Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins

Biochemical Journal

Volumn 348, Issue 2, 2000, Pages 273-280

  Gingras, Denis ^a   Lamy, Sylvie ^a   Béliveau, Richard ^a  

^a Lab de Med Molec Hop Sainte J   (Canada)

Author keywords

Angiogenesis; Signal transduction; VEGF

Indexed keywords

FOCAL ADHESION KINASE; PAXILLIN; PHOSPHOLIPASE C; RHO FACTOR; TYROSINE; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ADP RIBOSE TRANSFERASES; ANIMALS; AORTA; BACTERIAL TOXINS; BOTULINUM TOXINS; CATTLE; CELLS, CULTURED; CYTOTOXINS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ESCHERICHIA COLI PROTEINS; LYMPHOKINES; PHOSPHORYLATION; PHOSPHOTYROSINE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT PROTEINS; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA;

EID: 0034213668     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3480273     Document Type: Article

References (32)

1. 1 Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1, 149-153
2. 2 Hanahan, D. and Folkman, J. (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364
3. 3 Boehm, T., Folkman, J., Browder, T. and O'Reilly, M. S. (1997) Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (London) 390, 404-407
4. 4 Levy, A. P., Levy, N. S. and Goldberg, M. A. (1996) Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem. 271, 2746-2753
5. 5 Rak, J. W., St. Croix, B. D. and Kerbel, R. S. (1995) Consequences of angiogenesis for tumor progression, metastasis and cancer therapy. Anti-Cancer Drugs 6, 3-18
6. 6 Thomas, K. A. (1996) Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem. 271, 603-606
7. 7 Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M and Heldin, C.-H. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269, 26988-26995
8. 8 Guo, D., Jia, Q., Song, H.-Y., Warren, R. S. and Donner, D. B. (1995) Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J. Biol. Chem. 270, 6729-6733
9. 9 Xia, P., Aiello, L. P., Ishii, H., Jiang, Z. Y., Park, D. J., Robinson, G. S., Takagi, H., Newsome, W. P., Jirousek, M. R. and King, G. L. (1996) Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J. Clin. Invest. 98, 2018-2026
10. 10 Kroll, J. and Waltenberger, J. (1997) The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J. Biol. Chem. 272, 32521-32527
11. 11 Abedi, H. and Zachary, I. (1997) Vascular endothelial growth factor stimulates lyrosine phosphorylation and recruitment to new local adhesions of focal adhesion kinase and paxillin in endothelial cells. J. Biol. Chem. 272, 15442-15451
12. 12 Mackay, D. J. G. and Hall, A. (1998) Rho GTPases. J. Biol. Chem. 273, 20685-20688
13. 13 Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science 279, 509-514
14. 14 Udagawa, T. and McIntyre, B. W. (1996) ADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth. J. Biol. Chem 271, 12542-12548
15. 15 Fiorentini, C., Fabbri, A., Flatau, G., Donelli, G., Matarrese, P., Lemichez, E., Falzano, L. and Boquet, P. (1997) Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase. J. Biol. Chem. 272, 19532-19537
16. 16 Lacerda, H. M., Pullinger, G. D., Lax, A. J. and Rozengurt, E. (1997) Cytotoxic necrotizing factor 1 from Escherichia coli and dermonecrotic toxin from Bordetella bronchiseptica induce p21(rho)-dependent tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 cells. J. Biol. Chem. 272, 9587-9596
17. 17 Aktories, K. (1997) Bacterial toxins that target Rho proteins. J. Clin. Invest. 99, 827-829
18. 18 Neufeld, G., Cohen, T., Gengrinovitch, S. and Poltorak, Z. (1999) Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22
19. 19 Strawn, L. M., McMahon, G., App. H., Schreck, R., Kuchler, W. R, Longhi, M. P., Hui, T. H., Tang, C., Levitzki, A., Gazit, A. et al. (1996) Flk-1 as a target for tumor growth inhibition Cancer Res 56, 3540-3545
20. 20 Schmidt, G., Sehr, P., Wilm, M., Selzer, J., Mann, M. and Aktories, K. (1997) Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. Nature (London) 387, 725-729
21. 21 Flatau, G., Lemichez, E., Gauthier, M., Chardin, P., Paris, S., Fiorentini, C. and Boquet, P. (1997) Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine. Nature (London) 387, 729-733
22. 22 Riltinger, K., Walker, P. A., Eccleston, J. F., Smerdon, S. J. and Gamblin, S. J. (1997) Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature (London) 388, 693-698
23. 23 Edgell, C. T., Curiel, D. T., Hu, P. C. and Marr, H. S. (1998) Efficient gene transfer to human endothelial cells using DNA complexed to adenovirus particles. BioTechniques 25, 264-268
24. 24 Fiorentini, C., Gautnier, M., Donelli, G. and Boquet, P. (1998) Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation. Cell Death Diff. 5, 720-728
25. 25 Defilippi, P., Venturino, M., Gulino, D., Duperray, A., Boquet, P., Fiorentini, C., Volpe, G., Palmieri, M., Silengo, L. and Tarone, G. (1997) Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation. J. Biol. Chem. 272, 21726-21734
26. 26 Klemm, J. D., Schreiber, S. L. and Crabtree, G. R. (1998) Dimerization as a regulatory mechanism in signal transduction. Annu. Rev. Immunol. 16, 569-592
27. 27 Omura, T., Heldin, C.-H. and Ostman, A. (1997) Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization. J. Biol. Chem. 272, 12676-12682
28. 28 Fuh, G., Li, B., Crowley, C., Cunningham, B. and Wells, J. A. (1998) Requirements for binding and signalling of the kinase domain receptor for vascular endothelial growth factor. J. Biol. Chem. 273, 11197-11204
29. 29 McGuire, T. F., Qian, Y., Vogt, A., Hamilton, A. D and Sebti, S. M. (1996) Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. J. Biol. Chem. 271, 27402-27407
30. 30 Zubiaur, M., Sancho, J., Terhorst, C. and Faller, D. V. (1995) A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-beta receptor upon ligand binding. J. Biol. Chem. 270, 17221-17228
31. 31 Baxter, R. M., Secrist, J. P., Vaillancourt, R. R. and Kazlauskas, A. (1998) Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. J. Biol. Chem. 273, 17050-17055
32. 32 Kendall, R. L., Rutledge, R. Z., Mao, X., Tebben, A. J., Hungate, R. W. and Thomas, K. A. (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J. Biol. Chem. 274, 6453-6460