Cardiac chloride channels: Physiology, pharmacology and approaches for identifying novel modulators of activity

Drug Discovery Today

Volumn 5, Issue 11, 2000, Pages 492-505

  Mulvaney, Andrew W ^b   Spencer, C Ian ^a   Culliford, Steven ^a   Borg, John J ^a   Davies, Stephen G ^b   Kozlowski, Roland Z ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; ANTIARRHYTHMIC AGENT; BUMETANIDE; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CIPERMETHRIN; FLUOXETINE; GENISTEIN; LEFLUNOMIDE; TAMOXIFEN;

CHLORIDE CURRENT; DRUG MECHANISM; DRUG RESEARCH; DRUG TARGETING; ELECTROPHYSIOLOGY; HEART ARRHYTHMIA; HUMAN; PROTEIN STRUCTURE; REVIEW;

EID: 0034327506     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01561-0     Document Type: Review

References (120)

1. The cardiac ion channels: Relevance to management of arrhythmias
2. Overview of trends in the control of cardiac arrhythmia: Past and future
3. Cardiac chloride channels
4. The cardiac chloride channels as molecular targets for antiarrhythmic therapy
5. Role of cardiac chloride currents in changes in action potential characteristics and arrhythmias
6. Insights into the structure, distribution and function of the cardiac chloride channels
7. Chloride channels: Potential therapeutic targets
8. Anion transport in heart
9. Transmembrane I(Ca) contributes to rate-dependent changes of action potentials in human ventricular myocytes
10. Intracellular chloride activity in mammalian ventricular muscle
11. - activities in ventricular myocytes isolated from rabbit heart
12. Chloride activity and its control in skeletal and cardiac muscle
13. Isoproterenol activates a chloride current, not the transient outward current, in rabbit ventricular myocytes
14. Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes
15. Properties of a protein kinase C-activated chloride current in guinea pig ventricular myocytes
16. - currents in feline ventricular myocytes
17. - channel
18. Swelling-induced chloride-sensitive current in canine atrial cells revealed by whole-cell patch-clamp method
19. Stretch-activated anion currents of rabbit cardiac myocytes
20. Calcium-activated chloride current in rabbit ventricular myocytes
21. - dependent chloride current in single Purkinje cells from rabbit heart
22. 2+-sensitive transient outward current in rabbit ventricular myocytes
23. Cystic fibrosis gene encodes a cAMP-dependent chloride channel in heart
24. - channels in mouse heart: A novel, alternative pathway for CFTR regulation
25. Properties of voltage-gated chloride channels of the ClC gene family
26. Molecular identification of a volume-regulated chloride channel
27. A novel anionic conductance affects action potential duration in isolated rat ventricular myocytes
28. Distribution of the isoprenaline-induced chloride current in rabbit heart
29. Distribution of cAMP-activated chloride current and CFTR mRNA in the guinea pig heart
30. Swelling-activated and isoprenaline-activated chloride currents in guinea pig cardiac myocytes have distinct electrophysiology and pharmacology
31. Chloride conductance in human atrial cells
32. Forskolin stimulates swelling-induced chloride current, not cardiac cystic fibrosis transmembrane-conductance regulator current, in human cardiac myocytes
33. Kinetic evidence distinguishing volume-sensitive chloride current from other types in guinea-pig ventricular myocytes
34. On the mechanism of rectification of the isoproterenol-activated chloride current in guinea-pig ventricular myocytes
35. Chloride conductance pathways in heart
36. Autonomic regulation of a chloride current in heart
37. Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential
38. Anion and cation modulation of the guinea-pig ventricular action potential during β-adrenoceptor stimulation
39. Membrane mechanisms in volume and pH regulation in vertebrate cells
40. Mechanosensitivity as an integrative system in heart: An audit
41. Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium
42. Intracellular calcium activates a chloride current in canine ventricular myocytes
43. G(s) and adenylyl cyclase in transverse tubules of heart: Implications for cAMP-dependent signaling
44. A modified model of global ischaemia: Application to the study of syncytial mechanisms of arrhythmogenesis
45. Anion manipulation: A new antiarrhythmic approach. Action of substitution of chloride with nitrate on ischemia- and reperfusion-induced ventricular fibrillation and contractile function
46. Early action potential shortening in hypoxic hearts: Role of chloride current(s) mediated by catecholamine release
47. Use of chloride blockers: A novel approach for cardioprotection against ischemia-reperfusion damage
48. Anion manipulation, a novel antiarrhythmic approach: Mechanism of action
49. Proarrhythmia related to prolongation of repolarization: Mechanisms, monitoring, prevention and management
50. - channel blockers
51. Voltage-dependent block of endothelial volume-regulated anion channels by calix(4)arenes
52. Effects of anion channel blockers on hyposmotically induced amino acid release from the in vivo rat cerebral cortex
53. The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel
54. Anion channel blockers inhibit swelling-activated anion, cation, and nonelectrolyte transport in HeLa cells
55. Block by fluoxetine of volume-regulated anion channels
56. Bumetanide blocks CFTR GCl in the native sweat duct
57. The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels
58. Structural and ionic determinants of 5-nitro-2-(3-phenylprophyl-amino)-benzoic acid block of the CFTR chloride channel
59. Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX)
60. Anion transport in red blood cells, III. Sites and sidedness of inhibition by high-affinity reversible binding probes
61. Macromolecular conjugates of transport inhibitors: New tools for probing topography of anion transport proteins
62. Mechanism of NaCl secretion in rectal gland tubules of spiny dogfish (Squalus acanthias), II. Effects of inhibitors
63. Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein
64. Chloride channel blockers
65. Effects of pyrethroids on volume-sensitive chloride channels
66. Halide and alkyl phenols block volume-sensitive chloride channels in human glial cells (U-138MG)
67. Experimental and computational approaches to solubility and permeability in drug discovery and development settings
68. - channels expressed in a mammalian cell line and its regulation by a critical pore residue
69. Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells
70. Regulation of a swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins
71. Tyrosine protein kinase inhibitors prevent activation of cardiac swelling-induced chloride current
72. Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances
73. - conductance in mouse fibroblasts
74. The tyrosine kinase p56lck mediates activation of swelling-induced chloride channels in lymphocytes
75. Discovery of a novel, potent and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
76. Substituted 5,7-diphenyl-pyrrolo(2,3d)pyrimidines: Potent inhibitors of the tyrosine kinase c-Src
77. P-glycoprotein and swelling-activated chloride channels
78. The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease
79. Cell-based assays and instrumentation for screening ion-channel targets
80. - channels: Focus on 'molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland'
81. A microplate assay measuring chloride ion channel activity
82. Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications
83. Volume-regulatory taurine release from a human lung cancer cell line. Evidence for amino acid transport via a volume-activated chloride channel
84. Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux
85. Swelling-activated efflux of taurine and other organic osmolytes in endothelial cells
86. - channel
87. Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells
88. Separate taurine and chloride efflux pathways activated during regulatory volume decrease
89. - channels
90. - and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition
91. Volume-activated chloride channels in HeLa cells are blocked by verapamil and dideoxyforskolin
92. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
93. A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates
94. Isolation of cardiac myocytes
95. Chloride-sensitive nature of the adrenaline-induced current in guinea-pig cardiac myocytes
96. - channels in heart
97. +
98. Chemical probes for anion transporters of mammalian cell membranes
99. Characterization of the enhanced transport of L- and D-lactate into human red blood cells infected with Plasmodium falciparum suggests the presence of a novel saturable lactate proton cotransporter
100. Signature currents: A patch-clamp method for determining the selectivity of ion channel blockers in isolated cardiac myocytes
101. The Lambeth Conventions: Guidelines for the study of arrhythmias in ischaemia infarction and reperfusion
102. Torsades de pointes: Arrhythmia, syndrome, or chimera? A perspective in the light of the Lambeth Conventions
103. World leaders heap praise on human genome landmark
104. Characterization of a murine gene homologous to the bovine CaCC chloride channel
105. The CLC chloride channel family
106. - channel and activation by phorbol ester
107. Transmembrane topology of a CLC chloride channel
108. 2 and COOH terminus of the yeast CLC putative chloride channel Gef1p
109. Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase
110. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
111. Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis
112. Development of chloride channel modulators
113. + channel activity in isolated rat arterial smooth muscle cells
114. + currents in myocytes isolated from aorta, basilar and pulmonary artery
115. Chloride secretion induced by phorbol dibutyrate and forskolin in the human colonic carcinoma cell line HT-29Cl.19A is regulated by different mechanisms
116. 2+ currents in cardiac myocytes
117. 2+ channels by GTPγS in response to isoprenaline, forskolin and photoreleased nucleotides
118. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea
119. Inhibition of sodium current by 4,4'-diisothiocyanatostilbine-2,2'-disulfonic acid (DIDS) in guinea-pig cardiac ventricular cells