Syndrome X-like alterations in adult female rats due to neonatal insulin treatment

Metabolism: Clinical and Experimental

Volumn 47, Issue 7, 1998, Pages 855-862

  Harder, Thomas ^a   Plagemann, Andreas ^a   Rohde, Wolfgang ^a   Dörner, Günter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; PRASTERONE; TESTOSTERONE;

ANDROGEN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; FEMALE; FEMALE FERTILITY; HYPERINSULINEMIA; HYPERTENSION; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN TREATMENT; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SYNDROME X;

EID: 0031837952     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90126-3     Document Type: Article

References (65)

1. Bray GA, Fisler J, York DA: Neuroendocrine control of the development of obesity: Understanding gained from studies of experimental animal models. Front Neuroendocrinol 12:128-171, 1990
2. Balkan B, Steffens AB, Bruggink JE, et al: Hyperinsulinemia and glucose tolerance in obese rats with lesions of the ventromedial hypothalamus: Dependence on food intake and route of administration. Metabolism 40:1092-1100, 1991
3. Inoue S, Bray GA: The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology 100:108-114, 1977
4. Hanefeld M, Leonhardt W: Das metabolische Syndrom. Dtsch Ges Wes 36:545-551, 1980
5. Reaven GM: The role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
6. Camus JP: Goutte, diabete, hyperlipemie: un trisyndrome metabolique. Rev Rhum 33:10-14, 1966
7. Mehnert H, Kuhlmann H: Hypertonie und Diabetes mellitus. Dtsch Med J 19:567-571, 1968
8. Haffner SM, Stern MP, Mitchell BD, et al: Incidence of type II diabetes in Mexican Americans predicted by testing insulin and glucose levels, obesity, and body fat distribution. Diabetes 39:283-288, 1990
9. Charles MA, Fontbonne A, Thibult N, et al: Risk factors for NIDDM in white populations. Diabetes 40:796-799, 1991
10. Modan M, Halkin H, Almog S, et al: Hyperinsulinemia. A link between hypertension, obesity and glucose intolerance. J Clin Invest 75:809-817, 1985
11. Standley PR, Bakir MH, Sowers JR: Vascular insulin abnormalities, hypertension, and accelerated atherosclerosis. Am J Kidney Dis 21:3-46, 1993 (suppl 3)
12. Björntorp P: The android woman - A risky condition. J Intern Med 239:105-110, 1996
13. Weiss DJ, Charles MA, Dunaif A, et al: Hyperinsulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women. Metabolism 43:803-807, 1994
14. Silverman BL, Rizzo T, Green OC, et al: Long-term prospective evaluation of offspring of diabetic mothers. Diabetes 40:121-125, 1991 (suppl 2)
15. Plagemann A, Harder T, Kohlhoff R, et al: Glucose tolerance and insulin secretion in children of mothers with pregestational IDDM or gestational diabetes. Diabetologia 40:1094-1100, 1997
16. Dörner G, Plagemann A, Rückert J, et al: Teratogenetic maternofetal transmission and prevention of diabetes susceptibility. Exp Clin Endocrinol 91:247-258, 1988
17. Lee MO: Determination of the surface area of the white rat with its application to the expression of metabolic results. Am J Physiol 89:24-33, 1929
18. Cederholm J, Wibell L: Evaluation of insulin release and relative peripheral insulin resistance with use of the oral glucose tolerance test: A study in subjects with normoglycaemia, glucose intolerance and non-insulin-dependent diabetes mellitus. Scand J Clin Lab Invest 45:741-751, 1985
19. Bunag RD, Teräväinen TL: Tail-cuff detection of systolic hypertension in different strains of aging rats. Mech Ageing Dev 59:197-213, 1991
20. Legido A, Sarria A, Bueno M, et al: Relationship of body fat distribution to metabolic complications in obese prepubertal girls. Clin Pediatr 26:310-315, 1987
21. Dörner G: Hormones and Brain Differentiation. Amsterdam, The Netherlands, Elsevier, 1976
22. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. San Diego, CA, Academic, 1986
23. Weibel ER: Stereological Methods, vol 1. London, UK, Academic, 1979
24. Bereiter DA, Jeanrenaud B: Altered neuroanatomical organization in the central nervous system of the genetically obese (ob/ob) mouse. Brain Res 165:249-260, 1979
25. Stahl F: Radioimmunoassay of plasma testosterone without chromatography. Endokrinologie 65:288-292, 1975
26. Ziegler B, Hahn HJ, Ziegler M: Insulin recovery in pancreas and host organs of islet grafts. Exp Clin Endocrinol 85:53-60, 1985
27. Campfield LA, Smith FJ, Guisez Y, et al: Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
28. Considine RV, Caro JF: Leptin: Genes, concepts and clinical perspectives. Horm Res 46:249-256, 1996
29. Kalra SP, Kalra PS: Nutritional infertility: The role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front Neuroendocrinol 17:371-401, 1996
30. Kennedy GC: The development with age of hypothalamic restraint upon appetite of the rat. J Endocrinol 16:9-17, 1957
31. Bray GA, York DA: Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis. Physiol Rev 59:719-809, 1979
32. Combettes-Souverain M, Penicaud L, Ferré P, et al: Increased mitogen-activated protein kinase expression and activity in white adipose tissue of ventromedial hypothalamus-lesioned rats. Diabetologia 40:533-540, 1997
33. Bernardis LL, Bellinger LL: The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism. Neurosci Biobehav Rev 17:141-193, 1993
34. Luiten PGM, Room P: Interrelations between lateral, dorsomedial and ventromedial hypothalamic nuclei in the rat. An HRP study. Brain Res 190:321-332, 1980
35. Tokunaga K, Fukushima M, Kemnitz JW, et al: Comparison of ventromedial and paraventricular lesions in rats that become obese. Am J Physiol 251:R1221-R1227, 1986
36. Dörner G, Staudt J: Vergleichende morphologische Untersuchungen der Hypothalamusdifferenzierung bei Ratte und Mensch. Endokrinologie 59:152-155, 1972
37. Pozzo-Miller LD, Aoki A: Postnatal development of the ventromedial hypothalamic nucleus: Neurons and synapses. Cell Mol Neurobiol 12:121-129, 1992
38. Erikson P, Ahlbom J, Fredriksson A: Exposure to DDT during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behaviour in adult mice. Brain Res 582:277-281, 1992
39. Plagemann A, Harder T, Kolbe A, et al: Teratogenetic effects of hyperinsulinism during differentiation of the hypothalamus on obesity and diabetes susceptibility in rats. Int J Obes 18:P534, 1994 (suppl 1, abstr)
40. Oomura Y, Kita H: Insulin acting as a modulator of feeding through the hypothalamus. Diabetologia 20:290-298, 1981
41. Kappy M, Sellinger S, Raizada M: Insulin binding in four regions of the developing rat brain. J Neurochem 42:198-203, 1984
42. Devaskar SU, Karycki L, Devaskar UP: Varying insulin concentrations differentially regulate the fetal brain insulin receptor. Biochem Biophys Res Commun 136:208-219, 1986
43. Brennan WA: Developmental aspects of the rat brain insulin receptor: Loss of sialic acid and fluctuation in number characterize fetal development. Endocrinology 122:2364-2370, 1988
44. Schwartz MW, Figlewicz DP, Baskin DG, et al: Insulin in the brain: A hormonal regulator of energy balance. Endocr Rev 13:387-414, 1992
45. Raizada MK, Boyd FT, Clarke DW, et al: Physiologically unique insulin receptors on neuronal cells, in Raizada MK, Phillips MI, LeRoith D (eds): Insulin, Insulin-Like Growth Factors, and Their Receptors in the Central Nervous System. New York, NY, Plenum, 1987, pp 191-200
46. Weiss PAM, Hofmann H, Pürstner P, et al: Fetal insulin balance: Gestational diabetes and postpartal screening. Obstet Gynecol 64:65-68, 1984
47. Smith-West C, Garris DR: Diabetes-associated hypothalamic neuronal depopulation in the aging Chinese hamster. Dev Brain Res 9:385-389, 1983
48. Garris DR, West RL, Coleman DL: Morphometric analysis of medial basal hypothalamic degeneration in diabetes (db/db) mutant C57BL/KsJ mice: Relation to age and hyperglycemia. Dev Brain Res 20:161-168, 1985
49. Gahr M: How should brain nuclei be delineated? Consequences for developmental mechanisms and for correlations of area size, neuron numbers and functions of brain nuclei. Trends Neurosci 20:58-63, 1997
50. Plagemann A, Harder T, Rake A, et al: Acquired neuroendocrine disposition to diabetes and obesity due to perinatal quantitative malnutrition in rats. Exp Clin Endocrinol Diabetes 105:57-59, 1997 (suppl 3)
51. Plagemann A, Harder T, Melchior K, et al: Funktionelle und hypothalamische Befunde bei adulten Nachkommen gestationsdiabetischer Muttertiere. Diabetes Stoffwechsel 6:83, 1997 (suppl 1, abstr)
52. Bernardis LL, Patterson BD: Correlation between "Lee index" and carcass fat content in weanling and adult female rats with hypothalamic lesions. J Endocrinol 40:527-528, 1968
53. Stephens DN: Does the Lee obesity index measure general obesity? Physiol Behav 25:313-315, 1980
54. Simson EL, Gold RM: The Lee obesity index vindicated? Physiol Behav 29:371-376, 1982
55. Han PW, Frohman LA: Hyperinsulinemia in tube-fed hypophysectomized rats bearing hypothalamic lesions. Am J Physiol 219:1632-1636, 1970
56. Perkins MN, Rothwell NJ, Stock MJ, et al: Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Nature 289:401-402, 1981
57. Hall JE, Brands MW, Kivlighn SD, et al: Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines? Hypertension 15:519-527, 1990
58. Mondon CE, Reaven GM: Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension. Metabolism 37:303-305, 1988
59. Kurtz TW, Morris C, Pershadsigh HA: The Zucker fatty rat as a genetic model of obesity and hypertension. Hypertension 13:896-901, 1989
60. Satoh S, Inoue S, Egawa M, et al: Insulin increases triglyceride secretion rate in rats in vivo. Int J Obes 11:325-331, 1987
61. Dunaif A, Finegood DT: β-Cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 81:942-947, 1996
62. Poretsky L, Clemons J, Bogovich K: Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats. Metabolism 41:903-910, 1992
63. Aerts L, Holemans K, Van Assche FA: Maternal diabetes during pregnancy: Consequences for the offspring. Diabetes Metab Rev 6:147-167, 1990
64. Friedrichs J: Experimental investigations on etiopathogenesis of diabetes mellitus. Doctoral thesis, Humboldt University Medical School (Charité), Berlin, Germany, 1990
65. Plagemann A, Rückert JC, Friedrichs J, et al: Fetal and neonatal hyperinsulinism as risk factor of a lifelong enhanced diabetes susceptibility, in Laron Z, Karp M (eds): Genetic and Environmental Risk Factors for Type I Diabetes (IDDM) Including a Discussion on the Autoimmune Basis. London, UK, Freund, 1992, pp 73-78