Immunological myelin disruption does not alter expression of regeneration-associated genes in intact or axotomized rubrospinal neurons

Experimental Neurology

Volumn 163, Issue 1, 2000, Pages 149-156

  Hiebert, G W ^a   Dyer, J K ^a   Tetzlaff, W ^a   Steeves, J D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cell body response; GAP 43; Gene expression; Rat; Red nucleus; Spinal cord injury; Tubulin

Indexed keywords

ALPHA TUBULIN; MYELIN; NEUROMODULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; GENE EXPRESSION; IN SITU HYBRIDIZATION; MALE; NERVE FIBER; NERVE FIBER TRANSECTION; NERVE INJURY; NERVE REGENERATION; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; RAT; RED NUCLEUS; RUBROSPINAL TRACT; SPINAL CORD INJURY;

EID: 0034064957     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7351     Document Type: Article

References (54)

1. Andersen L. B., Schreyer D. J. Constitutive expression of GAP-43 correlates with rapid, but not slow regrowth of injured dorsal root axons in the adult rat. Exp. Neurol. 155:1999;157-164.
2. Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith K. A., Struhl K. Current Protocols in Molecular Biology. 1987;Wiley-Interscience, New York.
3. Becker T., Bernhardt R. R., Reinhard E., Wulliman M. F., Tongiorgi E., Melitta S. Readiness of zebrafish brain neurons to regenerate a spinal axon correlates with differential expression of specific cell recognition molecules. J. Neurosci. 18:1998;5789-5803.
4. Bisby M. A., Tetzlaff W. Changes in cytoskeletal protein synthesis following axon injury and during axon regeneration. Mol. Neurobiol. 6:1992;107-123.
5. Bisby M. A., Tetzlaff W., Brown M. C. GAP-43 mRNA in mouse motoneurons undergoing axonal sprouting in response to muscle paralysis or partial denervation. Eur. J. Neurosci. 8:1996;1240-1248.
6. Broude E., McAtee M., Kelley M. S., Bregman B. S. Fetal spinal cord transplants and exogenous neurotrophic support enhance c-Jun expression in mature axotomized neurons after spinal cord injury. Exp. Neurol. 155:1999;65-78.
7. Buffo A., Holtmaat A. J. D. G., Savio T., Verbeek J. S., Oberdick J., Oestreicher A. B., Gispen W. H., Verhaagen J., Rossi F., Strata P. Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting after growth-permissive transplants. J. Neurosci. 17:1997;8778-8791.
8. Caroni P. Intrinsic neuronal determinants that promote axonal sprouting and elongation. Bioessays. 19:1997;767-775.
9. Caroni P., Schwab M. E. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron. 1:1988;85-96.
10. Caroni P., Schwab M. E. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J. Cell Biol. 106:1988;1281-1288.
11. Cheng H., Cao Y., Olson L. Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function. Science. 273:1996;510-513.
12. Doster S. K., Lozano A. M., Aguayo A. J., Willard M. B. Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury. Neuron. 6:1991;635-647.
13. Dyer J. K., Bourque J. A., Steeves J. D. Regeneration of brain-stem spinal axons after immunological disruption of myelin in adult rat. Exp. Neurol. 154:1998;12-22.
14. Fan D. P., Kobayashi N. R., Tetzlaff W. Application of BDNF to the vicinity of rubrospinal neurons promotes regeneration into peripheral nerve grafts inserted into the thoracic spinal cord. Soc. Neurosci. Abstr. 23:1997;1450.
15. Fernandes K. J. L., Fan D.-P., Tsui B. J., Cassar S. L., Tetzlaff W. Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: Differential regulation of GAP-43, tubulins, and neurofilament-M. J. Comp. Neurol. 414:1999;495-510.
16. Filbin M. T. The muddle with MAG. Mol. Cell. Neurosci. 8:1996;84-92.
17. Gillen C., Gleichmann M., Spreyer P., Muller H. W. Differentially expressed genes after peripheral nerve injury. J. Neurosci. Res. 42:1995;159-171.
18. Gotzes S., Schmitt A. B., Schwaiger F. W., Hol E. M., Brook G. A., Horvat A., Kreutzburg G. W., Nacimiento W. Differential gene expression in the central and peripheral nervous system of the rat after axotomy. Soc. Neurosci. Abstr. 24:1999;66.
19. Guest J. D., Rao A., Olson L., Bunge M. B., Bunge R. P. The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord. Exp. Neurol. 148:1997;502-522.
20. Herdegen T., Skene P., Bahr M. The c-Jun transcription factor - Bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20:1997;227-231.
21. Huber A. B., Chen M. S., van der Haar M. E., Schwab M. E. Developmental expression pattern and functional analysis of NOGO (formerly NI-35/250), a major inhibitor of CNS regeneration. Soc. Neurosci. Abstr. 24:1998;1559.
22. Jenkins R., McMahon S. B., Bond A. B., Hunt S. P. Expression of c-Jun as a response to dorsal root and peripheral nerve section in damaged and adjacent intact primary sensory neurons in the rat. Eur. J. Neurosci. 5:1993;751-759.
23. Jenkins R., Tetzlaff W., Hunt S. P. Differential expression of immediate early genes in rubrospinal neurons following axotomy in rat. Eur. J. Neurosci. 5:1993;203-209.
24. Jones L. L., Kreutzberg G. W., Raivich G. Regulation of CD44 in the regenerating mouse facial motor nucleus. Eur. J. Neurosci. 9:1997;1854-1863.
25. Kapfhammer J. P., Schwab M. E. Inverse patterns of myelination and GAP-43 expression in the adult CNS: Neurite growth inhibitors as regulators of neuronal plasticity? J. Comp. Neurol. 340:1994;194-206.
26. Keirstead H. S., Dyer J. K., Sholomenko G. N., McGraw J., Delaney K. R., Steeves J. D. Axonal regeneration and physiological activity following transection and immunological disruption of myelin within the hatchling chick spinal cord. J. Neurosci. 15:1995;6963-6974.
27. Keirstead H. S., Hasan S. J., Muir G. D., Steeves J. D. Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord. Proc. Natl. Acad. Sci. USA. 89:1992;11664-11668.
28. Keirstead H. S., Hughes H. C., Blakemore W. F. A quantifiable model of axonal regeneration in the demyelinated adult rat spinal cord. Exp. Neurol. 151:1998;303-313.
29. Kobayashi N. R., Bedard A. M., Hincke M., Tetzlaff W. Increased expression of BDNF and trkB mRNA in rat facial motoneurons after axotomy. Eur. J. Neurosci. 8:1996;1018-1029.
30. Kobayashi N. R., Fan D. P., Giehl K. M., Bedard A. M., Wiegand S. J., Tetzlaff W. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and T alpha 1 tubulin mRNA expression and promote axonal regeneration. J. Neurosci. 17:1997;9583-9595.
31. Kuhn P. L., Cantrall J. L., Broude E., Bregman B. S. GAP-43 re-expression in red nucleus neurons after throacic spinal cord hemisection, transplantation, and exogenous neurotrophin administration in adult rats. Soc. Neurosci. Abstr. 24:1998;70.
32. Li Y., Field P. M., Raisman G. Regeneration of adult rat corticospinal axons induced by transplanted olfactory ensheathing cells. J. Neurosci. 18:1998;10514-10524.
33. McKerracher L., David S., Jackson D. L., Kottis V., Dunn R. J., Braun P. E. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron. 13:1994;805-811.
34. Meiri K. F., Saffell J. L., Walsh F. S., Doherty P. Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones. J. Neurosci. 18:1998;10429-10437.
35. Mukhopadhyay G., Doherty P., Walsh F. S., Crocker P. R., Filbin M. T. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron. 13:1994;757-767.
36. Muller H. W., Stoll G. Nerve injury and regeneration: Basic insights and therapeutic interventions. Curr. Opin. Neurol. 11:1998;557-562.
37. Pasterkamp R. J., De Winter F., Holtmaat A. J. G. D., Verhaagen J. Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons. J. Neurosci. 18:1998;9962-9976.
38. Pesheva P., Gennarini G., Goridis C., Schachner M. The F3/11 cell adhesion molecule mediates the repulsion of neurons by the extracellular matrix glycoprotein J1-160/180. Neuron. 10:1993;69-82.
39. Pesheva P., Spiess E., Schachner M. J1-160 and J1-180 are oligodendrocyte-secreted nonpermissive substrates for cell adhesion. J. Cell Biol. 109:1989;1765-1778.
40. Ramon-Cueto A., Plant G. W., Avila J., Bunge M. B. Long-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants. J. Neurosci. 18:1998;3803-3815.
41. Richardson P. M., Issa V. M. K., Aguayo A. J. Regeneration of long spinal axon in the rat. J. Neurocytol. 13:1984;165-182.
42. Schnell L., Schwab M. E. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature. 343:1990;269-272.
43. Schreyer D. J., Skene J. H. Injury-associated induction of GAP-43 expression displays axon branch specificity in rat dorsal root ganglion neurons. J. Neurobiol. 24:1993;959-970.
44. Smith D. S., Skene J. H. P. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. J. Neurosci. 17:1997;646-658.
45. Strittmatter S. M., Fankhauser C., Huang P. L., Mashimo H., Fishman M. C. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell. 80:1995;445-452.
46. Taylor J., Pesheva P., Schachner M. Influence of janusin and tenascin on growth cone behavior in vitro. J. Neurosci. Res. 35:1993;347-362.
47. Tetzlaff W., Alexander S. W., Miller F. D., Bisby M. A. Response of facial and rubrospinal neurons to axotomy: Change in mRNA expression for cytoskeletal proteins and GAP-43. J. Neurosci. 11:1991;2528-2544.
48. Tetzlaff W., Kobayashi N. R., Giehl K. M. G., Tsui B. j., Casar S. L., Bedard A. M. Response of rubrospinal and corticospinal neurons to injury and neurotrophins. Prog. Brain Res. 103:1994;271-286.
49. Verge V. M., Merlio J. P., Grondin J., Ernfors P., Persson H., Riopelle R. J., Hokfelt T., Richardson P. M. Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: Responses to injury and infusion of NGF. J. Neurosci. 12:1992;4011-4022.
50. Werner A., Mayer U., Kreutzburg G. W., Raivich G. Regulation of alpha-7-beta-1 integrin in the injured mouse nervous system. Soc. Neurosci. Abstr. 24:1998;1034.
51. Xiao M. X., Chen A., Guenard V., Kleitman N., Bunge M. B. Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord. J. Neurocytol. 26:1997;1-16.
52. Xu X. M., Guenard V., Kleitman N., Bunge M. B. Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord. J. Comp. Neurol. 351:1995;145-160.
53. Zagrebelsky M., Buffo A., Skerra A., Schwab M. E., Strata P., Rossi F. Retrograde regulation of growth-associated gene expression in adult rat Purkinje cells by myelin-associated neurite growth inhibitory proteins. J. Neurosci. 18:1998;7912-7929.
54. Zigmond R. E., Sun Y. Regulation of neuropeptide expression in sympathetic neurons: Paracrine and retrograde influences. Ann. N. Y. Acad. Sci. 814:1997;181-197.