Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 65, Issue , 2000, Pages 333-342

  Diffley, J F X ^a   Bousset, K ^a   Labib, K ^a   Noton, E A ^a   Santocanale, C ^a   Tercero, J A ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; HYDROXYUREA; RECOMBINANT PROTEIN; RIBONUCLEOTIDE REDUCTASE; FUNGAL DNA; CYCLIN DEPENDENT KINASE 45; CYCLIN DEPENDENT KINASE 7; MINICHROMOSOME MAINTENANCE PROTEIN 2; MINICHROMOSOME MAINTENANCE PROTEIN 3; MINICHROMOSOME MAINTENANCE PROTEIN 4; MINICHROMOSOME MAINTENANCE PROTEIN 5; MINICHROMOSOME MAINTENANCE PROTEIN 6; MINICHROMOSOME MAINTENANCE PROTEIN 7; UNCLASSIFIED DRUG;

CELL CYCLE S PHASE; CELL DIVISION; CONFERENCE PAPER; DNA CONTENT; DNA REPLICATION; DNA REPLICATION ORIGIN; DNA SYNTHESIS; GENE REARRANGEMENT; MITOSIS; PRIORITY JOURNAL; YEAST; CELL CYCLE; CYTOLOGY; DRUG EFFECT; GENETICS; REVIEW; SACCHAROMYCES CEREVISIAE; ARTICLE; BUDDING YEAST; CELL CYCLE ARREST; DNA DAMAGE CHECKPOINT; ENZYME ACTIVITY; GENETIC RECOMBINATION; NONHUMAN; PROTEIN FUNCTION;

FUNGI; SACCHAROMYCETALES;

CELL CYCLE; DNA REPLICATION; DNA, FUNGAL; HYDROXYUREA; SACCHAROMYCES CEREVISIAE; SUPPORT, NON-U.S. GOV'T;

EID: 0034437609     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2000.65.333     Document Type: Conference Paper

References (59)

1. Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication
2. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM complexes and Cdc45p during S phase
3. The Cdc7 protein kinase is required for origin firing during S phase
4. The topography of chromosome replication in yeast
5. A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase
6. The importance of repairing stalled replication forks
7. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of origins to a pre-replicative state
8. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
9. Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae
10. Heat-inducible degron: A method for constructing temperature-sensitive mutants
11. Cdc7 is required throughout the yeast S phase to activate replication origins
12. An overview of the clinical experience with hydroxyurea
13. Cdc6-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
14. Evidence suggesting that the ARS elements associated with silencers of the yeast mating-type locus HML do not function as chromosomal DNA replication origins
15. A question of time: Replication origins of eukaryotic chromosomes
16. A position effect on the time of replication origin activation in yeast
17. Temporal control of DNA replication in yeast
18. A yeast origin of replication is activated late in S phase
19. Clinical use of hydroxyurea in HIV-1 infected patients
20. Hydroxyurea induces recombination in dividing but not in G1 or G2 cell cycle arrested yeast cells
21. Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: Implications for gene amplification
22. Identification of Cdc45p, an essential factor required for DNA replication
23. Subcellular localization of yeast CDC46 varies with the cell cycle
24. Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication
25. Hydroxyurea in the treatment of sickle-cell anemia
26. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex
27. Ribonucleotide reductases
28. The single minichromosome maintenance protein of methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity
29. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
30. Uninterrupted MCM2-7 function required for DNA replication fork progression
31. Hydroxyurea as an inhibitor of human immunodeficiency virus-type-1 replication
32. Sensing and responding to DNA damage
33. Long-term hydroxyurea treatment in young sickle cell patients
34. Aneuploidy and other genetic effects induced by hydroxyurea in Saccharomyces cerevisiae
35. A cytogenetic investigation of DNA rereplication after hydroxyurea treatment: Implications for gene amplification
36. Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe
37. Hydroxyurea: New insights on an old drug
38. Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7
39. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
40. CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication
41. Think global, act local - How to regulate S phase from individual replication origins
42. Activation of S-phase promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast
43. Cell cycle-dependent establishment of a late replication program
44. New uses for old drugs in HIV infection: The role of hydroxyurea, cyclosporin and thalidomide
45. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae
46. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
47. Activation of dormant origins of DNA replication in budding yeast
48. RuvAB acts at arrested replication forks
49. The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum delta H minichromosome maintenance protein
50. Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae
51. p53 Inhibits entry into mitosis when DNA synthesis is blocked
52. DNA synthesis at individual replication forks requires the essential initiation factor, Cdc45p
53. Activation of silent replication origins at autonomously replicating sequence elements near the HML locus in budding yeast
54. Induction by adozelesin and hydroxyurea origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae
55. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast
56. Induction of mitotic recombination by UV and diepoxybutane and its enhancement by hydroxyurea in Saccharomyces cerevisiae
57. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase
58. CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication