Selection and characterization of HIV-1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thiocytidine (dOTC)

Antiviral Therapy

Volumn 4, Issue 3, 1999, Pages 171-177

  Richard, Nathalie ^a,b   Quan, Yudong ^a   Salomon, Horacio ^a   Hsu, Mayla ^a,b   Bedard, Jean ^c   Richard Harrigan, P ^d   Rando, Robert ^c   Mansour, Tarek ^c   Bowlin, Terry L ^a   Wainberg, Mark A ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Shire Canada   (Canada)

^d ST PAUL S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXY 3 OXA 4 THIOCYTADINE; ANTIVIRUS AGENT; LAMIVUDINE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ZIDOVUDINE; 2' DEOXY 3' OXA THIOCYTIDINE; 2'-DEOXY-3'-OXA-THIOCYTIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DEOXYCYTIDINE; DRUG DERIVATIVE; NUCLEOSIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CLONE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG RESISTANCE; ENANTIOMER; GENE MUTATION; GENE SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VIRAL GENETICS; VIROGENESIS; VIRUS RECOMBINANT; VIRUS RESISTANCE; VIRUS TYPING; ANTIBIOTIC RESISTANCE; DRUG EFFECT; GENETICS; MUTATION; STEREOISOMERISM;

ANTI-HIV AGENTS; DEOXYCYTIDINE; DRUG RESISTANCE, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MUTATION; STEREOISOMERISM; THIONUCLEOSIDES;

EID: 0032879386     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Telesnitsky A & Goff SP. Reverse transcriptase and generation of retroviral DNA. In Retroviruses. Edited by JM Coffin, SH Hughes and HE Varmus. 1997; pp 121-160. New York: Cold Spring Harbor Laboratory Press.
2. Arts EJ, Marois J-P, Gu Z, Le Grice SFJ & Wainberg MA. Effects of 3′-deoxynucleotide 5′-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type-1 reverse transcription of minus-strand strong-stop DNA. Journal of Virology 1996; 70:712-720.
3. Gu Z, Arts EJ, Parniak MA & Wainberg MA. Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2′,3′-dideoxycytidine 5′-triphosphate and other drugs. Proceedings of the National Academy of Sciences, USA 1995; 92:2760-2764.
4. Gao Q, Gu Z, Parniak MA, Li X & Wainberg MA. In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine. Journal of Virology 1992; 66:12-19.
5. Larder BA & Kemp SD. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 1989; 246:1155-1158.