Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 2, 1996, Pages 754-758

  Flory, Craig M ^a   Pavco, Pamela A ^b   Jarvis, Thale C ^b   Lesch, Mark E ^a   Wincott, Francine E ^b   Beigelman, Leonid ^b   Hunt III, Stephen W ^a   Schrier, Denis J ^a  

^a PFIZER INC   (United States)

^b Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1ALPHA; MESSENGER RNA; METALLOPROTEIN; RIBOZYME; STROMELYSIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME STABILITY; ENZYME THERAPY; IMMUNOMODULATION; KNEE ARTHRITIS; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RNA DEGRADATION; SYNOVIUM;

ANIMALS; ARTHRITIS; BASE SEQUENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IN SITU HYBRIDIZATION; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN-1; KNEE JOINT; MALE; MATRIX METALLOPROTEINASE 3; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; RABBITS; RIBONUCLEASES; RNA, CATALYTIC; RNA, MESSENGER; SYNOVIAL MEMBRANE;

EID: 0030042588     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.2.754     Document Type: Article

References (46)

1. Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E. & Cech, T. R. (1982) Cell 31, 147-157.
2. Zaug, A. J., Grabowski, P. J. & Cech, T. R. (1983) Nature (London) 301, 578-583.
3. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N. & Altman, S. (1983) Cell 35, 849-857.
4. Christoffersen, R. E. & Marr, J. J. (1995) J. Med. Chem. 38, 2023-2037.
5. Castanotto, D., Rossi, J. J. & Deshler, J. O. (1992) Crit. Rev. Eukaryotic Gene Expression 2, 331-357.
6. Zaug, A. J., Been, M. D. & Cech, T. R. (1986) Nature (London) 324, 429-431.
7. Uhlenbeck, O. C. (1987) Nature (London) 328, 596-600.
8. Symons, R. H. (1994) Curr. Biol. 4, 322-330.
9. Cech, T. R. (1992) Curr. Biol. 2, 605-609.
10. Heidenreich, O., Benseler, F., Fahrenholz, A. & Eckstein, F. (1994) J. Biol. Chem. 269, 2131-2138.
11. Yang, J. H., Usman, N., Chartrand, P. & Cedergren, R. J. (1992) Biochemistry 31, 5005-5009.
12. Sioud, M., Natvig, J. B. & Forre, O. (1992) J. Mol. Biol. 223, 831-835.
13. Snyder, D. S., Wu, Y., Wang, J. L., Rossi, J. J., Swiderski, P., Kaplan, B. E. & Forman, S. J. (1993) Blood 2, 600-605.
14. Kiehntopf, M., Brach, M. A., Licht, T., Petschauer, S., Karawajew, L., Kirschning, C. & Herrmann, F. (1994) EMBO J. 13, 4645-4652.
15. Usman, N., Beigelman, L., Draper, K., Gonzalez, C., Jensen, K., Karpeisky, A., Modak, A., Matulic-Adamic, J., DiRenzo, A., Haeberli, P., Tracz, D., Grimm, S., Wincott, F. & McSwiggen, J. (1994) Nucleic Acids Symp. Ser. 31, 163-164.
16. Zhao, J. J. & Pick, L. (1993) Nature (London) 365, 448-451.
17. Larsson, S., Hotchkiss, G., Andang, M., Nyholm, T., Inzunza, J., Jansson, I. & Ahrlund-Richter, L. (1994) Nucleic Acids Res. 22, 2242-2248.
18. Efrat, S., Leiser, M., Wu, Y. J., Fusco-DeMane, D., Emran, O., Surana, M., Jetton, T., Magnuson, M. A., Weir, G. & Fleischer, N. (1994) Proc. Natl. Acad. Sci. USA 91, 2051-2055.
19. Woessner, J. F. (1991) FASEB J. 5, 2145-2154.
20. Werb, Z., Alexander, C. M. & Adler, R. R. (1992) Matrix Suppl. 1, 337-343.
21. Henney, A. M., Wakeley, P. R., Davies, M. J., Foster, K., Hembry, R., Murphy, G. & Humphries, S. (1991) Proc. Natl. Acad. Sci. USA 88, 8154-8158.
22. Stetler-Stevenson, W. G., Aznavoorian, S. & Liotta, L. A. (1993) Annu. Rev. Cell Biol. 9, 541-573.
23. Murphy, G. & Hembry, R. M. (1992) J. Rheumatol. Suppl. 32, 61-64.
24. Bonassar, L. J., Frank, E. H., Murray, J. C., Paguio, C. G., Moore, V. L., Lark, M. W., Sandy, J. D., Wu, J. J., Eyre, D. R. & Grodzinsky, A. J. (1995) Arthritis Rheum, 38, 173-183.
25. Suzuki, K., Enghild, J. J., Morodomi, T., Salvesen, G. & Nagase, H. (1990) Biochemistry 29, 10261-10270.
26. Miyazaki, K., Umenishi, F., Funahashi, K., Koshikawa, N., Yasumitsu, H. & Umeda, M. (1992) Biochem. Biophys. Res. Commun. 185, 852-859.
27. Ogata, Y., Enghild, J. J. & Nagase, H. (1992) J. Biol. Chem. 267, 3581-3584.
28. Brinckerhoff, C. E. & Auble, D. T. (1990) Ann. N.Y. Acad. Sci. 580, 355-374.
29. Hembry, R. M., Bagga, M. R., Reynolds, J. J. & Hamblen, D. L. (1995) Ann. Rheum. Dis. 54, 25-32.
30. Okada, Y., Shinmei, M., Tanaka, O., Naka, K., Kimura, A., Nakanishi, I., Bayliss, M. T., Iwata, K. & Nagase, H. (1992) Lab. Invest. 66, 680-690.
31. Pettipher, E. R., Higgs, G. A. & Henderson, B. (1986) Proc. Natl. Acad. Sci. USA 83, 8749-8753.
32. Mehraban, F., Kuo, S., Riera, H., Chang, C. & Moskowitz, R. W. (1994) Arthritis Rheum. 37, 1189-1197.
33. Hutchinson, N. I., Lark, M. W., MacNaul, K. L., Harper, C., Hoerrner, L. A., McDonnell, J., Donatelli, S., Moore, V. & Bayne, E. K. (1992) Arthritis Rheum. 35, 1227-1233.
34. Beigelman, L., McSwiggen, J., Draper, K., Gonzalez, C., Jensen, K., Karpeisky, A., Modak, A., Matulic-Adamic, J., DiRenzo, A., Haeberli, P., Sweedler, D., Tracz, D., Grimm, S., Wincott, F., Thackaray, V. G. & Usman, N. (1995) J. Biol. Chem. 270, 25702-25708.
35. Wincott, F., DiRenzo, A., Shaffer, C., Grimm, S., Tracz, D., Workman, C., Sweedler, D., Gonzalez, C., Scaringe, S. & Usman, N. (1995) Nucleic Acids Res. 23, 2677-2684.
36. Flory, C. M., Jones, M. L. & Warren, J. S. (1993) Lab. Invest. 69, 396-404.
37. Funato, T., Shitara, T., Tone, T., Jiao, L., Kashani-Sabet, M. & Scanlon, K. J. (1994) Biochem. Pharmacol. 48, 1471-1475.
38. Kobayashi, H., Dorai, T., Holland, J. F. & Ohnuma, T. (1994) Cancer Res. 54, 1271-1275.
39. Yu, M., Poeschla, E., Yamada, O., Degrandis, P., Leavitt, M. C., Heusch, M., Yees, J., Wong-Staal, F. & Hampel, A. (1995) Virology 206, 381-388.
40. Ventura, M., Wang, P., Franck, N. & Saragosti, S. (1994) Biochem. Biophys. Res. Commun. 203, 889-898.
41. Zhou, C., Bahner, I. C., Larson, G. P., Zaia, J. A., Rossi, J. & Kohn, D. B. (1994) Gene 149, 33-39.
42. Zamecnik, P. C. & Stephenson, M. L. (1978) Proc. Natl. Acad. Sci. USA 75, 280-284.
43. Izant, J. G. & Weintraub, H. (1984) Cell 36, 1007-1015.
44. Wagner, R. W. (1994) Nature (London) 372, 333-335.
45. Bennett, C. F., Condon, T. P., Grimm, S., Chan, H. & Chiang, M. (1994) J. Immunol. 152, 3530-3540.
46. Villa, A. E., Guzman, L. A., Poptic, E. J., Labhasetwar, V., D'Souza, S., Farrell, C. L., Plow, E. F., Levy, R. J., DiCorleto, P. E. & Topol, E. J. (1995) Circ. Res. 76, 505-513.