Exclusive Th2 primary effector function in spleens but mixed Th1/Th2 function in lymph nodes of murine neonates

Journal of Immunology

Volumn 164, Issue 5, 2000, Pages 2347-2353

  Adkins, Becky ^a   Bu, Yurong ^a   Cepero, Enrique ^a   Perez, Rebecca ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TH2 CELL;

EID: 0034161737     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.5.2347     Document Type: Article

References (35)

1. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Atkins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Huston. 1991. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123:115.
2. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
3. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
4. Billingham, R. E., L. Brent, and P. B. Medawar. 1953. Actively acquired tolerance of foreign cells. Nature 172:603.
5. Adkins, B., and K. Hamilton. 1992. Freshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation. J. Immunol. 149:3448.
6. Adkins, B., A. Ghanei, and K. Hamilton. 1993. Developmental regulation of IL-4, IL-2, and IFN-γ production by murine peripheral T lymphocytes. J. Immunol. 151:6117.
7. Adkins, B., K. Chun, K. Hamilton, and M. Nassiri. 1996. Naive murine neonatal T cells undergo apoptosis in response to primary stimulation. J. Immunol. 157: 1343.
8. Forsthuber, T., H. C. Yip, and P. V. Lehmann. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science 217:1728.
9. Sarzotti, M., D. S. Robbins, and P. M. Hoffman. 1996. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271:1726.
10. Martinez, X., C. Brandt, F. Saddallah, C. Tougne, C. Barrios, F. Wild, G. Dougan, P. H. Lambert, and C. A. Siegrist. 1997, DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life. Proc. Natl. Acad. Sci. USA 94:8726.
11. Wang, Y., Z. Xiang, S. Pasquini, and H. C. Ertl. 1997. Immune response to neonatal genetic immunization. Virology 228:278.
12. Bot, A., S. Antohi, S. Bot, A. Garcia-Sastre, and C. Bona. 1997. Induction of humoral and cellular immunity against influenza virus by immunization of newborn mice with a plasmid bearing a hemagglutinin gene. Int. Immunol. 9:1641.
13. Bot, A., S. Bot, and C. Bona. 1999. Enhanced prelection against influenza virus of mice immunized as newborns with a mixture of plasmids expressing hemagglutinin and nucleoprotein. Vaccine 16:1675.
14. Adkins, B., and R.-Q. Du. 1998. Newborn mice develop balanced Th1/Th2 primary effector responses in vivo but are biased to Th2 secondary responses. J. Immunol. 160:4217.
15. Barrios, C., P. Brawand, M. Berney, C. Brandt, P. H. Lambert, and C. A. Siegrist. 1996. Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2-biased pattern which persists after adult boosting. Eur. J. Immunol. 26:1489.
16. Gottlieb, P., A. Marshak-Rothstein, K. Anditore-Hargremes, K. Barkoben, D. August, R. Rosche, and J. Benedetto. 1980. Construction and properties of new Lyt-congenic strains and anti-Lyt-2. 2 and anti-Lyt-3.1 monoclonal antibodies. Immunogenetics 10:545.
17. Ceredig, R. H., J. W. Lowenthal, M. Nabholz, and H. R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Nuture 314:98.
18. O'Hara, J., and W. E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1 Nature 315:333.
19. Adkins, B., K. Hamilton, and A. Ghanei. 1994. Upregulation of murine neonatal T helper cell function by accessory cell factors. J. Immunol. 153:3378.
20. Ridge, J. P., E. J. Fuchs, and P. Matzinger. 1996. Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells. Science 271:1723.
21. Baker, S. J., and E. P. Reddy. 1998. Modulation of life and death by the TNF receptor superfamily. Oncogene 17:3261.
22. Nissinen, M. J., and P. Panula. 1995. Developmental patterns of histamine-like immunoreactivity in the mouse. J. Histochem. Cytochem. 43:211.
23. Watkins, S. G., J. L. Dearin, L. C. Young, and D. I. Wilhelm. 1976. Association of mastopoiesis with haemopoietic tissues in the neonatal rat. Experientia 15: 1339.
24. Lu, C. Y., D. I. Beller, and E. R. Unanue. 1980. During ontogeny, la-bearing accessory cells are found early in the thymus but late in the spleen. Proc. Natl. Acad. Sci. USA 77:1597.
25. Levin, D., and H. Gershon. 1989. Antigen presentation by neonatal murine spleen cells. Cell. Immunol. 120:132.
26. Mosier, D. E., and B. M. Johnson. 1975. Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes. J. Exp. Med. 141:216.
27. Hooper, D. C., D. W. Hoskin, K. O. Gronvik, and R. A. Murgita. 1986. Murine neonatal spleen contains natural T and non-T suppressor cells capable of inhibiting adult alloreactive and newborn autoreactive T-cell proliferation. Cell. Immunol. 99:461.
28. Peeler, K., H. Wigzell, and A. B. Peck. 1983. Isolation and identification of the naturally occurring, newborn spleen-associated suppressor cells: a mixed monocyte/mast cell population with separable suppressor activities. Scand. J. Immunol. 17:443.
29. Gately, M. K., L. M. Renzetti, J. Magram, A. S. Stern, L. Adorini, U. Gubler, and D. H. Presky. 1998. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:495.
30. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741.
31. Takenaka, H., S. Maruo, N. Yamamoto, M. Wysocka, S. Ono, M. Kobayashi, H. Yagita, K. Okumura, T. Hamaoka, G. Trinchieri, et al. 1997. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-lype cytokines IL-10, IL-6, and IL-4. J. Leukocyte Biol. 61:110.
32. Sharma, D. P., A. J. Ramsay, D. J. Maguire, M. S. Rolph, and I. A. Ramshaw. 1996. Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo. J. Virol. 70:7103.
33. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production: activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1196.
34. Jadus, M. R., and A. B. Peck. 1986. Naturally occurring, spleen-associated suppressor activity of the newborn mouse: biochemical and functional identification of three monokines secreted by newborn suppressor-inducer monocytes. Scand. J. Immunol. 23:35.
35. Adkins, B. 1999. T-cell function in newborn mice and humans. Immunol. Today 20:330.