Molecular analysis of rheumatoid factor (RF)-negative B cell hybridomas from rheumatoid synovial tissue: Evidence for an antigen-induced stimulation with selection of high mutated IgV(H) and low mutated IgV(L)/λ genes

Clinical and Experimental Immunology

Volumn 115, Issue 1, 1999, Pages 168-175

  Krenn, Veit ^a,b   Konig A ^b   Hensel, F ^a   Berek, C ^c   Souto Carneiro, M M ^a   Haedicke, W ^a   Wang, Y K ^a   Vollmers, H P ^a   Muller Hermelink H K ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

Affinity maturation; Germinal centres; Rheumatoid arthritis; Rheumatoid factors; V(H) and V(L) repertoire

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RHEUMATOID FACTOR;

ADULT; AGED; ARTHRITIS; ARTICLE; B LYMPHOCYTE; CASE REPORT; DISEASE ACTIVITY; FEMALE; GENE MUTATION; GERMINAL CENTER; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; INFLAMMATION; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; SYNOVITIS;

EID: 0032943626     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00767.x     Document Type: Article

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