The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: Tumour development in female SWR mice does not require a K-ras mutational event

Carcinogenesis

Volumn 20, Issue 3, 1999, Pages 509-513

  Jackson, Peta E ^a,b   Cooper, Donald P ^a,c   O'Connor, Peter J ^a   Povey, Andrew C ^a,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c MICROMASS UK LTD   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CODON; COLON CARCINOGENESIS; COLON TUMOR; DESCENDING COLON; FEMALE; GENE MUTATION; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; SURVIVAL TIME; TUMOR GROWTH;

EID: 0033035378     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.3.509     Document Type: Article

References (37)

1. Pozharisski, K.M., Likhachev, A.J., Klimashevski, V.F. and Shaposhnikov, J.D. (1979) Experimental intestinal cancer research with special reference to human pathology. Adv. Cancer Res., 30, 165-237.
2. Rogers, A.E. and Nauss, K.M. (1985) Rodent models for carcinoma of the colon. Dig. Dis. Sci., 30, 87S-102S.
3. Weisburger, J.H., Reddy, B.S. and Wynder, E.L. (1977) Colon cancer: its epidemiology and experimental production. Cancer, 40, 2414-2420.
4. Herron, D.C. and Shank, R.C. (1982) DNA methylation during chronic administration of 1,2-dimethylhydrazine in a carcinogenic regimen. Carcinogenesis, 3, 857-860.
5. Cooper, H.K., Buecheler, J. and Kleihues, P. (1978) DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis. Cancer Res., 38, 3063-3065.
6. James, J.T. and Autrup, H. (1983) Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/ Ha mice given 1,2-diinethylhydrazine. J. Natl Cancer Inst., 70, 541-546.
7. Saffhill, R., Margison, G.P. and O'Connor, P.J. (1985) Mechanisms of Carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta, 823, 111-145.
8. 6-methylguanine built into a unique site in a viral genome. Proc. Natl Acad. Sci. USA, 81, 6271-6275.
9. Xiao, W., Nowak, M., Laferte, S. and Fontanie, T. (1996) Mutagenicity and toxicity of the DNA alkylation carcinogens 1,2-dimethylhydrazine and azoxymethane in Escherichia coli and Salmonella typhimurium. Mutagenesis, 11, 241-245.
10. Zeilmaker, M.J., Horsfall, M.J., van Helten, J.B.M., Glickman, B.W. and Mohn, G.R. (1991) Mutational specificities of environmental carcinogens in the lad gene of Escherichia coli H.V: DNA sequence analysis of mutations in bacteria recovered from the liver of Swiss mice exposed to 1,2-dimethylydrazine, azoxymethane and methylazoxymethanolacetate. Mol. Carcinogen., 4, 180-188.
11. Jacoby, R.F., Llor, X., Teng, B.-B., Davidson, N.O. and Brasitus, T.A. (1991) Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplasic and neoplastic rat colonic mucosa. J. Clin. Invest., 87, 624-630.
12. Vivona, A.A., Shpitz, B., Medline, A., Bruce, W.R., Hay, K., Ward, M.A., Stern, H.S. and Gallinger, S. (1993) K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis. Carcinogenesis, 14, 1777-1781.
13. Zaidi, N.H., Pretlow, T.P., O'Riordan, M.A., Dumenco, L.L., Allay, E. and Gerson, S.L. (1995) Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis, 16, 451-456.
14. Jackson, P.E., Hall, C.N., Badawi, A.F., O'Connor, P.J., Cooper, D.P. and Povey, A.C. (1996) Frequency of Ki-ras mutations and DNA alkylation in colorectal tissue from individuals living in Manchester. Mol. Carcinogen., 16, 12-19.
15. Hall, C.N., Badawi, A.F., O'Connor, P.J. and Saffhill, R. (1991) The detection of alkylation damage in the DNA of human gastrointestinal tissues. Br. J. Cancer, 64, 59-63.
16. Bos, J.L. (1989) ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-4689.
17. Vogelstein, B., Fearon, E.R., Hamilton, S.R. et al. (1988) Genetic alterations during colorectal-tumor development. N. Engl. J. Med., 319, 525-532.
18. Guerrero, I. and Pellicer, A. (1987) Mutational activation of oncogenes in animal model systems of carcinogenesis. Mutat. Res., 185, 293-308.
19. 6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC→AT transition in the K-ras oncogene. Carcinogenesis, 18, 1299-1302.
20. Diwan, B.A., Meier, H. and Blackman, K.E. (1977) Genetic differences in the induction of colorectal tumors by 1,2-dimethylhydrazine in inbred mice. J. Natl Cancer Inst., 59, 455-458.
21. Deschner, E.E., Long, F.C. and Maskens, A.P. (1979) Relationship between dose, time and tumor yield in mouse dimethylhydrazine-induced colon tumorigenesis. Cancer Lett., 8, 23-28.
22. Deschner, E.E. and Long, F.C. (1977) Colonic neoplasms in mice produced with six injections of 1,2-dimethylhydrazine. Oncology, 34, 255-257.
23. Thurnherr, N., Deschner, E.E., Stonehill, E.H. and Lipkin, M. (1973) Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine. Cancer Res., 33, 940-945.
24. Toth, B., Malick, L. and Shimizu, H. (1976) Production of intestinal and other tumors by 1,2-dimethylhydrazine dihydrochloride in mice. Am. J. Pathol., 84, 69-86.
25. Zaidi, N.H., O'Connor, P.J. and Butler, W.J. (1993) N-methyl-N′-nitro-N-nitrosoguanidine induced carcinogenesis: differential pattern of upper gastrointestinal tract tumours in Wistar rats after single or chronic oral doses. Carcinogenesis, 14, 1561-1567.
26. Wang, X. and Witschi, H. (1995) Mutations of the Ki-ras protooncogene in 3-methylcholanthrene and urethan-induced and butylated hydroxytoluene-promoted lung tumours of strain A/J and SWR mice. Cancer Lett., 91, 33-39.
27. Kahn, S.M, Jiang, W., Culbertson, T.A., Weinstein, I.B., Williams, G.M., Tomita, N. and Ronia, Z. (1991) Rapid and sensitive non-radioactive detection of mutant K-ras genes via 'enriched' PCR amplification. Oncogene, 6, 1079-1083.
28. Fox, T.R., Schumann, A.M., Watanabe, P.G., Yano, B.L., Maher, V.M. and McCormick, J.J. (1990) Mutational analysis of the H-ras oncogene in spontaneous C57BL/6×C3H/He mouse liver lumors and tumors induced with genoloxic and nongenotoxic hepatocarcinogens. Cancer Res., 50, 4014-4019.
29. 1 hybrid mice. Carcinogenesis, 16, 2659-2666.
30. Shivapurkar, N., Belinsky, S.A., Wolf, D.C., Tang, Z. and Alabaster, O. (1995) Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane. Cancer Lett., 96, 63-70.
31. Erdman, S.H., Wu, H.D., Hixson, L.J., Ahnen, D.J. and Gerner, E.W. (1997) Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane-and dimethylhydrazine-treated rats. Mol. Carcinogen., 19, 137-144.
32. Maltzman, T., Whittington, J., Driggers, L., Stephens, J. and Ahnen, D. (1997) AOM-induced mouse colon tumors do not express full-length APC protein. Carcinogenesis, 18, 2435-2439.
33. Llor, X., Jacoby, R.F., Teng, B.-B., Davidson, N.O., Sitrin, M.D. and Brasitus, T.A. (1991) K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency. Cancer Res., 51, 4305-4309.
34. Jacoby, R.F., Alexander, R.J., Raicht, R.F. and Brasitus, T.A. (1992) K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea. Carcinogenesis, 13, 45-49.
35. Shivapurkar, N., Tang, Z., Ferreira, A., Nasim, S., Garett, C. and Alabaster, O. (1994) Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumours induced by azoxymethane in Fischer-344 rats on high risk diet. Carcinogenesis, 15, 775-778.
36. Singh, J., Kulkarni, N., Kelloff, G. and Reddy, B.S. (1994) Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis. Carcinogenesis, 15, 1317-1323.
37. Matzinger, S.A., Gunning, W.T., You, M. and Castonguay, A. (1994) Ki-ras mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-initiated and butylated hydroxytoluene-promoted lung tumours in A/J mice. Mol. Carcinogen., 11, 42-48.