Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611

Journal of Medicinal Chemistry

Volumn 41, Issue 23, 1998, Pages 4475-4485

  Daley, Laurent ^a   Guminski, Yves ^b   Demerseman, Pierre ^a   Kruczynski, Anna ^b   Etiévant, Chantal ^b   Imbert, Thierry ^b   Hill, Bridget T ^b   Monneret, Claude ^a  

^a INSTITUT CURIE   (France)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 O (3'' AMINO 2'',3'' DIDEOXY 4'',6'' O ETHYLIDENE BETA DEXTRO ARABINO HEXOPYRANOSYL)EPIPODOPHYLLOTOXIN; 4 O (3'' AMINO 2'',3'' DIDEOXY 4'',6'' O ETHYLIDENE BETA DEXTRO RIBO HEXOPYRANOSYL)EPIPODOPHYLLOTOXIN; 4 O (3'' DIMETHYLAMINO 2'',3'' DIDEOXY 4'',6'' O ETHYLIDENE BETA DEXTRO ARABINO HEXOPYRANOSYL)EPIPODOPHYLLOTOXIN; 4 O (3'' N,N DIMETHYLAMINO 2'',3'' DIDEOXY 4'',6'' O ETHYLIDENE BETA DEXTRO RIBO HEXOPYRANOSYL)EPIPODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE DERIVATIVE; GLYCOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LEUKEMIA L 1210; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOPOLYMERS; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GLYCOSIDES; GLYCOSYLATION; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA L1210; LEUKEMIA P388; MICE; MICE, INBRED DBA; PODOPHYLLOTOXIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0032487837     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9800752     Document Type: Article

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