Intracellular signalling and antiviral effects of interferons

Digestive and Liver Disease

Volumn 32, Issue 3, 2000, Pages 257-263

  Heim, M H ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Interferon; Intracellular signalling

Indexed keywords

INTERFERON; JANUS KINASE; STAT PROTEIN; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHRONIC GRANULOMATOUS DISEASE; DRUG EFFECT; DRUG MECHANISM; DRUG RESISTANCE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT FAILURE; VIRUS HEPATITIS; VIRUS INTERFERENCE;

EID: 0034040417     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1590-8658(00)80831-2     Document Type: Article

References (70)

1. Allen G, Diaz MO, Nomenclature of the human interferon proteins. J Interferon Cytokine Res 1996;16:181-4.
2. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999;284:1835-7.
3. Pestka S, Langer JA, Zoon KC, Samuel CE. Interferons and their actions. Annu Rev Biochem 1987;56:727-77.
4. Uze G, Lutfalla G, Gesser I. Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell 1990;60:225-34.
5. Novick D, Cohen B, Rubinstein M. The human interferon alpha/beta receptor: characterization and molecular cloning. Cell 1994;77:391-400.
6. Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, et al. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J 1995;14:5100-8.
7. Aguet M, Dembic Z, Merlin G. Molecular cloning and expression of the human interferon-gamma receptor. Cell 1988;55:273-80.
8. Soh J, Donnelly RJ, Kotenko S, Mariano TM, Cook JR, Wang N, et al. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell 1994;76:793-802.
9. Hemmi S, Bohni R, Stark G, DiMarco F, Aguet M. A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell 1994;76:803+10.
10. Damell JE Jr, Kerr IM, Stark GR, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-21.
11. Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpux AG, et al. Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J Biol Chem 1994;269:1433-6.
12. Kotenko SV, Izotova LS, Pollack BP, Mariano TM, Donnelly RJ, Mutukumaran G, et al. Interaction between the components of the interferon gamma receptor complex. J Biol Chem 1995;270:20915-21.
13. Greenlund AC, Farrar MA, Viviano BL, Schreiber RD. Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J 1994;13:1591-600.
14. Heim MH, Kerr IM, Stark GR, Darnell JE Jr. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 1995;267:1347-9.
15. Shuai K, Stark GR, Kerr IM, Darnell JE Jr. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 1993;261:1744-6.
16. Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell JE Jr. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 1994;76:821-8.
17. Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-5.
18. Hilton DJ. Negative regulators of cytokine signal transduction. Cell Mol Life Sci 1999;55:1568-77.
19. Chung CD, Liao J, Liu B, Rao X, Jay P, Berta P, et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science 1997;278:1803-5.
20. Fu XY, Shindler C, Improta T, Aebersold R, Darnell JE Jr. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 1992;89:7840-3.
21. Reich N, Evans B, Levy D, Fahey D, Knight EJ, Darnell JE Jr. Inteferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci USA 1987;84:6394-8.
22. Heim MH. The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. J Recept Signal Transduct Res 1999;19:75-120.
23. Meraz MA, White JM, Sheehan KCF, Bach EA, Rodig SJ, Digne AS, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the Jak-Stat signaling pathway. Cell 1996;84:431-42.
24. Durbin JE, Hackenmiller R, Simon MO, Levy DE. Targeted disruption of the mouse Stat1 results in compromised innate immunity to viral disease. Cell 1996;84:443-50.
25. Horvath CM, Darnell JE Jr. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J Virol 1996;70:647-50.
26. Bromberg JF, Horvath CM, Wen ZL, Schreiber RD, Darnell JE. Transcriptionally Active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci USA 1996;93:7673-8.
27. Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-gamma. Annu Rev Immunol 1997;15:749-95.
28. Mach B, Steimle V, Martinez-Soria E, Reith W. Regulation of MHC class 1 genes: lessons from a disease. Annu Rev Immunol 1996;14:301-31.
29. Snapper CM, Paul WE. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987;236:944-7.
30. Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano J, Shapiro D, et al. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 1994;263:1612-5.
31. Govoni G, Vidal S, Cellier M, Lepage P, Malo D, Gros P. Genomic structure, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages. Genomics 1995;27:9-19.
32. Volanakis JE. Transcriptional regulation of complement genes. Annu Rev Immunol 1995;13:277-305.
33. Der SD, Zhou A, Williams BR, Silverman RH. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA 1998;95:15623-8.
34. Isaacs A, Lindenmann J. 1957 Virus interference. I. The interferon. J Interferon Res 1987;7:429-38.
35. Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, et al. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 1990;62:379-90.
36. Kerr IM, Brown RE. pppA2′p5′A2′p5′A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. Proc Natl Acad Sci USA 1978;75:256-60.
37. Carroll SS, Chen E, Viscount T, Geib J, Sardana MK, Gehman J, et al. Cleavage of oligoribonucleotides by the 2′,5′-oligoadenylate-dependenl ribonuclease L. J Biol Chem 1996;271:4988-92.
38. Hassel BA, Zhou A, Sotomayor C, Maran A, Silverman RH. A dominant negative mutant of 2-5A-dependent RNAse suppresses antiproliferative and antiviral effects of interferon. EMBO J 1993;12:3297-304.
39. Zhou A, Paranuape J, Brown TL, Nie H, Naik S, Dong B, et al. Interferon action and apoptosis are defective in mice devoid of 2′,5′-oligoadenylate-dependent RNAse L. EMBO J 1997;16:6355-63.
40. Arnheiter H, Frese M, Kambadur R, Meier E, Haller O. Mx transgenic mice - animal models of health. Curr Top Microbiol Immunol 1996;206:119-47.
41. Ploegh HL. Viral strategies of immune evasion. Science 1998;280:248-53.
42. Cerny A, Chisari FV. Pathogenesis of chronic hepatitis G: immunological features of hepatic injury and viral persistence. Hepatology 1999;30:595-601.
43. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995;96:224-30.
44. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996;334:77-81.
45. Squadrito G, Leone F, Sartori M, Nalpas B, Berthelot P, Raimondo G, et al. Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa. Gastroenterology 1997;113:567-72.
46. Hofgartner WT, Polyak SJ, Sullivan DG, Carithers RL Jr, Gretch DR. Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b. J Med Virol 1997;53:118-26.
47. Gale MJ Jr, Korth MJ, Tang NM, Tan S-L, Hopkins DA, Dever TE, et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5 A protein. Virology 1997;230:217-27.
48. Gale M Jr, Blakely CM, Kwieciszewski B, Tan SL, Dossett M, Tang NM, et al. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol 1998;18:5208-18.
49. Polyak SJ, Paschal DM, McArdle S, Gale MJ Jr, Moradpour D, Gretch DR. Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication. Hepatology 1999;29:1262-71.
50. Song J, Fujii M, Wang F, Itoh M, Hotta H. The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon. J Gen Virol 1999;80:879-86.
51. Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 1999;285:107-10.
52. Heim MH, Moradpour D, Blum HE. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J Virol 1999;73:8469-75.
53. Moradpour D, Kary P, Rice CM, Blum HE. Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins. Hepatology 1998;28:192-201.
54. Foster GR, Ackrill AM, Goldin RD, Kerr IM, Thomas HC, Stark GR. Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA. Proc Natl Acad Sci USA 1991;88:2888-92.
55. Pansky A, Hildebrand P, Fasler-Kan E, Baselgia L, Ketterer S, Beglinger C, et al. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha. Int J Cancer 2000;85:720-5.
56. Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998;93:373-83.
57. Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hepatopoiesis. Cell 1998;93:397-409.
58. Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998;93:385-95.
59. Nosaka T, Vandeursen JMA, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, et al. Defective lymphoid development in mice lacking Jak2. Science 1995;270:800-2.
60. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995;270:794-7.
61. Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 1997;94:3801-4.
62. Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired Il-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996;382:174-7.
63. Thierfelder WE, Vandeursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996;382:171-4.
64. Liu XW, Robinson GW, Wagner KU, Garret L, Wynshawboris A, Hennighausen L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 1997;11:179-86.
65. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, et al. Requirement of STATSb for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 1997;94:7239-44.
66. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998;93:841-50.
67. Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, et al. Stat5 is required for IL-2-induced cell cycle progression peripheral T cells. Immunity 1999;10:249-59.
68. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to Il-4 and for the development of Th2 cells. Immunity 1996;4:313-9.
69. Shimoda K, Vandeursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, et al. Lack of Il-4-induced Th2. Response and Ige class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-3.
70. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, et al. Essential role of Stat6 in Il-4 signalling. Nature 1996;380:627-30.