메뉴 건너뛰기




Volumn 173, Issue 2, 1997, Pages 196-201

Differential requirement of Grb2 and PI3-Kinase in HGF/SF-induced cell motility and tubulogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 0030779715     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199711)173:2<196::AID-JCP20>3.0.CO;2-D     Document Type: Conference Paper
Times cited : (67)

References (48)
  • 1
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker, M., Gherardi, E., and Gray, J. (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature, 327:239-242.
    • (1987) Nature , vol.327 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Gray, J.3
  • 2
    • 0029564113 scopus 로고
    • Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells
    • Brinkman, V., Foroutan, H., Sachs, M., Weidner, K.M., and Birchmeier, W. (1995) Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J. Cell Biol., 131:1573-1586.
    • (1995) J. Cell Biol. , vol.131 , pp. 1573-1586
    • Brinkman, V.1    Foroutan, H.2    Sachs, M.3    Weidner, K.M.4    Birchmeier, W.5
  • 4
    • 0027344558 scopus 로고
    • Roles of HGF as a pleiotropic factor in organ regeneration
    • I.D. Goldberg and E.M. Rosen, eds., Birkhauser Verlag, Basel
    • Matsumoto, K., and Nakamura, T. (1993) Roles of HGF as a pleiotropic factor in organ regeneration. In: Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the c-Met Receptor. I.D. Goldberg and E.M. Rosen, eds., Birkhauser Verlag, Basel, pp. 225-249.
    • (1993) Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the C-Met Receptor , pp. 225-249
    • Matsumoto, K.1    Nakamura, T.2
  • 7
    • 0027410889 scopus 로고
    • The met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/ hepatocyte growth factor in epithelial cells
    • Weidner, K.M., Sachs, M., and Birchmeier, W. (1993) The met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/ hepatocyte growth factor in epithelial cells. J. Cell Biol., 121:145-154.
    • (1993) J. Cell Biol. , vol.121 , pp. 145-154
    • Weidner, K.M.1    Sachs, M.2    Birchmeier, W.3
  • 8
    • 0027264590 scopus 로고
    • The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor
    • Komada, M., and Kitamura, N. (1993) The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor. Oncogene, 8: 2381-2390.
    • (1993) Oncogene , vol.8 , pp. 2381-2390
    • Komada, M.1    Kitamura, N.2
  • 9
    • 0028026665 scopus 로고
    • Receptor chimeras indicate that the Met tyrosine kinase mediates the motility and morphogenic responses of hepatocyte growth/scatter factor
    • Zhu, H., Naujokas, M.A., and Park, M. (1994) Receptor chimeras indicate that the Met tyrosine kinase mediates the motility and morphogenic responses of hepatocyte growth/scatter factor. Cell Growth Differ., 5:359-366.
    • (1994) Cell Growth Differ. , vol.5 , pp. 359-366
    • Zhu, H.1    Naujokas, M.A.2    Park, M.3
  • 10
    • 0028264403 scopus 로고
    • Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor (scatter factor/hepatocyte growth factor receptor)
    • Komada, M., and Kitamura, N. (1994) Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor (scatter factor/hepatocyte growth factor receptor). J. Biol. Chem., 269:16131-16136.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16131-16136
    • Komada, M.1    Kitamura, N.2
  • 11
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson, T. (1995) Protein modules and signalling networks. Nature, 373:573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 12
    • 0028028202 scopus 로고
    • Tyrosine 1356 in the carboxyl-terminal tail of the HGF/ SF receptor is essential for the transduction of signals for cell motility and morphogenesis
    • Zhu, H., Naujokas, M.A., Fixman, E.D., Torossian, K., and Park, M. (1994) Tyrosine 1356 in the carboxyl-terminal tail of the HGF/ SF receptor is essential for the transduction of signals for cell motility and morphogenesis. J. Biol. Chem., 269:29943-29948.
    • (1994) J. Biol. Chem. , vol.269 , pp. 29943-29948
    • Zhu, H.1    Naujokas, M.A.2    Fixman, E.D.3    Torossian, K.4    Park, M.5
  • 13
    • 0028940362 scopus 로고
    • Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells
    • Weidner, K.M., Sachs, M., Riethmacher, D., and Birchmeier, W. (1995) Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc. Natl. Acad. Sci. U.S.A., 92:2597-2601.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 2597-2601
    • Weidner, K.M.1    Sachs, M.2    Riethmacher, D.3    Birchmeier, W.4
  • 15
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., dalla Zonca, P., Giordano, S., Graziani, A., Panayotou, G., and Comoglio, P.M. (1994) A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell, 77:261-271.
    • (1994) Cell , vol.77 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3    Maina, F.4    Dalla Zonca, P.5    Giordano, S.6    Graziani, A.7    Panayotou, G.8    Comoglio, P.M.9
  • 16
    • 0028816813 scopus 로고
    • Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-Terminus
    • Fixman, E.D., Naujokas, M.A., Rodrigues, G.A., Moran, M.F., and Park, M. (1995) Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-Terminus. Oncogene, 10:237-249.
    • (1995) Oncogene , vol.10 , pp. 237-249
    • Fixman, E.D.1    Naujokas, M.A.2    Rodrigues, G.A.3    Moran, M.F.4    Park, M.5
  • 18
    • 17544371922 scopus 로고    scopus 로고
    • Pathways downstream of Shc and Grb2 are required for cell transformation by the Tpr-Met oncoprotein
    • Fixman, E.D., Fournier, T.M., Kamikura, D.M., Naujokas, M.A., and Park, M. (1996) Pathways downstream of Shc and Grb2 are required for cell transformation by the Tpr-Met oncoprotein. J. Biol. Chem., 271:13116-13122.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13116-13122
    • Fixman, E.D.1    Fournier, T.M.2    Kamikura, D.M.3    Naujokas, M.A.4    Park, M.5
  • 19
    • 0029809118 scopus 로고    scopus 로고
    • Branching tubulogenesis but not scatter of Madin-Darby Canine Kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase
    • Fournier, T.M., Kamikura, D.M., Teng, K., and Park, M. (1996) Branching tubulogenesis but not scatter of Madin-Darby Canine Kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase. J. Biol. Chem., 271: 22211-22217.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22211-22217
    • Fournier, T.M.1    Kamikura, D.M.2    Teng, K.3    Park, M.4
  • 20
    • 0027432424 scopus 로고
    • Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
    • Arcaro, A., and Wymann, M. (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J., 296:297-301.
    • (1993) Biochem. J. , vol.296 , pp. 297-301
    • Arcaro, A.1    Wymann, M.2
  • 21
    • 0028197377 scopus 로고
    • A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase
    • Woscholski, R., Kodaki, T., McKinnon, M., Waterfield, M.D., and Parker, P.J. (1994) A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase. FEBS Lett., 342:109-114.
    • (1994) FEBS Lett. , vol.342 , pp. 109-114
    • Woscholski, R.1    Kodaki, T.2    McKinnon, M.3    Waterfield, M.D.4    Parker, P.J.5
  • 22
    • 0027374488 scopus 로고
    • Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
    • Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y., and Matsuda, Y. (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem., 268:25846-25856.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25846-25856
    • Yano, H.1    Nakanishi, S.2    Kimura, K.3    Hanai, N.4    Saitoh, Y.5    Fukui, Y.6    Nonomura, Y.7    Matsuda, Y.8
  • 23
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos, C.J., Matter, W.F., Hui, K.Y., and Brown, R.F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem., 269:5241-5248.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 24
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham, B., Vlahos, C.J., Cheatham, L., Wang, L., Blenis, J., and Kahn, C.R. (1994) Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol., 14:4902-4911.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 25
    • 0028178928 scopus 로고
    • PDGF- And insulin-dependent pp70s6k activation mediated by phosphatidylinositol-3-OH kinase
    • Chung, J., Grammer, T.C., Lemon, K.P., Kazlauskas, A., and Blenis, J. (1994) PDGF-and insulin-dependent pp70s6k activation mediated by phosphatidylinositol-3-OH kinase. Nature, 370:71-75.
    • (1994) Nature , vol.370 , pp. 71-75
    • Chung, J.1    Grammer, T.C.2    Lemon, K.P.3    Kazlauskas, A.4    Blenis, J.5
  • 26
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P., and Snyder, S.H. (1994) RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell, 78:35-43.
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 28
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
    • Chung, J., Kuo, C.J., Crabtree, G.R., and Blenis, J. (1992) Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell, 69:1227-1236.
    • (1992) Cell , vol.69 , pp. 1227-1236
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 29
    • 0026759874 scopus 로고
    • Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
    • Price, D.J., Grove, J.R., Calvo, V., Avruch, J., and Biere, B.E. (1992) Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science, 257:973-977.
    • (1992) Science , vol.257 , pp. 973-977
    • Price, D.J.1    Grove, J.R.2    Calvo, V.3    Avruch, J.4    Biere, B.E.5
  • 30
    • 0028850053 scopus 로고
    • Hepatocyte growth factor induced scatter of MDCK cells requires phosphatidylinositol 3-kinase
    • Royal, I., and Park, M. (1995) Hepatocyte growth factor induced scatter of MDCK cells requires phosphatidylinositol 3-kinase. J. Biol. Chem., 270:27780-27787.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27780-27787
    • Royal, I.1    Park, M.2
  • 31
    • 0000752197 scopus 로고
    • Junctional complexes in various epithelia
    • Farquhar, M.G., and Palade, G.E. (1963) Junctional complexes in various epithelia. J. Cell Biol., 17:375-412.
    • (1963) J. Cell Biol. , vol.17 , pp. 375-412
    • Farquhar, M.G.1    Palade, G.E.2
  • 32
    • 0027548587 scopus 로고
    • Desmosomes and hemidesmosomes
    • Garrod, D.R. (1993) Desmosomes and hemidesmosomes. Curr. Opin. Cell Biol., 5:30-40.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 30-40
    • Garrod, D.R.1
  • 33
    • 0025894092 scopus 로고
    • Cadherin cell adhesion receptors as a morphogenetic regulator
    • Takeichi, M. (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251:1451-1455.
    • (1991) Science , vol.251 , pp. 1451-1455
    • Takeichi, M.1
  • 34
    • 0027229556 scopus 로고
    • Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
    • Gale, N.W., Kaplan, S., Lowenstein, E.J., Schlessinger, J., and Bar-Sagi, D. (1993) Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature, 363:88-92.
    • (1993) Nature , vol.363 , pp. 88-92
    • Gale, N.W.1    Kaplan, S.2    Lowenstein, E.J.3    Schlessinger, J.4    Bar-Sagi, D.5
  • 35
    • 0027153103 scopus 로고
    • Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor
    • Buday, L., and Downward, J. (1993) Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor. Cell, 73:611-620.
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downward, J.2
  • 36
    • 0028142230 scopus 로고
    • The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras
    • Hartmann, G., Weidner, K.M., Schwarz, H., and Birchmeier, W. (1994) The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras. J. Biol. Chem., 269:21936-21939.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21936-21939
    • Hartmann, G.1    Weidner, K.M.2    Schwarz, H.3    Birchmeier, W.4
  • 37
    • 0027952703 scopus 로고
    • Involvement of Rho p21small GTP-binding protein and its regulator in the HGF-induced cell motility
    • Takaishi, K., Sasaki, T., Kato, M., Yamochi, W., Kuroda, S., Nakamura, T., Takeichi, M., and Takai, Y. (1994) Involvement of Rho p21small GTP-binding protein and its regulator in the HGF-induced cell motility. Oncogene, 9:273-279.
    • (1994) Oncogene , vol.9 , pp. 273-279
    • Takaishi, K.1    Sasaki, T.2    Kato, M.3    Yamochi, W.4    Kuroda, S.5    Nakamura, T.6    Takeichi, M.7    Takai, Y.8
  • 38
    • 0028894787 scopus 로고
    • Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells
    • Ridley, A.J., Comoglio, P.M., and Hall, A. (1995) Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol. Cell. Biol., 15:1110-1122.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1110-1122
    • Ridley, A.J.1    Comoglio, P.M.2    Hall, A.3
  • 40
    • 0027934261 scopus 로고
    • Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins
    • Salcini, A.E., McGlade, J., Pelicci, G., Nicoletti, I., Pawson, T., and Pelicci, P.G. (1994) Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene, 9:2827-2836.
    • (1994) Oncogene , vol.9 , pp. 2827-2836
    • Salcini, A.E.1    McGlade, J.2    Pelicci, G.3    Nicoletti, I.4    Pawson, T.5    Pelicci, P.G.6
  • 42
    • 0027996869 scopus 로고
    • Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor
    • Basu, T., Warne, P.H., and Downward, J. (1994) . Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor. Oncogene, 9:3483-3489.
    • (1994) Oncogene , vol.9 , pp. 3483-3489
    • Basu, T.1    Warne, P.H.2    Downward, J.3
  • 43
    • 0028814087 scopus 로고
    • HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase
    • Derman, M.P., Cunha, M.J., Barros, E.J., Nigam, S.K., and Cantley, L.G. (1995) HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase. Am. J. Physiol., 268:F1211-1217.
    • (1995) Am. J. Physiol. , vol.268
    • Derman, M.P.1    Cunha, M.J.2    Barros, E.J.3    Nigam, S.K.4    Cantley, L.G.5
  • 46
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
    • Hu, Q., Klippel, A., Muslin, A.J., Fantl, W.J., and Williams, L.T. (1995) Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science, 268:100-102.
    • (1995) Science , vol.268 , pp. 100-102
    • Hu, Q.1    Klippel, A.2    Muslin, A.J.3    Fantl, W.J.4    Williams, L.T.5
  • 47
    • 0030056968 scopus 로고    scopus 로고
    • Cell adhesion: The molecular basis of tissue architecture and morphogenesis
    • Gumbiner, B.M. (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell, 84:345-357.
    • (1996) Cell , vol.84 , pp. 345-357
    • Gumbiner, B.M.1
  • 48
    • 0027170920 scopus 로고
    • SH3 domains direct cellular localization of signaling molecules
    • Bar-Sagi, D., Rotin, D., Batzer, A., Mandiyan. V., and Schlessinger, J. (1993) SH3 domains direct cellular localization of signaling molecules. Cell, 74:83-91.
    • (1993) Cell , vol.74 , pp. 83-91
    • Bar-Sagi, D.1    Rotin, D.2    Batzer, A.3    Mandiyan, V.4    Schlessinger, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.