Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC

DNA and Cell Biology

Volumn 19, Issue 2, 2000, Pages 121-130

  Maltais, Annie ^a,b   Labelle, Yves ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

ARTICLE; CELL PROLIFERATION; EXON; GENE EXPRESSION; GENE LOCUS; GENE STRUCTURE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TATA BOX;

EID: 0034059827     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454900314636     Document Type: Article

References (45)

1. Bandoh, S., Tsukada, T., Maruyama, K., Ohkura N., and Yamaguchi, K. (1997). Differential expression of NGFI-B and RNR-1 genes in various tissues and developing brain of the rat: Comparative study by quantitative reverse transcription-polymerase chain reaction. J. Neuroendocrinol. 9, 3-8.
2. Castillo, S.O., Qianxun, X., Lyu, M.S., Kozak, C.A., and Nikodem, V.M. (1997). Organization, sequence, chromosomal localization and promoter identification of the mouse orphan nuclear receptor NURR1 gene. Genomics 41, 250-257.
3. Cheng, L.E.-C., Chan, F.K.-M., Cado, D., and Winoto, A. (1997). Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 16, 1865-1875.
4. Clark, J., Benjamin, H., Gill, S., Sidhar, S., Goodwin, G., Crew, J., Gusterson, B.A., Shipley, J., and Cooper, C.S. (1996). Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene 12, 229-235.
5. Crawford, P.A., Sadovsky, Y., Woodson, K., Lee, S.L., and Milbrandt, J. (1995). Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol. Cell. Biol. 15, 4331-4336.
6. Danielsen, M., Hinck, L., and Ringold, G.M. (1989). Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor. Cell 57, 1131-1138.
7. Dynan, W.S., and Tjian, R. (1983). The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35, 79-87.
8. Enmark, E., and Gustafsson, J.-A. (1996). Orphan nuclear receptors - the first eight years. Mol. Endocrinol. 10, 1293-1307.
9. Gorski, D.H., Lepage, D.F., Patel, C.V., Copeland, N.G., Jenkins, N.A., and Walsh, K. (1993). Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells. Mol. Cell. Biol. 13, 3722-3733.
10. Hazel, T.G., Nathans, D., and Lau, L.F. (1988). A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc. Natl. Acad. Sci. USA 85, 8444-8448.
11. Hazel, T.G., Misra, R., Davis, I.J., Greenberg, M.E., and Lau, L.F. (1991). Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Mol. Cell. Biol. 11, 3239-3246.
12. Hedvat, C.V., and Irving, S.G. (1995). The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor. Mol. Endocrinol. 9, 1692-1700.
13. Heinemeyer, T., Chen, X., Karas, H., Kel, A.E., Kel, O.V., Liebich, I., Meinhardt, T., Reuter, I., Schacherer, F., and Wingender, E. (1999). Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res. 27, 318-322.
14. Hoeffler, J.P., Meyer, T.E., Yun, Y., Jameson, J.L., and Habener, J.F. (1988). Cyclic AMP-responsive DNA-binding protein: Structure based on a cloned placental cDNA. Science 242, 1430-1433.
15. Labelle, Y., Zucman, J., Stenman, G., Kindblom, L.-G., Knight, J., Turc-Carel, C., Dockhorn-Dworniczak, B., Mandahl, N., Desmaze, C., Peter, M., Aurias, A., Delattre, O., and thomas, G. (1995). Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. Hum. Mol. Genet. 4, 2219-2226.
16. Labelle, Y., Bussières, J., Courjal, F., and Goldring, M.B. (1999). The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. Oncogene 18, 3303-3308.
17. Lannoy, V.J., Burglin, T.R., Rousseau, G.G., and Lemaigre, F.P. (1998). Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins. J. Biol. Chem. 273, 13552-13562.
18. Lee, S.L., Wesselschmidt, R.L., Linette, G.P., Kanawaga, O., Russell, J.H., and Milbrandt, J. (1995). Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science 269, 532-535.
19. Lepage, D.F., Altomare, D.A., Testa, J.R., and Walsh, K. (1994). Molecular cloning and localization of the human GAX gene to 7p21. Genomics 24, 535-540.
20. Liu, Z.-G., Smith, S.W., Mclaughlin, K.A., Schwartz, L.M., and Osborne, B.A. (1994). Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 367, 281-284.
21. Lucero, M.A., Sanchez, D., Ochoa, A.R., Brunel, F., Cohen, G.N., Baralle, F.E., and Zarin, M.M. (1989). Interaction of DNA-binding proteins with the tissue-specific human apolipoprotein-AII enhancer. Nucleic Acids Res. 17, 2283-2300.
22. Mader, S. Kumar, V., de Vernevil, H., and Chambon, P. (1989). Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element. Nature 338, 271-274.
23. Milbrandt, J. (1988). Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1, 183-188.
24. Murphy, E.P., and Conneely, O.M. (1997). Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the Nurr1/nur77 subfamily of nuclear receptors. Mol. Endocrinol. 11, 39-47.
25. Ohkura, N., Hijikuro, M., Yamamoto, A., and Miki, K. (1994). Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem. Biophys. Res. Commun. 205, 1959-1965.
26. Ohkura, N., Ito, M., Tsukada, T., Sasaki, K., Yamaguchi, K., and Miki, K. (1998). Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA. Gene 211, 79-85.
27. Ohkura, N., Hosono, T., Maruyama, K., Tsukada, T., and Yamaguchi, K. (1999). An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B signaling family. Biochim. Biophys. Acta 1444, 69-79.
28. Perlmann, T., and Jansson, L. (1995). A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 9, 769-782.
29. Petropoulos, I., Part, D., Ochoa, A., Zakin, M.M., and Lamas, E. (1995). NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration. FEBS Lett. 372, 273-278.
30. Philips, A., Lesage, S., Gingras, R., Maira, M.-H., Gauthier, Y., Hugo, P., and Drouin, J. (1997). Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells. Mol. Cell. Biol. 17, 5946-5951.
31. Saucedo-Cardenas, O., Kardon, R., Ediger, T.R., Lydon, J.P., and Conneely, O. (1997). Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, Nurr1. Gene 187, 135-139.
32. Saucerdo-Cardenas, O., Quintina-Hau, J.D., Le, W.-D., Smidt, M.P., Cox, J.J., De Mayo, F., Burbach, J.P.H., and Conneely, O. (1998). Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95, 4013-4018.
33. Scearce, L.M., Laz, T.M., Hazel, T.G., Lau, L.F., and Taub, R. (1993). RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J. Biol. Chem. 268, 8855-8861.
34. Treisman, R. (1986). Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 46, 567-574.
35. Umesono, K., and Evans, R.M.(1989). Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57, 1139-1146.
36. Watson, M.A., and Milbrandt, J. (1989). The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: Genomic structure and expression in rat brain after seizure induction. Mol. Cell. Biol. 9, 4213-4219.
37. Wilson, T.E., Fahrner, T.J., Johnston, M., and Milbrandt, J. (1991). Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252, 1296-1300.
38. Wilson, T.E., Paulsen, R.E., Padgett, K.A., and Milbrandt, J. (1992). Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Science 256, 107-110.
39. Wilson, T.E., Mouw, A.R., Weaver, C.A., Milbrandt, J., and Parker, K.L. (1993). The orphan nuclear receptor NGFI-B regulates the expression of the gene encoding steroid 21-hydroxy-lase. Mol. Cell. Biol. 13, 861-868.
40. Woronicz, J.D., Calnan, B., Ngo, V., and Winoto, A. (1994). Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 367, 277-281.
41. Woronicz, J.D., Lina, A., Calnan, B.J., Szychowski, S., Cheng, L., and Winoto, A. (1995). Regulation of the Nurr77 orphan steroid receptor in activation-induced apoptosis. Mol. Cell. Biol. 15, 6364-6376.
42. Xiao, Q., Castillo, S.O., and Nikodem, V.M. (1996). Distribution of messenger RNAs for the orphan nuclear receptors NURR1 and NUR77(NGFI-B) in adult rat brain using in situ hybridization. Neuroscience 75, 221-230.
43. Zetterström, R.H., Solomin, L., Mitsiadis, T., Olson. L., and Perlmann, T. (1996a). Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1 and Nor1. Mol. Endocrinol. 10, 1656-1666.
44. Zetterström, R.H., Williams, R., Perlmann, T., and Olson, L. (1996b). Cellular expression of the immediate-early transcription factors NURR1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Mol. Brain Res. 41, 111-120.
45. Zetterström, R.H., Solomin, L., Jansson, L., Hoffer, B.J., Olson, L., and Perlmann, T. (1997). Dopamine neuron agenesis in Nurr1-deficient mice. Science 276, 248-250.