Bacterial toxins and the Rho GTP-binding protein: What microbes teach us about cell regulation

Cell Death and Differentiation

Volumn 5, Issue 9, 1998, Pages 720-728

  Florentini, Carla ^a   Gauthier, Michel ^b   Donelli, Gianfranco ^a   Boquet, Patrice ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b INSERM   (France)

Author keywords

C3; Cell regulation; CNF1; Rho

Indexed keywords

ACTIN; BACTERIAL TOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; RHO FACTOR;

ANIMAL CELL; APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; CLOSTRIDIUM BOTULINUM; CONTROLLED STUDY; CYTOSKELETON; ESCHERICHIA COLI; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SIGNAL TRANSDUCTION;

EID: 0031786657     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400412     Document Type: Review

References (62)

1. Aktones K, Weller U and Chatwal GS (1987) Clostridium botulinum type C produces a novel ADP-ribosyltransferase distinct to botulinum C2 toxin. FEBS Lett. 212: 109-113
2. Amano M, Chihara K, Kimura K, Fukuta Y, Nakamura N, Matsuura Y and Kaibuchi K (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho kinase. Science 275: 1308-1311
3. Aullo P, Giry M, Olsnes S, Popoff MR, Kocks Cand Boquet P (1993) A chimerictoxin to study the role of the 21 kDa GTP-binding protein Rho in the control of actin microfilament assembly EMBOJ 12 921-931
4. Bobak D, Moorman J, Guanzon A, Gilmer L and Hahn C (1997) Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion dependent and adhesion independent apoptosis. Oncogene 15 2179-2189
5. Boquet P, Popoff MR, Giry M, Lemichez E and Bergez-Aullo P (1995) Inhibition of p21 Rho in intact cells by C3 diphtheria toxin chimera proteins. Methods in Enzymol. 256 297-306
6. Capnoli A, Falbo V, Roda LG, Ruggen FM and Zona C (1983) Partial purification and characterization of an Escherichia coli toxic factor that induces morphological cell alterations. Infect Immun. 39: 1300-1306
7. Chang EH, Furth ME, Scolnick EM and Lowry DR (1982) Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature, 297: 479-483
8. Chardin P, Boquet P, Madaule P, Popoff MR, Rubin EJ and Gill DM (1989) The mammalian G protein Rho C is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J. 8: 1087-1092
9. Chong LD, Traynor-Kaplan A, Bokoch GM and Schwartz MA (1994) The small GTP-binding protein Rho regulates a phosphatidylinositol4-phosphate5-kinase in mammalian cells. Cell 79. 507-513
10. Chrzanowska-Wodnicka M and Burndge K (1996) Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 6: 1403-1415
11. Clark EA and Brugge JS (1995) Integrin and signal transduction pathways: the road taken Science 268. 233-239
12. Conrad PA, Smart EJ, Ying YS, Anderson RGW and Bloom G (1995) Caveolin cycles between plasma membrane and the Golgi complex by microtubule-dependent and microtubule-independent steps. J. Cell Biol. 131: 1421-1433
13. Cramer LP and Mitchison TJ (1995) Myosin is involved in postmitotic cell spreading. J Cell Biol 131: 179-189
14. Donelli G and Fiorentini C (1997) Cytotoxic necrotizing factors (Escherichia coli). In. Guidebook to protein toxins and their use in Cell Biology. Rappuoli R and Montecucco C., eds (Oxford University Press) pp. 69-71
15. Downward J (1990) The Ras superfamily of small GTP-binding proteins. Trends in Biochem. Sci 15: 469-472
16. Fiorentini C, Arancia G, Caprioli A, Falbo V, Ruggeri FM and Donelli G (1988) Cytoskeletal changes induced in Hep-2 cells by the cytotoxic necrotizing factor of Escherichia coli. Toxicon 26: 1047-1056
17. Fiorentini C, Donelli G, Matarrese P, Fabbri A, Paradisi S and Boquet P (1995) Escherichia coli cytotoxic necrotizing factor 1: evidence for induction of actin assembly by constitutive activation of the p21 Rho GTPase Infect. Immun 63: 3936-3944
18. Fiorentini C, Fabbri A, Flatau G, Donelli G, Matarrese P, Lemichez E, Falzano L and Boquet P (1997a) Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase. J. Biol Chem 272: 19532-19537
19. Fiorentini C, Fabbn A, Matarrese P, Falzano L, Boquet P and Malorni W (1997b) Hinderance of apoptosis and phagocytic behaviour induced by E coli cytotoxic necrotizing factor 1 (CNF1): two related activities in epithelial cells. Biochem. Biophys Res. Comm 241: 341-346
20. Fiorentini C, Matarrese P, Straface E, Falzano L, Fabbri A, Donelli G, Cossarizza A, Boquet P and Malomi W (1998) Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. Exp Cell Res , in press
21. Flatau G, Lemichez E, Gauthier M, Chardin P, Paris S, Fiorentini C and Boquet P (1997) Toxin-induced activation of the G protein Rho by deamidation of glutamine Nature 387: 729-733
22. Frost JA, Xu S, Hutchinson MR, Marcus S and Cobb M (1996) Actions of Rho family small G-proteins and p21 activated protein kinases on mitogen-activated protein kinases members. Mol Cell Biol. 16: 3707-3713
23. Fujihara H, Walker LA, Gong MC, Lemichez E, Boquet P, Somlyo AV and Somlyo AP (1997) Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric DC3B Mol Biol Cell 8: 2437-2447
24. Fukumoto Y, Kaibuchi K, Hori Y, Fujioka H, Araki S, Ueda T, Kikuchi A and Takai Y (1990) Molecular cloning and characterization of a novel type of regulatory protein (GDl) for the Rho proteins, Ras p21-like small GTP-binding proteins. Oncogene 5 1321-1328
25. Gallwitz D, Donath C and Sander C (1983) A yeast gene encoding a protein homologous to the human c-ras.bas proto-oncogene product. Nature 306: 704-707
26. Gilmore AP and Burridge K (1996) Regulation of vinculin binding to talin and actin by phosphatidyl-inositol 4-5 biphosphate. Nature 381: 531-535
27. Gomez J, Martinez C, Giry M, Garcia A and Rebollo A (1997) Rho prevents apoptosis through Bcl-2 expression, implication for interleukin-2 receptor signal transduction. Eur. J. Immunol. 27. 2793-2799
28. Hartwig JH, Bokoch GM, Carpenter CL, Jeanmey PA, Taylor LA, Toker A and Stossel TP (1995) Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets Cell 82: 643-653
29. Henning SW, Galandrini R, Hall A and Cantrell DA (1997) The GTPase Rho has a critical regulatory role in thymus development. EMBO J. 16: 2397-2407
30. Hill CS, Wynne J and Treisman R (1995) The Rho family GTPases RhoA, Rac1 and Cdc42Hs regulate transcriptional activation by SRF. Cell 81. 1159-1170
31. Hirao M, Sato N, Kondo T, Yonemura S, Monden M, Sasaki T, Takai Y, Tsukita S and Tsukita S (1996) Regulation mechanism of ERM (ezrin/radixin/moesin) protein/ plasma association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J. Cell Biol 135: 37-51
32. Horiguchi Y, Inoue N, Masuda M, Kashimoto T, Katahira J, Sugimoto N and Matsuda M (1997) Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho. Proc. Natl. Acad. Sci. USA 94: 11623-11626
33. Hynes RO (1992) Integrins: versatility, modulation and signalling in cell adhesion. Cell 69: 11-25
34. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N and Narumiya S (1996) The small GTP-binding Rho binds to and activates a 160 kDa ser/thr protein kinase homologous to myotonic dystrophy kinase EMBO J 15: 1885-1893
35. Jimenez B, Arends M, Esteve P, Perona R, Sanchez R, Ramony Cajal S, Wyllie A and Lacal JC (1995) Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of Rho-p21, a GTPase protein of the Ras superfamily. Oncogene 10: 811-816
36. Kimura K, Ito M, Amano M, Chihara K, Fukuta Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A and Kaibuchi K (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273: 245-247
37. Lacerda HM, Pullinger GD, Lax AJ and Rozengurt E (1997) Cytotoxic necrotizing factor 1 from Escherichia coli and dermonecrotic toxin from Bordetella bronchiseptica induce p21 Rho-dependent tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 cells. J. Biol. Chem. 272: 9587-9596
38. Lamaze C, Chuang TH, Terlecki LJ, Bokoch GM and Schmid SL (1996) Regulation of receptor mediated endocytosis by Rho and Rac. Nature 382: 177-179
39. Lisanti MP, Scherer PE, Tang Z and Sargiacomo M (1994) Caveolae, caveolin, and caveolin rich membrane domains: a signalling hypothesis. Trends Cell Biol. 4: 231-235
40. Mackay DJG, Esch F, Furthmayr H and Hall A (1997) Rho-and Rac-dependent assembly of focal adhesion complexes and actin filament in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins J. Cell Biol. 138: 927-938
41. Madaule P and Axel R (1985) A novel ras-related gene family. Cell 41: 31-40
42. Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, Ito M, Nakano T, Okawa K, Iwamatsu A and Kaibuchi K (1996) Rho-associated kinase, a novel serine/ threonine kinase, as a putative target for the small GTP-binding protein Rho. EMBO J. 15: 2208-2216
43. Milbum M, Tong L, de Vos A, Brunger A, Yamaizumi Z, Nishimura S and Kim SH (1990) Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins Science 247 939-945
44. Olson FM, Ashworth A and Hall A (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272
45. Parton RG (1996) Caveolae and caveolins. Curr. Op Cell Biol. 8 542-548
46. Paterson HF, Self AJ, Garrett MD, Just I, Aktones K and Hall A (1990) Microinjection of recombinant p21 Rho induces rapid changes in cell morphology J. Cell Biol. 111: 1001-1007
47. Pawson T (1995) Protein modules and signalling networks Nature 373: 573-580
48. Ren X, Bokoch GM, Traynor-Kaplan A, Jenkins GH, Anderson RA and Schwartz MA (1996) Physical association of the small GTPase Rho with a 68 KDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol. Biol. Cell 7. 435-442
49. Rittinger K, Walker PA, Eccleston JF, Smerdon SJ and Gamblin SJ (1997) Structure at 1,65 Angstrom of RhoA and its GTPase-activating protein in complex with a transition state analog. Nature 389: 758-762
50. Rubin EJ, Gill DM, Boquet P and Popoff MR (1988) Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum. Mol. Cell Biol. 8: 418-426
51. Ruoslahti E and Reed JC (1994) Anchorage-dependence, integrins and apoptosis. Cell 77: 477-478
52. Schmalzing G, Richter H-P, Hansen A, Schwartz W, Just I and Aktories K (1996) Involvement of the GTP-binding Rho in constitutive endocytosis in Xenopus laevi ovocytes J Cell Biol. 130: 1319-1332
53. Schmidt G, Sehr P, Wilm M, Selzer J, Mann M and Aktones K (1997) Gln63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. Nature 387: 725-728
54. Sekine A, Fujiwara M and Narumiya S (1989) Asparagine residue in the Rho gene product is the modification site for botulinum ADP-ribosyltransferase. J Biol. Chem. 264. 8602-8605
55. Senda T, Horiguchi Y, Umemoto M, Sugimoto N and Matsuda M (1997) Bordetella bronchiseptica dermonecrotiztng toxin, which activates a small GTP-binding Rho, induces membrane organelle proliferation and caveolae formation. Exp. Cell Res. 230: 163-168
56. Simons K and Ikonen E (1997) Functional rafts in cell membranes. Nature 387: 569-572
57. Uehata M, Ishisaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H Yamagami K, Inui J, Maekawa Mand Narumiya S (1997) Calcium sensitization of smooth muscle mediated by Rho-associated protein kinase hypertension Nature 389: 990-994
58. Viera AV, Lamaze C and Schmid SL (1996) Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274: 2086-2089
59. Wary KK, Mainiero F, Isakoff SJ, Marcantonio Eand Giancotti FG (1996) The adaptor protein shc couples a class of integrins to the control of cell cycle progression Cell 87. 733-743
60. Wittinghofer A and Nassar N (1996) How ras-related proteins talk to their effectors. Trends in Biochem. Sci. 21: 488-491
61. Xia Z, Dickens M, Raingeaud J, Davis RJ and Greenberg ME (1995) Opposing effects of ERK and JNK-p38 kinases on apoptosis. Science 270: 1326-1329
62. Zerial M and Huber LA (1995) Guidebook to the small GTPases Oxford University Press, Oxford