DNA repair and gene therapy: Implications for translational uses

Environmental and Molecular Mutagenesis

Volumn 35, Issue 2, 2000, Pages 71-81

  Limp Foster, Melissa ^a   Kelley, Mark R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; DNA repair; Gene therapy; Hematopoiesis

Indexed keywords

BLEOMYCIN; THIOTEPA;

CANCER; CANCER CHEMOTHERAPY; DNA REPAIR; GENE THERAPY; HUMAN; IONIZING RADIATION; MULTIDRUG RESISTANCE; REVIEW; RNA TRANSLATION;

ANIMALS; BASE SEQUENCE; COMBINED MODALITY THERAPY; DNA; DNA REPAIR; GENE THERAPY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; NEOPLASMS;

ZIZIPHUS MAURITIANA;

EID: 0034121347     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(2000)35:2<71::AID-EM1>3.0.CO;2-P     Document Type: Review

References (91)

1. Allay JA, Dumenco LL, Koc ON, Liu L, Gerson SL. 1995. Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells. Blood 85: 3342-3351.
2. Allay JA, Koc ON, Davis BM, Gerson SL. 1996. Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors. Clin Cancer Res 2:1353-1359.
3. Angel P, Karin M. 1991. The role of Jun, Fos, and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072: 129-157.
4. Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ, Cheadle JP, Sampson JR, Lindahl T, Harris PC, Hickson ID. 1997. Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. Proc Natl Acad Sci USA 94: 109-114.
5. Bailly V, Verly WG. 1987. Escherichia coli endonuclease III is not an endonuclease but a β-elimination catalyst. J Biochem 242:565-572.
6. Bilbao G, Gomez-Navarro J, Curiel D. 1998. Targeted adenoviral vectors for cancer gene therapy. Adv Exp Med Biol 451:365-374.
7. Bjoras M, Luna L, Johnsen B, Hoff E, Haug T, Ragnes T, Seeberg E. 1997. Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites. EMBO J 16:6314-6322.
8. Bodine DM, Moritz T, Donahue RE, Luskey BD, Kessler SW, Martin DI, Orkin SH, Nienhuis AW, Williams DA. 1993. Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood 82:1975-1980.
9. Bogden JM, Eastman A, Bresnick E. 1981. A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA. Nucleic Acids Res 9:3089-3103.
10. Bogenhagen DF, Pinz KG. 1998. The action of DNA ligase at abasic sites in DNA J Biol Chem 273:7888-7893.
11. Bregni M, Magni M, Siena S, Di Nicola M, Bonadonna G, Gianni AM. 1992. Human peripheral blood hematopoietic progenitors are optimal targets of retroviral-mediated gene transfer. Blood 80:1418-1422.
12. Breimer LH, Lindahl T. 1984. DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation, or ring contraction are functions of endonuclease III in Escherichia coli. J Biol Chem 259:5543-5548.
13. Calleja F, Jansen JG, Vrieling H, Laval F, van Zeeland AA. 1999. Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of rat N-alkylpurine-DNA glycosylase. Mutat Res 425:185-194.
14. Canitrot Y, Cazaux C, Frechet M, Bouayadi K, Lesca C, Salles B, Hoffmann J.-S. 1998. Overexpression of DNA polymerase β in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs. Proc Natl Acad Sci USA 95:12586-12590.
15. Canitrot Y, Frechet M, Servant L, Cazaux C, Hoffmann J.-S. 1999. Overexpression of DNA polymerase b: a genomic instability enhancer process. FASEB J. 13:1107-1111.
16. Carter SK, Schabel FM Jr, Broder LE, Johnston TP. 1972. 1,3-bis(2-Chloroethyl)-1-nitrosourea (benu) and other nitrosoureas in cancer treatment: a review. Adv Cancer Res 16:273-332.
17. Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA. 1992. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions. J Biol Chem 267:166-172.
18. Cooper M. 1996. Noninfectious gene transfer and expression systems for cancer gene therapy. Semin Oncol 23:172-187.
19. Coquerelle T, Dosch J, Kaina B. 1995. Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents-a case of imbalanced DNA repair. Mutat Res 336:9-17.
20. Cornetta K. 1992. Annotation: safety aspects of gene therapy. Br J Haematol 80:421-426.
21. DeMott MS, Zigman S, Bambara RA. 1998. Replication protein A stimulates long patch DNA base excision repair. J Biol Chem 273: 27492-27498.
22. Demple B, Linn S. 1980. DNA N-glycosylases and UV repair. Nature 287:203-208.
23. Demple B, Herman T, Chen DS. 1991. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci USA 88:11450-11454.
24. Dirven HA, Dictus EL, Broeders NL, van Ommen B, van Bladeren PJ. 1995. The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa. Cancer Res 55:1701-1706.
25. Dolan ME, Moschel RC, Pegg AE. 1990. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by 06-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci USA 87:5368-5372.
26. Dzhataev S, Tanirbergenov TB, Tarasov VA. 1980. Formation of single-stranded breaks in newly-synthesized Escherichia coli DNA following treatment with bleomycin. Genetika 16:733-735.
27. Encell LP, Coates MM, Loeb LA. 1998. Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis. Cancer Res 58:1013-1020.
28. Fink D, Aebi S, Howell SB. 1998. The role of DNA mismatch repair in drug resistance. Clin Cancer Res 4:1-6.
29. Fortini P, Parlanti E, Sidorkina OM, Laval J, Dogliotti E. 1999. The type of DNA glycosylase determines the base excision repair pathway in mammalian cells. J Biol Chem 274:15230-15236.
30. Frosina G, Fortini P, Rossi O, Carrozzino F, Raspaglio G, Cox LS, Lane DP, Abbondandolo A, Dogliotti E. 1996. Two pathways for base excision repair in mammalian cells. J Biol Chem 271:9573-9578.
31. Gallardo HF, Tan C, Sadelain M. 1997. The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes. Gene Ther 4:1115-1119.
32. Gerson SL, Willson JK. 1995. O6-alkylguanine-DNA alkyltransferase: a target for the modulation of drug resistance. Hematol Oncol Clin North Am 9:431-450.
33. Gerson SL, Miller K, Berger NA. 1985. O6-Alkylguanine-DNA alkyltransferase activity in human myeloid cells. J Clin Invest 76:2106-2114.
34. Gill RD, Cussac C, Souhami RL, Laval F. 1996. Increased resistance to N,N′,N″-triethylenethiophosphoramide (thiolepa) in cells expressing the Escherichia coli formamidopyrimidine-DNA glycosylase. Cancer Res 56:3721-3724.
35. Graves RJ, Fekenszwalb I, Laval J, O'Connor TR. 1992. Excision of 5′-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli. J Biol Chem 267: 14429-14435.
36. Hanania EG, Deisseroth AB. 1994. Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model. Cancer Gene Ther 1:21-25.
37. Hanenberg H, Xiao XL, Dilloo D, Hashino K, Kato I, Williams DA. 1996. Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nat Med 2:876-882.
38. Hansen WK, Deutsch WA, Yacoub A, Xu Y, Williams DA, Kelley MR. 1998. Creation of a fully functional human chimeric DNA repair protein. J Biol Chem 273:756-762.
39. Haring M, Rudiger H, Demple B, Boiteux S, Epe B. 1994. Recognition of oxidized abasic sites by repair endonucleases. Nucleic Acids Res 22:2010-2015.
40. Hatahet Z, Kow YW, Purmal AA, Cunningham RP, Wallace SS. 1994a. New substrates for old enzymes: 5-hydroxy-2′-deoxycytidine and 5-hydroxy-2′-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2′-deoxyuridine is a substrate for uracil DNA N-glycosylase. J Biol Chem 269:18814-18820.
41. Hatahet Z, Purmal AA, Wallace SS. 1994b. Oxidative DNA lesions as blocks to in vitro transcription by phage T7 RNA polymerase. Ann N Y Acad Sci 726:346-348.
42. Hickson I, Fairbairn LJ, Chinnasamy N, Dexter TM, Margison GP, Rafferty JA. 1996. Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase. Gene Ther 3:868-877.
43. Hock RA, Miller AD. 1986. Retrovirus-mediated transfer and expression of drug resistance genes in humans haematopoietic progenitor cells. Nature 320:275-277.
44. Kasai H, Nishimura S. 1991. Oxidative stress: oxidants and antioxidants. London: Academic Press, p 99-116.
45. Kirch HSF, Rumpf H, Brockmann D, Esche H. 1999. Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB, and Myc/Max. Oncogene 18:2728-2738.
46. Kleibl KM, Margison GP. 1998. Increasing DNA repair capacity in bone marrow by gene transfer as a prospective tool in cancer therapy. Neoplasma 45:181-186.
47. Klimatcheva E, Rosenblatt JD, Planelles V. 1999. Lentiviral vectors and gene therapy. Front Biosci 4:D481-D496.
48. Klungland A, Lindahl T. 1997. Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). EMBO J 16:3341-3348.
49. Kunkel TA. 1985. The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations. J Biol Chem 260:5787-5796.
50. Levin JD, Johnson AW, Demple B. 1988. Homogeneous escherichia coli endonuclease IV: characterization of an enzyme that recognizes oxidative damage in DNA. J Biol Chem 263:8066-8071.
51. Lu R, Nash HM, Verdine GL. 1997. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. Curr Biol 7:397-407.
52. McGown AT, Fox BW. 1986. A proposed mechanism of resistance to cyclophosphamide and phosphoramide mustard in a Yoshida cell line in vitro. Cancer Chemother Pharmacol 17:223-226.
53. Michaels ML, Cruz C, Grollman AP, Miller JH. 1992. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc Natl Acad Sci USA 89:7022-7025.
54. Mickisch GH, Aksentijevich I, Schoenlein PV, Goldstein H, Stahle C, Sachs DH, Pastan I, Gottesman MM. 1992. Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice. Blood 79:1087-1093.
55. Moritz T, Williams DA. 1997. Transfer of drug resistance genes to hematopoietic precursors. In: Encyclopedia of Cancer. Vol. III. San Diego, CA: Academic Press, p 1765-1776.
56. Moritz T, Dutt P, Xiao X, Carstanjen D, Vik T, Hanenherg H, Williams DA. 1996. Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments. Blood 88: 855-862.
57. Morrow CS, Smitherman PK, Townsend AJ. 1998. Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase p1-1 (GSTp1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin. Biochem Pharmacol 56:1013-1022.
58. Naldini L. 1998. Lentiviruses as gene transfer agents for delivery to non-dividing cells. Curr Opin Biotechnol 9:457-463.
59. Nicholl ID, Nealon K, Kenny MK. 1997. Reconstitution of human base excision repair with purified proteins. Biochemistry 36:7557-7566.
60. Ortiz TMJF, Pinero J, Cortes F. 1997. T4 DNA ligase reduces chromosome damage and enhances cell survival in CHO cells treated with bleomycin. Cytogenet Cell Genet 78:197-201.
61. Patijn G, Kay MA. 1999. Hepatic gene therapy using adeno-associated virus vectors. Semin Liver Dis 19:61-69.
62. Pegg AE. 1990. Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 50:6119-6129.
63. Povirk LF, Houlgrave W. 1988. Effect of apurinic/apyrimidinic endonucleases and polyamines on DNA treated with bleomycin and neocarzinostatin: specific formation and cleavage of closely opposed lesions in complementary strands. Biochemistry 27:3850-3857.
64. Prasad RWB, Strauss PR, Wilson SH. 1998. Human DNA polymerase beta deoxyrihose phosphate lyase: substrate specificity and catalytic mechanism. J Biol Chem 273:15263-15270.
65. Prieto-Alamo MJ, Laval F. 1999. Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs. Carcinogenesis 20:415-419.
66. Ramotar D. 1997. The apurinic-apyrimidinic endonuclease IV family of DNA repair enzymes. Biochem Cell Biol 75:327-336.
67. Ramotar D, Popoff SC, Gralla EB, Demple B. 1991. Cellular role of yeast Apn1 apurinic endonuclease/3′-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11:4537-4544.
68. Reese JS, Koc ON, Lee KM, Liu L, Allay JA, Phillips WP Jr, Gerson SL. 1996. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguaninc plus 1,3-bis(2-chloroethyl)-1-notrosourea. Proc Natl Acad Sci USA 93:14088-14093.
69. Rekha GK, Sreetama L, Sladek NE. 1952. Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class-3 aldehyde dehydrogenase. Biochem Pharmacol 48:1943-1994.
70. Robson CN, Hickson ID. 1991. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nucleic Acids Res 19:5519-5523.
71. Siegert W, Beyer J, Strohscheer I, Baurmann H, Oettle H, Zingsem J, Zimmermann R, Bokemeyer C, Schmoll HJ, Huhn D. 1994. High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologons stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. J Clin Oncol 12:1223-1231.
72. Shcherhakova PV, Kunkel TA. 1999. Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. Mol Cell Biol 19:3177-3183.
73. Shibutani S, Takeshita M, Grollman AP. 1991. Insertion of specific bases during DNA synthesis past the oxidation-Jamaged base 8-oxodG. Nature 349:431-434.
74. Suzuki M, Sugimoto Y, Tsuruo T. 1998. Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA methyltransferase using biscistronic vectors with human multidrug resistance gene 1. Mutat Res 401:133-141.
75. Toft NJ, Arends MJ. 1998. DNA mismatch repair and colorectal cancer. J Pathol 185:123-129.
76. Tomicic M, Eschbach E, Kaina B. 1997. Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents. Mutat Res 383:155-165.
77. Tomkinson AE, Mackey ZB. 1998. Structure and function of mammalian DNA ligases. Mutat Res 407:1-9.
78. Ueda K, Cardarelli C, Gottesman MM, Pastan I. 1987. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastinc. Proc Natl Acad Sci USA 84:3004-3008.
79. Ward M, Rechardson C, Pioli P, Smith L, Podda S, Goff S, Hisdorffer C, Bank A. 1994. Transfer and expression of the human multiple drug resistance gene in human CD34+ cells. Blood 84:1408-1414.
80. Warner HR, Demple BF, Deutsch WA, Kane CM, Linn S. 1980. Apurinic/ apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA. Proc Natl Acad Sci USA 77:4602-4606.
81. Williams D. 1999. Retroviral-fibronectin interactions in transduction of mammalian cells. Ann N Y Acad Sci 872:109-113.
82. Williams DA, Lemischka IR, Nathan DG, Mulligan RC. 1984. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature 310:476-480.
83. Williams DA, Hsieh K, DeSilva A, Mulligan RC. 1987. Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow. J Exp Med 166:210-218.
84. Wilson SH. 1998. Mammalian base excision repair and DNA polymerase beta. Mutat Res 407:203-215.
85. Wood RD. 1996. DNA repair in eukaryotes. Annu Rev Biochem 65:135-167.
86. Wood RD. 1997. Nucleotide excision repair in mammalian cells. J Biol Chem 272:23465-23468.
87. Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T. 1992. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 11:3323-3235.
88. Xu-Welliver M, Kanugula S, Pegg AE. 1998. Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine. Cancer Res 58:1936-1945.
89. Yotsuyanagi T, Hazemoto N. 1998. Cationic liposomes in gene delivery. Nippon Rinsho 56:705-712.
90. Zeng L, Quilliet X, Chevallier-Lagente O, Eveno E, Sarasin A, Mezzina M 1997. Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C. Gene Ther 4:1077-1084.
91. Zhang HBR, Wilson T, Lloyd M, Cranston A, Thorburn A, Fishel R, Meuth M. 1999. Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res 59:3021-3027.