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Volumn 39, Issue 2-3, 1996, Pages 357-372

Controllable gene therapy pharmaceutics of non-viral gene delivery systems

Author keywords

Controllable gene therapy; Dendrimer; Fusogenic peptide; Gene delivery system; Gene expression system; Liposome; Non viral gene therapy

Indexed keywords

LIPOSOME; PLASMID DNA; POLYMER; SYNTHETIC PEPTIDE;

EID: 0030002508     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00166-2     Document Type: Conference Paper
Times cited : (150)

References (76)
  • 1
    • 0027502876 scopus 로고
    • Are contempory methods for somatic gene therapy suitable for clinical applications?
    • F.D. Ledley, Are contempory methods for somatic gene therapy suitable for clinical applications?, Clin. Invest. Med. 16 (1993) 78-88.
    • (1993) Clin. Invest. Med. , vol.16 , pp. 78-88
    • Ledley, F.D.1
  • 2
    • 0028074478 scopus 로고
    • Development in somatic gene therapy
    • F.D. Ledley, Development in somatic gene therapy, Exp. Op. Invest. Drugs 3 (1994) 913-921.
    • (1994) Exp. Op. Invest. Drugs , vol.3 , pp. 913-921
    • Ledley, F.D.1
  • 3
    • 0028585823 scopus 로고
    • Non-viral gene therapies
    • F.D. Ledley, Non-viral gene therapies, Curr. Opin. Biotechnol. 5 (1994) 626-636.
    • (1994) Curr. Opin. Biotech , vol.5 , pp. 626-636
    • Ledley, F.D.1
  • 4
    • 0026530097 scopus 로고
    • Human gene therapy
    • W.F. Anderson, Human gene therapy, Science 256 (1992) 808-813.
    • (1992) Science , vol.256 , pp. 808-813
    • Anderson, W.F.1
  • 5
    • 0029147628 scopus 로고
    • Non-viral gene therapy: The promise of genes as pharmaceutical products
    • in press
    • F.D. Ledley, Non-viral gene therapy: the promise of genes as pharmaceutical products, Hum. Gene Ther. (1995) in press.
    • (1995) Hum. Gene Ther.
    • Ledley, F.D.1
  • 6
    • 0342771780 scopus 로고
    • Gene therapy for adenosine deaminase deficiency and malignant solid tumors
    • J.A. Wolff (Ed.), Birkhauser, Boston
    • K.W. Culver and R.M. Blaese, Gene therapy for adenosine deaminase deficiency and malignant solid tumors, in: J.A. Wolff (Ed.), Gene Therapeutics: Methods and Applications of Direct Gene Transfer, Birkhauser, Boston, 1994, pp. 263-280.
    • (1994) Gene Therapeutics: Methods and Applications of Direct Gene Transfer , pp. 263-280
    • Culver, K.W.1    Blaese, R.M.2
  • 7
    • 0026718123 scopus 로고
    • Human gene therapy comes of age
    • A.D. Miller, Human gene therapy comes of age, Nature 357 (1992) 455-460.
    • (1992) Nature , vol.357 , pp. 455-460
    • Miller, A.D.1
  • 11
    • 0342771768 scopus 로고
    • Regulatory elements of the chicken α-skeletal actin gene direct high level and tissue specific expression of a hIGF-I cDNA in cultured myogenic cells and transgenic mice resulting in enhanced myogenesis and pronounced muscle hypertrophy
    • Keystone Symposium on Molecular Biology of Muscle Development
    • M.E. Coleman, K.C. Yin, F.J. DeMayo and R.J. Schwartz, Regulatory elements of the chicken α-skeletal actin gene direct high level and tissue specific expression of a hIGF-I cDNA in cultured myogenic cells and transgenic mice resulting in enhanced myogenesis and pronounced muscle hypertrophy, Keystone Symposium on Molecular Biology of Muscle Development, J. Cell Biochem. (1994) W25.
    • (1994) J. Cell Biochem.
    • Coleman, M.E.1    Yin, K.C.2    DeMayo, F.J.3    Schwartz, R.J.4
  • 14
    • 0028170358 scopus 로고
    • A multicompartment, numerical model of cellular events in the pharmacokinetics of gene therapies
    • T.A.S. Ledley and F.D. Ledley, A multicompartment, numerical model of cellular events in the pharmacokinetics of gene therapies, Hum. Gene Ther. 5 (1994) 679-691.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 679-691
    • Ledley, T.A.S.1    Ledley, F.D.2
  • 15
    • 0026922764 scopus 로고
    • Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle
    • J.A. Wolff, J.J. Ludtke, G. Acsadi, P. Williams and A. Jani, Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle, Hum. Mol. Genet. 1 (1992) 363-369.
    • (1992) Hum. Mol. Genet. , vol.1 , pp. 363-369
    • Wolff, J.A.1    Ludtke, J.J.2    Acsadi, G.3    Williams, P.4    Jani, A.5
  • 19
    • 0028050467 scopus 로고
    • In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection
    • M. Sikes, B.W. O'Malley Jr, M.J. Finegold and F.D. Ledley, In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection, Hum. Gene Ther.5 (1994) 837-844.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 837-844
    • Sikes, M.1    O'Malley B.W., Jr.2    Finegold, M.J.3    Ledley, F.D.4
  • 20
    • 0029131828 scopus 로고
    • Gene transfer to synovial cells by intra-articular administration of plasmid DNA
    • in press
    • J. Yovandich, B.W. O'Malley Jr, M. Sikes and F.D. Ledley, Gene transfer to synovial cells by intra-articular administration of plasmid DNA, Hum. Gene Ther. (1995) in press.
    • (1995) Hum. Gene Ther.
    • Yovandich, J.1    O'Malley B.W., Jr.2    Sikes, M.3    Ledley, F.D.4
  • 22
    • 0027155874 scopus 로고
    • In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment
    • L. Cheng, P.R. Ziegelhoffer and N.S. Yang, In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment, Proc. Natl. Acad. Sci. USA 90 (1993) 4455-4459.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4455-4459
    • Cheng, L.1    Ziegelhoffer, P.R.2    Yang, N.S.3
  • 23
    • 0027727904 scopus 로고
    • Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization
    • M.D. Eisenbraun, D.H. Fuller and J.R. Haynes, Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization, DNA Cell Biol. 12 (1993) 791-797.
    • (1993) DNA Cell Biol. , vol.12 , pp. 791-797
    • Eisenbraun, M.D.1    Fuller, D.H.2    Haynes, J.R.3
  • 26
    • 0343206453 scopus 로고
    • Novel methods for delivery of gene medicines to the epidermis - Hypospray method for transfection in gene therapy
    • F.D. Ledley, B.W. O'Malley Jr, J. Borchardt, D. Roop, A. Rolland and E. Tomlinson, Novel methods for delivery of gene medicines to the epidermis - Hypospray method for transfection in gene therapy, J. Cell Biochem. 18A (1994) 226.
    • (1994) J. Cell Biochem. , vol.18 A , pp. 226
    • Ledley, F.D.1    O'Malley B.W., Jr.2    Borchardt, J.3    Roop, D.4    Rolland, A.5    Tomlinson, E.6
  • 29
    • 0025938020 scopus 로고
    • Conditions affecting direct gene transfer into rodent muscle in vivo
    • J.A. Wolff, P. Williams, G. Acsadi, S. Jiao, A. Jani and W. Chong, Conditions affecting direct gene transfer into rodent muscle in vivo, Biotechniques 11 (1991) 474-485.
    • (1991) Biotechniques , vol.11 , pp. 474-485
    • Wolff, J.A.1    Williams, P.2    Acsadi, G.3    Jiao, S.4    Jani, A.5    Chong, W.6
  • 31
    • 0027369829 scopus 로고
    • DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody
    • H.L. Davis, M.L. Michel and R.G. Whalen, DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody, Hum. Mol. Genet. 2 (1993) 1847-1851.
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 1847-1851
    • Davis, H.L.1    Michel, M.L.2    Whalen, R.G.3
  • 33
    • 0011269588 scopus 로고
    • In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I
    • C. Nicolau, A. Le Pape, P. Soriano, F. Fargette and M.F. Juhel, In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I, Proc. Natl. Acad. Sci. USA 80 (1983) 1068-1072.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 1068-1072
    • Nicolau, C.1    Le Pape, A.2    Soriano, P.3    Fargette, F.4    Juhel, M.F.5
  • 34
    • 0023447237 scopus 로고
    • pH-sensitive immunoliposomes mediate target-cell-specific delivery and controlled expression of a foreign gene in mouse
    • C.Y. Wang and L. Huang, pH-sensitive immunoliposomes mediate target-cell-specific delivery and controlled expression of a foreign gene in mouse, Proc. Natl. Acad. Sci. USA 84 (1987) 7851-7855.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7851-7855
    • Wang, C.Y.1    Huang, L.2
  • 36
    • 0025719339 scopus 로고
    • Direct injection of hepatitis B virus DNA into liver induced hepatitis in adult rats
    • K. Kato, Y. Kaneda, M. Sakurai, M. Nakanishi and Y. Okada, Direct injection of hepatitis B virus DNA into liver induced hepatitis in adult rats, J. Biol. Chem. 266 (1991) 22071-22074.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22071-22074
    • Kato, K.1    Kaneda, Y.2    Sakurai, M.3    Nakanishi, M.4    Okada, Y.5
  • 37
    • 0026786522 scopus 로고
    • Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: Comparison with cationic liposomes
    • J.Y. Legendre and F.C. Szoka Jr, Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes, Pharm. Res. 9 (1992) 1235-1242.
    • (1992) Pharm. Res. , vol.9 , pp. 1235-1242
    • Legendre, J.Y.1    Szoka F.C., Jr.2
  • 38
    • 0024311006 scopus 로고
    • Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes
    • C.Y. Wang and L. Huang, Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes, Biochemistry 28 (1989) 9508-9514.
    • (1989) Biochemistry , vol.28 , pp. 9508-9514
    • Wang, C.Y.1    Huang, L.2
  • 40
    • 0024978864 scopus 로고
    • Cationic liposome-mediated transfection
    • P.L. Felgner and G.M. Ringold, Cationic liposome-mediated transfection, Nature 337 (1989) 387-388.
    • (1989) Nature , vol.337 , pp. 387-388
    • Felgner, P.L.1    Ringold, G.M.2
  • 43
    • 0026094167 scopus 로고
    • A novel cationic liposome reagent for efficient transfection of mammalian cells
    • X.A. Gao and L. Huang, A novel cationic liposome reagent for efficient transfection of mammalian cells, Biochem. Biophys. Res. Commun. 179 (1991) 280-285.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 280-285
    • Gao, X.A.1    Huang, L.2
  • 44
    • 0028174762 scopus 로고
    • High-efficiency transfection of primary human keratinocytes with positively charged lipopolyamine: DNA complexes
    • C. Staedel, J.S. Remy, Z. Hua, T.R. Broker, L.T. Chow and J.P. Behr, High-efficiency transfection of primary human keratinocytes with positively charged lipopolyamine: DNA complexes, J. Invest. Dermatol. 102 (1994) 768-772.
    • (1994) J. Invest. Dermatol. , vol.102 , pp. 768-772
    • Staedel, C.1    Remy, J.S.2    Hua, Z.3    Broker, T.R.4    Chow, L.T.5    Behr, J.P.6
  • 46
    • 0343206440 scopus 로고
    • The effect of Lipofectin™ complexation on the characteristics and stability of DNA expression vectors
    • L. Gong, J. Claspell and A. Rolland, The effect of Lipofectin™ complexation on the characteristics and stability of DNA expression vectors, Pharm. Res. 11 (1994) S-77.
    • (1994) Pharm. Res. , vol.11
    • Gong, L.1    Claspell, J.2    Rolland, A.3
  • 48
    • 0024743528 scopus 로고
    • In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle
    • K.L. Brigham, B. Meyrick, B. Christman, M. Magnuson, G. King and L.C. Berry Jr, In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle, Am. J. Med. Sci. 298 (1989) 278-281.
    • (1989) Am. J. Med. Sci. , vol.298 , pp. 278-281
    • Brigham, K.L.1    Meyrick, B.2    Christman, B.3    Magnuson, M.4    King, G.5    Berry L.C., Jr.6
  • 50
    • 0027313072 scopus 로고
    • Systemic gene expression after intravenous DNA delivery into adult mice
    • N. Zhu, D. Liggitt, Y. Liu and R. Debs, Systemic gene expression after intravenous DNA delivery into adult mice, Science 261 (1993) 209-211.
    • (1993) Science , vol.261 , pp. 209-211
    • Zhu, N.1    Liggitt, D.2    Liu, Y.3    Debs, R.4
  • 51
    • 0025132571 scopus 로고
    • Site-specific gene expression in vivo by direct gene transfer into arterial wall
    • E.G. Nabel, G. Plautz and G.J. Nabel, Site-specific gene expression in vivo by direct gene transfer into arterial wall, Science 249 (1990) 1285-1288.
    • (1990) Science , vol.249 , pp. 1285-1288
    • Nabel, E.G.1    Plautz, G.2    Nabel, G.J.3
  • 52
    • 0028056371 scopus 로고
    • Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits
    • A.E. Canonico, J.T. Conary, B.O. Meyrick and K.L. Brigham, Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits, Am. J. Respir. Cell Mol. Biol. 10 (1994) 24-29.
    • (1994) Am. J. Respir. Cell Mol. Biol. , vol.10 , pp. 24-29
    • Canonico, A.E.1    Conary, J.T.2    Meyrick, B.O.3    Brigham, K.L.4
  • 54
    • 0027250330 scopus 로고
    • In vivo gene delivery. Efficient transfection of T lymphocytes in adult mice
    • R. Philip, D. Liggitt, M. Philip, P. Dazin and R. Debs, In vivo gene delivery. Efficient transfection of T lymphocytes in adult mice, J. Biol. Chem. 268 (1993) 16087-16090.
    • (1993) J. Biol. Chem. , vol.268 , pp. 16087-16090
    • Philip, R.1    Liggitt, D.2    Philip, M.3    Dazin, P.4    Debs, R.5
  • 55
    • 0026684170 scopus 로고
    • Transduction of a foreign histocompatibility gene into the arterial wall induces vasculitis
    • E.G. Nabel, G. Plautz and G.J. Nabel, Transduction of a foreign histocompatibility gene into the arterial wall induces vasculitis, Proc. Natl. Acad. Sci. USA 89 (1992) 5157-5161.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5157-5161
    • Nabel, E.G.1    Plautz, G.2    Nabel, G.J.3
  • 59
    • 0028269736 scopus 로고
    • Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene
    • J.T. Conary, R.E. Parker, B.W. Christman, R.D. Faulks, G.A. King, B.O. Meyrick and K.L. Brigham, Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene, J. Clin. Invest. 93 (1994) 1834-1840.
    • (1994) J. Clin. Invest. , vol.93 , pp. 1834-1840
    • Conary, J.T.1    Parker, R.E.2    Christman, B.W.3    Faulks, R.D.4    King, G.A.5    Meyrick, B.O.6    Brigham, K.L.7
  • 60
    • 0026625385 scopus 로고
    • Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer
    • K. Yoshimura, M.A. Rosenfeld, H. Nakamura, E.M. Scherer, A. Pavirani, J.P. Lecocq and R.G. Crystal, Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer, Nucl. Acids Res. 20 (1992) 3233-3240.
    • (1992) Nucl. Acids Res. , vol.20 , pp. 3233-3240
    • Yoshimura, K.1    Rosenfeld, M.A.2    Nakamura, H.3    Scherer, E.M.4    Pavirani, A.5    Lecocq, J.P.6    Crystal, R.G.7
  • 61
    • 0026703125 scopus 로고
    • High efficiency gene transfer into mammalian cells by a double transfection protocol
    • Y. Ishikawa and C.J. Homcy, High efficiency gene transfer into mammalian cells by a double transfection protocol, Nucl. Acids Res. 20 (1992) 4367.
    • (1992) Nucl. Acids Res. , vol.20 , pp. 4367
    • Ishikawa, Y.1    Homcy, C.J.2
  • 62
    • 0021219156 scopus 로고
    • New procedure for DNA transfection with polycation and dimethyl sulfoxide
    • S. Kawai and M. Nishizawa, New procedure for DNA transfection with polycation and dimethyl sulfoxide, Mol. Cell. Biol. 4 (1984) 1172-1174.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 1172-1174
    • Kawai, S.1    Nishizawa, M.2
  • 63
    • 0027655718 scopus 로고
    • Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
    • J. Haensler and F.C. Szoka, Jr., Polyamidoamine cascade polymers mediate efficient transfection of cells in culture, Bioconjug. Chem. 4 (1993) 372-379.
    • (1993) Bioconjug. Chem. , vol.4 , pp. 372-379
    • Haensler, J.1    Szoka F.C., Jr.2
  • 64
    • 0025373701 scopus 로고
    • Starburst cascade polymers: Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter
    • D.A. Tomalia, A.M. Naylor and W.A. Goddard, Starburst cascade polymers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter, Angew. Chem. Int. Ed. Engl. 29 (1990) 138-175.
    • (1990) Angew. Chem. Int. Ed. Engl. , vol.29 , pp. 138-175
    • Tomalia, D.A.1    Naylor, A.M.2    Goddard, W.A.3
  • 65
    • 35348819496 scopus 로고
    • Dendrimers: Dream molecules approach real applications
    • R.F. Service, Dendrimers: dream molecules approach real applications, Science 267 (1995) 458-459.
    • (1995) Science , vol.267 , pp. 458-459
    • Service, R.F.1
  • 66
    • 0026315433 scopus 로고
    • Receptor-mediated gene delivery in vivo, Partial correction of genetic analbuminemia in Nagase rats
    • G.Y. Wu, J.M. Wilson, F. Shalaby, M. Grossman, D.A. Shafritz and C.H. Wu, Receptor-mediated gene delivery in vivo, Partial correction of genetic analbuminemia in Nagase rats, J. Biol. Chem. 266 (1991) 14338-14342.
    • (1991) J. Biol. Chem. , vol.266 , pp. 14338-14342
    • Wu, G.Y.1    Wilson, J.M.2    Shalaby, F.3    Grossman, M.4    Shafritz, D.A.5    Wu, C.H.6
  • 67
    • 0026502766 scopus 로고
    • Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits
    • J.M. Wilson, M. Grossman, C.H. Wu, N.R. Chowdhury, G.Y. Wu and J.R. Chowdhury, Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits, J. Biol. Chem. 267 (1992) 963-967.
    • (1992) J. Biol. Chem. , vol.267 , pp. 963-967
    • Wilson, J.M.1    Grossman, M.2    Wu, C.H.3    Chowdhury, N.R.4    Wu, G.Y.5    Chowdhury, J.R.6
  • 68
    • 0025891831 scopus 로고
    • Transferrin-polycation-DNA complexes: The effect of polycations on the structure of the complex and DNA delivery to cells
    • E. Wagner, M. Cotten, R. Foisner and M.L. Birnstiel, Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells, Proc. Natl. Acad. Sci. USA 88 (1991) 4255-4259.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4255-4259
    • Wagner, E.1    Cotten, M.2    Foisner, R.3    Birnstiel, M.L.4
  • 69
    • 0028430957 scopus 로고
    • Folate receptor mediated DNA delivery into tumor cells: Potosomal disruption results in enhanced gene expression
    • S. Gottschalk, R.J. Cristiano, L.C. Smith and S.L.C. Woo. Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression, Gene Ther. 1 (1994) 185-191.
    • (1994) Gene Ther. , vol.1 , pp. 185-191
    • Gottschalk, S.1    Cristiano, R.J.2    Smith, L.C.3    Woo, S.L.C.4
  • 70
    • 0028223310 scopus 로고
    • Gene transfer in vivo: Sustained expression and regulation of genes introduced into the liver receptor-targeted uptake
    • J.C. Perales, T. Ferkol, H. Beegen, O.D. Ratnoff and R.W. Hanson, Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver receptor-targeted uptake, Proc. Natl. Acad. Sci. USA 91 (1994) 4086-4090.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4086-4090
    • Perales, J.C.1    Ferkol, T.2    Beegen, H.3    Ratnoff, O.D.4    Hanson, R.W.5
  • 71
    • 0025949812 scopus 로고
    • Adenovirus enhancement of transferrin-polylysine-mediated gene delivery
    • D.T. Curiel, S. Agarwal, E. Wagner and M. Cotten, Adenovirus enhancement of transferrin-polylysine-mediated gene delivery, Proc. Natl. Acad. Sci. USA 88 (1991) 8850-8854.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8850-8854
    • Curiel, D.T.1    Agarwal, S.2    Wagner, E.3    Cotten, M.4
  • 72
    • 0026755818 scopus 로고
    • High-efficiency receptor-mediated delivery of small and large 48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles
    • M. Cotten, E. Wagner, K. Zatloukal, S. Phillips, D.T. Curiel and M.L. Birnstiel, High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles, Proc. Natl. Acad. Sci. USA 89 (1992) 6094-6098.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6094-6098
    • Cotten, M.1    Wagner, E.2    Zatloukal, K.3    Phillips, S.4    Curiel, D.T.5    Birnstiel, M.L.6
  • 73
    • 0026687453 scopus 로고
    • Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes
    • E. Wagner, K. Zatloukal, M. Cotten, H. Kirlappos, K. Mechtler, D.T. Curiel and M.L. Birnstiel, Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes, Proc. Natl. Acad. Sci. USA 89 (1992) 6099-6103.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6099-6103
    • Wagner, E.1    Zatloukal, K.2    Cotten, M.3    Kirlappos, H.4    Mechtler, K.5    Curiel, D.T.6    Birnstiel, M.L.7
  • 74
    • 0025042733 scopus 로고
    • Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA
    • R.A. Parente, S. Nir and F.C. Szoka, Jr., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA, Biochemistry 29 (1990) 8720-8728.
    • (1990) Biochemistry , vol.29 , pp. 8720-8728
    • Parente, R.A.1    Nir, S.2    Szoka F.C., Jr.3
  • 75
    • 0023488488 scopus 로고
    • Theory and practice of site-specific drug delivery
    • E. Tomlinson, Theory and practice of site-specific drug delivery, Adv. Drug Deliv. Rev. 1 (1987) 87-198.
    • (1987) Adv. Drug Deliv. Rev. , vol.1 , pp. 87-198
    • Tomlinson, E.1


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