메뉴 건너뛰기




Volumn 45, Issue 1, 1998, Pages 66-71

The role of alcohol dehydrogenase in the metabolism of the colon carcinogen methylazoxymethanol

Author keywords

Alcohol dehydrogenase; Colon carcinogenesis; Genetic susceptibility; Methylazoxymethanol; Mouse colon

Indexed keywords

ALCOHOL DEHYDROGENASE; METHYLAZOXYMETHANOL; NICOTINAMIDE ADENINE DINUCLEOTIDE;

EID: 0031722695     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2499     Document Type: Article
Times cited : (11)

References (34)
  • 1
    • 0021003828 scopus 로고
    • Purification and molecular properties of mouse alcohol dehydrogenase isoenzymes
    • Algar, E. M., Seeley, T. L., and Holmes, R. S. (1983). Purification and molecular properties of mouse alcohol dehydrogenase isoenzymes. Eur. J. Biochem. 137, 139-147.
    • (1983) Eur. J. Biochem. , vol.137 , pp. 139-147
    • Algar, E.M.1    Seeley, T.L.2    Holmes, R.S.3
  • 2
    • 0024456817 scopus 로고
    • Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism
    • Boleda, M. D., Julia, P., Moreno, A., and Pares, X. (1989). Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism. Arch. Biochem. Biophys. 274, 74-81.
    • (1989) Arch. Biochem. Biophys. , vol.274 , pp. 74-81
    • Boleda, M.D.1    Julia, P.2    Moreno, A.3    Pares, X.4
  • 3
    • 0023782843 scopus 로고
    • Target tissue DNA damage in inbred mouse strains with differing susceptibility to the colon carcinogen, 1,2-dimethyhydrazine
    • Bolognesi, C., Mariani, M. R., and Boffa, L. C. (1988). Target tissue DNA damage in inbred mouse strains with differing susceptibility to the colon carcinogen, 1,2-dimethyhydrazine. Carcinogenesis 9, 1347-1350.
    • (1988) Carcinogenesis , vol.9 , pp. 1347-1350
    • Bolognesi, C.1    Mariani, M.R.2    Boffa, L.C.3
  • 4
    • 0018123870 scopus 로고
    • DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis
    • Cooper, H. K., Buecheler, J., and Kleihues, P. (1978). DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis. Cancer Res. 38, 3063-3065.
    • (1978) Cancer Res. , vol.38 , pp. 3063-3065
    • Cooper, H.K.1    Buecheler, J.2    Kleihues, P.3
  • 5
    • 0021984109 scopus 로고
    • Fatty acid-stimulated oxidation of methylazocymethanol by rat colonic mucosa
    • Craven, P. A., Neidig, M., and DeRubertis, F. R. (1985). Fatty acid-stimulated oxidation of methylazocymethanol by rat colonic mucosa. Cancer Res. 45, 1115-1121.
    • (1985) Cancer Res. , vol.45 , pp. 1115-1121
    • Craven, P.A.1    Neidig, M.2    DeRubertis, F.R.3
  • 7
    • 0029969560 scopus 로고    scopus 로고
    • A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine
    • Delker, D. A., Bammler, T. K., and Rosenberg, D. W. (1996). A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine. Drug Metab. Dispos. 24, 408-414.
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 408-414
    • Delker, D.A.1    Bammler, T.K.2    Rosenberg, D.W.3
  • 8
    • 0017764610 scopus 로고
    • Genetic differences in the induction of colorectal tumors by 1,2-dimethylhydrazine in inbred mice
    • Diwan, B. A., Meier, H., and Blackman, K. E. (1977). Genetic differences in the induction of colorectal tumors by 1,2-dimethylhydrazine in inbred mice. J. Natl. Cancer Inst. 59, 455-458.
    • (1977) J. Natl. Cancer Inst. , vol.59 , pp. 455-458
    • Diwan, B.A.1    Meier, H.2    Blackman, K.E.3
  • 9
    • 0001870312 scopus 로고
    • Production of colonic carcinomas by 1,2-dialkylhydrazinesand azoxyalkanes
    • Burdette, W. J., Ed., Thomas, Springfield, IL
    • Druckrey, H. (1970). Production of colonic carcinomas by 1,2-dialkylhydrazinesand azoxyalkanes. In Carcinomas of Colon and Antecedent Epithelium (Burdette, W. J., Ed.), pp. 267-279. Thomas, Springfield, IL.
    • (1970) Carcinomas of Colon and Antecedent Epithelium , pp. 267-279
    • Druckrey, H.1
  • 10
    • 0027231651 scopus 로고
    • Extrahepatic, differential expression of four classes of human alcohol dehydrogenase
    • Engelhand, K., and Maret, W. (1993). Extrahepatic, differential expression of four classes of human alcohol dehydrogenase. Biochem. Biophys. Res. Commun. 193, 47-53.
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 47-53
    • Engelhand, K.1    Maret, W.2
  • 11
    • 0015979296 scopus 로고
    • Differential susceptibility of four mouse strains to induction of multiple large-bowel neoplasms by 1,2-dimethyLhydrazine
    • Evans, J. T., Hauschka, T. S., and Mittelman, A. (1974). Differential susceptibility of four mouse strains to induction of multiple large-bowel neoplasms by 1,2-dimethyLhydrazine. J. Natl. Cancer Inst. 52, 999-1000.
    • (1974) J. Natl. Cancer Inst. , vol.52 , pp. 999-1000
    • Evans, J.T.1    Hauschka, T.S.2    Mittelman, A.3
  • 12
    • 0019200277 scopus 로고
    • Production of a highly reactive alkylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase
    • Feinberg, A., and Zedeck, M. S. (1980). Production of a highly reactive alkylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase. Cancer Res. 40, 4446-4450.
    • (1980) Cancer Res. , vol.40 , pp. 4446-4450
    • Feinberg, A.1    Zedeck, M.S.2
  • 13
    • 0017671634 scopus 로고
    • Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane
    • Fiala, E. S. (1977). Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer 40, 2436-2445.
    • (1977) Cancer , vol.40 , pp. 2436-2445
    • Fiala, E.S.1
  • 14
    • 0021269287 scopus 로고
    • Non-alcohol dehydrogenase-mediated metabolism of methylazoxymethanol in the deer mouse, Peromyscus maniculatus
    • Fiala, E. S., Caswell, N., Sohn, O. S., Felder, M. R., McCoy, G. D., and Weisburger, J. H. (1984). Non-alcohol dehydrogenase-mediated metabolism of methylazoxymethanol in the deer mouse, Peromyscus maniculatus. Cancer Res. 44, 2885-2891.
    • (1984) Cancer Res. , vol.44 , pp. 2885-2891
    • Fiala, E.S.1    Caswell, N.2    Sohn, O.S.3    Felder, M.R.4    McCoy, G.D.5    Weisburger, J.H.6
  • 15
    • 0023138543 scopus 로고
    • Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylaing species by rat liver and rat colon mucosa in vivo
    • Fiala, E. S., Sohn, O., Puz, C., and Czerniak, R. (1987). Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylaing species by rat liver and rat colon mucosa in vivo. J. Cancer Res. Clin. Oncol. 113, 145-150.
    • (1987) J. Cancer Res. Clin. Oncol. , vol.113 , pp. 145-150
    • Fiala, E.S.1    Sohn, O.2    Puz, C.3    Czerniak, R.4
  • 16
    • 0017698329 scopus 로고
    • Organ-specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases
    • Grab, D. J., and Zedeck, M. S. (1977). Organ-specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases. Cancer Res. 37, 4182-4189.
    • (1977) Cancer Res. , vol.37 , pp. 4182-4189
    • Grab, D.J.1    Zedeck, M.S.2
  • 17
    • 0023093115 scopus 로고
    • Characterization of three isoenzymes of rat alcohol dehydrogenase: Tissue distribution and physical and enzymatic properties
    • Julia, P., Farres, J., and Pares, X. (1987). Characterization of three isoenzymes of rat alcohol dehydrogenase: Tissue distribution and physical and enzymatic properties. Eur. J. Biochem. 162, 179-189.
    • (1987) Eur. J. Biochem. , vol.162 , pp. 179-189
    • Julia, P.1    Farres, J.2    Pares, X.3
  • 19
    • 0026504711 scopus 로고
    • Comparison of rat pulmonary and hepatic cytosolic alcohol dehydrogenase activities
    • Manautou, J., and Carlson, G. (1992). Comparison of rat pulmonary and hepatic cytosolic alcohol dehydrogenase activities. J. Toxicol. Environ. Health 35, 7-18.
    • (1992) J. Toxicol. Environ. Health , vol.35 , pp. 7-18
    • Manautou, J.1    Carlson, G.2
  • 20
    • 0020053058 scopus 로고
    • Inhibition of methylazoxymethanol-induced intestinal tumors in the rat by pyrazole with paradoxical effects on skin and kidney
    • Notman, J., Hui Tan, Q., and Zedeck, M. S. (1982). Inhibition of methylazoxymethanol-induced intestinal tumors in the rat by pyrazole with paradoxical effects on skin and kidney. Cancer Res. 42, 1774-1780.
    • (1982) Cancer Res. , vol.42 , pp. 1774-1780
    • Notman, J.1    Hui Tan, Q.2    Zedeck, M.S.3
  • 21
    • 0018187392 scopus 로고
    • Induction of colon tumors in 1,2-dimethylhydrazine-resistant Lobund Wistar rats by methylazoxymethanol acetate
    • Pollard, M., and Zedeck, M. S. (1978). Induction of colon tumors in 1,2-dimethylhydrazine-resistant Lobund Wistar rats by methylazoxymethanol acetate. J. Natl. Cancer Inst. 61, 493-494.
    • (1978) J. Natl. Cancer Inst. , vol.61 , pp. 493-494
    • Pollard, M.1    Zedeck, M.S.2
  • 22
    • 0021328252 scopus 로고
    • Purification and characterization of mouse alcohol dehydrogenase from two inbred strains that differ in total liver enzyme activity
    • Rex, D. K., Bosron, W. F., and Li, T.-K. (1984). Purification and characterization of mouse alcohol dehydrogenase from two inbred strains that differ in total liver enzyme activity. Biochem. Genet. 22, 115-122.
    • (1984) Biochem. Genet. , vol.22 , pp. 115-122
    • Rex, D.K.1    Bosron, W.F.2    Li, T.-K.3
  • 23
    • 0025883461 scopus 로고
    • Dietary modulation of cytochrome P450 in the small intestinal epithelium
    • Rosenberg, D. W. (1991). Dietary modulation of cytochrome P450 in the small intestinal epithelium. Pharmacology 43, 36-46.
    • (1991) Pharmacology , vol.43 , pp. 36-46
    • Rosenberg, D.W.1
  • 24
    • 0028273173 scopus 로고
    • Induction of Cyp2e-1 protein in mouse colon
    • Rosenberg, D. W., and Mankowski, D. C. (1994). Induction of Cyp2e-1 protein in mouse colon. Carcinogenesis 15, 73-78.
    • (1994) Carcinogenesis , vol.15 , pp. 73-78
    • Rosenberg, D.W.1    Mankowski, D.C.2
  • 25
    • 0019514191 scopus 로고
    • Colon epithelium. II. in vivo studies of colon carcinogenesis: Light microscopic, histochemical and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats
    • Shamsuddin, A. K. M., and Trump, B. F. (1981). Colon epithelium. II. In vivo studies of colon carcinogenesis: Light microscopic, histochemical and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats. J. Natl. Cancer Inst. 66, 389-401.
    • (1981) J. Natl. Cancer Inst. , vol.66 , pp. 389-401
    • Shamsuddin, A.K.M.1    Trump, B.F.2
  • 26
    • 0026082126 scopus 로고
    • Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1
    • Sohn, O. S., Ishizaki, H., Yang, C. S., and Fiala, E. S. (1991). Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis 12, 127-131.
    • (1991) Carcinogenesis , vol.12 , pp. 127-131
    • Sohn, O.S.1    Ishizaki, H.2    Yang, C.S.3    Fiala, E.S.4
  • 27
    • 0023185512 scopus 로고
    • Enhancement of rat liver microsomal metabolism of azoxymethane to methylazoxymethanol by chronic ethanol administration: Similarity to the microsomal metabolism of N-nitrosodimethylamine
    • Sohn, O. S., Fiala, E. S., Puz, C., Hamilton, S. R., and Williams, G. M. (1987). Enhancement of rat liver microsomal metabolism of azoxymethane to methylazoxymethanol by chronic ethanol administration: Similarity to the microsomal metabolism of N-nitrosodimethylamine. Cancer Res, 47, 3123-3129.
    • (1987) Cancer Res , vol.47 , pp. 3123-3129
    • Sohn, O.S.1    Fiala, E.S.2    Puz, C.3    Hamilton, S.R.4    Williams, G.M.5
  • 28
    • 0023949443 scopus 로고
    • DNA alkylation by 1,2-dimethylhydrazine in the rat large intestine and liver: Influence of diet and enzyme induction
    • Tacchi-Bedford, A. M., Whyman, G. D., and McLean, A. E. M. (1988). DNA alkylation by 1,2-dimethylhydrazine in the rat large intestine and liver: Influence of diet and enzyme induction. Toxicology 50, 181-191.
    • (1988) Toxicology , vol.50 , pp. 181-191
    • Tacchi-Bedford, A.M.1    Whyman, G.D.2    McLean, A.E.M.3
  • 29
    • 0015097207 scopus 로고
    • Colon carcinogens: Their metabolism and mode of action
    • Weisburger, J. H. (1971). Colon carcinogens: Their metabolism and mode of action. Cancer 28, 60-70.
    • (1971) Cancer , vol.28 , pp. 60-70
    • Weisburger, J.H.1
  • 30
    • 0000736193 scopus 로고
    • Metabolism of chemical carcinogens
    • F. F. Becker, Ed., Plenum, New York
    • Weisburger, J. H., and Williams, G. M. (1975). Metabolism of chemical carcinogens. In Cancer: A Comprehensive Treatise (F. F. Becker, Ed.), Vol. 1, pp. 185-234. Plenum, New York.
    • (1975) Cancer: A Comprehensive Treatise , vol.1 , pp. 185-234
    • Weisburger, J.H.1    Williams, G.M.2
  • 31
    • 0020379324 scopus 로고
    • Metabolism of 1,2-dimethylhydrazine in isolated perfused rat liver
    • Wolter, S., and Frank, N. (1982). Metabolism of 1,2-dimethylhydrazine in isolated perfused rat liver. Chem. Biol. Interact. 42, 335-344.
    • (1982) Chem. Biol. Interact. , vol.42 , pp. 335-344
    • Wolter, S.1    Frank, N.2
  • 32
    • 0028947552 scopus 로고
    • Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family
    • Zgombic-Knight, M., Ang, H. L., Foglio, M. H., and Duester, G. (1995). Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family. J. Biol. Chem. 270, 10868-10877.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10868-10877
    • Zgombic-Knight, M.1    Ang, H.L.2    Foglio, M.H.3    Duester, G.4
  • 33
    • 0023618824 scopus 로고
    • Structure of the mouse Adh-1 gene and identification of a deletion in a long alternating purine-pyrimidine sequence in the first intron of strains expressing low alcohol dehydrogenase activity
    • Zhang, K., Bosron, W. R., and Edenberg, H. J. (1985). Structure of the mouse Adh-1 gene and identification of a deletion in a long alternating purine-pyrimidine sequence in the first intron of strains expressing low alcohol dehydrogenase activity. Gene 57, 27-36.
    • (1985) Gene , vol.57 , pp. 27-36
    • Zhang, K.1    Bosron, W.R.2    Edenberg, H.J.3
  • 34
    • 0027420810 scopus 로고
    • Molecular basis of the alcohol dehydrogenase-negative deer mouse
    • Zheng, Y-W., Bey, M., Liu, H., and Felder, M. R. (1993). Molecular basis of the alcohol dehydrogenase-negative deer mouse. J. Biol. Chem. 268, 24933-24939.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24933-24939
    • Zheng, Y.-W.1    Bey, M.2    Liu, H.3    Felder, M.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.