEUS; GENE EXPRESSION REGULATION; HUMANS; LEUKEMIA; MODELS, BIOLOGICAL; NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 0034448642     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. The new paradigm: Integrating genomic function and nuclear architecture
2. Runt homology domain proteins in osteoblast differentiation: AML-3/CBFA1 is a major component of a bone specific complex
3. The organization of replication and transcription
4. Actively transcribed genes are associated with the nuclear matrix
5. Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF
6. The capacity of polyomavirus enhancer binding protein 2alphaB (AML1/ Cbfa2) to stimulate polyomavirus DNA replication is related to its affinity for the nuclear matrix
7. Regulation and regulatory parameters of histone modifications
8. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
9. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
10. The coregulator exchange in transcriptional functions of nuclear receptors
11. The nuclear matrix protein NMP-1 is the transcription factor YY1
12. Modified intranuclear organization of regulatory factors in human acute leukemias: Reversal after treatment
13. RNA polymerase II and the integration of nuclear events
14. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera
15. Exploring the transcription-chromatin interface
16. Dimer formation by an N-terminal coiled coil in the APC protein
17. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D responsive transcription and contribute to chromatin organization
18. Groucho/TLE/R-Esp proteins associate with the nuclear matrix and repress RUNX (CBFα/AML/ PEBP2α) dependent activation of tissue-specific gene transcription
19. Quantitation of RNA polymerase II and its transcription factors in all HeLa cell: Little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure
20. Structure and function in the nucleus
21. Orchestrated response: A symphony of transcription factors for gene control
22. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization
23. Intranuclear targeting of DNA replication factors
24. Dynamics of DNA replication factories in living cells
25. Cell biology of transcription and pre-mRNA splicing: Nuclear architecture meets nuclear function
26. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo
27. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
28. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/ CBF/PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter
29. AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia
30. Spatial and temporal dynamics of DNA replication sites in mammalian cells
31. Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: The C-terminus is a principal determinant for nuclear trafficking
32. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor
33. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription
34. The glucocorticoid receptor: Rapid exchange with regulatory sites in living cells
35. Leukemia-associated AML1/ ETO (8;21) chromosomal translocation protein increases the cellular representation of PML bodies
36. Nuclear lamins A and B1. Different pathways of assembly during nuclear envelope formation in living cells
37. The nucleus: A target site for parathyroid hormone-related peptide (PTHrP) action
38. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ protooncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
39. Rethinking cell structure
40. Half a century of "the nuclear matrix"
41. The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes
42. Subunits of the yeast SWI/SNF complex are members of the actin-related protein (ARP) family
43. The critical role of chromosome translocations in human leukemias
44. Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix
45. The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner
46. In search of the tumour-suppressor functions of BRCA1 and BRCA2
47. Domains of the human androgen receptor and glucocorticoid receptor involved in binding to the nuclear matrix
48. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
49. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
50. Interrelationships of nuclear structure and transcriptional control: Functional consequences of being in the right place at the right time
51. Functional subnuclear partitioning of transcription factors
52. Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific
53. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
54. Subnuclear trafficking of estrogen receptor-alpha and steroid receptor coactivator-1
55. PML in tumour suppression
56. FRAP reveals estrogen receptor-α mobility is ligand- and proteasome-dependent
57. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2- mediated degradation of p53
58. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
59. Positive and negative regulation of granulocyte-macrophage colony stimulating factor promoter activity by AML1-related transcription factor, PEBP2
60. The DNA-binding and τ2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix targeting signal
61. Crystal structure of the nuclear matrix targeting signal of the transcription factor AML-1/PEBP2αB/CBFα2
62. Spatial relationship between transcription sites and chromosome territories
63. Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells
64. Segregation of transcription and replication sites into higher order domains
65. Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles
66. Independence of R/M/N focus formation and the presence of intact BRCA1
67. Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein
68. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF α transcription factors
69. Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains
70. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling
71. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription