TrkA glycosylation regulates receptor localization and activity

Journal of Neurobiology

Volumn 39, Issue 2, 1999, Pages 323-336

  Watson, Fiona L ^a,c   Porcionatto, Marimelia A ^b,c   Bhattacharyya, Anita ^c   Stiles, Charles D ^c   Segal, Rosalind A ^a,c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Glycosylation; Neurotrophins; Receptor tyrosine kinases; Trks

Indexed keywords

NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR; PROTEIN TYROSINE KINASE; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; GLYCOSYLATION; GTPASE-ACTIVATING PROTEINS; HUMANS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PC12 CELLS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEINS; PROTO-ONCOGENE PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR;

EID: 0032954335     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(199905)39:2<323::AID-NEU15>3.0.CO;2-4     Document Type: Article

References (48)

1. Airas L, Niemela J, Salmi M, Puurunen T, Smith DJ, Jalkanen S. 1997. Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocyte and endothelial cells. J Cell Biol 136:421-431.
2. Barbacid M. 1993. Nerve growth factor: a tale of two receptors. [Review]. Oncogene 8:2033-2042.
3. Barbacid M, Lamballe F, Pulido D, Klein R. 1991. The trk family of tyrosine protein kinase receptors. Biochim Biophys Acta 1072:115-127.
4. Barde YA. 1989. Trophic factors and neuronal survival. [Review]. Neuron 2:1525-1534.
5. Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV, Rosenthal A. 1991. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7:857-866.
6. Bhattacharyya A, Watson FL, Bradlle TA, Pomeroy SL, Stiles CD, Segal RA. 1997. Trk receptors function as rapid retrograde signal carriers in the adult nervous system. J Neurosci 17:7007-7016.
7. Cabrera N, Diaz-Rodriguez E, Becker E, Martin-Zanca D, Pandiella A. 1996. TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment. J Cell Biol 132:427-436.
8. Chao M. 1992. Neurotrophin receptors: a window into neuronal differentiation. Neuron 9:583-593.
9. Cohen RI, Marmur R, Norton WT, Mehler MF, Kessler JA. 1996. Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes. J Neurosci 16:6433-6442.
10. Collier E, Carpentier J-L, Beitz L, Caro HP, Taylor SI, Gorgen P. 1993. Specific glycosylation site mutations of the insulin receptor alpha subunit impairs intracellular transport. Biochemistry 32:7818-7823.
11. Coulier F, Kumar R, Ernst M, Klein R, Martin-Zanca D, Barbacid M. 1990. Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Mol Cell Biol 10:4202-4210.
12. Ehlers MD, Kaplan DR, Price DL, Koliatsos VE. 1995. NGF-stimulated retrograde transport of trkA in the mammalian nervous system. J Cell Biol 130:149-156.
13. Garner AS, Large TH. 1994. Isoforms of the avian TrkC receptor: a novel kinase insertion dissociates transformation and process outgrowth from survival. Neuron 13: 457-472.
14. Grimes ML, Zhou J, Beattie E, Yuen EC, Hall DE, Valletta JS, Topp KS, LaVail JH, Bunnett NW, Mobley WC. 1996. Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci 16:7950-7964.
15. Hempstead BL, Rabin SJ, Kaplan L, Reid S, Parada LF, Kaplan DR. 1992. Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron 9:883-896.
16. Hill C, Treisman R. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 73:199-211.
17. Hubbard S, Wei L, Ellis L, Hendrickson W. 1994. Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372:746-754.
18. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. 1991. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor [see comments]. Science 252:554-558.
19. Keating MT, Harryman CC, Williams LT. 1989. Platelet-derived growth factor receptor inducibility is acquired immediately after translation and does not require glycosylation. J Biol Chem 264:9129-9132.
20. Klein R, Nanduri V, Jing SA, Lamballe F, Tapley P, Bryant S, Cordon-Cardo C, Jones KR, Reichardt LF, Barbacid M. 1991. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66:395-403.
21. Klein R, Parada LF, Coulier F, Barbacid M. 1989. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J 8:3701-3709.
22. Korsching S. 1993. The neurotrophic factor concept: a reexamination. [Review]. J Neurosci 13:2739-2748.
23. Lamballe F, Klein R, Barbacid M. 1991. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66:967-979.
24. Leconte I, Auzan C, Debant A, Rossi B, Clauser E. 1992. N-linked oligosaccharide chains of the insulin receptor beta subunit are essential for transmembrane signaling. J Biol Chem 267:17415-17423.
25. Lewin GR, Barde YA. 1996. Physiology of the neurotrophins. Annu Rev Neurosci 19:289-317.
26. Martin-Zanca D, Oskam R, Mitra G, Copeland T, Barbacid M. 1989. Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol 9:24-33.
27. Meakin SO, Shooter EM. 1992. The nerve growth factor family of receptors. [Review]. Trends Neurosci 15:323-331.
28. Middlemas DS, Lindberg RA, Hunter T. 1991. TrkB, a neural receptor protein-tyrosine kinase: evidence for a full length and two truncated receptors. Mol Cell Biol 11:143-153.
29. Mitra G. 1991. Mutational analysis of conserved residues in the tyrosine kinase domain of the human trk oncogene. Oncogene 6:2237-2241.
30. Mitra G, Martin-Zanca D, Barbacid M. 1987. Identification and biochemical characterization of p70 TRK, product of the human TRK oncogene. Proc Natl Acad Sci USA 84:6707-6711.
31. Obermeier A, Bradshaw RA, Seedorf K, Choidas A, Schlessinger J, Ullrich A. 1994. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. EMBO J 13: 1585-1590.
32. Olden K, Parent JB, White SL. 1982. Carbohydrate moieties of glycoproteins: a re-evaluation of their function. Biochim Biophys Acta 650:209-232.
33. Olson TS, Lane MD. 1987. Post-translational acquisition of insulin binding activity by the insulin proreceptor: correlation to recognition by autoimmune antibody. J Biol Chem 262:6816-6822.
34. Parada LF, Tsoulfas P, Tessarollo L, Blair J, Reid SW, Soppet D. 1992. The Trk family of tyrosine kinases: receptors for NGF-related neurotrophins. Cold Spring Harbor Symp Quant Biol 57:43-51.
35. Reed BC, Lane MD. 1980. Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 77:285-289.
36. Reed BC, Ronnett GV, Lane MD. 1981. Role of glycosylation and protein synthesis in insulin receptor metabolism by 3T3-L1 mouse adipocytes. Proc Natl Acad Sci USA 78:2908-2912.
37. Ronnett GV, Lane MD. 1981. Post-translational glycosylation-induced activation of aglycoinsulin receptor accumulated during tunicamycin treatment. J Biol Chem 256: 4704-4707.
38. Rosen OM, Chia GH, Fung C, Rubin CS. 1979. Tunicamycin-mediated depletion of insulin receptors in 3T3-L1 adipocytes. J Cell Physiol 99:37-42.
39. Segal R, Bhattacharyya A, Rua L, Alberta J, Stephens R, Kaplan D, Stiles C. 1996. Differential utilization of Trk autophosphorylation sites. J Biol Chem 271: 20175-20181.
40. Segal R, Greenberg M. 1996. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 19:463-489.
41. Slieker LJ, Lane MD. 1985. Post-translational processing of the epidermal growth factor receptor: glycosylation-dependent acquisition of ligand-binding capacity. J Biol Chem 260:687-690.
42. Slieker LJ, Martensen TM, Lane MD. 1986. Synthesis of epidermal growth factor receptor in human A431 cells: glycosylation-dependent acquisition of ligand binding activity occurs post-translationally in the endoplasmic reticulum. J Biol Chem 261:15233-152241.
43. Soderquist AM, Carpenter G. 1984. Glycosylation of the epidermal growth factor receptor in A431 cells. J Biol Chem 259:12586-12594.
44. Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA, Kaplan DR. 1994. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12:691-705.
45. Takahashi T, Shibuya M. 1997. The 230kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-y pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 14:2079-2089.
46. Valenzuela DM, Maisonpierre PC, Glass DJ, Rojas E, Nunez L, Kong Y, Gies DR, Stitt TN, Ip NY, Yancopoulos GD. 1993. Alternative forms of rat TrkC with different functional capabilities. Neuron 10:963-974.
47. Varki A. 1993. Biological roles of oligosaccharides: all of the theories are correct. Glycobiology 3:97-130.
48. West C. 1986. Current ideas on the significance of protein glycosylation. Mol Cell Biochem 72:3-20.