Molecular analysis of the immunoglobulin V(H) gene rearrangement in a primary cutaneous immunoblastic b-cell lymphoma by micromanipulation and single-cell PCR

Journal of Investigative Dermatology

Volumn 109, Issue 4, 1997, Pages 541-545

  Gellrich, Sylke ^a   Golembowski, Sven ^a   Audring, Heike ^a   Jahn, Sigbert ^a,b   Sterry, Wolfram ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cutaneous B cell lymphoma; Ig gene rearrangement

Indexed keywords

CD20 ANTIGEN; IMMUNOGLOBULIN;

ADULT; ARTICLE; B CELL LYMPHOMA; BIOPSY TECHNIQUE; CASE REPORT; CELL CLONE; CELL INFILTRATION; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; MICROMANIPULATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION;

EID: 0030756388     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12336753     Document Type: Article

References (35)

1. Bahler DW, Zelenetz AD, Chen TT, Levy R: Antigen selection in human lymphomagenesis. Cancer Res (Suppl.) 52:5547s-5551s, 1992
2. Bakkus MH, Herman C, Van Riet I, Van Camp B, Theilemans K: Evidence that multiple mycloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 80:2326-2335, 1992
3. Berek C, Berger A, Apel M: Maturation of the immune response in germinal centers. Cell 67:1121-1129, 1991
4. H4 genes in AIDS-associated B-cell lymphom... Blood 88:252-260, 1996
5. Betz AG, Neuberger MS, Milstein C: Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14:405-411, 1993
6. Both GW, Taylor L, Pollard JW, Steele EJ: Distribution of mutations around rearranged heavy-chain antibody variable region genes. Mol Cell Biol 10:5187-5196, 1990
7. Burg G, Kerl H, Przybilla B, Braun-Falco O: Some statistical data, diagnosis and staging of cutaneous B-cell lymphomas. J Dermatol Surg Oncol 10:256-262, 1984
8. I, genes display a high inherent susceptibility to amino acid replacement. Ann N Y Acad Sci 764:170-176, 1995
9. H genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 85:2176-2181, 1995
10. Cleary ML, Meeker IC, Levy S, Lee E, Trela M, Sklar J, Levy R: Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B-cell lymphoma. Cell 44:97-108, 1987
11. Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L: Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia 10:1190-1197, 1996
12. Du M, Peng H, Singh N, Isaacson PG, Pan L: The accumulation of p53 abnormality is associated with progression of mucosa-associated lymphoid tissue lymphoma. Blood 86:4587-4593, 1995
13. Garbe K, Stein H, Dienemann D, Orfanos CE: Borrelia burgdorferi-associated cutaneous B cell lymphoma: clinical and immunologic characterization of four cases. J Am Acad Dermatol 24:584-590, 1991
14. H genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 84:403-407, 1994
15. Hussell T, Isaacson PG, Crabtree JE, Spencer J: The response of cells from low grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 342:571-574, 1993
16. Jacob J, Kelsoe G, Rajewsky K, Weiss U: Intraclonal generarion of antibody mutants in germinal centers. Nature 354:389-392, 1991
17. Küppers R, Hansmann M-L, Rajewsky K: Micromanipulation and PCR analysis of single cells from tissue sections. In Weir DM, Blackwell C, Herzenberg LA, Herzenberg LA (eds): Handbook of Experimental Immunology. 5th edn. Blackwell Scientific Publishers, Cambridge, MA, 1995
18. Küppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fischer R, Hansmann M-L: Hodgkin disease: Hodgkin and Red-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci 91:10962-10966, 1994
19. Küppers R, Zhao M, Hansman ML, Rajewsky K: Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J 12:4955-4967, 1993
20. Landa NG, Zelickson BD, Peters MS, Muller SA, Pittelkow MR: Lymphoma versus pseudolymphoma of the skin: gene rearrangement study of 21 cases with clinicopathologic correlation. J Am Acad Dermatol 29:945-953, 1993
21. Lennert K, Stein H, Kaiserling E: Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer 31:29-43, 1975
22. Lieber RM: The mechanism of V (D) J recombination: a balance of diversity, specificity, and stability. Cell 70:873-876, 1992
23. MacLennan IC, Gray D: Antigen-driven selection of virgin and memory B cells. Immunol Rev 91:61-85, 1986
24. Meeker TC, Grimaldi GC, O'Rourke R, Loeb J, Juliusson G, Einhorn S: Lack of detectable somatic hypermutation in the V region of the IgH chain gene of a human chronic B lymphocytic leukemia. J Immunol 141:3994-3998, 1988
25. Nagatani T, Miyazawa M, Matsuzaki T, Hayakawa H, Iemoto G, Kim SI, Baba N, Aihara M, Miyamoto H, Nakajima H: Cutaneous B-cell lymphoma - a clinical, pathological and immunohistochemical study. Clin exp Dermatol 18:530-536, 1993
26. Peris K, Caracciolo E, Weirich G, Chimenti S: Primary centroblastic centrocytic lymphoma of the skin. Detection of monoclonality by polymerase chain reaction. Am J Dermatopathol 17:506-510, 1995
27. Rijlaardam JU, Toonstra J, Meijer OW, Noordijk EM, Willemze R: Treatment of primary cutaneous B-cell lymphomas of follicle center cell origin: a clinical follow-up study of 55 patients treated with radiotherapy or polychemotherapy. J Clin Oncol 14:549-555, 1996
28. Santucci M, Pimpinelli N, Arganini L: Primary cutaneous B-cell lymphoma: a unique type of low grade lymphoma - clinicopathologic and immunologic study of 83 cases. Cancer 67:311-326, 1991
29. Slater DN: Cutaneous B-cell lymphoproliferative diseases: a centenary celebration classification. J Pathol 172:301-305, 1994
30. Sterry W, Hauschild A: Use of monoclonal antibodies (UCHI-1, K1-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens. J Am Acad Dermatol 21:98-107, 1989
31. H segments with different hypervariable loops. J Mol Biol 227:776-791, 1992
32. Van Kricken JH, Raffeld M, Raghoebier S, Jaffe ES, van Ommen GJ, Klum PM: Molecular genetics of gastrointestinal non-Hodgkin's lymphomas: unusual prevalence of pattern of c-myc rearrangements in aggressive lymphomas. Blood 76:797-800, 1990
33. Vermeer MH, Geelen FAMJ, Van Haselen CW, van Voorst CW, Vader MI, Geerts MI, van Vloten W, Willemze R: Primary cutaneous large B-cell lymphomas of the leg. Arch Dermatol 132:1304-1308, 1996
34. Willemze R, Meijer CJLM, Sentis JH, Scheffer E, van Vloten WA, Toonstra J, van der Putte SCJ: Primary cutaneous large cell lymphomas of follicular center origin. A clinical follow-up study of nineteen patients. J Am Acad Dermatol 16:518-526, 1987
35. Willemze R, Kerl H, Sterry W, Beerti E, Cerroni I, Chimenti S, Diaz-Perez JI, Geerts ML, Goos M, Raltkiaer E, Santucci M, Smith N, Wechsler J, van Vloten WA, Mejer CJLM: EORTC classification for primary cutaneous lymphomas. Blood 89:in press, 1997