Selective use of TBP and TFIIB revealed by a TATA-TBP-TFIIB array with altered specificity

Science

Volumn 275, Issue 5301, 1997, Pages 829-830

  Tansey, William P ^a   Herr, Winship ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TATA BINDING PROTEIN;

ARTICLE; BINDING AFFINITY; GENETIC TRANSCRIPTION; MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TATA BOX;

DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENES, FOS; GENES, REPORTER; HELA CELLS; HUMANS; MUTAGENESIS, SITE-DIRECTED; SP1 TRANSCRIPTION FACTOR; TATA BOX; TATA-BOX BINDING PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR TFIIB; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0031024906     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5301.829     Document Type: Article

References (20)

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11. WT.
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13. W. P. Tansey and W. Herr, unpublished data.
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20. We thank M. Tanaka for the original human TFIIB expression construct; D. Aufiero for DNA sequencing; D. Nikolov and S. Burley for the TATA-TBP-TFIIB cocrystal coordinates; M. Green for helpful discussion; and N. Hemandez, S. Lowe, and M. Tanaka for critical reading of the manuscript. W.P.T. was supported by an Andrew Seligson Memorial Fellowship and is a Leukemia Society of America Special Fellow. These studies were supported by U.S. Public Health Service grant CA-13106 from the National Cancer Institute.