Differentiating and proliferative effects of HGF in renal proximal tubular cells are mediated via different signalling pathways

Nephrology Dialysis Transplantation

Volumn 13, Issue 6, 1998, Pages 1398-1405

  Stracke, Sylvia ^a   Ernst, Friedlinde ^a   Jehle, Daniela R ^a   Grunewald, R Willi ^b   Haller, Hermann ^c   Keller, Frieder ^a   Jehle, Peter M ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

HGF; pp60(c src); Protein tyrosine kinase inhibitors; Renal proximal tubular cells; Signal transduction

Indexed keywords

GELDANAMYCIN; GENISTEIN; HERBIMYCIN A; MEMBRANE RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR; CINNAMIC ACID DERIVATIVE; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CELL GROWTH; CELL LINE; CELL STIMULATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH REGULATION; MICROVILLUS; PROTEIN BINDING; PROTEIN FUNCTION; PT 1 CELL;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL MOVEMENT; HEPATOCYTE GROWTH FACTOR; HUMANS; KIDNEY TUBULES, PROXIMAL; MICROSCOPY, ELECTRON; MICROVILLI; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RABBITS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0031798899     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/13.6.1398     Document Type: Article

References (31)

1. Shusterman N, Strom BL, Murray TG, Morrison G, West SL, Maislin G. Risk factor and outcome of hospital-acquired acute renal failure. Am J Med 1987; 83: 65-71
2. Humes HD, Beals TF, Cieslinski DA, Sanchez IO, Page TP. Effects of transforming growth factor-beta, transforming growth factor-alpha, and other growth factors on renal proximal tubule cells. Lab Invest 1991; 64: 538-545
3. Zarnegar R, Michalopoulos G. Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res 1989; 49: 3314-3320
4. Nakamura T, Nawa K, Ichihara A, Kaise N, Nishino T. Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 1987; 224: 311-316
5. Giordano S, Ponzetti C, Di Renzo MF et al. Tyrosine kinase receptor indistinguishable from the c-Met protein. Nature 1989; 339: 155-156
6. Bottaro DP, Rubin JS, Faletto DL et al. Identification of the hepatocyte growth factor receptor as the c-Met proto-oncogene product. Science 1990; 251: 802-804
7. Ponzetto C, Bardelli A, Zhen Z et al. A multifunctional docking site mediates signalling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994; 77: 261-271
8. Zhu H, Naujokas MA, Fixman ED et al. Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis. J Biol Chem 1994; 269: 29943-29948
9. Nagaike M, Hirao S, Tajima H et al. Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy. J Biol Chem 1991; 266: 22781-22784
10. Kawaida K, Matsumoto K, Shimazu H et al. Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice. Proc Natl Acad Sci USA 1994; 91: 4357-4361
11. Gherardi E, Gray J, Stoker M, Perryman M, Furlong R. Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Nail Acad Sci USA 1989; 86: 5844-5848
12. Frank BH, Beckage MJ, Willey KA. High-performance liquid Chromatographic preparation of single-site carrier-free pancreatic polypeptide hormone radiotracers. J Chromatogr 1983; 266: 239-248
13. Jehle PM, Fußgänger RD, Stracke S, Grunewald W, Keller F. Different binding and degradation of proinsulin, insulin and IGF-1 in cultured renal proximal tubular cells: implications for the prolonged serum half-life of proinsulin. Acta Diabetol 1996; 33: 159-165
14. Rosen EM, Meromsky L, Goldberg ID et al. Studies on the mechanism of scatter factor/hepatocyte growth factor; effects of agents that modulate intracellular signal transduction, macromolecule synthesis and cytoskeleton assembly. J Cell Sci 1990; 96: 639-649
15. Stoker M, Gherardi E, Perryman M et al. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 1987; 327: 239-242
16. Rosen EM, Meromsky L, Setter E et al. Quantitation of cytokine-stimulated migration of endothelium and epithelium by a new assay using microcarrier beads. Exp Cell Res 1990; 186: 22-31
17. Naldini L, Weidner E, Vigna E et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the met receptor. EMBO J 1991; 10: 2867-2878
18. Mizuno K, Inoue H, Hagiya M et al. Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor. J Biol Chem 1994; 269: 1131-1136
19. Graziani A, Gramaglia D, Cantley LC et al. The tyrosinephosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem 1991; 266: 22087-22090
20. Ponzetto C, Bardelli A, Maina F et al. A novel recognition motif for phosphatidylinositol-3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol Cell Biol 1993; 13: 4600-4608
21. Villa-Moruzzi E, Lapi S, Prat M et al. A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor. J Biol Chem 1993; 268: 18176-18180
22. Graziani A, Gramaglia D, Zonca dalla P et al. Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J Biol Chem 1993; 268: 9165-9168
23. Hartmann G, Weidner KM, Schwarz H et al. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras. J Biol Chem 1994; 269: 21936-21939
24. Ridley AJ, Comoglio PM and Hall A. Regulation of scatter factor/hepatocyte growth factor responses by ras, rac and rho in MDCK cells. Mol Cell Biol 1995; 15: 1110-1122
25. Akiyama T, Ishida J, Nakagawa S et al. Genistein, a specific inhibitor of tyrosine specific protein kinases. J Biol Chem 1987; 262: 5592-5595
26. src in rat kidney cells infected with Rous sarcoma virus. Mol Cell Biol 1986; 6: 2198-2206
27. v-src1. Cancer Res 1989; 49: 780-785
28. Uehara Y, Fukazawa H, Murakami Y, Mizuno S. Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds. Biochem Biophys Res Commun 1989; 163: 803-809
29. Cooper JA, Howell B. The when and how of src regulation. Cell 1993; 73: 1051-1054
30. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993; 268: 14553-14556
31. Rodriguez-Viciana P, Warne PH, Dhand R et al. Phosphatidylinositol-3-OH kinase as a direct target of ras. Nature 1994; 370: 527-532