Testosterone as well as estrogen increases serotonin(2A) receptor mRNA and binding site densities in the male rat brain

Molecular Brain Research

Volumn 59, Issue 2, 1998, Pages 205-214

  Sumner, Barbara E h ^a   Fink, George ^a  

^a ROYAL EDINBURGH HOSPITAL   (United Kingdom)

Author keywords

5 HT(2A) receptor; Aromatase; Caudate putamen; Frontal, cingulate and piriform cortex; Nucleus accumbens; Serotonin

Indexed keywords

ANDROSTANOLONE; ESTROGEN; HALOTHANE; MESSENGER RNA; SEROTONIN 2A RECEPTOR; TESTOSTERONE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CASTRATION; CONTROLLED STUDY; DEPRESSION; DORSAL RAPHE NUCLEUS; FEMALE; MALE; MENTAL HEALTH; MOOD; NONHUMAN; NUCLEUS ACCUMBENS; OLFACTORY CORTEX; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SCHIZOPHRENIA;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BRAIN CHEMISTRY; CYCLIC S-OXIDES; ESTROGENS; FEMALE; FRONTAL LOBE; GYRUS CINGULI; MALE; NAPHTHALENES; NEOSTRIATUM; NUCLEUS ACCUMBENS; ORCHIECTOMY; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RNA, MESSENGER; SEROTONIN ANTAGONISTS; SEX CHARACTERISTICS; TESTOSTERONE; TRITIUM;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0032584945     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00148-X     Document Type: Article

References (62)

1. Aghajanian G.K., Marek G.J. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36:1997;589-599.
2. G.K. Aghajanian, J.S. Sprousse, K. Rasmussen, Physiology of the midbrain serotonin system, in: H.Y. Meltzer (Ed.), Psychopharmacology: The Third Generation of Progress, Raven Press, New York, 1987, pp. 141-149.
3. Alves S.E., Weiland N.G., Hayashi S., McEwen B.S. Immunocytochemical localization of nuclear estrogen receptors and progestin receptors within the rat dorsal raphe nucleus. J. Comp. Neurol. 391:1998;322-334.
4. Beyreuther K., Multhaup G., Masters C.L. Alzheimer's disease - genesis of amyloid. CIBA Found. Symp. 199:1996;119-131.
5. Biegon A., Reches A., Snyder L., McEwen B.S. Serotonergic and noradrenergic receptors in the rat brain: modulation by chronic exposure to ovarian hormones. Life Sci. 32:1983;2015-2021.
6. Birge S.J. The role of estrogen in the treatment of Alzheimer's disease. Neurology. 48:1997;S36-S41. Suppl. 7.
7. 2A receptor imaging in major depression: focal changes in orbito-insular cortex. Br. J. Psychiatry. 171:1997;444-448.
8. 2A receptor expression. NeuroReport. 6(6):1995;901-904.
9. 2A receptors: emphasis on the rat frontal cortex. Neuroscience. 83:1998;829-836.
10. De Lignieres B. Transdermal dihydrotestosterone treatment of 'andropause'. Ann. Med. 25:1993;235-241.
11. 2 receptors, depression and anxiety. Pharmacol. Biochem. Behav. 29:1988;819-920.
12. Deslypere J.P., Kaufman J.M., Vermeulen T., Vogelaers D., Vandalem J.L., Vermeulen A. Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J. Clin. Endocrinol. Metab. 64:1987;68-73.
13. Di Paolo T. Modulation of brain dopamine transmission by sex steroids. Rev. Neurosci. 5:1994;27-42.
14. 2 receptor antagonist. Br. J. Pharmacol. 105:1992;27-36.
15. Fink G. Steroid control of brain and pituitary function. Q. J. Exp. Physiol. 73:1988;257-293.
16. G. Fink, The psychoprotective action of oestrogen is mediated by central 5-hydroxytryptamine as well as dopamine receptors, in: K. Fuxe, T. Hokfelt, L. Olson, D. Ottoson, A. Dahlstrom, A. Bjorklund (Eds.), Molecular Mechanisms of Neuronal Communication, Pergamon, Oxford, 1996, pp. 177-204.
17. 2A receptor antagonists block the oestradiol-17β-induced surge of luteinizing hormone-releasing hormone (LHRH) into hypophysial portal blood but do not affect LHRH synthesis, J. Physiol. 495.P (1996) 117p.
18. Fink G., Henderson S.R. Steroids and pituitary responsiveness in female, androgenized female and male rats. J. Endocrinol. 73:1977;157-164.
19. Fink G., Sumner B.E.H. Oestrogen and mental state. Nature. 383:1996;306.
20. Gregoire A.J.P., Kumar R., Everitt B., Henderson A.F., Studd J.W.W. Transdermal oestrogen for treatment of severe postnatal depression. Lancet. 347:1996;930-933.
21. Häfner H., Riecher-Rössler A., An Der Heiden W., Maurer K., Fätkenheuer B., Löffler W. Generating and testing a causal explanation of the gender difference in age at first onset of schizophrenia. Psychol. Med. 23:1993;925-940.
22. Halbreich U., Endicott J., Goldstein S., Nee J. Premenstrual changes and changes in gonadal hormones. Acta Psychiatr. Scand. 74(6):1986;576-586.
23. Halbreich U., Rojansky N., Palter S., Tworek H., Hissin P., Wang K. Estrogen augments serotonergic activity in postmenopausal women. Biol. Psychiatry. 37:1995;434-441.
24. Hay A.G., Bancroft J., Johnstone E.C. Affective symptoms in women attending a menopause clinic. Br. J. Psychiatry. 164:1994;513-516.
25. Henderson S.R., Baker C., Fink G. Oestradiol-17β and pituitary responsiveness to luteinizing hormone releasing factor in the rat: a study using rectangular pulses of oestradiol-17β monitored by non-chromatographic radioimmunoassay. J. Endocrinol. 73:1977;441-453.
26. Jolas T., Aghajanian G.K. Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro. Brain Res. 755:1997;229-245.
27. 2 dopamine receptor mRNA levels in rats. Neurosci. Lett. 140:1992;5-8.
28. Lewis S. Sex and schizophrenia: Vive la différence. Br. J. Psychiatry. 161:1992;445-450.
29. Li S., Pelletier G. Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain. Neuropeptides. 29:1995;21-25.
30. 2 receptor antagonist. In vitro and ex vivo selectivity profile. Eur. J. Pharmacol. 233:1993;29-35.
31. 3H -RP 62203 binding in the rat brain Eur. J. Pharmacol. 233:1993;37-45.
32. Mastrogiacomo I., Feghali G., Foresta C., Ruzza G. Andropause: incidence and pathogenesis. Arch. Androl. 9:1982;293-296.
33. McKinlay J.B., Longcope C., Gray A. The questionable physiologic and epidemiologic basis for a male climacteric syndrome: preliminary results from the Massachusetts Male Aging Study. Maturitas. 11:1989;103-115.
34. H.Y. Meltzer, Atypical antipsychotic drugs, in: F.E. Bloom, D.J. Kupfer (Eds.), Psychopharmacology: The Fourth Generation of Progress, Raven Press, New York, 1995, pp. 1277-1286.
35. Mitchell R., Hollist S., Rothwell C., Robertson W.R. Age related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive. Clin. Endocrinol. 42:1995;501-507.
36. Moss R.L., Gu Q., Wong M. Estrogen: nontranscriptional signalling pathway. Recent Prog. Horm. Res. 52:1997;33-68.
37. Nicol-Smith L. Causality, menopause, and depression: a critical review of the literature. BMJ. 313:1996;1229-1232.
38. 2C receptors stimulate amyloid precursor protein ectodomain secretion. J. Biol. Chem. 271(8):1996;4188-4194.
39. Nitsch R.M., Slack B.E., Farber S.A., Schulz J.G., Deng M., Kim C., Borghesani P.R., Korver W., Wurtman R.J., Growdon J.H. Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices. J. Neural Transm. 44:1994;21-27. Suppl.
40. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 2nd edn., Academic Press, Sydney, 1986, 264 pp.
41. Pearlstein T., Rosen K., Stone A.B. Mood disorders and menopause. Endocrinol. Metab. Clin. North Am. 26(2):1997;279-294.
42. D.W. Pfaff, Estrogens and Brain Function, Springer-Verlag, 1980, 281 pp.
43. Reid R.L., Yen S.S.C. Premenstrual syndrome. Am. J. Obstet. Gynecol. 139:1981;85-104.
44. Rosie R., Wilson H., Fink G. Testosterone induces an all-or-none, exponential increase in arginine vasopressin mRNA in the bed nucleus of stria terminalis of the hypogonadal mouse. Mol. Cell. Neurosci. 4:1993;121-126.
45. 18F ]altanserin and positron emission tomographic imaging Psychiatry Res. 68:1996;11-12.
46. Seeman M.V., Lang M. The role of estrogens in schizophrenia gender differences. Schizophr. Bull. 16:1990;185-195.
47. Sherwin B.B., Gelfand M.M. Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. Am. J. Obstet. Gynecol. 151(2):1985;153-160.
48. Sherwood N.M., Chiappa S.A., Fink G. Immunoreactive luteinizing hormone releasing factor in pituitary stalk blood from female rats: sex steroid modulation of response to electrical stimulation of preoptic area or median eminence. J. Endocrinol. 70:1976;501-511.
49. Shughrue P.J., Lane M.V., Merchenthaler I. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J. Comp. Neurol. 388:1997;507-525.
50. 2A receptor induces an antidepressant-like effect in mice. Mol. Pharmacol. 52:1997;1056-1063.
51. Studd J., Zamblera D. Premenstrual depression. Focus on Depression. 2:1994;6-9.
52. Sumner B.E.H., Fink G. Effects of acute estradiol on 5-hydroxytryptamine and dopamine receptor subtype mRNA expression in female rat brain. Mol. Cell. Neurosci. 4:1993;83-92.
53. 2A receptors in cerebral cortex and nucleus accumbens in the female rat. J. Steroid Biochem. Mol. Biol. 54:1995;15-20.
54. 2A receptors in forebrain is increased at pro-estrus in intact female rats. Neurosci. Lett. 234:1997;1-4.
55. Tang M., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H., Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 348:1996;429-432.
56. Tansey E.M., Arbuthnott G.W., Fink G., Whale D. Oestradiol-17β increases the firing rate of antidromically identified neurones of the rat neostriatum. Neuroendocrinology. 37:1983;106-110.
57. Tenover J.S., Matsumoto A.M., Plymate S.R., Bremner W.J. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J. Clin. Endocrinol. Metab. 65(6):1987;1118-1126.
58. Urban R.J., Veldhuis J.D., Blizzard R.M., Dufau M.L. Attenuated release of biologically active luteinizing hormone in healthy aging men. J. Clin. Invest. 81:1988;1020-1029.
59. Vermeulen A. The male climacterium. Ann. Med. 25:1993;531-534.
60. Wagner C.K., Morrell J.I. Distribution and steroid hormone regulation of aromatase mRNA expression in the forebrain of adult male and female rats: a cellular-level analysis using in situ hybridization. J. Comp. Neurol. 370(1):1996;71-84.
61. Wang C., Alexander G., Berman N., Salehian B., Davidson T., McDonald V., Steiner B., Hull L., Callegari C., Swerdloff R.S. Testosterone replacement therapy improves mood in hypogonadal men - a clinical research center study. J. Clin. Endocrinol. Metab. 81:1996;3578-3583.
62. Wright D.E., Jennes L. Lack of expression of serotonin receptor subtype -1a, -1c, and -2 mRNAs in gonadotropin-releasing hormone producing neurons of the rat. Neurosci. Lett. 163:1993;1-4.