Hepatocyte growth factor in renal failure: Promise and reality

Kidney International

Volumn 57, Issue 4, 2000, Pages 1426-1436

  Vargas, Gustavo A ^a,b   Hoeflich, Andreas ^a,b   Jehle, Peter M ^a,b  

^a UNIVERSITY OF ULM   (Germany)

^b Gene Center   (Germany)

Author keywords

Cell proliferation; Growth factors; HGF; Nephroprotection; Renotropic growth factor; Tumorigenesis

Indexed keywords

SCATTER FACTOR; SCATTER FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONFERENCE PAPER; HUMAN; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; KIDNEY TUBULE CELL; NONHUMAN; PRIORITY JOURNAL; TISSUE REGENERATION; TUMOR GROWTH;

EID: 0034112258     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00987.x     Document Type: Conference Paper

References (154)

1. 1. ULLRICH A, SCHLESINGER J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212, 1990
2. 2. HELDIN CH: Dimerization of cell surface receptors in signal transduction. Cell 80:213-223, 1995
3. 3. FURLONG, RA: The biology of hepatocyte growth factor/scatter factor. Bioessays 14:613-617, 1992
4. 4. RUBIN JS, BOTTARO DP, AARONSON SA: Hepatocyte growth factor/ scatter factor and its receptor, the c-met proto-oncogene product. Biochem Biophys Acta 1155:357-371, 1993
5. 5. ZARNEGAR R, MICHALOPOULOS GK: The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis. J Cell Biol 129:1177-1180, 1995
6. 6. MICHALOPOULOS G, HOUCK KA, DOLAN ML, LUETTEKE NC: Control of hepatocytes replication by two serum factors. Cancer Res 44:4414-4419, 1984
7. 7. THALER J, MICHALOPOULOS G: Hepatopoietin A: Partial characterization and trypsin activation of a hepatocyte growth factor. Cancer Res 45:2545-2549, 1985
8. 8. NAKAMURA T, NAWA K, ICHIHARA A, KAISE N, NISHINO T: Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 224:311-316, 1987
9. 9. ZARNEGAR R, MICHALOPOULOS G: Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res 49:3314-3320, 1989
10. 10. STOKER M, PERRYMAN M: An epithelial scatter factor released by embryo fibroblasts. J Cell Sci 77:209-223, 1985
11. 11. STOKER M, GHERARDI E, PERRYMAN M, GRAY J: Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327:239-242, 1987
12. 12. STOKER M: Effect of scatter factor on motility of epithelial cells and fibroblasts. J Cell Physiol 139:565-569, 1989
13. 13. GHERARDI E, GRAY J, STOKER M, PERRYMAN M, FURLONG R: Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Natl Acad Sci USA 86:5844-5848, 1989
14. 14. WEIDNER KM, ARAKAKI N, HARTMANN G, VANDEKERCHOVE J, WEINGARDT S, RIEDER H, FONATSCH C, TSUBIUCHI H, HISHIDA T, DAIKUHARA Y, BIRCHMEIER W: Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci USA 88:7001-7005, 1991
15. 15. FURLONG RA, TAKEHARA T, TAYLOR WG, NAKAMURA T, RUBIN JS: Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable. J Cell Sci 100:173-177, 1991
16. 16. NALDINI L, WEIDNER KM, VIGNA E, GAUDINO G, BARDELLI A, PONZETTO C, NARSHIMAN RP, HARTMANN G, ZAMEGAR R, MICHALOPOULOS GK: Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J 10:2867-2878, 1991
17. 17. MIYAZAWA K, TSUBOUCHI H, NAKA D, TAKAHASHI K, OKIGAKI M, ARAKAKI N, NAKAYAMA H, HIRONO S, SAKIYAMA O, TAKAHASHI K, GOHDA E, DAIKUHARA I, KITAMURA N: Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun 163:967-973, 1989
18. 18. NAKAMURA T, NISHIZAWA T, HAGIYA M, NAKAMURA T, NISHIZAWA T, HAGIYA M, SEKI T, SHIMONISHI M, SUGIMURA A, TASHIRO K, SHIMISU S: Molecular cloning and expression of human hepatocyte growth factor. Nature 342:440-443, 1989
19. 19. HIGASHIO K, SHIMA N, GOTO M, ITAGAKI Y, NAGAO M, YASUDO H, MORINAGA T: Identity of a tumour cytotoxic factor from human fibroblasts and hepatocyte growth factor. Biochem Biophys Res Commun 170:397-404, 1990
20. 20. RUBIN JS, CHAN AM-L, BOTTARO DP, BURGESS WH, TAYLOR WG, CECH AC, HIRSCHFIELD DW, WONG J, MIKI T, FINCH PW, AARONSON SA: A broad spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci USA 88:415-419, 1991
21. 21. PLASCHKE-SCHLUTTER A, BEHRENS J, GHERARDI E, BIRCHMEIER W: Characterization of the scatter factor/hcpatocyte growth factor gene promoter: Positive and negative regulatory elements direct gene expression to mesenchymal cells. J Biol Chem 270:830-836, 1995
22. 22. NALDINI L, TAMAGNONE L, VIGNA E, SACHS M, HARTMANN G, BIRCHMEIER W, DAIKUHARA Y, TSUBOUCHI H, BLASI F, COMOGLIO PM: Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 11:4825-4833, 1992
23. 23. MARS WM, ZARNEGAR R, MICHALOPOULOS GK: Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am J Pathol 143:949-958, 1993
24. 24. MIYAZAWA K, SHIMOMURA T, KITAMURA A, KONDO J, MORIMOTO Y, KITAMURA N: Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor: Structural similarity of the protease precursor to blood coagulation factor XII. J Biol Chem 268:10024-10028, 1993
25. 25. SHIMOMURA T, MIYAZAWA K, KOMIYAMA Y, HIRAOKA H, NAKA D, MORIMOTO Y, KITAMURA N: Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur J Biochem 229:257-261, 1995
26. 26. MIYAZAWA K, SHIMOMURA T, NAKA D, KITAMURA N: Proteolytic activation of hepatocyte growth factor in response to tissue injury. J Biol Chem 269:8966-8970, 1994
27. 27. SHIMOMURA T, DENDA K, KITAMURA A, KAWAGUCHI T, KITO M, KONDO J, KAGAYA S, QIN L, TAKATA H, MIYAZAWA K, KITAMURA N: Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem 272:6370-6376, 1997
28. 28. DONATE LE, GHERADI E, SRINIVASAN N, SOWDHAMINI R, APARICIO S, BLUNDELL TL: Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Protein Sci 3:2378-2394, 1994
29. 29. YOSHIMURA T, YUHKI N, WANG MH, SKEEL A, LEONARDI EJ: Cloning, sequencing and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. J Biol Chem 268:15461-15468, 1993
30. 30. CHAN AM, RUBIN JS, BOTTARO DP, HIRSCHFIELD DW, CHEDID M, AARONSON SA: Identification of a competitive HGF antagonist encoded by an alternative transcript. Science 254:1382-1385, 1991
31. 31. HARTMANN G, NALDINI L, WEIDNER KM, SACHS M, VIGNA E, COMOGLIO P, BIRCHMEIER W: A functional domain in the heavy chain of scatter factor/hepatocyle growth factor binds the c-met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci USA 89:11574-11578, 1992
32. 32. MIYAZAWA K, KITAMURA A, NAKA D, KITAMURA N: An alternatively processed mRNA generated from human hepatocyte growth factor gene. Eur J Biochem 197:15-22, 1991
33. 33. LOKKER NA, PRESTA LG, GODOWSKI PJ: Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-met receptor. Protein Eng 7:895-903, 1994
34. 34. LOKKER NA, GODOWSKI PJ: Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1. J Biol Chem 268:17145-17150, 1993
35. 35. SCHWALL RH, CHANG LY, GODOWSKI PJ, KAHN DW, HILLAN KJ, BAUER KD, ZIONCHECK TF: Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2. J Cell Biol 133:709-718, 1996
36. 36. JAKUBCZAK JL, LAROCHELLE WJ, MERLINO G: NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo. Mol Cell Biol 18:1275-1283, 1998
37. 37. DATE K, MATSUMOTO K, SHIMURA H, TANAKA M, NAKAMURA T: HGF/NK4 is a specific antagonist for pleotropic actions of hepatocyte growth factor. FEBS Lett 420:1-6, 1997
38. 38. BOTTARO DP, RUBIN S, FALETTO DL, CHAN A-L, KMIECIK TE, VAN DE WOUDE GF, ARONSON SA: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251:802-804, 1991
39. 39. DEAN M, PARK M, LE-BEAU MM, ROBINS TS, DIAZ MO, ROWLEY JD, BLAIR DG, VAN DE WOUDE GF: The human met oncogene is related to the tyrosine kinase oncogenes. Nature 318:385-388, 1985
40. 40. GIORDANO S, PONZETTO C, DI RENZO RF, COOPER CS, COMOGLIO PM: Tyrosine kinase receptor indistinguishable from the c-met protein. Nature 339:155-156, 1989
41. 41. GIORDANO S, DI RENZO MF, NARSIMHAN R, COOPER CS, ROSA C, COMOGLIO PM: Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene 4:1383-1388, 1989
42. 42. LEE CC, YAMADA KM: Alternatively spliced juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site: Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte growth factor receptor. J Biol Chem 270:507-510, 1995
43. 43. PARK M, DEAN M, KAUL K, BRAUN MJ, GONDA MA, VAN DE WOUDE G: Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci USA 84:6379-6383, 1987
44. 44. NECKAMEYER WS, WANG LH: Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family. J Virol 53:879-884, 1985
45. 45. ULLRICH A, BELL JR, CHEN EY, HERRERA R, PETRUZZELLI LM, DULL TJ, GRAY A, COUSSENS L, LIAO YC, TSUBOKAWA M, MASON A, SEEBURG PH, GRUNFELD C, ROSEN OM, RAMACHANDRAN J: Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313:756-761, 1985
46. 46. GAUDINO G, FOLLENZI A, NALDINI L, COLLESI C, SANTORO M, GALLO KA, GODOWSKI PJ, COMOGLIO PM: RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J 13:3524-3532, 1994
47. 47. MEDICO E, MONGIOVI AM, HUFF J, JELINEK M-A, FOLLENZI A, GAUDINO G, PARSONS JT, COMOGLIO PM: The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vivo. Mol Biol Cell 7:495-504, 1996
48. 48. MAESTRINI E, TAMAGNONE L, LONGAH P, CREMONA O, GULISANO M, BIONE S, TAMANINI F, NEEL BG, TONIOLO D, COMOGLIO PM: A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. Proc Natl Acad Sci USA 93:674-678, 1996
49. 49. MAGGIORA P, GAMBAROTTA G, OLIVERO M, GIORDANO S, DI RENZO MF, COMOGLIO PM: Control of invasive growth by the HGF receptor family. J Cell Physiol 173:183-186, 1997
50. 50. GONZATTI-HACES M, SETH A, PARK M, COPELAND T, OROSZLAN S, VAN DE WOUDE GF: Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc Natl Acad Sci USA 85:21-25, 1988
51. 51. NALDINI L, VIGNA E, NARSIMHAN RP, GAUDINO G, ZARNEGAR R, MICHALOPOULOS GK, COMOGLIO PM: Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene 6:501-504, 1991
52. 52. ZHEN Z, GIORDANO S, LONGATI P, MEDICO E, CAMPIGLIO M, COMOGLIO PM: Structural and functional domains critical for constitutive activation of the HGF-receptor (Met). Oncogene 9:1691-1697, 1994
53. 53. FERRACINI R, LONGATI P, NALDINI L, VIGNA E, COMOGLIO PM: Identification of the major autophosphorylation site of the Met/ hepatocyte growth factor receptor tyrosine kinase. J Biol Chem 266:19558-19564, 1991
54. 54. GANDINO L, LONGAH P, MEDICO E, PRAT M, COMOGLIO PM: Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J Biol Chem 269:1815-1820, 1994
55. 55. VILLA MORUZZI E, LAPI S, PRAI M, GAUDINO G, COMOGLIO PM: A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor. J Biol Chem 268: 18176-18180, 1993
56. 56. ZHU H, NAUJOKAS MA, PARK M: Receptor chimeras indicate that the met tyrosine kinase mediates the motility and morphogenic responses of hepatocyte growth/scatter factor. Cell Growth Differ 5:359-366, 1994
57. 57. ZHU H, NAUJOKAS MA, FIXMAN ED, TOROSSIAN K, PARK M: Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis. J Biol Chem 269:29943-29948, 1994
58. 58. ASHIKARI S, HABUCHI H, KIMATA K: Characterization of heparan sulfate oligosaccharides that bind to hepatocyte growth factor. J Biol Chem 270:29586-29593, 1995
59. 59. SAKATA H, STAHL SJ, TAYLOR WG, ROSENBERG JM, SAKAGUCHI K, WINGFIELD PT, RUBIN JS: Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms: Heparan sulfate glycosaminoglycan requirement for Met binding and signaling. J Biol Chem 272:9457-9463, 1997
60. 60. ZIONCHECK TF, RICHARDSON L, LIU J, CHANG L, KING KL, BENNETT GL, FÜGEDI P, CHAMOW SM, SCHWALL RH, STACK RJ: Sulfated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity. J Biol Chem 270:16871-16878, 1995
61. 61. HARTMANN G, PROSPERO T, BRINKMANN V, OZCELIK Ö, WINTER G, HEPPLE J, BATLEY S, BLADT F, SACHS M, BIRCHMEIER C, BIRCHMEIER W, GHERARDI E: Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo. Curr Biol 8:125-134, 1997
62. 62. NAKAMURA H, TASHIRO K, NAKAMURA T, SHIOKAWA K: Molecular cloning of Xenopus HGF cDNA and its expression studies in Xenopus early embryogenesis. Mech Dev 49:123-131, 1995
63. 63. YANG XM, PARK M: Expression of the hepatocyte growth factor/ scatter factor receptor tyrosine kinase is localized to epithelia in the adult mouse. Lab Invest 73:483-491, 1995
64. 64. DI RENZO MF, NARSIMHAN RP, OLIVERO M, BRETTI S, GIORDANO S, MEDICO E, GAGLIA P, ZARA P, COMOGLIO PM: Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene 6:1997-2003, 1991
65. 65. ROLETTO F, GALVANI AP, CRISTIANI C, VALSASINA B, LANDONIO A, BERTOLERO F: Basic fibroblast growth factor stimulates hepatocyte growth factor/scatter factor secretion by human mesenchymal cells. J Cell Physiol 166:105-111, 1996
66. 66. SHIMIZU M, TAKAKUWA Y, NITTA S: Study of stimulation-secretion coupling in a flow culture system: Periodic secretion of hepatocyte growth factor by interleukin-1 alpha-stimulated human embryonic lung fibroblasls. Biochim Biophys Acta 1244:357-362, 1995
67. 67. SHIOTA G, KAWASAKI H, NAKAMURA T, SCHMIDT EV: Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha. Res Commun Mol Pathol Pharmacol 90:17-24, 1995
68. 68. BORSET M, WAAGE A, SUNDAN A: Hepatocyte growth factor reverses the TGF-beta-induced growth inhibition of CCL-64 cells: A novel bioassay for HGF and implications for the TGF-beta bioassay. J Immunol Methods 189:59-64, 1996
69. 69. STOLZ DB, MICHALOPOULOS GK: Synergistic enhancement of EGF, but not HGF, stimulated hepatocyte motility by TGF-beta 1 in vitro. J Cell Physiol 170:57-68, 1997
70. 70. TAKEUCHI K, SHIBAMOTO S, HAYAKAWA M, HORI T, MIYAZAWA K, KITAMURA N, IYO F: Hepatocyte growth factor (HGF)-induced cell migration is negatively modulated by epidermal growth factor through tyrosine phosphorylation of the HGF receptor. Exp Cell Res 223:420-425, 1996
71. 71. SHIOTA G, KAWASAKI H, NAKAMURA T, SCHMIDI EV: Assessment of in vitro growth potential of hepatocytes expressing hepatocyte growth factor in an autocrine fashion. Res Commun Mol Pathol Pharmacol 85:151-156, 1994
72. 72. LIU Y, SUN AM, DWORKIN LD: Hepatocyte growth factor protects renal epithelial cells from apoptotic cell death. Biochem Biophys Res Commun 246:821-826, 1998
73. 73. YO Y, MORISHITA R, YAMAMOTO K, TOMITA N, KIDA I, HAYASHI S, MORIGUCHI A, KATO S, MUSUMOTO K, NAKAMURA T, HIGAKI J, OGIHARA T: Actions of hepatocyte growth factor as a local modulator in the kidney: Potential role in pathogenesis of renal disease. Kidney Int 53:50-58, 1998
74. 74. GOHDA E, YAMASAKI T, TSUBOUCHI H, KUROBE M, SAKIYAMA O, AOKI H, HIIDANI N, SHIN S, HAYASHI K, HASHIMOTO S, DAIKUHARA Y, YAMAMOTO I: Biological and immunological properties of human hepatocyte growth factor from human plasma of patients with fulminant hepatic failure. Biochim Biophys Acta 1053:21-26, 1990
75. 75. SCHMIDT C, BLADI F, GOEDECKE S, BRINKMANN V, ZSCHIESCHE W, SHARPE M, GHERARDI E, BIRCHMEIER W: Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373:699-702, 1995
76. 76. ROOS F, RYAN AM, CHAMOW SM, BENNETT GL, SCHWALL RH: Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Am J Physiol 268:G380-G386, 1995
77. 77. SHIOTA G, WANG TC, NAKAMURA T, SCHMIDT EV: Hepatocyte growth factor in transgenic mice: Effects on hepatocyte growth, liver regeneration and gene expression. Hepatology 19:962-972, 1994
78. 78. SAKATA H, TAKAYAMA H, SHARP R, RUBIN JS, MERLINO G, LAROCHELLE WJ: Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ 7:1513-1523, 1996
79. 79. SANTONI-RUGIU E, PREISEGGER KH, KISS A, AUDOLFSSON T, SHIOTA G, SCHMIDT EV, THORGEIRSSON SS: Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc Natl Acad Sci USA 93:9577-9582, 1996
80. 80. KAIDO T, YAMAOKA S, SETO S, FUNAKI N, KASAMATSU T, TANAKA J, NAKAMURA T, IMANURA M: Continuous hepatocyte growth factor supply prevents lipopolysaccharide-induced liver injury in rats. FEBS Lett 411:378-382, 1997
81. 81. TSUBOUCHI H, HIRONO S, GOHDA E, NAKAYAMA H, TAKAHASHI K, SAKIYAMA O, MIYAZAKI H, SUGIHARA J, TOMITA E, MUTO Y, DAIKUHARA Y, HASHIMOTO S: Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure. Hepatology 96:875-881, 1989
82. 82. TSUBOUCHI H, HIRONO S, GOHDA E, NAKAYAMA H, TAKAHASHI K, SAKIYAMA O, KIMOTO M, KAWAKAMI S, MIYOSHI H, KUBOZONO O, KAWARADA Y, MIZUMOTO R, ARAKAKI N, DAIKUHARA Y, HASHIMOTO S: Human hepatocyte growth factor in blood of patients with fulminant hepatic failure. I. Clinical aspects. Dig Dis Sci 36:780-784, 1991
83. 83. TSUBOUCHI H, NIITANI Y, HIRONO S, NAKAYAMA H, GOHDA E, ARAKAKI N, SAKIYAMA S, TAKAHASHI K, KIMOTO M, KAWAKAMI S, SETOGUCHI M, TACHIKAWA T, SHIN S, ARIMA T, DASIKUHARA Y: Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay. Hepatology 13:1-5, 1991
84. 84. KEE N, MCTAVISH AJ, PAPILLON J, CYBULSKY AV: Receptor protein tyrosine kinases in perinatal developing rat kidney. Kidney Int 52:309-317, 1997
85. 85. WOOLF AS, KOLATSI-JOANNOU M, HARDMAN P, ANDERMACHER E, MOORBY C, FINE LG, JAT PS, NOBLE MD, GHERARDI E: Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol 128:171-184, 1995
86. 86. SANTOS OF, NIGAM SK: HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta. Dev Biol 160:293-302, 1993
87. 87. KARP SL, ORTIZ-ARDUAN A, LI S, NEILSON EG: Epithelial differentiation of metanephric mesenchymal cells after stimulation with hepatocyte growth factor or embryonic spinal cord. Proc Natl Acad Sci USA 91:5286-5290, 1994
88. 88. KADONO Y, SHIBAHARA K, NAMIKI M, WATANABE Y, SEIKI M, SATOH H: Membrane type 1-matrix metalloproteinase is involved on the formation of hepatocyte growth factor/scatter factor-induced branching tubules in madin-darby canine kidney epithelial cells. Biochem Biophys Res Commun 251:681-687, 1998
89. 89. KJELSBERG C, SAKURAI H, SPOKES K, BIRCHMEIER C, DRUMMOND I, NIGAM S, CANTLEY LG: Met-/-kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands. Am J Physiol 272:F222-F228, 1997
90. 90. BARROS EJ, SANTOS OF, MATSUMOTO K, NAKAMURA T, NIGAM SK: Differential tubulogenic and branching morphogenetic activities of growth factors: Implications for epithelial tissue development. Proc Natl Acad Sci USA 92:4412-4416, 1995
91. 91. LI Y, JOSEPH A, BHARGAVA MM, ROSEN EM, NAKAMURA T, GOLDBERG I: Effect of scatter factor and hepatocyte growth factor on motility and morphology of MDCK cells. In Vitro Cell Dev Biol 28A:364-368, 1992
92. 92. BRINKMANN V, FOROUTAN H, SACHS M, WEIDNER KM, BIRCHMEIER W: Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J Cell Biol 131:1573-1586, 1995
93. 93. SORIANO JV, PEPPRER MS, NAKAMURA T, ORCI L, MONTESANO R: Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. J Cell Sci 108:413-430, 1995
94. 94. JEHLE PM, STRACKE S, ERNST F, JEHLE DR, GRUNEWALD RW, HALLER H, KELLER F: Pleiotropic effects of hepatocyte growth factor in proximal tubule involve different signaling pathways. Kidney Int 54(Suppl 67):S152-S154, 1998
95. 95. STRACKE S, ERNST F, JEHLE DR, GRUNEWALD RW, HALLER H, KELLER F, JEHLE PM: Differentiating and proliferative effects of HGF in renal proximal tubular cells are mediated via different signaling pathways. Nephrol Dial Transplant 13:1398-1405, 1998
96. 96. MOORBY CD, STOKER M, GHERARDI E: HGF/SF inhibits junctional communication. Exp Cell Res 219:657-663, 1995
97. 97. PASDAR M, LI Z, MARRELI M, NGUYEN BT, PARK M, WONG K: Inhibition of junction assembly in cultured epithelial cells by hepatocyte growth factor/scatter factor is concomitant with increased stability and altered phosphorylation of the soluble junctional molecules. Cell Growth Differ 8:451-462, 1997
98. 98. MARTEL C, HARPER F, CEREGHINI S, NOE V, MAREEI M, CREMISI C: Inactivation of retinoblastoma family proteins by SV40 T antigen results in creation of a hepatocyte growth factor/scatter factor autocrine loop associated with an epithelial-fibroblastoid conversion and invasiveness. Cell Growth Differ 8:165-178, 1997
99. 99. LIU Y, CENTRACCHIO JN, LIN L, SUN AM, DWORKIN LD: Constitutive expression of HGF modulates renal epithelial cell phenotype and induces c-met and fibronectin expression. Exp Cell Res 242:174-185, 1998
100. 100. BARDELLI A, PUGLIESE L, COMOGLIO PM: "Invasive growth" signaling by the Met/HGF receptor: The hereditary renal carcinoma connection. Biochim Biophys Acta 1333:M43-M51, 1997
101. 101. CHEN HC, CHAN PC, TANG MJ, CHENG CH, CHANG TJ: Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation. J Biol Chem 273:25777-25782, 1998
102. 102. CANTLEY LG, CANTLEY LC: Signal transduction by the hepatocyte growth factor/scatter factor receptor, c-met: Activation of the phosphatidylinositol 3-kinase. J Am Soc Nephrol 5:1872-1881, 1995
103. 103. TAMIMURA S, CHATANI Y, HOSHINO R, SATO M, WATANABE S, KATAOKA T, NAKAMURA T, KOHNO M: Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering. Oncogene 17:57-65, 1998
104. 104. KOTELEVETS L, NOE V, BRUYNEE E, MYSSIAKINE E, CHASTRE E, MARCEL M, GESPACH C: Inhibition by a platelet-activating factor of src-and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. J Biol Chem 273:14138-14145, 1998
105. 105. ROVAI I, PARK M: Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase. J Biol Chem 270:27780-27787, 1995
106. 106. ROYAL I, FOURNIER TM, PARK M: Differential requirement of Grb2 and PI3-kinase in HGF/SF induced cell motility and tubulogenesis. J Cell Physiol 173:196-201, 1997
107. 107. KHWAJA A, LEHMANN K, MARTE BM, DOWNWARD J: Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. J Biol Chem 273:18793-18801, 1998
108. 108. RIDLEY AJ, COMOGLIO PM, HALL A: Regulation of scatter factor/ hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol 15:1110-1122, 1995
109. 109. BALKOVETZ DF, POLLACK L, MOSTOV KE: Hepatocyte growth factor alters the polarity of Madin-Darby canine kidney cell monolayers. J Biol Chem 272:3471-3477, 1997
110. 110. DERMAN MP, CUNHA MJ, BARROS EJ, NIGAM SK, CANTLEY LG: HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase. Am J Physiol 268:F1211-F1217, 1995
111. 111. SANTOS OF, MOURA LA, ROSEN EM, NIGAM SK: Modulation of HGF-induced tubulogenesis and branching by multiple phosphorylation mechanisms. Dev Biol 159:535-548, 1993
112. 112. CREPALDI T, GAUTREAU A, COMOGLIO PM, LOUVARD D, ARPJN M: Ezrin is an effector of hepatocyte growth factor-mediate migration and morphogenesis in epithelial cells. J Cell Biol 138:423-434, 1997
113. 113. BOCACCIO C, ANDO M, TAMAGNONE L, BARDELLI A, MICHIELI P, BATTISTINI C, COMOGLIO PM: Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 391:285-288, 1998
114. 114. IGAWA T, KANDA S, KANETAKE H, SAITOH Y, ICHIHARA A, TOMITA Y, NAKAMURA T: Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells. Biochem Biophys Res Commun 174:831-838, 1991
115. 115. KAWAGUCHI M, KAWASHIMA F, OHSHIMA K, KAWAGUCHI S, WADA H: Hepatocyte growth factor is a potent promoter of mitogenesis in cultured rat visceral glomerular epithelial cells. Cell Mol Biol (Noisy-le-grand) 40:1103-1111, 1994
116. 116. LIU Y, TOLBERT EM, LIN L, THURSBY MA, SUN AM, NAKAMURA T, DWORKIN LD: Up-regulation of hepatocyte growth factor receptor: An amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure. Kidney Int 55:442-453, 1999
117. 117. JOANNIDIS M, SPOKES K, NAKAMURA T, FALETTO D, CANTLEY LG: Regional expression of hepatocyte growth factor/c-met in experimental renal hypertrophy and hyperplasia. Am J Physiol 267: F231-F236, 1994
118. 118. KONO S, NAGAIKE M, MATSUMOTO K, NAKAMURA T: Marked induction of hepatocyte growth factor mRNA in intact kidney and spleen in response to injury of distant organs. Biochem Biophys Res Commun 186:991-998, 1992
119. 119. NAGAIKE M, HIRAO S, TAJIMA H, NOJI S, TANIGUCHI S, MASTSUMOTO K, NAKAMURA S: Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy. J Biol Chem 266:22781-22784, 1991
120. 120. YANO T, YANO Y, HORIKAWA S, OSAZA H, OKADA S, OTANI S, HAGIWARA K: Regenerative response in acute renal failure due to vitamin E deficiency and glutathione depletion in rats. Biochem Pharmacol 56:543-546, 1998
121. 121. KAWAIDA K, MATSUMOTO K, SHIMAZU H, NAKAMURA T: Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice. Proc Natl Acad Sci USA 91:4357-4361, 1994
122. 122. ISHIBASHI K, SASAKI S, SAKAMOTO H, HOSHINO Y, NAKAMURA T, MARUMO F: Expressions of receptor gene for hepatocyte growth factor in kidney after unilateral nephrectomy and renal injury. Biochem Biophys Res Commun 187:1454-1459, 1992
123. 123. LIU Y, TOLBERT EM, SUN AM, DWORKIN LD: In vivo and in vitro evidence for increased expression of HGF receptor in kidney of diabetic rat. Am J Physiol 271:F1202-F1210, 1996
124. 124. MIZUNO S, KUROSAWA T, MATSUMOTO K, MIZUNO-HORIKAWA Y, OKAMOTO M, NAKAMURA T: Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of a chronic renal disease. J Clin Invest 101:1827-1834, 1998
125. 125. YAMAGUCHI K, NALESNIK MA, MICHALOPOULOS GK: Expression of HGF mRNA in human rejecting kidney as evidenced by in situ hybridization. Urol Res 24:349-354, 1996
126. 126. TAKADA S, NAMIKI M, TAKAHARA S, MATSUMIYA K, KONDOH N, KOKADO Y, MATSUMOTO K, NAKAMURA T, OKUYAMA A: Serum HGF levels in acute renal rejection after living related renal transplantation. Transplant Int 9:151-154, 1996
127. 127. LIBETTA C, RAMPINO T, ESPOSITO C, FORNONI A, SEMERARO L, DAL CANTON A: Stimulation of hepatocyte growth factor in human acute renal failure. Nephron 80:1-41, 1998
128. 128. TAMAN M, LIU Y, TOLBERT E, DWORKIN LD: Increase urinary hepatocyte growth factor excretion in human acute renal failure. Clin Nephrol 48:241-245, 1997
129. 129. RAMPINO T, LIBETTA C, DE SIMONE W, RANGHINO A, SOCCIO C, GREGORINI M, GUALLINI P, TAMAGNONE L, DAL CANTON A: Hemodialysis stimulates hepatocyte growth factor release. Kidney Int 53:1382-1388, 1998
130. 130. HORIE S, HIGASHIHARA E, NUTAHARA K, MIKAMI Y, OKUBO A, KANO M, KAWABE K: Mediation of renal cyst formation by hepatocyte growth factor. Lancet 344:789-791, 1994
131. 131. LIU Y, TOLBERT EM, SUN AM, DWORKIN LD: Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells. Am J Physiol 271:F679-F688, 1996
132. 132. HAUG C, GRILL C, SCHMiD-KOTSAS A, GRUENERI A, JEHLE PM: Endothelin release by rabbit proximal tubule cells: Modulatory effects of cyclosporine A, tacrolimus, HGF and EGF. Kidney Int 54:1626-1636, 1998
133. 133. KANDA H, TAJIMA H, LEE G-H, NOMURA K, OHTAKE K, MATSUMOTO K, NAKAMURA T, KITAGAWA T: Hepatocyte growth factor transforms immortalized mouse liver epithelial cells. Oncogene 8:3047-3053, 1993
134. 134. JOHNSON M, KOUKOULIS G, KOCHHAR K, KUBO C, NAKAMURA T, IYER A: Selective tumorigenesis in non-parenchymal liver epithelial cell lines by hepatocyte growth factor transfection. Cancer Lett 96:37-48, 1995
135. 135. RONG S, BODESCOI M, BLAIR D, DUNN J, NAKAMURA T, MIZUNO K, PARK M, CHAN A, AARONSON S, VAN DE WOUDE GF: Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol 12:5152-5158, 1992
136. 136. BELLUSCI S, MOENS G, GAUDINO G, COMOGLIO P, NAKAMURA T, THIERY J-P, JOURNEAU J: Creation of an hepatocyte growth factor/ scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene 9:1091-1099, 1994
137. 137. NATALI PG, PRAT M, NICOTRA MR, BIGOTTI A, OLIVERO M, COMOGLIO PM, DI RENZO MF: Overexpression of the met/HGF receptor in renal cell carcinomas. Int J Cancer 69:212-217, 1996
138. 138. KOBAYASHI T, HONKE K, GASA S, MIYAZAKI T, TAJIMA H, MATSUMOTO K, NAKAMURA T, MAKITA A: Hepatocyte growth factor elevates the activity levels of glycolipid sulfotransferases in renal cell carcinoma cells. Eur J Biochem 219:407-413, 1994
139. 139. HIGINBOTHAM KG, KARAVANOVA ID, DIWAN BA, PERANTONI AO: Deficient expression of mRNA for the putative inductive factor bone morphogenetic protein-7 in chemically initiated rat nephroblastomas. Mol Carcinog 23:53-61, 1998
140. 140. TAKAYAMA H, LAROCHELLE WJ, SHARP R, OTSUKA T, KRIEBEL P, ANVER M, AARONSON SA, MERLINO G: Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci USA 94:701-706, 1997
141. 141. BARDELLI A, LONGATI P, ALBERO D, GORUPPI S, SCHNEIDER C, PONZETTO C, COMOGLIO P: HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J 15:6205-6212, 1996
142. 142. BARDELLI A, LONGATI P, GRAMAGLIA D, STELLA MC, COMOGLIO PM: Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene 15:3103-3111, 1997
143. 143. MATSUMOTO K, NAKAMURA T, KRAMER RH: Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem 269:31807-31813, 1994
144. 144. TAJIMA H, MATSUMOTO K, NAKAMURA T: Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines. FEBS Lett 291:229-232, 1991
145. 145. SHIOTA G, RHOADS DB, WANG TC, NAKAMURA T, SCHMIDT EV: Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA 89:373-377, 1992
146. 146. CONNER EA, WIRTH PJ, KISS A, SANTONI-RUGIU E, THORGEIRSSON SS: Growth inhibition and induction of apoptosis by HGF in transformed rat liver epithelial cells. Biochem Biophys Res Commun 236:396-401, 1997
147. 147. BRADBURY J: A two-pronged approach to the clinical use of HGF. Lancet 351:272, 1998
148. 148. UEKI T, KANEDA Y, TSUTSUI H, NAKANISHI K, SAWA Y, MORISHITA R, MATSUMOTO K, NAKAMURA T, TAKAHASHI H, OKAMOTO E, FUJIMOTO J: Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med 5:226-230, 1999
149. 149. NAKAMURA S, MORIGUCHI A, MORISHITA R, AOKI M, YO Y, HAYASHI S, NAKANO N, KATSUYA T, NAKATA S, TAKAMI S, MATSUMOTO K, NAKAMURA T, HIGAKI J, OGIHARA T: A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension. Biochem Biophys Res Commun 241:238-243, 1998
150. 150. MATSUMORI A, FURUKAWA Y, HASHIMOTO T, ONO K, SHIOI T, OKADA M, IWASAKI A, NISHIO R, SASAYAMA S: Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction. Biochem Biophys Res Commun 221:391-395, 1996
151. 151. HAMMERMAN MR, MILLER SB: Therapeutic use of growth factors in renal failure. J Am Soc Nephrol 5:1-11, 1994
152. 152. MILLER SB, MARTIN DR, KISSANE J, HAMMERMAN MR: Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats. Am J Physiol 266:F129-F134, 1994
153. 153. IGAWA T, MATSUMOTO K, KANDA S, SAITO Y, NAKAMURA T: Hepatocyte growth factor may function as a renotropic factor for regeneration in rats with acute renal injury. Am J Physiol 265:F61-F69, 1993
154. 154. TAKAYAMA H, LAROCHELLE WJ, SABNIS SG, OTSUKA T, MERLINO G: Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor. Lab Invest 77:131-138, 1997