Protective role of endogenous nitric oxide (NO) in lipopolysaccharide - Induced pancreatic damage. (A new experimental model of acute pancreatitis)

Journal of Physiology and Pharmacology

Volumn 51, Issue 1, 2000, Pages 85-102

  Jaworek, J ^a   Jachimczak, B ^a   Bonior, J ^a   Kot, M ^a   Tomaszewska, R ^a   Karczewska, E ^a   Stachura, J ^a   Pawlik, W ^a   Konturek, S J ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Isolated pancreatic acini; Lipopolysaccharides; Nitric oxide; Pancreatic inflammation; Tumor necrosis factor alpha

Indexed keywords

AMYLASE; ARGININE; LIPOPOLYSACCHARIDE; N(G) NITROARGININE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MORTALITY; NONHUMAN; PANCREAS BLOOD FLOW; RAT;

ACUTE DISEASE; AMYLASES; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; LIPOPOLYSACCHARIDES; MALE; NITRIC OXIDE; NITROARGININE; ORGAN SIZE; PANCREAS; PANCREATITIS; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034108776     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Raetz CHR. Bacterial endotoxins. Extraordinary lipids that activate eucaryotic signal tranduction. J Bacteriol 1993; 175: 5745-5753.
2. Rietschel ET, Brade L, Holst O, et al. Molecular structure of bacterial endotoxin in relation to bioactivity; in Novotny A, Springer JJ, Ziegler ET (eds.): Cellular and Molecular Aspects of Endotoxin Reactions. Endotoxin Research Series. Amsterdam, Elsevier Science, 1990, vol: 1, pp. 15-32.
3. Moran AP. Structure-bioactivity relationship of bacterial endotoxins. J Toxical Toxin Rev 1994; 14: 47-83.
4. Gianoti L, Munda R, Alexander JW, Tchervenkov J, Babcock GF. Baterial translocation: a potent source for infection in acute pancreatitis. Pancreas 1993, 8 (5): 551-558.
5. Extley AR, Leese T, Holliday MP, Swann RA, Cohen J. Endotoxemia and serum tumor necrosis factor as prognostic markers in severe acute pancreatitis. Gut 1992; 33: (126-1128.
6. Kikuchi Y, Shimosegawa T, Satoh A, Abe A, Abe T, Koizumi M, Toyota T. The role of nitric oxide in mouse caerulein-induced pancreatitis with and without lipopolysaccharide pretreatment. Pancreas 1996; 12 (1): 68-75.
7. Vaccaro MI, Dagrosa MA, Mora MI, Tiscornia OM, Sordelli DO. The effect of chronic intraperitoneal infusion of bacterial endotoxin on exocrine pancreas function in rats. Int J Pancreatol 1996; 19 (1): 49-54.
8. Emanuelli G, Montrucchio G, Dughera L, Gaia E, Lupia E, Nattaglia E, De Martino A, De Giulli P, Gubetta L, Camussi G. Role of platelet activating factor in acute pancreatitis induced by lipopolysaccharide pretreatment. Eur J Pharmacol 1994; 261: 265-272.
9. Abe R, Schimosegawa T, Morizumi S, Kikuchi Y, Kimura K, Satoh A, Koizumi M, Toyota T. Lipopolysaccharide induces Superoxide dismutase in the rat pancreas: its role in caerulein pancreatitis. Biopch Biophys Res Commun 1995; 217 (3): 1216-1222.
10. Jaworek J, Jachimczak B, Bilski J, Dembiński A, Warzecha Z, Konturek SJ Protective effects of lipopolysaccharide (LPS) in caerulein-induced pancreatitis. Digestion 1997; 57 (suppl 2): 34.
11. Jersmann HP, Rvthjen DA, Ferrante A. Enhancement of lipopolysaccharide-induced neutrophil oxygen radical production by tumor necrosis factor. Infect Immun 1998, 66 (4): 1774-7.
12. Carter AB, Monick MM, Hunninghake GW. Lipopolysaccharide-induced NK-kappaß activation and cytokine release in human alveolar macrophages id PKC-independent and TK- and Pc-PLC-dependent. AMJ. Respir Cell Mol Biol 198; 18 (3): 384-391.
13. Raabe T, Bukrinsky M, Currie RA. Relative contribution of transcription and trabslation to the induction of tumor necrosis factor-alpha by lipopolysaccharide. J Biol Chem 1998 273 (2): 974-980.
14. Fu K, Sarras MP Jr, De Lisle RC, Andrews GK. Expression of oxidative stress-responsive genes and cytokines during caerulein-induced acute pancreatitis. Am J Physiol 1997 273 (3 Pt 1): G696-G705.
15. Norman JG, Fink GW, Denham W, Yang J, Carter G, Sexton Ch, Falkner J, Gower W, Franz MG. Tissue-specific cytokine production during experimental acute pancreatitis. A probable mechanisms for distant organ dysfunction. Dig Dis Sci 1997, 42 (8): 1783-1788.
16. Gukovskaja A, Gukovsky I, Zaninovic V, Song M, Sandoval D, Gukovsky S, Pandol SJ. Pancreatic acinar cells produce, release and respond to tumor necrosis factor-α. Role in regulating cell death and pancreatitis. J Clin Invest 1997; 100: 1853-1862.
17. Whittle BJR. Nitric oxide in gastrointestinal physiology and pathology. In Physiology of the Gastrointestinal Tract, Third edition, ed. LR. Johnson Raven Press, N, York, 1994, pp. 267-293.
18. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664-666.
19. Shimsegawa T, Abe T, Satoh A et al. Histochemical demonstration of NADPH-diaphorase activity, a marker for nitric oxide synthase, in neurons of the rat pancreas. Neurosci Lett 1992; 148: 67-70.
20. Molero SX, Guarner F, Salas A, Mourelle M, Puig V, Malageleda JR. Nitric oxide modulates pancreatic basal secretion and response to caerulein in the rat: effect in acute pancreatitis basal secretion and response to caerulein in the rat: effect in acute pancreatitis. Gastroenterology 1995; 108: 1855-1962.
21. Konturek SJ, Szlachcic A, Dembiriski A, Warzecha Z, Jaworek J, Stachura J. Nitric oxide in pancreatic secretion and hormone-induced pancreatitis in rats. Int J Pancreatol 1994; 15 (1): 19-28.
22. Dobosz M, Hac S, Wajda Z. Does nitric oxide protect from microcirculatory disturbances in experimental acute pancreatitis in rats? Int J Microcirc Clin Exp 1996 16 (5): 221-276.
23. Bernfeld P. Amylases alpha and beta. Meth Enzymol 1955; 5: 139-148.
24. Green L, Tannenbaum SR, Goldman P. Nitrate synthesis in the germ-free and conventional rats. Science (981; 212: 56-58.
25. Ranson JH, Balthazar E, Caccavale R, Copper M. Computered tomography and the prediction of pancreatic abscess in acute pancreatitis. Ann Surg 1985, 201 (5): 656-65.
26. Heresbach D, Letourner JP, Bahon I, Pagenault M, Guillou YM, Dyrd F, Fauchet R, Malledant Y, Bretagne JF, Gosselin M. Value of early blood cytokine determination in predicting severity of acute pancreatits. Scand J Gastroenterol 1998; 33: 554-560.
27. Runkel NS, Moody FG, Smith GS, Rodriquez LF, La Rocco MT, Miller TA. The role of the gut in the development of sepsis in acute pancreatitis. J Surg Res 1991, 51 (1): 18-23.
28. Tarpila E, Franzen L, Nystrom PO, Ihse I. Bacterial peritonitis with hyperamylasemia in the absence of ultrastructural changes of pancreas. Int J Pancreatol 1993; 13 (3): 209-215.
29. Yamano M, Umeda M, Miyata K. Yamada T. Protective effect of the combined treatment of pancreatic elicited by lipopolysaccharide in rats given intraductal injection of taurocholate plus trypsin. Naunyn Schmiedebergs Arch Pharmacol 1998, 357 (5): 558-564.
30. Werner J, Rivera J, Fernandez del Castillo C, Lewadrowski K, Asdrie Ch, Rattner D, Warsaw A. Differing roles of nitric oxide in the pathogenesis of acute edematous versus necrotizing pancreatitis. Surgery 1997; 121: 23-30.
31. Inaguchi H, Nakano A, Tsuyoshi K, Nonami T, Harada A, Takapi H. Neutrophil behaviour in pancreas and liver and the role of nitric oxide in rats acute pancreatitis. Pancreas 1997, 5 (3): 304-309.
32. Minamiyama Y, Takemura S, Koyama K, Yu W, Miyamoto M, Inoue M. Synamic aspects of glutatione and nitric oxide metabolism in endotoxemia rats. Am J Physiol 1996, 271 (4 Pt 1): G575-G581.
33. Waldner H. Vascular mechanisms to induce acute pancreatitis. Eur Surg Res 1992: 24 (suppl 1): 62-67.
34. Menger MD, Boukhof K, Vollmar B. Ischemia-reperfusion-induced pancreatic microvascular injury. An intravital fluorescence microscopic study in rats. Dig Dis Sci 1996, 41 (5): 823-830.
35. Laine VJO, Nyman KM, Peuravuori HJ, Henriksen K, Parvinen M, Nevalainen TJ. Lipopolysaccharide induced apoptosis of rats pancreatic acinar cells. Gut 1996, 38: 747-752.
36. Kimura K, Shimosegawa T, Abe R, Masamune A, Satoh A, Takasu A, Koizumi M, Toyota T. Low doses of lipopolysaccharide upregulate acinar cell apoptosis in caerulein pancreatitis. Pancreas 1998; 17 (2): 120-126.
37. Davenpeck KL, Zagorski J, Schleimer PP, Bochner BS, Lipopolysaccharide-induced leukocyte rolling and adhesion in the rat mesenteric circulation: regulation by glucocorticoids and role of cytokines. J Immunol 1998; 161 (12): 6861
38. Beutler B, Grau EG. Tumor necrosis factor in the pathogenesis of infectious diseases. Crit Care Med 1993, 10: S423-S425.
39. Luthen R, Grendell JH, Niederau C, Haussinger D. Trypsinogen actiavtion and glutatione content are linked to pancreatic injury in models of biliary acute pancreatitis. Int J Pancreatol 1998, 24 (3): 193-202.