Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria

Lancet

Volumn 351, Issue 9098, 1998, Pages 265-266

  Kun, Jürgen F J ^b   Mordmüller, Benjamin ^b   Lell, Bertrand ^b   Lehman, Leopold G ^b   Luckner, Doris ^b   Kremsner, Peter G ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE;

ARTICLE; DISEASE RESISTANCE; DISEASE SEVERITY; ENZYME INDUCTION; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALARIA; MALE; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0001153209     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)78273-8     Document Type: Article

References (5)

1. 1 Hill AV. Malaria resistance genes: a natural selection. Trans R Soc Trop Med Hyg 1992; 86: 225-26.
2. 2 Allison AC. Protection afforded by sickle cell trait against subtertian malarial infection. BMJ 1954; 1: 290-94.
3. 3 Kremsner PG, Winkler S, Wildling E, et al. High plasma levels of nitrogen oxides are associated with severe disease and correlate with rapid parasitological and clinical cure in Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 1996; 90: 44-47.
4. 4 Kun JFJ, Schmidt-Ott RJ, Lehman LG, et al. Merozoite surface antigen 1 and 2 genotypes and resetting of Plasmodium falciparum in severe versus mild malaria in Lambaréné, Gabon. Trans R Soc Trop Med Hyg 1998; 92: 110-14.
5. 5 Spitsin SV, Koprowski H, Michaels FH. Characterization and functional analysis of the human inducible nitric oxide synthase gene promoter. Mol Med 1996; 2: 226-35.