The multidrug-resistant human lung tumour cell line, DLKP-A10, expresses novel drug accumulation and sequestration systems

Biochemical Pharmacology

Volumn 53, Issue 10, 1997, Pages 1493-1502

  Cleary, Irene ^a   Doherty, Gerard ^a   Moran, Elizabeth ^a   Clynes, Martin ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Antimycin A; Drug accumulation; Monensin; Multidrug resistance; P glycoprotein; Subcellular distribution

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; ANTINEOPLASTIC AGENT; CARBOPLATIN; CARRIER PROTEIN; CYCLOSPORIN A; DEOXYGLUCOSE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GLYCOPROTEIN P; IONOPHORE; MONENSIN; NIGERICIN; SODIUM AZIDE; VERAPAMIL; VINCRISTINE;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LUNG TUMOR; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CALCIUM CHANNEL BLOCKERS; CYCLOSPORINE; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG NEOPLASMS; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED; VERAPAMIL; VINCRISTINE;

EID: 0030844320     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00003-8     Document Type: Article

References (31)

1. Wang J, DNA topoisomerases. Ann Rev Biochem 54: 664-697, 1985.
2. Takano H, Kohno K, Matsuo K, Matsuda T and Kuwano M, DNA topoisomerase II-targerting antitumour agents and drug resistance. Anticancer Drugs 3: 323-330, 1992.
3. Moscow J and Dixon H, Glutathione related enzymes, glutathione and multidrug resistance. Cytotechnology 12: 155-170, 1993.
4. Fojo A, Akiyama S, Gottesman M and Pastan I, Reduced drug accumulation in multidrug resistant human KB carcinoma cell lines. Cancer Res 45: 3002-3007, 1985.
5. Willingham M, Cornwell M, Cadarelli C, Gottesman M and Pastan I, Single cell analysis of daunorubicin uptake and efflux in multidrug-resistant and sensitive KB cells: Effect of verapamil and other drugs. Cancer Res 46: 5941-5946, 1986.
6. Endicott J and Ling V, The biochemistry of P-glycoprotein mediated multidrug resistance. Ann Rev Biochem 58: 137-171, 1989.
7. Ling V, P-glycoprotein and resistance to anticancer drugs. Cancer 69: 2603-2609, 1992.
8. Hindenburg A, Baker M, Gleyzer E, Stewart V, Case N and Taub R, Effect of verapamil and other agents on the distribution of anthracyclines and on reversal of drug resistance. Cancer Res 47: 1421-1425, 1987.
9. Barrand M, Rhodes T, Center M and Twentyman P, Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190 k membrane protein distinct from P-glycoprotein. Eur J Cancer 29A: 408-415, 1993.
10. Loe D, Deeley R and Cole S, Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 32A: 6, 945-957, 1996.
11. Scheper R, Broxterman H, Scheffer G, Kaaijk P, Dalton W, Van Heijningen T, Van Kallen C, Slovak M, de Vries E, Van der Valk P, Meijer C and Pinedo H, Overexpression of Mr 110,000 vesicular protein in non P-glycoprotein-mediated multidrug resistance. Cancer Res 53: 1475-1479, 1993.
12. Law E, Gilvarry U, Lynch V, Gregory B, Grant G and Clynes M, Cytogenetic comparison of two poorly differentiated human lung squamous cell carcinoma lines. Cancer Genet Cytogenet, 59: 111-118, 1992.
13. Clynes M, Redmond A, Moran E and Gilvarry U, Multiple drug resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A. Cytotechnology, 10: 75-89, 1992.
14. Martin A and Clynes M, Acid-phosphatase endpoint for in vitro toxicity testing. In Vitro Dev Biol, 27A: 183-184, 1991.
15. Gerlach JH, Bell DR, Karakousis C, Slocum HM, Kartner N, Rustum YM, Ling V and Baker RM, P-glycoprotein in human sarcoma: Evidence for multidrug resistance. J Clin Oncol, 5: 1452-1460, 1987.
16. Smith P, Krohn R, Hermanson G, Mallia A, Gartner F, Provenzano M, Fujimoto E, Goeke N, Olson B and Klenk D, Measurement of protein using bicinchoninic acid. Anal Biochem, 150: 76-85, 1985.
17. Laemmli UK, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond), 227: 680-685, 1970.
18. Towbin H, Staehelin T and Gordon J, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedures and some applications. Proc Natl Acad Sci USA, 76: 4350-4354, 1979.
19. Ganapathi R and Grabowski D, Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluroperazine. Cancer Res, 43: 3696-3699, 1983.
20. Friche E, Skovsgaard T and Nissen N, Effect of verapamil on daunorubicin accumulation in Ehrlich ascites tumor cells. Cancer Chemother Pharmacol, 19: 35-39, 1987.
21. Cleary I, Grant G, Moran E, Doherty G, O'Driscoll D and Clynes M, Adriamycin transport studies in a MDR human bladder carcinoma cell line. Exp & Clin Cancer Res, 14: 55-57, 1995.
22. Simon S, Roy D and Schlindler M, Intracellular pH and the control of multidrug resistance. Proc Natl Acad Sci USA, 91: 1128-1132, 1994.
23. Klohs W and Steinkampt R, The effect of lysosomotropic agents and secretory inhibitors on adriamycin retention and activity in multidrug-resistant cells. Mol Pharmacol, 34: 180-185, 1988.
24. Sehested M, Stovsgaard T and Roed H, The carboxylic ionophore monensin inhibits active drug efflux and modulates in vitro resistant Ehrlich ascites tumor cells. Biochem Pharmacol, 37: 3305-3310, 1988.
25. Marquardt D and Center M, Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: Evidence for nuclear drug accumulation and redistribution in resistant cells. Cancer Res, 52: 3157-3163, 1992.
26. Ling YH, Priebe W and Perez-Soler R, Intrinsic cytotoxicity and reversal of multidrug resistance by monensin in KB parent and MDR cells. Int J Oncol, 3: 971-977, 1993.
27. Naito M, Hoshino T, Matsushita Y, Hirai R and Tsuruo T, Two types of interaction between P-glycoprotein and ionophore antibiotics. J Cell Pharmacol, 2: 263-267, 1991.
28. Borrel M, Pereira E, Fiallo M and Garnier-Suillerot A, Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effect of ionophores on 4′-0-tetrahydrophranyladriamycin incorporation in K562 drug resistant cells. Eur J Boichem, 223: 125-133, 1994.
29. Sehested M, Stovsgaard T, van Deurs B and Winter-Nielsen H, Increase in nonspecific absorptive endocytosis in anthracycline and vinca alkaloid resistant Ehrlich ascites tumor cell lines. J Natl Cancer Inst, 78: 171-176, 1987.
30. Beck W, The cell biology of multidrug resistance. Biochem Pharmacol, 36: 2887-2897, 1987.
31. Meschini S, Molinari A, Calcabrini A, Citro G and Arancia G, Intracellular localisation of the anticancer drug adriamycin in living cultured cells: A confocal microscopy study. J Microscopy, 176: 204-210, 1994.