Mapping of the human IL10 gene and further characterization of the 5' flanking sequence

Immunogenetics

Volumn 46, Issue 2, 1997, Pages 120-128

  Eskdale, Joyce ^a   Kube, Dieter ^b   Tesch, Hans ^b   Gallagher, Grant ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10;

ARTICLE; CHROMOSOME 1; DINUCLEOTIDE REPEAT; DNA FLANKING REGION; GENE MAPPING; HUMAN; IMMUNOGENETICS; POINT MUTATION; PRIORITY JOURNAL; TRANSCRIPTION INITIATION;

BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; GENOME, HUMAN; HUMANS; INTERLEUKIN-10; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA;

EID: 0030910899     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510050250     Document Type: Article

References (63)

1. Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S., Nishio, Y., Nakajima, T., Hirano, T., and Kishimoto, T. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9: 1897-1906, 1990
2. Aman, M. J., Tretter, T., Eisenbeis, I., Bug, G., Decker, T., Aulitzky, W. E., Tilg, H., Huber, C., and Peschel, C. Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes. Blood 87: 4731-4736, 1996
3. Becker, J.C., Czerny, C., and Brocker, E.B. Maintainance of clonal anergy by endogenously produced IL-10. Int Immunol 6: 1605-1612, 1994
4. Bejarano, M.T., Malefyt, R.D., Abrams, J.S., Bigler, M., Bacchetta, R., DeVries, J.E., and Roncarolo, M.G. Interleukin-10 inhibits allospecific proliferative and cytotoxic T-cell responses generated in mixed lymphocyte cultures, Int Immunol 4: 1389-1397, 1992
5. Bièche, I., Champeme, M.H., and Lidereau, R. Loss and gain of distinct regions of chromosome 1q in primary breast cancer. Clin Cancer Res 1: 123-127, 1995
6. Blay, J.Y., Burdin, N., Rousset, F., Lenoir, G., Biron, P., Philip, T., Banchereau, J., and Favori, M.C. Serum IL-10 in non-Hodgkin's lymphoma: a prognostic factor. Blood 87: 2169-2174, 1993
7. Burdin, N., Peronne, C., Banchereau, J., and Rousset, F. Epstein-Barr virus induces B-lymphocytes to produce human interleukin 10. J Exp Med 177: 295-304, 1993
8. Cox, D.R., Burmeister, M., Price, E.R., Kim, S., and Myers, R.M. Radiation hybrid mapping: A somatic cell genetic method for constructing high resolution maps of human chromosomes. Science 250: 245-250, 1990
9. Curtiss, V.E., Smilde, R., and McGuire, K.L. Requirements for interleukin-2 promoter transactivation by the tax protein of human T-cell leukaemia-virus type-1. Mol Cell Biol 16: 3567-3575, 1996
10. David, M. Transcription factors in interferon signaling. Pharmacol Ther 65: 149-161, 1995
11. Darnell, J. Jr, Kerr, I.M., and Stark, G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins Science 264: 1415-1421, 1994
12. Dummer, W., Becker, J.C., Schwaaf, A., Leverkus, M., Moll, T. and Brocker, E.B. Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma. Melanoma Res 5: 67-68. 1995
13. Eskdale, J. and Gallagher, G. A polymorphic dinucleotide repeat in the human IL-10 promoter. Immunogenetics 42: 444-445, 1995
14. Eskdale, J. Kube, D., and Gallagher, G. A second polymorphic dinucleotide repeat in the 5′ flanking region of the human IL10 gene. Immunogenetics 45: 82-83, 1996
15. Eskdale, J., Wordsworth, P., Bowman, S., Field, M., and Gallagher, G. Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus. Tissue Antigens, in press
16. Fantuzzi, L., Gessani, S., Borghi, P., Varano, B., Conti, L., Puddu, P., and Belardelli, F. Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: Requirement of gamma interferon for IL-12 secretion. J Virol 70: 4121-4124, 1996
17. Finbloom, D.S. and Winestock, K.D. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J Immunol 155: 1079-1090, 1995
18. Fiorentino, D.F., Zlotnik, A., Vieira, P., Mosmann, T.R., Howard, M., Moore, K.W., and O'Garra, A. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by ThI cells. J Immunol 146: 3444-3451, 1991
19. Fortis, C., Foppoli, M., Gianotti, L., Galli, L., Citterio, G., Consogno, G., Gentilini, O., and Braga, M. Increased interleukin-10 levels in the serum of patients with solid tumors. Cancer Lett 104: 1-5, 1996
20. Galsgaard, E.D., Gouilleux, F., Groner, B., Serup, P., Nielsen, J.H., and Billestrup, N. Identification of a growth-hormone-responsive STAT-5 element in the rat insulin 1 gene. Mol Endicrinol 10: 652-660, 1996
21. Gerosa, F., Paganin, C., Peritt, D., Paiola, F., Scupoli, M. T., Asteamezaga, M., Frank, I., and Trinchieri, G. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med 183: 2559-2569, 1996
22. Herbst, H., Foss, H.D., Samol, J., Araujo, I., Klotzbach, H., Krause, H., Agathanggelou, A., Niedobitek, G., and Stein, H. Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor-cells of Hodgkin's disease. Blood 87: 2918-2929, 1996
23. Hou, J., Baichwal, V., and Cao, Z. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intracellular adhesion molecule 1. Proc Natl Acad Sci USA 91: 11641-11645, 1994
24. Ihle, J.N. STATs: signal transducers and activators of transcription. Cell 84: 331-334, 1996
25. Kim, J.M., Brannan, C.I., Copeland, N.G., Jenkins, N.A., Khan, T.A., and Moore, K.W. Structure of the mouse IL-10 gene and chromosomal localisation of the mouse and human genes. J Immunol 148: 3618-3623, 1992
26. Kim, J., Modlin, R.L., Moy, R.L., Dubinett, S.M., McHugh, T., Nickloff, B.J., and Uyemura, K. Interleukin-10 production in cutaneous basal and squamous cell carcinomas: a model for evading the local T-cell immune response. J Immunol 155: 2240-2247, 1995
27. Kube, D., Platzer, C., von Kneuthen, A., Fanai, S., Ohlen, H., Tesch, T., and Diehl, V. The influence of EBV on the regulation of the IL-10 promoter in Burkitt lymphomas. J Cell Biochem (Suppl 18c): 232, 1994
28. Kube, D., Platzer, C., von Knethen, A., Straub, H., Bohlen, H., Hafner, M., and Tesch, H. Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines. Cytokine 7: 1-7, 1995
29. Lehmann, J., Seegert, D., Strehlow, I., Schindler, C., Lohmann-Matthes, M.I., and Decker, T. IL-10-induced factors belonging to the p91 family of proteins bind to IFN-gamma-responsive promoter elements. J Immunol 153: 165-172, 1994
30. Llorente, L., Richaud-Patin, Y. Fior, R., Alcocer-Varela, J., Wijdnes, J., Morel-Fourrier, B., Galanaud, P., and Emilie, D. In vivo production of Interleukin-10 by non-T-cells in rheumatoid arthritis, Sjogren's syndrome and systemic lupus erythematosus. Arth Rheum 37: 1647-1655, 1994
31. Llorente, L., Zou, W., Levy, Y., Richaud-Patin, Y., Wijdenes, J., Alcocer-Varela, J., Morel-Fourrier, B., Brouet, J.-C., Alarcon-Segovia, D., Galanaud, P., and Emilie, D. Role of Interleukin-10 in the B-lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 181: 839-844, 1995
32. Lüscher, U., Filgueira, L., Juretic, A., Zuber, M., Lüscher, N.J., Heberer, M., and Spagnoli, G.C. The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor infiltrating lymphocytes. Int J Cancer 57: 612-619, 1994
33. Malefyt, R.D., Haanen, J., Spits, H., Roncarolo, M.G., Tevelde, A., Figor, C., Johnson, K., Kastelein, R., Yssel, H., and DeVries, J.E. Interleukin-10 (IL-10) and viral-IL-10 strongly reduce antigen specific T-cell prolifertion by diminishing the antigen presentation capacity of monocytes via down-regulation of class-II MHC expression. J Exp Med 174: 915-924, 1991a
34. Malefyt, R.D., Abrams, J., Bennet, B., Figdor, C.G., and de Vries, J.E. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174: 1209-1220, 1991b
35. Masood, R., Zhang, Y., Bond, M.W., Scadden, D.T., Moudgil, T., Law, R.E., Kaplan, M.H., Jung, B., Espina, B.M., Lunardi-Iskandar, Y., Levine, A.M., and Gill, P.S. Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. Blood 85: 3423-3430, 1995
36. Matsuda, M., Salazar, F., Petersson, M., Masucci, G., Hansson, J., Pisa, P., Zhang, Q.J., Masucci, M.G., and Kiessling, R. Interleukin-10 protects target cells from tumor specific and allospecitic cytotoxic T-cells by down-regulating HLA class-I expression. J Exp Med 180: 2371-2376, 1994
37. Meisel, C., Vogt, K., Platzer, C., Randow, F., Liebenthal, C., and Volk, H. D. Differential regulation of monocytic tumor necrosis factor-alpha and interleukin-10 expression. Eur J Immunol 26: 1580-1586, 1996
38. Meyer, C.F., Wang, X., Chang, C., Templeton, D., and Tan, T.H. Interaction between c-Rel and the mitogen-activated protein kinase 1 signalling cascade in mediating kappaB enhancer activation. J Biol Chem 271: 8971-8976, 1996
39. Moore, K.W., O'Garra, A., de Waal-Malefyt, R., Viera, P., and Mosmann, T.R. IL-10. Annu Rev Immunol 11: 165-290, 1993
40. Mori, N., and Prager, D. Transactivation of the interleukin-1 alpha promoter by human T-cell leukemia virus type I and type II tax proteins. Blood 87: 3410-3417, 1996
41. Mori, N., Gill, P.S., Mougdil, T., Murakami, S., Eto, S., and Prager D. Interleukin 10 gene expression in adult T-cell leukemia. Blood 87: 1035-1045, 1996
42. Mossmann, T.R. Properties and functions of interleukin-10. Adv Immunol 65: 1, 1994
43. Nakagomi, H., Pisa, P., Pisa, E.K., Yamamoto, Y., Halapi, E., Backlin, K., Juhlin, C., and Kiessling, R. Lack of interleukin-2 expression and selective expression of interleukin-10 mRNA in human renal cell carcinoma. Int J Cancer 63: 366-371, 1995
44. Nakagomi, H., Dolcetti, R., Bejarano, M. T., Pisa, P., Kiessling, R., and Masucci, M. G. The Epstein-Barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in Burkitt lymphoma lines. Int J Cancer 57: 240-244, 1994
45. Nimer, S., Fraser, J., Richards, J., Lynch, M., and Gasson, J. The repeated sequence CATT(A/T) is required for granulocyte-macrophage colony-stimulating factor promoter activity. Mol Cell Biol 10: 6084-6088, 1990
46. Ohmori, Y. and Hamilton, T.A. The interferon-stimulated response element and a kappa-B site mediate synergistic induction of the murine IP-10 gene transcription by IFN-gamma and TNF-alpha. J Immunol 154: 5235-5244, 1995
47. Pawelec, G., Pohla, H., Scholtz, E., Rehbein, A., Schaudt, K., Hambrecht, A., and Friccius, H. Interleukin-10 is a human T-cell growth-factor in-vitro. Cytokine 7: 355-363, 1995
48. Perez, L., Orte, J., and Brieva, J.A. Terminal differentiation of spontaneous rheumatoid factor-secreting B-cells from rheumatoid arthritis patients depends on endogenous interleukin-10. Arth Rheum 38: 1771-1776, 1995
49. Platzer, C., Meisel, C.H., Vogt, K., Platzer, K., and Volk, H.D. Upregulation of monocytic IL-10 by tumor necrosis factor-alpha and CAMP elevating drugs. Int Immunol 7: 517-523, 1995
50. Rousset, F., Garcia, E., Defrance, T., Perone, C., Vezzio, N., Hsu, D.H., Kastein, R., Moore, K.W., and Banchereau, J. IL-10 is a potent growth and differentiation factor for human B-cells. Proc Natl Acad Sci USA 89: 1890-1893, 1992
51. Salmon, J.E., Millard, S., Schachter, L.A., Arnett, F.C., Ginzler, E.M., Gourley, M.F., Ramsey-Goldman, R., Peterson, M.G.E., and Kimberley, R.P. Fc-gamma RIIA alleles are heritable risk-factors for lupus nephritis in African-Americans. J Clin Inv 97: 1348-1354, 1996
52. Schols, D. and de Clercq, E. Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production. J Virol 70: 4953-4960, 1996
53. Staynov, D.Z., Cousins, D.J., and Lee, T.H. A regulatory element in the promoter of human granulocyte-macrophage colony-stimulating factor gene that has related sequences in other T-cell-expressed cytokine genes. Proc Nat Acad Sci USA 92: 3606-3610, 1996
54. Suzuki, T., Tahara, H., Narula, S., Moore, K.W., Robbins, P.D., and Lotze, M.T. Viral interleukin-10 (IL-10). the human herpes-virus-4 cellular IL-10 homolog, induces local anergy to allogeneic and syngeneic tumors. J Exp Med 182: 447-486, 1995
55. Taga, K., Mostowski, H., and Tosato, G. Human interleukin-10 can directly inhibit T-cell growth. Blood 81: 2964-2971, 1993a
56. Taga, K., Cherney, B., and Tosado, G. IL-10 inhibits apoptotic cell-death in human T-cell starved of IL-2. Intl Immunol 5: 1599-1608, 1993b
57. Tsukada, J., Waterman, W.R., Koyama, Y., Webb, A.C., and Auron, P.E. A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL-1) and IL-6 signalling and recognises a gamma interferon activation site-like element in the IL1B gene. Mol Cell Biol 16: 2183-2194, 1996
58. Turner, D.M., Williams, D.M., Sankaran, D., Lazarus, M., Sinnott, P. J., and Hutchinson, I.V. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogen 24: 1-8, 1997
59. Wang, F., Tsang, S.F., Kurilla, M., Cohen, J.I., und Kieff, E. Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMPI. J Virol 64: 3407-3413, 1990
60. Wanidworanun, C. and Strober, W. Predominant role of tumor necrosis factor-α in human monocyte IL-10 synthesis. J Immunol 151: 6853-6861, 1993
61. Windhagen, A., Anderson, D.E., Caririzosa, A., Williams, R.E., and Hafler, D.A. IL-12 induces human T-cells secreting IL-10 with IFN-gamma. J Immunol 157: 1127-1131, 1996
62. Yang, Z., Sugawara, M., Ponath, P.D., Wessendorf, L., Banerji, J., Li, Y., and Strominger, J.L. Interferon-gamma response region in the promoter of human DPA. Proc Natl Acad Sci USA 87: 9226-9230, 1990
63. Yant, S.R., Zhu, W., Millinoff, D., Slightom, J.L., Goodman, M., and Gumucio, D.L. High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human β globin cluster. Nucleic Acids Res 23: 4353-4362, 1995