Leukemia-associated AML1/ETO (8;21) chromosomal translocation protein increases the cellular representation of PML bodies

Journal of Cellular Biochemistry

Volumn 79, Issue 1, 2000, Pages 103-112

  Ritter, Matthew R ^a   Zhou, Qing ^a   Markland Jr , Francis S ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Acute myelogenous leukemia (AML); Cancer; Nuclear matrix; Promyelocytic leukemia (PML); Transcription factor

Indexed keywords

CHROMOSOME PROTEIN; TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CANCER; CELL NUCLEUS INCLUSION BODY; CELL NUCLEUS MATRIX; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHROMOSOME TRANSLOCATION; DIPLOIDY; DISEASE COURSE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DOMAIN; RAT;

ANIMALS; CELL NUCLEUS; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 8; CORE BINDING FACTOR ALPHA 2 SUBUNIT; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICROSCOPY, FLUORESCENCE; ONCOGENE PROTEINS, FUSION; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033840678     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4644(2000)79:1<103::AID-JCB100>3.0.CO;2-B     Document Type: Article

References (64)

1. Identification of a novel nuclear domain
2. The new paradigm: Integrating genomic function and nuclear architecture
3. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia
4. Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies
5. A novel nuclear substructure, ND10: Distribution in normal and neoplastic human tissues
6. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
7. Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure
8. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
9. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
10. A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein
11. Differing functional responses of simple and complex nuclear bodies in uterine luminal epithelial cells following estrogenic stimuli
12. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia
13. Modified intranuclear organization of regulatory factors in human acute leukemias: Reversal following treatment
14. Interferon-modulated expression of genes encoding the nuclear-dot-associated proteins Spl00 and promyelocytic leukemia protein (PML)
15. Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies
16. The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition
17. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML
18. Disruption of PML-associated nuclear bodies during human cytomegalovirus infection
19. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine, induced disease in SCA1 transgenic mice
20. Syndromes of acute nonlymphocytic leukemia
21. The t(15;17) translocation alters a nuclear body in a retinoic acid- reversible fashion
22. The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1
23. Significance of MTG8 in leukemogenesis
24. The coiled body
25. The acute promyelocytic leukaemia-associated PML gene is induced by interferon
26. Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia
27. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
28. PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu
29. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
30. ETO, a target of t(8;21) in acute leukemia, interacts with the N- CoR and mSin3 corepressors
31. Nuclear domain 10, the site of DNA virus transcription and replication
32. Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0)
33. Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress
34. Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: The C-terminus is a principal deternminant for nuclear trafficking
35. The t(8;21) Chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFA2 transcription factor
36. Indirect and direct disruption of transcriptional regulation in cancer: E2F and AML-1
37. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
38. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
39. t(8;21) Breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
40. PML, a growth suppressor disrupted in acute promyelocytic leukemia
41. The biologic function of PML and its role in acute promyelocytic leukemia
42. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
43. The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells
44. Nuclear dreams: The malignant alteration of nuclear architecture
45. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
46. Nuclear bodies as structural indicators of estrogenic stimulation in uterine luminal epithelial cells
47. PML induces a novel caspase-independeht death process
48. Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes
49. Biological implications of consistent chromosome rearrangements in leukemia and lymphoma
50. Molecular genetics of acute leukaemia
51. Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia
52. The PML nuclear bodies: Actors or extras?
53. Ataxin-1 with an expanded glutamine tract alters nuclear matrix- associated structures
54. A new transcription factor family associated with human leukemias
55. Core-binding factor: A central player in hematopoiesis and leukemia
56. Interrelationships of nuclear structure and transcriptional control: Functional consequences of being in the right place at the right time
57. Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis
58. The prognostic value of cytogenetic analyses in patients with acute nonlymphocytic leukemia treated with the same intensive chemotherapy
59. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
60. PML is essential for multiple apoptotic pathways
61. Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells
62. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
63. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF α transcription factors
64. Proto-oncogene PML controls genes devoted to MHC class I antigen presentation