Design of two etoposide-amsacrine conjugates: Topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity

Anti-Cancer Drug Design

Volumn 15, Issue 6, 2000, Pages 413-421

  Arimondo, P ^a   Boukarim, C ^a   Bailly, C ^a   Dauzonne, D ^a   Monneret, C ^a  

^a INSERM   (France)

Author keywords

Amsacrine; Antitumour drugs; Cytotoxicity; DNA cleavage; Etoposide; Topoisomerase II

Indexed keywords

3 METHOXYMETHANE SULFONAMIDE ANILINO DERIVATIVE; 4' O DEMETHYL 4BETA (2'' METHOXY 4'' METHANESULFONYLAMIDOANILINO) 4 DEOXYPODOPHYLLOTOXIN; 4' O DEMETHYL BETA [2 (2'' METHOXY 4'' METHANESULFONYLAMIDOANILINO)ETHYL] 4 DEOXYPODOPHYLLOTOXIN; AMSACRINE DERIVATIVE; CYTOTOXIC AGENT; DNA TOPOISOMERASE INHIBITOR; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE; ETOPOSIDE DERIVATIVE; GYRASE INHIBITOR; ICP 114; ICP 147; KINETOPLAST DNA; PLASMID DNA; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DNA CLEAVAGE; DNA STRAND BREAKAGE; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; ENZYME MECHANISM; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

AMSACRINE; ANIMALS; BASE SEQUENCE; BIOPOLYMERS; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; ETOPOSIDE; LEUKEMIA L1210; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; TUBULIN; TUBULIN MODULATORS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034434229     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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