Toward trophic treatment in parkinsonism: A primate step. GDNF delivery to the brain decreases cardinal symptoms in a monkey model of Parkinson's disease

Nature Medicine

Volumn 2, Issue 4, 1996, Pages 400-401

  Olson, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; NERVE GROWTH FACTOR; NEURITE PROMOTING FACTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TYROSINE 3 MONOOXYGENASE;

ANIMAL MODEL; DOPAMINERGIC NERVE CELL; INTRAARTERIAL DRUG ADMINISTRATION; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MONKEY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; NOTE; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

ANIMALS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MACACA MULATTA; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PARKINSON DISEASE;

ANIMALIA; PRIMATES;

EID: 0030003264     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0496-400     Document Type: Article

References (18)

1. Lindsay, R.B. Neuron saving schemes. Nature 373, 289-290 (1995).
2. Lin, L.-F. H., Doherty, D.H., Lile, J.D., Bektesh. S. & Collins F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-1132 (1993).
3. Strömberg, I. et al. Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp. Neurol. 124, 401-412 (1993).
4. Tomac, A. et al. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373, 335-339 (1995).
5. Beck, K.D. et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373, 339-341 (1995).
6. Hudson, J. et al. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Res. Bull. 36, 425-432 (1995).
7. Sauer, H., Rosenblad, C. & Björklund, A. GDNF but not TGF-β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxy-dopamine-lesion. Proc. Natl. Acad. Sci. USA 92, 8935-8939 (1995).
8. Gash, D.M. et al. Functional recovery in GDNF-treated parkinsonian monkeys. Nature 380, 252-255 (1996).
9. Arenas, E., Trupp, M., Åkerud, P. & Ibáñez, C.F. GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15, 1465-1473 (1995).
10. Henderson, C.E. et al. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062-1064 (1994).
11. Mount, H.T.J., Dean, D.O., Alberch, J., Dreyfus, C.F. & Black, I.B. Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. Proc. Natl. Acad. Sci. USA 92, 9092-9096 (1995).
12. Ebendal, T., Tomac A., Hoffer B.J. & Olson L. Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J. Neurosci. Res. 40, 276-284 (1995).
13. Buj-Belio, A., Buchman, V.L., Horton, A., Rosenthal, A. & Davies, A.M. GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821-828 (1995).
14. Tomac, A. et al. Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc. Natl. Acad. Sci. USA 92, 9274-8278 (1995).
15. Sydow, O. et al. Long-term beneficial effects of adrenal medullary autografts supported by nerve growth factor in Parkinson's disease. Eur. J. Neurol. 2, 1-10 (1995).
16. Olson, L. NGF and the treatment of Alzheimer's disease. Exp. Neurol. 124, 5-15 (1993).
17. Gash, D.M., et al. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. J. Comp. Neurol. 363, 345-358 (1995).
18. Kotzbauer, P.T., Lampe, P.A., Johnson, E.M. & Milbrandt, J. Neurturin: A novel neurotrophic factor related to GDNF. [Poster replacing Soc. Neurosci. Abstr. 21 (part 1), 544 (1995)].