B-Cell Epitopes of Intracellular Autoantigens: Myth and Reality

Molecular Medicine

Volumn 6, Issue 3, 2000, Pages 141-151

  Moutsopoulos, N M ^a   Routsias, J G ^b   Vlachoyiannopoulos, P G ^b   Tzioufas, A G ^b   Moutsopoulos, H M ^b  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Epitope Analogues; Epitope Spreading; Intermolecular Spreading; Recombinant Fragment; Ro Protein

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; EPITOPE; RIBONUCLEOPROTEIN; SMALL CYTOPLASMIC RNA; SSA2 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ANIMAL; B LYMPHOCYTE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; EPITOPES; HUMANS; MOLECULAR SEQUENCE DATA; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC;

MLCS; MLOWN;

EID: 0034149594     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.1007/BF03402110     Document Type: Review

References (84)

1. W.J. Van Venrooij Autoantigens in connective tissue diseases Immun. Con. Tis. Dis. 1992 22 305 334
2. K.M. Pollard G. Reimer E.M. Tan Autoantigens in scleroderma Clin. Exp. Rheumatol. 1989 7 Suppl 3 S57 62 2691161
3. P.L. Cohen R.L. Cheek J.A. Hadler et al. The subclass distribution of human IgG rheumatoid factor J. Immunol. 1987 139 1466 1471 3624864 1:STN:280:DyaL2szgvFOnsQ%3D%3D
4. F.W. Miller S.A. Twitty T. Biswas et al. Origin and regulation of a disease-specific autoantibody response. Antigenic epitopes, spectrotype stability, and isotype restriction of anti-Jo-1 autoantibodies J. Clin. Invest. 1985 85 468 475 10.1172/JCI114461
5. M.D. Radar C. Codding M. Reiclin Differences in the fine specificity of anti-Ro(SS-A) in relation to the presence of other precipitating autoantibodies Arthr. Rheum. 1989 32 1563 1571 10.1002/anr.1780321210
6. P.H. Plotz R.R.P. de Vries I.R. Cohen J.J. van Rood What drives autoantibodies? The evidence from spontaneous human autoimmune diseases The Role of Micro-Organisms in Non-Infectious Diseases 1990 London Springer-Verlag 111 121 10.1007/978-1-4471-1796-4_10
7. K.B. Elkon Use of synthetic peptides for the detection and quantification of autoantibodies Mol. Biol. Rep. 1992 16 207 212 10.1007/BF00464709 1:CAS:528:DyaK38XltV2mtbk%3D
8. M. Wahren L. Solomin I. Pettersson D. Isenberg Autoantibody repertoire to Ro/SSA and La/SSB antigens in patients with primary and secondary Sjogren’s syndrome J. Autoimmun. 1996 9 537 544 10.1006/jaut.1996.0072 1:STN:280:DyaK2s%2FhvVaitg%3D%3D
9. H.M. Geysen S.J. Rodda T.J. Mason R. Porter J. Whelan The delineation of peptides able to mimic assembled epitopes Synthetic Peptides as Antigens 1986 London Pit man 130 149
10. I. Pettersson Methods of epitope mapping Mol. Biol. Rep. 1992 16 149 153 10.1007/BF00464702 1:CAS:528:DyaK38XltV2mtb4%3D
11. G.E. Morris Epitope mapping Methods Mol. Biol. 1998 80 161 172 10.1007/978-1-59259-257-9_16 1:CAS:528:DyaK1cXjsleqsbs%3D
12. H.M. Geysen S.J. Rodda T.J. Mason G. Tribbick P.G. Schoofs Strategies for epitope analysis using peptide synthesis J. Immunol. Meth. 1987 102 259 274 10.1016/0022-1759(87)90085-8 1:CAS:528:DyaL1cXpt1Oitg%3D%3D
13. R. Dietzgen M. Zaitlin Alleged common antigenic determinant of tobacco mosaic virus coat protein and the host protein ribulose-1,5-biphosphate carboxylase is an artifact of indirect ELISA and western blotting Virology 1991 184 397 398 10.1016/0042-6822(91)90857-8 1:CAS:528:DyaK3MXlsFClsbg%3D
14. Y. Itoh M. Reishlin Autoantibodies to the Ro/SSA antigen are conformation dependent. II. Anti-60 kD antibodies are mainly directed to the native protein; anti-52 kD antibodies are mainly directed to the denatured protein Autoimmunity 1992 14 57 65 10.3109/08916939309077357 1:STN:280:DyaK3s3ivFKmug%3D%3D
15. M. Sakarellos-Daitsiotis V. Tsikaris C. Sakarellos P.G. Vlahogiannopoulos A.G. Tzioufas H.M. Moutsopoulos Peptide carrier: a new helicoid-type sequential oligopeptide carrier (SOCn) for developing potent antigens and immunogens Methods in Enzymology 1999 19 133 141 10.1006/meth.1999.0838 1:CAS:528:DyaK1MXms1Cqt7w%3D
16. R.H. Scofield D.A. Farris A.C. Horsfall J.B. Harley Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins Arthr. Rheum. 1999 42 199 209 10.1002/1529-0131(199902)42:2<199::AID-ANR1>3.0.CO;2-1 1:CAS:528:DyaK1MXhtlarsrc%3D
17. D.P. McCauliffe H. Yin L.-X. Wang L. Lucas Autoimmune sera react with multiple epitopes on recombinant 52 and 60 kDa Ro(SSA) proteins J. Rheumatol. 1994 21 1073 1080 7523671 1:CAS:528:DyaK2cXlsFGjtro%3D
18. K. Tsuzaka T. Fujii M. Akizuki et al. Clinical significance of antibodies to native or denatured 60-kd or 52-kd Ro/SS-A proteins in Sjogren’s syndrome Arthritis Rheum. 1994 37 88 92 10.1002/art.1780370113 1:STN:280:DyaK2c7nsF2msw%3D%3D
19. M. Wahren U. Ruden B. Andersson N.R. Ringertz I. Pettersson Identification of antigenic regions of the human Ro 60 kD protein using recombinant antigen and synthetic peptides J. Autoimmun. 1992 5 19 32 10.1016/0896-8411(92)90146-H
20. D.P. McCauliffe H. Yin L.X. Wang et al. Autoimmune sera react with multiple epitopes on recombinant 52 and 60 kDa Ro(SSA) proteins J. Rheumatol. 1994 21 1073 1080 7523671 1:CAS:528:DyaK2cXlsFGjtro%3D
21. M.R. Saitta F.C. Arnett J.D. Keene 60-kDa Ro protein autoepitopes identified using recombinant polypeptides J. Immunol. 1994 152 4192 4202 7511672 1:CAS:528:DyaK2cXjt1Whsrk%3D
22. C.H. Veldhoven G.J. Pruijn J.F. Meilof et al. Characterization of murine monoclonal antibodies against 60-kD Ro/SS-A and La/SS-B autoantigens Clin. Exp. Immunol. 1995 101 45 54 10.1111/j.1365-2249.1995.tb02275.x 1:CAS:528:DyaK2MXnsF2ktbY%3D
23. M. Wahren S. Muller D. Isenberg Analysis of B-cell epitopes of the Ro/SS-A autoantigen Immunology Today 1999 20 234 239 10.1016/S0167-5699(99)01458-9
24. J.G. Routsias A.G. Tzioufas D.M. Sakarellos et al. Epitope mapping of the Ro/SSA 60KD autoantigen reveals disease-specific antibody-binding profiles Eur. J. Clin. Invest. 1996 26 514 521 10.1046/j.1365-2362.1996.186316.x 1:CAS:528:DyaK28XkslSku7k%3D
25. R.H. Scofield J.B. Harley Autoantigenicity of Ro/SSA antigen is related to a nucleocapsid protein of vesicular stomatitis virus Proc. Natl. Acad. Sci. U.S.A. 1991 88 3343 3347 10.1073/pnas.88.8.3343 1:CAS:528:DyaK3MXkt1Ohu7w%3D
26. S.C. Huang H. Yu R.H. Scofield et al. Human anti-Ro autoantibodies bind peptides accessible to the surface of the native Ro autoantigen Scand. J. Immunol. 1995 41 220 228 10.1111/j.1365-3083.1995.tb03557.x 1:CAS:528:DyaK2MXkslGmsbk%3D
27. J.A. James R.H. Scofield J.B. Harley Lupus humoral autoimmunity after short peptide immunization Ann. N. Y. Acad. Sci. 1997 815 124 127 10.1111/j.1749-6632.1997.tb52054.x 1:CAS:528:DyaK2sXktlamtrs%3D
28. R.H. Scofield W.E. Henry B.T. Kurien et al. Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro autoantigen results in anti-Ro ribonucleoprotein autoimmunity J. Immunol. 1996 156 4059 4066 8621949 1:CAS:528:DyaK28XivVamtro%3D
29. R.H. Scofield W.D. Dickey K.W. Jackson J.A. James J.B. Harley A common autoepitope near the carboxyl terminus of the 60kD Ro ribonucleoprotein: sequence similarity with a viral protein J. Clin. Immunol. 1991 11 378 388 10.1007/BF00918804 1:CAS:528:DyaK38XitFantLc%3D
30. J.G. Routsias M. Sakarellos-Daitsiotis E. Detsikas et al. Antibodies to EYRKK vesicular stomatitis virus-related peptide account only for a minority of anti-60KD antibodies Clin. Exp. Immunol. 1994 98 414 418 10.1111/j.1365-2249.1994.tb05506.x 1:CAS:528:DyaK2MXjsVGmsLY%3D
31. B. Bozic G.J. Pruijn B. Rozman et al. Sera from patients with rheumatic diseases recognize different epitope regions on the 52-kD Ro/SS-A protein Clin. Exp. Immunol. 1993 94 227 235 10.1111/j.1365-2249.1993.tb03436.x 1:CAS:528:DyaK2cXlt1CntA%3D%3D
32. J.P. Byuon S.G. Slade J.D. Reveille J.C. Hamel E.K.L. Chan Autoantibody responses to the “native” 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjogren;s syndrome J. Immunol. 1994 152 3675 3684
33. I. Blange N.R. Ringertz I. Pettersson Identification of antigenic regions of the human 52kD Ro/SS-A protein recognized by patient sera J. Autoimmun. 1994 7 263 274 10.1006/jaut.1994.1020 1:STN:280:DyaK2czht1SisA%3D%3D
34. T. Dorner E. Feist A. Wagenmann et al. Anti-52 kDa Ro(SSA) autoantibodies in different autoimmune diseases preferentially recognize epitopes on the central region of the antigen J. Rheumatol. 1996 23 462 468 8832984 1:STN:280:DyaK28vivFygtg%3D%3D
35. T. Dorner E. Feist C. Held et al. Differential recognition of the 52-kd Ro(SS-A) antigen by sera from patients with primary biliary cirrhosis and primary Sjogren’s syndrome Hepatology 1996 24 1404 1407 10.1002/hep.510240616 1:STN:280:DyaK2s%2Fpt1Omsg%3D%3D
36. T. Kato H. Sasakawa S. Suzuki et al. Autoepitopes of the 52-kd SS-A/Ro molecule Arthr. Rheum. 1995 38 990 998 10.1002/art.1780380716 1:CAS:528:DyaK2MXnvFyks70%3D
37. M.B. Frank K. Itoh V. McCubbin Epitope mapping of the 52-kD Ro/SSA autoantigen Clin. Exp. Immunol. 1994 95 390 396 10.1111/j.1365-2249.1994.tb07009.x 1:CAS:528:DyaK2cXjt1Whs78%3D
38. V. Ricchiuti J.P. Briand O. Meyer D.A. Isenberg G. Pruijn S. Muller Epitope mapping with synthetic peptides of 52-kD SSA/Ro protein reveals heterogenous antibody profiles in human autoimmune sera Clin. Exp. Immunol. 1994 95 397 407 10.1111/j.1365-2249.1994.tb07010.x 1:CAS:528:DyaK2cXktVOju7k%3D
39. N. Pourmand I. Pettersson The Zn2+ binding domain of the human Ro 52 kDa protein is a target for conformation dependent autoantibodies J. Autoimmun. 1998 11 11 17 10.1006/jaut.1997.0171 1:STN:280:DyaK1c7kvFOqsQ%3D%3D
40. L.J. McNeilage E.M. Macmillan S.F. Whittingham Mapping of epitopes on the La(SS-B) autoantigen of primary Sjogren’s syndrome: identification of a cross-reactive epitope J. Immunol. 1990 145 3829 3835 1700996 1:CAS:528:DyaK3MXmtVSqtg%3D%3D
41. Y.M. Weng J. McNeilage F. Topfer et al. Identification of a human-specific epitope in a conserved region of the La/SS-B autoantigen J. Clin. Invest. 1993 92 1104 1108 10.1172/JCI116617 1:CAS:528:DyaK2cXivFahsA%3D%3D
42. M. Rischmueller L.J. McNeilage J. McCluskey et al. Human autoantibodies directed against the RNA recognition motif of La (SS-B) bind to a conformational epitope present on the intact La (SS-B)/Ro (SS-A) ribonucleoprotein particle Clin. Exp. Immunol. 1995 101 39 44 10.1111/j.1365-2249.1995.tb02274.x 1:CAS:528:DyaK2MXnsF2ktbk%3D
43. Haaheim LR, Kvakestad R, et al. (1993) Immunodominant epitopes on the La/SSB autoantigen recognized by sera from patients with primary Sjogren syndrome and systemic lupus erythematosus. Sjogren’s Syndrome: State of the Art-4th International Symposium, Tokyo, Japan, pp. 11–13.
44. H. Troster H. Bartsch R. Klein et al. Activation of a murine autoreactive B cell by immunization with human recombinant autoantigen La/SS-B: characterization of the autoepitope J. Autoimmun. 1995 8 825 842 10.1016/S0896-8411(95)80020-4 1:STN:280:DyaK28vit1SqsA%3D%3D
45. H. Kohsaka K. Yamamoto H. Fujii et al. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein J. Clin. Invest. 1990 85 1566 1574 10.1172/JCI114606 1:CAS:528:DyaK3cXktlGlu7c%3D
46. A.G. Tzioufas E. Yiannaki D.M. Sakarellos J.G. Routsias et al. Fine specificity of autoantibodies to La/SSB: epitope mapping, and characterization Clin. Exp. Immunol. 1997 108 191 198 10.1046/j.1365-2249.1997.d01-1003.x 1:CAS:528:DyaK2sXjsFGhs70%3D
47. E.E. Yiannaki A.G. Tzioufas M. Bachmann J. Hantoumi V. Tsikaris Sakarellos-Daitsiotis H.M. Moutsopoulos The value of synthetic linear epitope analogues if La/SSB; specificity, sensitivity and comparison of methods Clin. Exp. Immunol. 1998 112 152 158 10.1046/j.1365-2249.1998.00558.x 1:CAS:528:DyaK1cXivVKlsb0%3D
48. C.J. Petrovas P.G. Vlahoyiannopoulos A.G. Tzioufas C. Alexopoulos V. Tsikaris M. Sakarellos-Daitsiotis C. Sakarellos H.M. Moutsopoulos A major Sm epitope anchored to sequential oligopeptide carriers is a suitable antigenic substrate to detect anti-Sm antibodies J. Immunol. Meth. 1998 220 59 68 10.1016/S0022-1759(98)00146-X 1:CAS:528:DyaK1cXntVygsLY%3D
49. L.S. The D.A. Isenberg Antiribosomal P protein antibodies in systemic lupus erythematosus. A reappraisal Arthr. Rheum. 1994 37 307 315 10.1002/art.1780370303
50. A.G. Tzioufas N.G. Tzortzakis E. Panou-Pomonis K.A. Boki M. Sakarellos-Daitsiotis C. Sakarellos H.M. Moutsopoulos The clinical relevance of antibodies to ribosomal-P common epitope in two targeter SLE populations: a large cohort of the consecutive patients and patients with active CNS disease Ann. Rheum. Dis. 2000 59 99 104 10.1136/ard.59.2.99 1:CAS:528:DC%2BD3cXhvFertrc%3D
51. C. Rizou J.P.A. Ioannidis E. Panou-Pomonis M. Sakarellos-Daitsiotis C. Sakarellos H.M. Moutsopoulos B-cell epitope mapping of DNA topoisomerase I defines epitopes strongly associated with pulmonary fibrosis in systemic sclerosis Am. J. Resp. Cell Mol. Biol. 2000 22 344 351 10.1165/ajrcmb.22.3.3850 1:CAS:528:DC%2BD3cXitFajs7o%3D
52. M. Kuwana J. Kaburaki T. Mimori T. Tojo M. Homma Autoantigenic epitopes on DNA topoisomerase I. Clinical and immunogenetic associations in systemic sclerosis Arthr. Rheum. 1993 36 1406 1413 10.1002/art.1780361013 1:CAS:528:DyaK2cXhs1Wnt7c%3D
53. L.R. Haaheim A.K. Halse R. Kvakestad B. Stern O. Normann R. Jonsson Serum antibodies from patients with primary Sjogren’s syndrome and systemic lupus erythematosus recognize multiple epitopes on the La(SS-B) autoantigen resembling viral protein sequences Scand. J. Immunol. 1996 43 115 121 10.1046/j.1365-3083.1996.d01-2.x 1:CAS:528:DyaK28Xhtl2rt78%3D
54. M. Incaprera L. Rindi A. Bazzichi C. Garzelli Potential role of the Epstein-Barr virus in systemic lupus erythematosus autoimmunity Clin. Exp. Rheumatol. 1998 16 289 294 9631751 1:STN:280:DyaK1c3psFantA%3D%3D
55. A. Sabbatini S. Bombardieri P. Migliorini Antibodies from patients with systemic lupus erythematosus bind a shared sequence of SmD and Epstein-Barr virus-encoded nuclear antigen EBNA I Eur. J. Immunol. 1993 23 1146 1152 10.1002/eji.1830230525 1:CAS:528:DyaK3sXktVOjtLc%3D
56. J.A. James T. Gross R.H. Scofield et al. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity J. Exp. Med. 1995 181 453 461 10.1084/jem.181.2.453 1:CAS:528:DyaK2MXjtFyhurg%3D
57. F. De Keyser S.O. Hoch M. Takei H. Dang H. De Keyser L.A. Rokeach N. Talal Cross-reactivity of the B/B′ subunit of the Sm ribonucleoprotein autoantigen with proline-rich polypeptides Clin. Immunol. Immunopathol. 1992 62 285 290 10.1016/0090-1229(92)90104-V
58. N. Talal R.F. Garry P.H. Schur S. Alexander M.J. Dauphinee I.H. Livas et al. A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus J. Clin. Invest. 1990 85 1866 1871 10.1172/JCI114647 1:CAS:528:DyaK3cXksFOhsb8%3D
59. A. Douvas Y. Takehana G. Ehresmann T. Chernyovskiy E.S. Daar Neutralization of HIV type 1 infectivity by serum antibodies from a subset of autoimmune patients with mixed connective tissue disease AIDS Res. Hum. Retroviruses 1996 12 1509 1517 10.1089/aid.1996.12.1509 1:CAS:528:DyaK28XntVemur4%3D
60. C.C. Query J.D. Keene A human autoimmune protein associated with U1 RNA contains a regional homology that is cross-reactive with retroviral p30gag antigen Cell 1987 51 211 220 10.1016/0092-8674(87)90148-6 1:CAS:528:DyaL1cXltl2gtQ%3D%3D
61. Y. Misaki K. Yamamoto K. Yanagi H. Miura H. Ichijo T. Kato T. Mato S. Welling-Wester K. Nishioka K. Ito B cell epitope on the U1 snRNP-C autoantigen contains a sequence similar to that of the herpes simplex virus protein Eur. J. Immunol. 1993 23 1064 71 10.1002/eji.1830230513 1:CAS:528:DyaK2cXisVWqt7o%3D
62. G.G. Maul S.A. Jimenez E. Riggs D. Ziemnicka-Kotula Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis Proc. Natl. Acad. Sci. U.S.A. 1989 86 8492 8496 10.1073/pnas.86.21.8492 1:CAS:528:DyaK3cXps1Ohtw%3D%3D
63. J.G. Routsias M. Sakarellos-Daitsiotis C. Sakarellos et al. Structural, molecular and immunological properties of linear B-cell epitopes of Ro60KD autoantigen Scand. J. Immunol. 1998 47 280 287 10.1046/j.1365-3083.1998.00301.x 1:CAS:528:DyaK1cXitlChu7o%3D
64. J. Kaye J. Janeway-CA The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic Ia or antigen and self-Ia J. Exp. Med. 1984 159 1397 1412 10.1084/jem.159.5.1397 1:CAS:528:DyaL2cXkt1Wks7c%3D
65. J.C. Cambier K.R. Lehmann Ia-mediated signal transduction leads to proliferation of primed B lymphocytes J. Exp. Med. 1989 170 877 886 10.1084/jem.170.3.877 1:CAS:528:DyaL1MXlvFaksrc%3D
66. C. Bernatchez D.R. Al P.E. Mayer et al. Functional analysis of Mycoplasma arthritidisderived mitogen interactions with class II molecules Infect. Immun. 1997 65 2000 2005 9169724 175276 1:CAS:528:DyaK2sXjsFWht7k%3D
67. A. Roussel B.F. Anderson H.M. Baker et al. Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules Nat. Struct. Biol. 1997 4 635 643 10.1038/nsb0897-635 1:CAS:528:DyaK2sXltlWgsb4%3D
68. J.A. Todd From genes to aetiology in a multifactorial disease, type 1 diabetes Bioessays 1999 21 164 174 10.1002/(SICI)1521-1878(199902)21:2<164::AID-BIES10>3.0.CO;2-4 1:STN:280:DyaK1M3gvFaluw%3D%3D
69. J.A. James J.B. Harley B-cell epitope spreading in autoimmunity Immunol. Rev. 1998 164 185 200 10.1111/j.1600-065X.1998.tb01220.x 1:CAS:528:DyaK1cXmvVWguro%3D
70. R.H. Scofield M.K. Kaufman U. Baber et al. Immunization of mice with human 60kD Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse Arthr. Rheum. 1999 42 1017 1024 10.1002/1529-0131(199905)42:5<1017::AID-ANR22>3.0.CO;2-7 1:CAS:528:DyaK1MXjtlKjurg%3D
71. A. Kaliyapermal C. Mohan W. Wu S.K. Datta Nucleosomal peptide epitopes for nephritis inducing T helper cells of murine lupus J. Exp. Med. 1996 183 2459 2469 10.1084/jem.183.6.2459
72. L. Caponi The cross reactivity if autoantibodies in connective tissue diseases Clin. Exp. Rheumatol. 1996 14 425 431 8871844 1:STN:280:DyaK2s%2FisFKltw%3D%3D
73. W. van Venroij P. Charles R.N. Maini The consensus workshops for the detection of autoantibodies to intracellular antigens in rheumatic diseases J. Immunol. Meth. 1991 140 181 189 10.1016/0022-1759(91)90369-Q
74. M. Reichlin N. Talal Antibodies to RNA proteins in Systemic Lupus Erythematosus The significance of paired immune responses 1991 New York Academic Press 51 63
75. T. Igarashi Y. Itoh Y. Fukunaga et al. Stress-induced cell surface expression and antigenic alteration of the Ro/SSA autoantigen Autoimmunity 1995 22 33 42 10.3109/08916939508995297 1:CAS:528:DyaK28XjsVentLY%3D
76. J. Zhu Cytomegalovirus infection induces expression of 60 KD/Ro antigen on human keratinocytes Lupus 1995 4 396 406 10.1177/096120339500400511 1:CAS:528:DyaK2MXpslShsLk%3D
77. F. Furukawa M.B. Lyons L.A. Lee et al. Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A/Ro and SS-B/La. Another possible mechanism for estradiol influence of lupus erythematosus J. Immunol. 1988 141 1480 1488 2457617 1:CAS:528:DyaL1cXlsVarsro%3D
78. F. Furukawa S.M. Kashihara M.B. Lyons et al. Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus J. Invest. Dermatol. 1990 94 77 85 10.1111/1523-1747.ep12873930 1:STN:280:DyaK3c7htFansg%3D%3D
79. R.L. Casciola G. Anhalt A. Rosen Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes J. Exp. Med. 1994 179 1317 1330 10.1084/jem.179.4.1317
80. A. Rosen L. Casiola-Rosen J. Ahearn Novel packages of viral and self-antigens are generated during apoptosis J. Exp. Med. 1995 181 1557 1561 10.1084/jem.181.4.1557 1:CAS:528:DyaK2MXkslWntLk%3D
81. P.G. Vlachoyiannopoulos C. Petrovas A.G. Tzioufas C. Alexopoulos V. Tsikaris A. Guialis L. Nakopoulou M. Sakarellos-Daitsiotis C. Sakarellos P. Davaris H.M. Moutsopoulos No evidence of epitope spreading after immunization with the major Sm epitope P-P-G-M-R-P-P anchored to sequential oligopeptide carriers J. Autoimmunity 2000 14 53 61 10.1006/jaut.1999.0344 1:STN:280:DC%2BD3c7hsFahtw%3D%3D
82. T. Gordon F. Topfer C. Keech et al. How does autoimmunity to La and Ro initiate and spread? Autoimmunity 1994 18 87 92 10.3109/08916939409007981 1:STN:280:DyaK2M3mtV2kuw%3D%3D
83. W.H. Reeves M. Satoh Features of autoantigens Mol. Biol. Rep. 1996 23 217 26 10.1007/BF00351172 1:CAS:528:DyaK2sXisF2qur0%3D
84. D.C. Feller V.F. de la Cruz Identifying antigenic T-cell sites Nature 1991 349 720 723 10.1038/349720a0 1:STN:280:DyaK3M7ktFGrtQ%3D%3D