Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers

Journal of Medical Genetics

Volumn 37, Issue 5, 2000, Pages 336-341

  De Vivo, Immaculata ^a,b   Gertig, Dorota M ^a   Nagase, Satoru ^c   Hankinson, Susan E ^a,b   O'Brien, Robert ^b   Speizer, Frank E ^a,b   Parsons, Ramon ^c   Hunter, David J ^a,b,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c Columbia University ^*  (United States)

^d HARVARD CENTER FOR CANCER PREVENTION   (United States)

Author keywords

Germline mutations; Multiple cancers; Population based; Tumour suppressor

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL MUTANT; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; EXON; FEMALE; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GERM CELL TUMOR; HETEROZYGOSITY; HUMAN; HUMAN CELL; INTRON; MAJOR CLINICAL STUDY; MISSENSE MUTATION; MULTIPLE CANCER; PHENOTYPE; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; CASE-CONTROL STUDIES; COHORT STUDIES; EXONS; FEMALE; GENES, TUMOR SUPPRESSOR; GERM-LINE MUTATION; HEALTH SURVEYS; HUMANS; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; NURSES; PHOSPHORIC MONOESTER HYDROLASES; PHYLOGENY; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PTEN PHOSPHOHYDROLASE; SEQUENCE ANALYSIS, DNA; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034097541     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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