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Volumn 5, Issue 10, 2000, Pages 465-476

Development of novel nucleoside analogues for use against drug resistant strains of HIV-1

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NUCLEOSIDE ANALOG; PHOSPHAZID; PRODRUG; TENOFOVIR; UNCLASSIFIED DRUG;

EID: 0034307881     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01558-0     Document Type: Review
Times cited : (28)

References (66)
  • 1
    • 0027258343 scopus 로고
    • Molecular and biological aspects of AZT resistant viruses derived from HIV-1 infected individuals
    • Levantis P.et al. Molecular and biological aspects of AZT resistant viruses derived from HIV-1 infected individuals. Antivral Chem. Chemother. 4:1993;131-138.
    • (1993) Antivral Chem. Chemother. , vol.4 , pp. 131-138
    • Levantis, P.1
  • 2
    • 0029086438 scopus 로고
    • Antiretroviral activity of stavudine (2′, 3′-didehydro-3′-deoxythymidine, d4T)
    • Riddler S.A.et al. Antiretroviral activity of stavudine (2′, 3′-didehydro-3′-deoxythymidine, d4T). Antiviral Res. 27:1995;189-203.
    • (1995) Antiviral Res. , vol.27 , pp. 189-203
    • Riddler, S.A.1
  • 3
    • 0029850308 scopus 로고    scopus 로고
    • Didanosine: An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease
    • Perry C.M., Balfour J.A. Didanosine: an update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 52:1996;928-962.
    • (1996) Drugs , vol.52 , pp. 928-962
    • Perry, C.M.1    Balfour, J.A.2
  • 4
    • 0029933341 scopus 로고    scopus 로고
    • DdC (zalcitabine)
    • Skowron G. ddC (zalcitabine). Adv. Exp. Med. Biol. 394:1996;257-269.
    • (1996) Adv. Exp. Med. Biol. , vol.394 , pp. 257-269
    • Skowron, G.1
  • 5
    • 0027213446 scopus 로고
    • Lamivudine
    • Cameron J.M.et al. Lamivudine. Drugs Future. 1:1993;319-323.
    • (1993) Drugs Future , vol.1 , pp. 319-323
    • Cameron, J.M.1
  • 6
    • 0030982931 scopus 로고    scopus 로고
    • 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity
    • Daluge S.M.et al. 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob. Agents Chemother. 41:1997;1082-1093.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1082-1093
    • Daluge, S.M.1
  • 7
    • 2642640455 scopus 로고    scopus 로고
    • Recent advances in antiretroviral therapy and HIV infection monitoring
    • Schmit J-C., Weber B. Recent advances in antiretroviral therapy and HIV infection monitoring. Intervirology. 40:1998;304-321.
    • (1998) Intervirology , vol.40 , pp. 304-321
    • Schmit, J-C.1    Weber, B.2
  • 8
    • 0022996630 scopus 로고
    • Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase
    • Furman P.A.et al. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. U. S. A. 83:1986;8333-8337.
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 8333-8337
    • Furman, P.A.1
  • 9
    • 0026651622 scopus 로고
    • Effect of (-)2′-deoxy-3′-thiacytidine (3TC) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerase α, β and γ
    • Hart G.J.et al. Effect of (-)2′-deoxy-3′-thiacytidine (3TC) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerase α, β and γ Antimicrob. Agents Chemother. 36:1992;1688-1694.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 1688-1694
    • Hart, G.J.1
  • 10
    • 0001587762 scopus 로고
    • Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides
    • Mitsuya H., Broder S. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides. Proc. Natl. Acad. Sci. U. S. A. 83:1986;1911-1915.
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 1911-1915
    • Mitsuya, H.1    Broder, S.2
  • 11
    • 0023475103 scopus 로고
    • 3′-azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase
    • St Clair M.et al. 3′-azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob. Agents Chemother. 3:1987;1972-1977.
    • (1987) Antimicrob. Agents Chemother. , vol.3 , pp. 1972-1977
    • St Clair, M.1
  • 12
    • 0024436217 scopus 로고
    • Clinical pharmacology of 3′-azido-2′,3′-dideoxythymidine (zidovudine) and related dideoxynucleosides
    • Yarchoan R.et al. Clinical pharmacology of 3′-azido-2′,3′-dideoxythymidine (zidovudine) and related dideoxynucleosides. New Engl. J. Med. 321:1989;726-738.
    • (1989) New Engl. J. Med. , vol.321 , pp. 726-738
    • Yarchoan, R.1
  • 13
    • 0023732121 scopus 로고
    • Factors determining the activity of 2′,3′-dideoxynucleosides in suppressing human immunodeficiency virus in vitro
    • Hao Z.et al. Factors determining the activity of 2′,3′-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol. Pharmacol. 34:1988;431-435.
    • (1988) Mol. Pharmacol. , vol.34 , pp. 431-435
    • Hao, Z.1
  • 14
    • 0032562985 scopus 로고    scopus 로고
    • Public health implications of antiretroviral therapy and HIV drug resistance
    • Wainberg M.A., Friedland G. Public health implications of antiretroviral therapy and HIV drug resistance. J. Am. Med. Assoc. 279:1998;1977-1983.
    • (1998) J. Am. Med. Assoc. , vol.279 , pp. 1977-1983
    • Wainberg, M.A.1    Friedland, G.2
  • 15
    • 0008017419 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho D.et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Science. 273:1995;123-126.
    • (1995) Science , vol.273 , pp. 123-126
    • Ho, D.1
  • 16
    • 0001488972 scopus 로고
    • Viral dynamics in human immunodeficiency virus type 1 infection
    • Wei X.et al. Viral dynamics in human immunodeficiency virus type 1 infection. Science. 273:1995;117-122.
    • (1995) Science , vol.273 , pp. 117-122
    • Wei, X.1
  • 17
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • Coffin J.M. HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy. Science. 267:1995;483-489.
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 18
    • 0030868897 scopus 로고    scopus 로고
    • + T cell homeostasis and function in advanced HIV disease
    • + T cell homeostasis and function in advanced HIV disease. Science. 277:1997;112-116.
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1
  • 19
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1 infected compartments during combination therapy
    • Perelson A.S.et al. Decay characteristics of HIV-1 infected compartments during combination therapy. Nature. 387:1997;188-191.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1
  • 20
    • 0030979361 scopus 로고    scopus 로고
    • Antiretroviral therapy for HIV infection in 1997. Update recommendations of the international AIDS society-USA panel
    • Carpenter C.C.J.et al. Antiretroviral therapy for HIV infection in 1997. Update recommendations of the international AIDS society-USA panel. J. Am. Med. Assoc. 277:1997;1962-1969.
    • (1997) J. Am. Med. Assoc. , vol.277 , pp. 1962-1969
    • Carpenter, C.C.J.1
  • 21
    • 0028940084 scopus 로고
    • Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
    • Shirasaka T.et al. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc. Natl. Acad. Sci. U. S. A. 92:1995;2398-2402.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 2398-2402
    • Shirasaka, T.1
  • 22
    • 0028940368 scopus 로고
    • Mutated K65R recombinant HIV-1 reverse transcriptase shows diminished chain termination in the presence of 2′,3′-dideoxycytidine-5′-triphosphate and other drugs
    • Gu Z.et al. Mutated K65R recombinant HIV-1 reverse transcriptase shows diminished chain termination in the presence of 2′,3′-dideoxycytidine-5′-triphosphate and other drugs. Proc. Natl. Acad. Sci. U. S. A. 92:1995;2760-2764.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 2760-2764
    • Gu, Z.1
  • 23
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder B.A., Kemp S.D. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science. 246:1989;1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 24
    • 0029024089 scopus 로고
    • Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant populations in persons treated with lamivudine (3TC)
    • Schuurman R.et al. Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant populations in persons treated with lamivudine (3TC). J. Infect. Dis. 171:1995;1411-1419.
    • (1995) J. Infect. Dis. , vol.171 , pp. 1411-1419
    • Schuurman, R.1
  • 25
    • 0025950055 scopus 로고
    • Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase
    • St Clair M.H.et al. Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science. 253:1991;1557-1559.
    • (1991) Science , vol.253 , pp. 1557-1559
    • St Clair, M.H.1
  • 26
    • 0027373308 scopus 로고
    • High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase
    • Boucher C.A.B.et al. High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 37:1993;2231-2234.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 2231-2234
    • Boucher, C.A.B.1
  • 27
    • 0026570624 scopus 로고
    • Ordered appearance of zidovudine resistant mutations during treatment of 18 human immunodeficiency virus-positive subjects
    • Boucher C.A.B.et al. Ordered appearance of zidovudine resistant mutations during treatment of 18 human immunodeficiency virus-positive subjects. J. Infect. Dis. 165:1992;105-110.
    • (1992) J. Infect. Dis. , vol.165 , pp. 105-110
    • Boucher, C.A.B.1
  • 28
    • 0025237157 scopus 로고
    • High frequency of isolation of defective human immunodeficiency virus type 1 and heterogeneity of viral gene expression in clones of infected U-937 cells
    • Boulerice F.et al. High frequency of isolation of defective human immunodeficiency virus type 1 and heterogeneity of viral gene expression in clones of infected U-937 cells. J. Virol. 64:1990;1745-1755.
    • (1990) J. Virol. , vol.64 , pp. 1745-1755
    • Boulerice, F.1
  • 29
    • 0029843986 scopus 로고    scopus 로고
    • Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility
    • Harrigan P.R.et al. Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility. J. Virol. 70:1996;5930-5934.
    • (1996) J. Virol. , vol.70 , pp. 5930-5934
    • Harrigan, P.R.1
  • 30
    • 0026565278 scopus 로고
    • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high level resistance to zidovudine
    • Kellaam P.et al. Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high level resistance to zidovudine. Proc. Natl. Acad. Sci. U. S. A. 89:1992;1934-1938.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 1934-1938
    • Kellaam, P.1
  • 31
    • 0002035867 scopus 로고    scopus 로고
    • Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use
    • Salomon H.et al. Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. AIDS. 14:2000;F17-F23.
    • (2000) AIDS , vol.14 , pp. 17-F23
    • Salomon, H.1
  • 32
    • 0028260316 scopus 로고
    • Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells
    • Paff M.T.et al. Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells. Antimicrob. Agents Chemother. 38:1994;1230-1238.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 1230-1238
    • Paff, M.T.1
  • 33
    • 0026480950 scopus 로고
    • Selective inhibition of human immunodeficiency virus by racemates and enatiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
    • Schinazi R.F.et al. Selective inhibition of human immunodeficiency virus by racemates and enatiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob. Agents Chemother. 36:1992;2423-2431.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 2423-2431
    • Schinazi, R.F.1
  • 34
    • 0025866982 scopus 로고
    • Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2′-deoxy-3′-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog
    • Soudeyns H.et al. Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2′-deoxy-3′-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog. Antimicrob. Agents Chemother. 35:1991;1386-1390.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 1386-1390
    • Soudeyns, H.1
  • 35
    • 0027379732 scopus 로고
    • Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro
    • Mathez D.et al. Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro. Antimicrobial. Agents Chemother. 37:1993;2206-2211.
    • (1993) Antimicrobial. Agents Chemother. , vol.37 , pp. 2206-2211
    • Mathez, D.1
  • 36
    • 0029965190 scopus 로고    scopus 로고
    • Favorable interactions of β-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus
    • Bridges E.G.et al. Favorable interactions of β-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus. Biochem. Pharmacol. 51:1996;731-736.
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 731-736
    • Bridges, E.G.1
  • 37
    • 0032823357 scopus 로고    scopus 로고
    • Mechanism of action and in vitro activity of 1′,3′-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants
    • Gu Z.et al. Mechanism of action and in vitro activity of 1′,3′-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants. Antimicrobial. Agents Chemother. 43:1999;2376-2382.
    • (1999) Antimicrobial. Agents Chemother. , vol.43 , pp. 2376-2382
    • Gu, Z.1
  • 38
    • 0027530506 scopus 로고
    • 1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes
    • Kim K.O.et al. 1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes. J. Med. Chem. 36:1993;30-37.
    • (1993) J. Med. Chem. , vol.36 , pp. 30-37
    • Kim, K.O.1
  • 39
    • 0001154599 scopus 로고
    • Pharmacokinetics of (-)-β-D-2,6-diaminopurine dioxolane and its metabolite guanosine in rhesus monkeys
    • Rajagopalan P.et al. Pharmacokinetics of (-)-β-D-2,6-diaminopurine dioxolane and its metabolite guanosine in rhesus monkeys. Pharm. Res. 11(Suppl.):1994;381-386.
    • (1994) Pharm. Res. , vol.11 , Issue.SUPPL. , pp. 381-386
    • Rajagopalan, P.1
  • 40
    • 0029879074 scopus 로고    scopus 로고
    • Pharmacokinetics of (-)-β-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, in woodchucks (marmota monax)
    • Rajagopalan P.et al. Pharmacokinetics of (-)-β-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, in woodchucks (marmota monax). Antiviral Chem. Chemother. 7:1996;65-70.
    • (1996) Antiviral Chem. Chemother. , vol.7 , pp. 65-70
    • Rajagopalan, P.1
  • 41
    • 0018090383 scopus 로고
    • (S)-9-(2,3-dihydroxypropyl)adenine: An aliphatic nucleoside analog with broad-spectrum antiviral activity
    • De Clercq E.et al. (S)-9-(2,3-dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity. Science. 200:1978;563-565.
    • (1978) Science , vol.200 , pp. 563-565
    • De Clercq, E.1
  • 42
    • 0030708683 scopus 로고    scopus 로고
    • In search of a selective antiviral chemotherapy
    • De Clercq E. In search of a selective antiviral chemotherapy. Clin. Microbiol. Rev. 10:1997;674-693.
    • (1997) Clin. Microbiol. Rev. , vol.10 , pp. 674-693
    • De Clercq, E.1
  • 43
    • 0030955396 scopus 로고    scopus 로고
    • Effects of (R)-9-(2-phosphonylmethoxypropyl) adenine monotherapy on chronic SIV infection in macaques
    • Tsai C.C.et al. Effects of (R)-9-(2-phosphonylmethoxypropyl) adenine monotherapy on chronic SIV infection in macaques. AIDS Res. Hum. Retroviruses. 13:1997;707-712.
    • (1997) AIDS Res. Hum. Retroviruses , vol.13 , pp. 707-712
    • Tsai, C.C.1
  • 44
    • 0028791836 scopus 로고
    • Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine
    • Tsai C.C.et al. Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science. 270:1995;1197-1199.
    • (1995) Science , vol.270 , pp. 1197-1199
    • Tsai, C.C.1
  • 45
    • 0031861195 scopus 로고    scopus 로고
    • Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxy-methylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains
    • Srinivas R.V., Fridland A. Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxy-methylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains. Antimicrob. Agents Chemother. 42:1998;1484-1487.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 1484-1487
    • Srinivas, R.V.1    Fridland, A.2
  • 46
    • 0031710248 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults
    • Deeks S.G.et al. Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults. Antimicrob. Agents Chemother. 42:1998;2380-2384.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2380-2384
    • Deeks, S.G.1
  • 47
    • 0026335577 scopus 로고
    • Inhibition of human immunodeficiency virus (HIV) production by 5′-hydrogenphosphonates of 3′-azido-2′,3′-dideoxynucleosides
    • Tarussova N.B.et al. Inhibition of human immunodeficiency virus (HIV) production by 5′-hydrogenphosphonates of 3′-azido-2′,3′-dideoxynucleosides. Nucleosides Nucleotides. 10:1991;351-354.
    • (1991) Nucleosides Nucleotides , vol.10 , pp. 351-354
    • Tarussova, N.B.1
  • 48
    • 0033031762 scopus 로고    scopus 로고
    • Antiviral activity and resistance profile of phosphazid - a novel prodrug of AZT
    • Machado J.et al. Antiviral activity and resistance profile of phosphazid - a novel prodrug of AZT. Nucleosides Nucleotides. 18:1999;901-906.
    • (1999) Nucleosides Nucleotides , vol.18 , pp. 901-906
    • Machado, J.1
  • 49
    • 0008109714 scopus 로고    scopus 로고
    • A phase I study of PZT (3′-azido-2′,3′dideoxythymidine-5′H-phosphonate) in patients with HIV infection
    • Tsoukas C.et al. A phase I study of PZT (3′-azido-2′,3′dideoxythymidine-5′H-phosphonate) in patients with HIV infection. Antiviral Ther. 3:1998;83-84.
    • (1998) Antiviral Ther. , vol.3 , pp. 83-84
    • Tsoukas, C.1
  • 50
    • 0032819048 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa-4′-thiocytidine
    • De Muys J-M.et al. Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa-4′-thiocytidine. Antimicrob. Agents Chemother. 43:1999;1834-1844.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 1834-1844
    • De Muys, J-M.1
  • 51
    • 0033998526 scopus 로고    scopus 로고
    • Antiviral activity of 2′-deoxy-3′-oxa-4′-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice
    • Stoddart C.A.et al. Antiviral activity of 2′-deoxy-3′-oxa-4′-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice. Antimicrob. Agents Chemother. 44:2000;783-786.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 783-786
    • Stoddart, C.A.1
  • 52
    • 0032879386 scopus 로고    scopus 로고
    • Selection and characterization of HIV-1 variants resistant to the (+) and (-) enantiomers of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC)
    • Richard N.et al. Selection and characterization of HIV-1 variants resistant to the (+) and (-) enantiomers of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC). Antiviral Ther. 4:1999;171-177.
    • (1999) Antiviral Ther. , vol.4 , pp. 171-177
    • Richard, N.1
  • 54
    • 0031057088 scopus 로고    scopus 로고
    • 2′-Fluoro-2′,3′-dideoxyarabinosyladenine (F-ddA): Activity against drug-resistant human immunodeficiency virus strains and clades A-E
    • Driscol J.S.et al. 2′-Fluoro-2′,3′-dideoxyarabinosyladenine (F-ddA): activity against drug-resistant human immunodeficiency virus strains and clades A-E. Antiviral Chem. Chemother. 8:1997;107-111.
    • (1997) Antiviral Chem. Chemother. , vol.8 , pp. 107-111
    • Driscol, J.S.1
  • 55
    • 0031009294 scopus 로고    scopus 로고
    • In vitro induction of human immunodeficiency virus type 1 variants resistant to 2′-β-fluoro-2′,3′-dideoxyadenosine
    • Tanaka M.et al. In vitro induction of human immunodeficiency virus type 1 variants resistant to 2′-β-fluoro-2′,3′-dideoxyadenosine. Antimicrob. Agents Chemother. 41:1997;1313-1318.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1313-1318
    • Tanaka, M.1
  • 56
    • 0344242002 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus type 1 (HIV-1) activity of 2′-fluoro-2′,3′-dideoxyarabinosyladenine (FddA) used in combination with other mechanistically diverse inhibitors of HIV-1 replication
    • Buckheit R.W. Jr. et al. Anti-human immunodeficiency virus type 1 (HIV-1) activity of 2′-fluoro-2′,3′-dideoxyarabinosyladenine (FddA) used in combination with other mechanistically diverse inhibitors of HIV-1 replication. Antiviral Chem. Chemother. 10:1999;115-119.
    • (1999) Antiviral Chem. Chemother. , vol.10 , pp. 115-119
    • Buckheit R.W., Jr.1
  • 57
    • 0028057581 scopus 로고
    • Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encode human immunodeficiency virus resistance to 2′,3′-dideoxycytidine and 2′,3′-dideoxy-3′-thiacytidine
    • Gu Z.et al. Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encode human immunodeficiency virus resistance to 2′,3′-dideoxycytidine and 2′,3′-dideoxy-3′-thiacytidine. Antimicrob. Agents Chemother. 38:1994;275-281.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 275-281
    • Gu, Z.1
  • 58
    • 0030842430 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloylomethyl)-phosphonomethoxymethyl]adenine) in HIV-infected patients
    • Barditch-Crovo P.et al. Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloylomethyl)-phosphonomethoxymethyl]adenine) in HIV-infected patients. J. Infect. Dis. 176:1997;406-413.
    • (1997) J. Infect. Dis. , vol.176 , pp. 406-413
    • Barditch-Crovo, P.1
  • 59
    • 0000055156 scopus 로고
    • The cyclic congener of cidofovir has reduced nephrotoxicity in three species
    • Hitchcock M.J.M.et al. The cyclic congener of cidofovir has reduced nephrotoxicity in three species. Antiviral Res. 26:1995;A358.
    • (1995) Antiviral Res. , vol.26 , pp. 358
    • Hitchcock, M.J.M.1
  • 60
    • 0032823876 scopus 로고    scopus 로고
    • Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics
    • Tan X.et al. Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics. Adv. Drug Deliv. Rev. 39:1999;117-151.
    • (1999) Adv. Drug Deliv. Rev. , vol.39 , pp. 117-151
    • Tan, X.1
  • 61
    • 10544223739 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of 5-chloro-2′,3′-dideoxy-3′-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults
    • Riddler S.A.et al. Safety and pharmacokinetics of 5-chloro-2′,3′-dideoxy-3′-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults. Antimicrob. Agents Chemother. 40:1996;2842-2847.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2842-2847
    • Riddler, S.A.1
  • 62
    • 0033557321 scopus 로고    scopus 로고
    • Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: Role of the 3′-hydroxyl group of the L-(β)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphophate analogs
    • Maga G.et al. Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3′-hydroxyl group of the L-(β)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphophate analogs. Nucleic Acids Res. 27:1999;972-978.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 972-978
    • Maga, G.1
  • 63
    • 0031836316 scopus 로고    scopus 로고
    • Metabolism of 2′,3′-dideoxy-2′3′-didehydro-β-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus β-D(+) nucleoside analogs in vitro
    • Dutschman G.E.et al. Metabolism of 2′,3′-dideoxy-2′3′-didehydro-β-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus β-D(+) nucleoside analogs in vitro. Antimicrob. Agents Chemother. 42:1998;1799-1804.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 1799-1804
    • Dutschman, G.E.1
  • 64
    • 0033535597 scopus 로고    scopus 로고
    • Synthesis and anti-HIV and anti-HBV activities of 2′ -fluoro-2′,3′-unsaturated L-nucleosides
    • Lee K.et al. Synthesis and anti-HIV and anti-HBV activities of 2′ -fluoro-2′,3′-unsaturated L-nucleosides. J. Med. Chem. 42:1999;1320-1328.
    • (1999) J. Med. Chem. , vol.42 , pp. 1320-1328
    • Lee, K.1
  • 65
    • 0000777110 scopus 로고
    • Anti-HIV and anti-HBV activities of L-2′,3′-dideoxynucleoside analogues: DdC, 5FddC, 5-Aza ddC and ddG
    • Mansour T.S.et al. Anti-HIV and anti-HBV activities of L-2′,3′-dideoxynucleoside analogues: ddC, 5FddC, 5-Aza ddC and ddG. Med. Chem. Res. 5:1995;417-425.
    • (1995) Med. Chem. Res. , vol.5 , pp. 417-425
    • Mansour, T.S.1
  • 66
    • 0000342562 scopus 로고    scopus 로고
    • Mutations in retroviral genes associated with drug resistance
    • Schinazi R.F.et al. Mutations in retroviral genes associated with drug resistance. Int. Antiviral News. 5:1997;129.
    • (1997) Int. Antiviral News , vol.5 , pp. 129
    • Schinazi, R.F.1


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