Low doses of lipopolysaccharide upregulate acinar cell apoptosis in cerulein pancreatitis

Pancreas

Volumn 17, Issue 2, 1998, Pages 120-126

  Kimura, Kenji ^a   Shimosegawa, Tooru ^a   Abe, Reishi ^a   Masamune, Atsushi ^a   Satoh, Akihiko ^a   Takasu, Atsuko ^a   Koizumi, Masaru ^a   Toyota, Takayoshi ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Cn pancreatitis; Lipopolysaccharide; Pancreatic acinar cell; Rat

Indexed keywords

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROTECTION; DISEASE COURSE; DISEASE SEVERITY; ELECTRON MICROSCOPY; ENDOTOXEMIA; INFLAMMATORY INFILTRATE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031817371     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199808000-00002     Document Type: Article

References (19)

1. Walker NI. Ultrastructure of the rat pancreas after experimental duct ligation. The role of apoptosis and intraepithelial macrophages in acinar cell deletion. Am J Pathol 1987;126:439-51.
2. Walker NI, Winterford CM, Kerr JFR. Ultrastructure of the rat pancreas after experimental duct ligation. II. Duct and stromal cell proliferation, differentiation, and deletion. Pancreas 1992;7:420-34.
3. Kazacos EA, Van Vleet JF. Sequential ultrastructural changes of the pancreas in zinc toxicosis in ducklings. Am J Pathol 1989;134: 581-95.
4. Rao MS, Yeldandi AV, Subbarao V, Reddy JK. Role of apoptosis in copper deficiency-induced pancreatic involution in the rat. Am J Pathol 1993;142:1952-7.
5. Walker NI, Winterford CM, Williamson RM, Kerr JFR. Ethionine-induced atrophy of the rat pancreas involves apoptosis of acinar cells. Pancreas 1993;8:443-9.
6. Kaiser AM, Saluja AK, Sengupta A, Saluja M, Steer ML. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;269:C1295-340.
7. Kaisar AM, Saluja AK, Lu L, Yamanaka K, Yamaguchi Y, Steer ML. Effects of cycloheximide on pancreatic endonuclease activity, apoptosis, and seventy of acute pancreatitis. Am J Physiol 1996; 271:C982-93.
8. Sandoval D, Gukovskaya A, Reavey P, Gukovsky S, Sisk A, Braquet P, Pandol SJ, Poucell-Hatton S. The role of neutrophils and platelet activating factor in mediating experimental pancreatitis. Gastroenterology 1996;111:1081-91.
9. Laine VJO, Nyman KM, Peuravuori HJ, Henriksen K, Parvinen M, Nevalainen TJ. Lipopolysaccharide induced apoptosis of rat pancreatic acinar cells. Gut 1996;38:747-52.
10. Abe R, Shimosegawa T, Moriizumi S, Kikuchi Y, Kimura K, Satoh A, Koizumi M, Toyota T. Lipopolysaccharide induces manganese superoxide dismutase in the rat pancreas: its role in caerulein pancreatitis. Biochem Biophys Res Commun 1995;217:1216-22.
11. Kimura K, Sasano H, Shimosegawa T, Kato K, Noguchi T, Mochizuki S, Sawai T, Koizumi M, Toyota T. Ultrastructural and confocal laser scanning microscopic examinations of TUNEL-positive cells. J Pathol 1997;181:235-42.
12. Gavrieli Y, Sherman Y, Ben Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
13. Abe R, Shimosegawa T, Kimura K, Takasu A, Koizumi M, Toyota T. Lipopolysaccharide-induced desensitization to pancreas edema formation in rat caerulein pancreatitis. Pancreas 1998;16:539-44.
14. Guice KS, Oldham KT, Remick DG, Kunkel SL, Ward PA. Antitumor necrosis factor antibody augments edema formation in caerulein-induced acute pancreatitis. J Surg ReS 1991;51:495-9.
15. Bone RC. Review. The pathogenesis of sepsis. Ann Intern Med 1991;115:457-69.
16. Grewal HP, Mohey el Din A, Gaber L, Kotb M, Gaber AO. Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-α polyclonal antibody. Am J Surg 1994;167:214-9.
17. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57.
18. Majno G, Joris I. Review. Apoptosis, oncosis, and necrosis. Am J Pathol 1995;146:3-15.
19. Hockenbery D. Review. Defining apoptosis. Am J Pathol 1995; 146:16-9.