The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells

International Immunology

Volumn 9, Issue 1, 1997, Pages 9-15

  Guéry, Jean Charles ^a,b   Ria, Francesco ^a,c   Galbiati, Francesca ^a   Smiroldo, Simona ^a   Adorini, Luciano ^a  

^a ROCHE MILANO RICERCHE   (Italy)

^b CHU PURPAN   (France)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Antigen presentation; Lysozyme

Indexed keywords

ADJUVANT; ANTIGEN; EGG WHITE; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN; SYNTHETIC PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HYBRIDOMA; IMMUNIZATION; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; B-LYMPHOCYTES; CELL SEPARATION; DENDRITIC CELLS; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPH NODES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MURAMIDASE; PEPTIDES; SOLUBILITY;

EID: 0031054358     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.1.9     Document Type: Article

References (27)

1. Schwartz, R. H. 1985. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3:237.
2. Möller, G. 1988. Antigen processing. Immunol. Rev. 106:1.
3. + T cells to protein antigens in vivo. J. Immunol. 155:3734.
4. Epstein, M. M., Di Rosa, R, Jankovic, D., Sher, A. and Matzinger, P. 1995. Successful T cell priming in B cell-deficient mice J. Exp. Med. 182:915.
5. Crowley, M. T., Inaba, K. and Steinman, R. M. 1990. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172:383.
6. Romani, N. and Schuler, G. 1992. The immunological properties of epidermal Langerhans cells as a part of the dendritic cell system. Semin Immunopathol. 13:265.
7. Steinman, R. M. 1991, The dendritic cell system and its role in immunogenicity. Annu Rev. Immunol. 9:271.
8. Macatonia, S. E., Knight, S. C., Edwards, A, J., Griffiths, S, and Fryer P. 1987. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate J. Exp. Med 166:1654.
9. Schuler, G. and Steinman, R. M. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp. Med. 161:526
10. Romani, N., Koide, S , Crowley, M., Witmer-Pack, M., Livingstone, A. M., Fathman, C. G., Inaba, K. and Steinman, R. M. 1989. Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 169:1169.
11. Quéry, J.-C., Sette, A., Leighton, J., Dragomir, A. and Adorini, L. 1992. Selective immunosuppression by administration of MHC class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation. J. Exp Med. 175:1345.
12. Guéry, J.-C., Neagu, M., Rodriguez-Tarduchy, G. and Adorini, L. 1993. Selective immunosuppression by administration of major histocompatibility complex class II-binding peptides. II. Preventive inhibition of primary and secondary antibody responses. J. Exp. Med. 177:1461.
13. Guéry, J. C., Ria, F. and Adorini, L. 1996, Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells following administration of protein in adjuvant, J. Exp. Med. 183:751.
14. Metlay, J. P., Witmer-Pack, M. D., Agger, R., Crowley, M. T., Lawless, D and Steinman, R. M. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753.
15. Crowley, M. T., Inaba, K., Witmer-Pack, M. D., Gezelter, S. and Steinman, R. M. 1990. Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen. J. Immunol. Methods. 133:55.
16. Adorini, L., Sette, A., Buus, S., Grey, H. M., Darsley, M., Lehmann, P. V., Doria, G., Nagy, Z. A. and Appella, E. 1988. Interaction of an immunodominant epitope with la molecules in T-cell activation. Proc. Natl Acad. Sci. USA. 85:5181.
17. Guéry, J.-C., Sette, A., Appella, E. and Adorini, L 1995. Constitutive presentation of dominant epitopes from endogenous naturally processed self β2 microglobulin to class II-restricted T cells leads to self tolerance. J. Immunol. 154:545.
18. Kyewski, B. A., Fathman, C. G. and Rouse. R V. 1986. Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation J. Exp. Med 163:231
19. Müller, K. P, Schumacher, J. and Kyewski, B, 1993. Half-life' of antigen/major histocompatibility complex class II complexes in vivo: intra- and interorgan variations. Eur. J. Immunol. 23:3203.
20. + T cells. J. Immunol. 154:4915.
21. Sallusto, F. and Lanzavecchia, A 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor a. J. Exp. Med. 179:1109.
22. Bhardwaj, N., Young, J. W., Nisanian, A, J., Baggers, J. and Steinman, R. M. 1993. Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. J. Exp. Med. 178:633
23. Fuchs, E. F. and Matzinger, P. 1992. B cells turn off virgin but not memory T cells. Science. 258:1156.
24. Ronchese, F. and Hausmann, B. 1993. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes. J. Exp. Med. 177:679.
25. Eynon, E. E. and Parker, D. C. 1992. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175:131.
26. Gajewski, T, F., Pinnas, M., Wong, T, and Fitch, F. W. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146:1750.
27. + T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med. 176:1431.